Trib1 (tribbles pseudokinase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Trib1 (tribbles pseudokinase 1) Rattus norvegicus
Analyze
Symbol: Trib1
Name: tribbles pseudokinase 1
RGD ID: 621596
Description: Predicted to enable several functions, including enzyme binding activity; transcription regulator inhibitor activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in several processes, including negative regulation of signal transduction; regulation of myeloid leukocyte differentiation; and regulation of primary metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TRIB1 (tribbles pseudokinase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein-coupled receptor induced protein GIG2; Gig2; tribbles homolog 1; tribbles homolog 1 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8793,096,001 - 93,102,547 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl793,095,973 - 93,117,480 (+)EnsemblGRCr8
mRatBN7.2791,206,579 - 91,213,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl791,206,579 - 91,214,731 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx793,092,395 - 93,098,946 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0795,293,606 - 95,300,157 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0795,125,539 - 95,132,086 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,954,492 - 99,961,026 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,954,492 - 99,961,026 (+)Ensemblrn6Rnor6.0
Rnor_5.07100,534,391 - 100,540,925 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4796,442,239 - 96,448,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera787,967,385 - 87,973,931 (+)NCBICelera
RGSC_v3.1796,477,093 - 96,482,772 (+)NCBI
Cytogenetic Map7q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fentin chloride  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylseleninic acid  (ISO)
mitoxantrone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trametinib  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Information Derived from GenBank Report RGD, Sept. 2003
10. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
Additional References at PubMed
PMID:8889548   PMID:15299019   PMID:17452330   PMID:17724128   PMID:20410507   PMID:23515163  


Genomics

Comparative Map Data
Trib1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8793,096,001 - 93,102,547 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl793,095,973 - 93,117,480 (+)EnsemblGRCr8
mRatBN7.2791,206,579 - 91,213,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl791,206,579 - 91,214,731 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx793,092,395 - 93,098,946 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0795,293,606 - 95,300,157 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0795,125,539 - 95,132,086 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0799,954,492 - 99,961,026 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl799,954,492 - 99,961,026 (+)Ensemblrn6Rnor6.0
Rnor_5.07100,534,391 - 100,540,925 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4796,442,239 - 96,448,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera787,967,385 - 87,973,931 (+)NCBICelera
RGSC_v3.1796,477,093 - 96,482,772 (+)NCBI
Cytogenetic Map7q33NCBI
TRIB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388125,430,358 - 125,438,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8125,430,358 - 125,438,403 (+)Ensemblhg38GRCh38
GRCh378126,442,600 - 126,450,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,511,745 - 126,519,827 (+)NCBIBuild 36Build 36hg18NCBI36
Build 348126,511,744 - 126,519,824NCBI
Celera8122,631,533 - 122,639,615 (+)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8121,766,406 - 121,774,484 (+)NCBIHuRef
CHM1_18126,482,807 - 126,490,884 (+)NCBICHM1_1
T2T-CHM13v2.08126,563,804 - 126,571,849 (+)NCBIT2T-CHM13v2.0
Trib1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391559,520,503 - 59,528,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1559,520,199 - 59,528,948 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381559,648,654 - 59,657,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1559,648,350 - 59,657,099 (+)Ensemblmm10GRCm38
MGSCv371559,480,209 - 59,488,654 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361559,478,335 - 59,486,780 (+)NCBIMGSCv36mm8
Celera1561,178,271 - 61,186,716 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1525.41NCBI
Trib1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955461494,003 - 501,990 (+)Ensembl
ChiLan1.0NW_004955461494,003 - 501,928 (+)NCBIChiLan1.0ChiLan1.0
TRIB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27142,852,443 - 142,860,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18118,364,202 - 118,371,720 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08122,115,194 - 122,123,319 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18124,867,334 - 124,874,863 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8124,867,359 - 124,872,924 (+)EnsemblpanPan2panpan1.1
