Tpp2 (tripeptidyl peptidase 2) - Rat Genome Database

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Gene: Tpp2 (tripeptidyl peptidase 2) Rattus norvegicus
Analyze
Symbol: Tpp2
Name: tripeptidyl peptidase 2
RGD ID: 621584
Description: Enables peptide binding activity and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TPP-2; TPP-II; tripeptidyl aminopeptidase; tripeptidyl peptidase II; tripeptidyl-peptidase 2; tripeptidyl-peptidase II; tripeptidylpeptidase II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,538,788 - 53,620,253 (+)NCBIGRCr8
mRatBN7.2946,046,712 - 46,128,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,558,681 - 54,643,682 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,681,484 - 59,766,488 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,961,710 - 58,046,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,664,048 - 50,744,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0950,578,868 - 50,628,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,244,904 - 50,293,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0950,328,059 - 50,409,442 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,984,834 - 43,066,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,986,247 - 43,067,609 (+)NCBI
Celera943,759,380 - 43,840,712 (+)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methidathion  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
propanal  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
vanadyl sulfate  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Wray CJ, etal., Biochem Biophys Res Commun 2002 Aug 9;296(1):41-7.
Additional References at PubMed
PMID:8602240   PMID:9668046   PMID:11062501   PMID:22483107   PMID:22871113   PMID:25095668  


