Vdac2 (voltage-dependent anion channel 2) - Rat Genome Database

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Gene: Vdac2 (voltage-dependent anion channel 2) Rattus norvegicus
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Symbol: Vdac2
Name: voltage-dependent anion channel 2
RGD ID: 621576
Description: Predicted to enable several functions, including phosphatidylcholine binding activity; phospholipid scramblase activity; and sterol binding activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; mitochondrial outer membrane permeabilization; and negative regulation of intrinsic apoptotic signaling pathway. Located in synaptic vesicle. Used to study myocardial infarction. Biomarker of temporal lobe epilepsy. Orthologous to human VDAC2 (voltage dependent anion channel 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; Huntington's disease pathway; Parkinson's disease pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B36-VDAC; non-selective voltage-gated ion channel VDAC2; outer mitochondrial membrane protein porin 2; VDAC-2; voltage-dependent anion-selective channel protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,512,214 - 2,526,105 (-)NCBIGRCr8
mRatBN7.2152,462,877 - 2,476,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,463,056 - 2,476,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,470,328 - 2,484,006 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,856,774 - 3,870,452 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,469,123 - 2,482,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,634,622 - 2,648,548 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,634,624 - 2,648,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,615,635 - 2,629,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4152,515,297 - 2,528,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1152,515,298 - 2,528,969 (-)NCBI
Celera152,105,517 - 2,119,199 (+)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Qualifier
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Notes
Source
Original Reference(s)
Vdac2RatBurns  IEP 10003047 RGD 
Vdac2RatExperimental Seizures treatmentIDA 10003051 RGD 
Vdac2Ratmyocardial infarction treatmentIDA 10003049 RGD 
Vdac2Rattemporal lobe epilepsy  IEP 10003053protein:increased expression:hippocampusRGD 
Object Symbol
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Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Vdac2RatGenitopatellar Syndrome  ISOVDAC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Genitopatellar syndromeClinVarPMID:22077973 more ...
Vdac2Ratsevere combined immunodeficiency  ISOVDAC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Severe combined immunodeficiency diseaseClinVarPMID:25741868
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Original Reference(s)
Vdac2RatDiabetic Nephropathies  ISOVDAC2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19634143
Vdac2Ratepilepsy  ISOVDAC2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17893921
Vdac2RatMouth Neoplasms  ISOVDAC2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15274141
Vdac2Ratosteoarthritis  ISOVDAC2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066
Vdac2Ratsquamous cell carcinoma  ISOVDAC2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15274141

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Original Reference(s)
Vdac2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOVDAC2 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of VDAC2 mRNACTDPMID:22079256
Vdac2Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of VDAC2 proteinCTDPMID:17337753
Vdac2Rat1,2-dimethylhydrazine decreases expressionISOVdac2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of VDAC2 mRNACTDPMID:22206623
Vdac2Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOVdac2 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Vdac2Rat2,2,2-tetramine multiple interactionsEXP 6480464Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC2 protein]CTDPMID:19634143
Vdac2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOVdac2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of VDAC2 mRNACTDPMID:21570461
Vdac2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of VDAC2 mRNACTDPMID:34747641
Vdac2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of VDAC2 proteinCTDPMID:17998243
Vdac2Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of VDAC2 mRNACTDPMID:21346803
Vdac2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOVDAC2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of VDAC2 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of VDAC2 mRNACTDPMID:28628672
Vdac2Rat4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid multiple interactionsISOVDAC2 (Homo sapiens)64804644 more ...CTDPMID:29229420
Vdac2Rat4,4'-sulfonyldiphenol increases expressionISOVdac2 (Mus musculus)6480464bisphenol S results in increased expression of VDAC2 mRNACTDPMID:39298647
Vdac2Rat4,4'-sulfonyldiphenol increases expressionISOVDAC2 (Homo sapiens)6480464bisphenol S results in increased expression of VDAC2 proteinCTDPMID:34186270
Vdac2Rat4,4'-sulfonyldiphenol multiple interactionsISOVDAC2 (Homo sapiens)6480464[bisphenol S co-treated with Fulvestrant] results in increased methylation of VDAC2 geneCTDPMID:31601247
Vdac2Rat4-hydroxynon-2-enal affects bindingISOVDAC2 (Homo sapiens)6480464VDAC2 protein binds to 4-hydroxy-2-nonenalCTDPMID:20043646
Vdac2Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of VDAC2 mRNACTDPMID:30047161
Vdac2Rataconitine decreases expressionEXP 6480464Aconitine results in decreased expression of VDAC2 proteinCTDPMID:33236894
Vdac2Ratall-trans-retinoic acid decreases expressionISOVdac2 (Mus musculus)6480464Tretinoin results in decreased expression of VDAC2 mRNACTDPMID:16604517
Vdac2Ratall-trans-retinoic acid decreases expressionISOVDAC2 (Homo sapiens)6480464Tretinoin results in decreased expression of VDAC2 mRNACTDPMID:33167477
Vdac2Ratamiodarone increases expressionISOVdac2 (Mus musculus)6480464Amiodarone results in increased expression of VDAC2 mRNACTDPMID:24489787