TRIB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11323,337,788 - 23,346,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1323,337,788 - 23,346,304 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1323,310,655 - 23,319,064 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01323,683,492 - 23,691,935 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1323,682,916 - 23,691,935 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11323,404,842 - 23,413,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01323,511,711 - 23,520,081 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01323,755,679 - 23,764,091 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trib1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530314,975,282 - 14,983,509 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647022,401,379 - 22,409,490 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647022,401,713 - 22,408,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl414,289,751 - 14,297,663 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1414,289,739 - 14,298,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRIB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18120,013,757 - 120,021,823 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8120,014,339 - 120,019,887 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603920,151,213 - 20,159,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trib1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473529,879,310 - 29,888,305 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473529,880,732 - 29,888,117 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Trib1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11234,161,260 - 234,169,234 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trib1
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:49
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000005885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH134126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,205,354 - 91,205,535 (+)MAPPERmRatBN7.2
Rnor_6.0799,953,268 - 99,953,448NCBIRnor6.0
Rnor_5.07100,533,167 - 100,533,347UniSTSRnor5.0
RGSC_v3.4796,441,015 - 96,441,195UniSTSRGSC3.4
Celera787,966,161 - 87,966,341UniSTS
RH 3.4 Map7651.28UniSTS
Cytogenetic Map7q33UniSTS
RH143669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,206,640 - 91,206,831 (+)MAPPERmRatBN7.2
Rnor_6.0799,954,554 - 99,954,744NCBIRnor6.0
Rnor_5.07100,534,453 - 100,534,643UniSTSRnor5.0
RGSC_v3.4796,442,301 - 96,442,491UniSTSRGSC3.4
Celera787,967,447 - 87,967,637UniSTS
RH 3.4 Map7651.9UniSTS
Cytogenetic Map7q33UniSTS
BE100119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2791,213,351 - 91,213,532 (+)MAPPERmRatBN7.2
Rnor_6.0799,961,252 - 99,961,432NCBIRnor6.0
Rnor_5.07100,541,151 - 100,541,331UniSTSRnor5.0
RGSC_v3.4796,449,011 - 96,449,191UniSTSRGSC3.4
Celera787,974,157 - 87,974,337UniSTS
Cytogenetic Map7q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 355 192 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005885   ⟹   ENSRNOP00000005885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl793,095,973 - 93,117,480 (+)Ensembl
mRatBN7.2 Ensembl791,206,579 - 91,213,126 (+)Ensembl
Rnor_6.0 Ensembl799,954,492 - 99,961,026 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105083   ⟹   ENSRNOP00000088193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl793,095,973 - 93,104,127 (+)Ensembl
mRatBN7.2 Ensembl791,210,314 - 91,214,731 (+)Ensembl
RefSeq Acc Id: NM_023985   ⟹   NP_076475
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8793,096,001 - 93,102,547 (+)NCBI
mRatBN7.2791,206,579 - 91,213,126 (+)NCBI
Rnor_6.0799,954,492 - 99,961,026 (+)NCBI
Rnor_5.07100,534,391 - 100,540,925 (+)NCBI
RGSC_v3.4796,442,239 - 96,448,785 (+)RGD
Celera787,967,385 - 87,973,931 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_076475 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG35664 (Get FASTA)   NCBI Sequence Viewer  
  EDM16196 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005885.5
  ENSRNOP00000088193
  ENSRNOP00000088193.2
RefSeq Acc Id: NP_076475   ⟸   NM_023985
- UniProtKB: G3V6J8 (UniProtKB/TrEMBL),   Q9EQL6 (UniProtKB/TrEMBL),   A6HRM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005885   ⟸   ENSRNOT00000005885
Ensembl Acc Id: ENSRNOP00000088193   ⟸   ENSRNOT00000105083
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6J8-F1-model_v2 AlphaFold G3V6J8 1-372 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695360
Promoter ID:EPDNEW_R5884
Type:initiation region
Name:Trib1_1
Description:tribbles pseudokinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0799,954,592 - 99,954,652EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621596 AgrOrtholog
BioCyc Gene G2FUF-33279 BioCyc
Ensembl Genes ENSRNOG00000004100 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005885.7 UniProtKB/TrEMBL
  ENSRNOT00000105083 ENTREZGENE
  ENSRNOT00000105083.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  TRB1 UniProtKB/TrEMBL
  Tribbles/Ser_Thr_kinase_40 UniProtKB/TrEMBL
KEGG Report rno:78969 UniProtKB/TrEMBL
NCBI Gene 78969 ENTREZGENE
PANTHER PTHR22961 UniProtKB/TrEMBL
  PTHR22961:SF17 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Trib1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004100 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6A5Q0_RAT UniProtKB/TrEMBL
  A6HRM6 ENTREZGENE, UniProtKB/TrEMBL
  G3V6J8 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Trib1  tribbles pseudokinase 1  Trib1  tribbles homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Trib1  tribbles homolog 1 (Drosophila)  Gig2  G-protein-coupled receptor induced protein GIG2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gig2  G-protein-coupled receptor induced protein GIG2      Symbol and Name status set to provisional 70820 PROVISIONAL