Genomics

Comparative Map Data
Tpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,538,788 - 53,620,253 (+)NCBIGRCr8
mRatBN7.2946,046,712 - 46,128,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx954,558,681 - 54,643,682 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0959,681,484 - 59,766,488 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0957,961,710 - 58,046,719 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0950,664,048 - 50,744,803 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0950,578,868 - 50,628,943 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,244,904 - 50,293,192 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0950,328,059 - 50,409,442 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4942,984,834 - 43,066,195 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1942,986,247 - 43,067,609 (+)NCBI
Celera943,759,380 - 43,840,712 (+)NCBICelera
Cytogenetic Map9q22NCBI
TPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,596,986 - 102,679,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,596,958 - 102,679,958 (+)EnsemblGRCh38hg38GRCh38
GRCh3713103,249,336 - 103,332,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,047,374 - 102,129,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413102,047,373 - 102,129,522NCBI
Celera1384,091,643 - 84,173,864 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1383,841,839 - 83,924,038 (+)NCBIHuRef
CHM1_113103,218,763 - 103,300,981 (+)NCBICHM1_1
T2T-CHM13v2.013101,812,992 - 101,895,917 (+)NCBIT2T-CHM13v2.0
Tpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39143,973,130 - 44,042,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl143,972,807 - 44,042,160 (+)EnsemblGRCm39 Ensembl
GRCm38143,933,970 - 44,003,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl143,933,647 - 44,003,000 (+)EnsemblGRCm38mm10GRCm38
MGSCv37143,990,852 - 44,059,816 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36143,878,553 - 43,947,517 (+)NCBIMGSCv36mm8
Celera144,277,065 - 44,346,020 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.5NCBI
Tpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,463,715 - 8,528,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,465,877 - 8,528,372 (-)NCBIChiLan1.0ChiLan1.0
TPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,113,261 - 104,195,967 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113102,781,660 - 102,863,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01383,756,757 - 83,838,997 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113102,892,037 - 102,974,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13102,892,037 - 102,974,974 (+)Ensemblpanpan1.1panPan2
TPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,105,821 - 52,176,213 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,105,886 - 52,175,426 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2251,885,525 - 51,955,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,556,648 - 52,627,124 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,556,638 - 52,627,381 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,205,955 - 52,276,357 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,222,152 - 52,292,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,263,035 - 52,333,679 (+)NCBIUU_Cfam_GSD_1.0
Tpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,513,772 - 187,581,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,369,736 - 8,438,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,370,607 - 8,438,376 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1170,943,141 - 71,009,627 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11170,943,142 - 71,009,381 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,219,920 - 78,323,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,151,769 - 81,234,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,151,801 - 81,236,235 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,688,665 - 37,771,717 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,779,967 - 8,848,539 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,782,956 - 8,848,547 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpp2
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:156
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000015393
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
RH134792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2946,127,914 - 46,128,118 (+)MAPPERmRatBN7.2
Rnor_6.0950,744,561 - 50,744,764NCBIRnor6.0
Rnor_5.0950,409,200 - 50,409,403UniSTSRnor5.0
RGSC_v3.4943,065,953 - 43,066,156UniSTSRGSC3.4
Celera943,840,470 - 43,840,673UniSTS
RH 3.4 Map9392.19UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015393   ⟹   ENSRNOP00000015393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,046,632 - 46,128,156 (+)Ensembl
Rnor_6.0 Ensembl950,664,150 - 50,744,002 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078220   ⟹   ENSRNOP00000074045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,046,632 - 46,128,157 (+)Ensembl
Rnor_6.0 Ensembl950,581,234 - 50,744,803 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085267   ⟹   ENSRNOP00000074556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl946,046,734 - 46,127,485 (+)Ensembl
Rnor_6.0 Ensembl950,581,247 - 50,743,999 (+)Ensembl
RefSeq Acc Id: NM_031137   ⟹   NP_112399
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,892 - 53,620,253 (+)NCBI
mRatBN7.2946,046,805 - 46,128,157 (+)NCBI
Rnor_6.0950,664,137 - 50,744,803 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
RGSC_v3.4942,984,834 - 43,066,195 (+)RGD
Celera943,759,380 - 43,840,712 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244852   ⟹   XP_006244914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,620,253 (+)NCBI
mRatBN7.2946,046,712 - 46,128,157 (+)NCBI
Rnor_6.0950,664,048 - 50,744,803 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244853   ⟹   XP_006244915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,615,206 (+)NCBI
mRatBN7.2946,046,712 - 46,123,161 (+)NCBI
Rnor_6.0950,664,048 - 50,739,548 (+)NCBI
Rnor_5.0950,328,059 - 50,409,442 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063267773   ⟹   XP_063123843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8953,538,788 - 53,606,626 (+)NCBI
RefSeq Acc Id: NP_112399   ⟸   NM_031137
- UniProtKB: Q64560 (UniProtKB/Swiss-Prot),   A6INR9 (UniProtKB/TrEMBL),   A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244915   ⟸   XM_006244853
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244914   ⟸   XM_006244852
- Peptide Label: isoform X1
- UniProtKB: A6INR8 (UniProtKB/TrEMBL),   A0A8L2R9L9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074556   ⟸   ENSRNOT00000085267
Ensembl Acc Id: ENSRNOP00000074045   ⟸   ENSRNOT00000078220
Ensembl Acc Id: ENSRNOP00000015393   ⟸   ENSRNOT00000015393
RefSeq Acc Id: XP_063123843   ⟸   XM_063267773
- Peptide Label: isoform X3
Protein Domains
Peptidase S8   Peptidase S8/S53   Tripeptidyl peptidase II C-terminal   Tripeptidyl peptidase II second Ig-like   Tripeptidyl-peptidase II first Ig-like   Tripeptidyl-peptidase II galactose-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64560-F1-model_v2 AlphaFold Q64560 1-1249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696642
Promoter ID:EPDNEW_R7166
Type:initiation region
Name:Tpp2_1
Description:tripeptidyl peptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0950,664,085 - 50,664,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621584 AgrOrtholog
BioCyc Gene G2FUF-27661 BioCyc
Ensembl Genes ENSRNOG00000011194 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015393.6 UniProtKB/TrEMBL
  ENSRNOT00000078220.2 UniProtKB/TrEMBL
  ENSRNOT00000085267.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.710 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.25.690 UniProtKB/TrEMBL
  2.60.40.3170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.3080 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8A_TPPII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP_II_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_C_art UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_GBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_Ig-like-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_Ig-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81815 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81815 ENTREZGENE
PANTHER PEPTIDASE S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIPEPTIDYL-PEPTIDASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_GBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPPII_Ig-like-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpp2 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011194 RatGTEx
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q8D6_RAT UniProtKB/TrEMBL
  A0A8L2R8U1_RAT UniProtKB/TrEMBL
  A0A8L2R9L9 ENTREZGENE, UniProtKB/TrEMBL
  A6INR8 ENTREZGENE, UniProtKB/TrEMBL
  A6INR9 ENTREZGENE, UniProtKB/TrEMBL
  Q64560 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tpp2  tripeptidyl peptidase 2  Tpp2  tripeptidyl peptidase II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tpp2  tripeptidyl peptidase II    tripeptidylpeptidase II  Name updated 1299863 APPROVED
2002-08-07 Tpp2  tripeptidylpeptidase II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activity and expression are increased in skeletal muscle during sepsis 634435