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Biological Process
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Original Reference(s)
Vdac2Ratbinding of sperm to zona pellucida involved_inISOVDAC2 (Homo sapiens)1624291 PMID:23355646RGDPMID:23355646
Vdac2Ratbiological_process  ND 159840704/2015: no relevant rat dataRGD 
Vdac2Ratlipid transport involved_inIEAUniProtKB-KW:KW-04451600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratmitochondrial outer membrane permeabilization involved_inISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratmitochondrial outer membrane permeabilization involved_inISOVDAC2 (Homo sapiens)1624291 PMID:31015432RGDPMID:31015432
Vdac2Ratmitochondrial transmembrane transport involved_inISOVDAC2 (Homo sapiens)1624291 PMID:38065946RGDPMID:38065946
Vdac2Ratmonoatomic anion transmembrane transport involved_inIEAInterPro:IPR0019251600115GO_REF:0000002InterProGO_REF:0000002
Vdac2Ratmonoatomic anion transport involved_inISOVDAC2 (Homo sapiens)1624291 PMID:8420959RGDPMID:8420959
Vdac2Ratmonoatomic anion transport involved_inISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratnegative regulation of intrinsic apoptotic signaling pathway involved_inISOVdac2 (Mus musculus)1624291 PMID:12881569RGDPMID:12881569
Vdac2Ratnegative regulation of protein polymerization involved_inISOVdac2 (Mus musculus)1624291 PMID:12881569RGDPMID:12881569
Vdac2Ratphospholipid translocation involved_inISOVDAC2 (Homo sapiens)1624291 PMID:38065946RGDPMID:38065946
Vdac2Ratplasma membrane phospholipid scrambling involved_inIEAGO:00171281600115GO_REF:0000108GOCGO_REF:0000108
Vdac2Rattransmembrane transport involved_inIEAInterPro:IPR0272461600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
Vdac2Ratacrosomal vesicle located_inISOVDAC2 (Homo sapiens)1624291 PMID:23355646RGDPMID:23355646
Vdac2Ratintracellular membrane-bounded organelle located_inIEAARBA:ARBA000290851600115GO_REF:0000117UniProtGO_REF:0000117
Vdac2Ratmembrane located_inISOVDAC2 (Homo sapiens)1624291 PMID:27641616RGDPMID:27641616
Vdac2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Vdac2Ratmembrane located_inISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratmembrane raft located_inISOVDAC2 (Homo sapiens) and UniProtKB:P45880-21624291 PMID:25204797RGDPMID:25204797
Vdac2Ratmitochondrial membrane located_inISOVDAC2 (Homo sapiens)1624291 PMID:31015432RGDPMID:31015432
Vdac2Ratmitochondrial nucleoid located_inISOVDAC2 (Homo sapiens)1624291 PMID:18063578RGDPMID:18063578
Vdac2Ratmitochondrial outer membrane located_inISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratmitochondrial outer membrane located_inIEAInterPro:IPR001925 and InterPro:IPR0272461600115GO_REF:0000002InterProGO_REF:0000002
Vdac2Ratmitochondrial outer membrane is_active_inIBAFB:FBgn0004363 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Vdac2Ratmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
Vdac2Ratmitochondrial outer membrane located_inISOVDAC2 (Homo sapiens)1624291 PMID:7539795RGDPMID:7539795
Vdac2Ratmitochondrion located_inISOVdac2 (Mus musculus)1624291UniProtKB:Q60930 and PMID:22561200RGDPMID:22561200
Vdac2Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratmitochondrion located_inISOVDAC2 (Homo sapiens) and UniProtKB:P45880-31624291 RGDGO_REF:0000052
Vdac2Ratpore complex part_ofIEAUniProtKB-KW:KW-06261600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratsperm midpiece located_inISSUniProtKB:Q609301600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Vdac2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratceramide binding enablesISSUniProtKB:P217961600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratceramide binding enablesISOVDAC2 (Homo sapiens)1624291 PMID:31015432RGDPMID:31015432
Vdac2Ratcholesterol binding enablesISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratcholesterol binding enablesISOVDAC2 (Homo sapiens)1624291 PMID:31015432RGDPMID:31015432
Vdac2Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratoxysterol binding enablesISSUniProtKB:Q609301600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratoxysterol binding enablesISOVdac2 (Mus musculus)1624291 PMID:34799735RGDPMID:34799735
Vdac2Ratphosphatidylcholine binding enablesISSUniProtKB:P458801600115GO_REF:0000024UniProtGO_REF:0000024
Vdac2Ratphosphatidylcholine binding enablesISOVDAC2 (Homo sapiens)1624291 PMID:31015432RGDPMID:31015432
Vdac2Ratphospholipid scramblase activity enablesISOVDAC2 (Homo sapiens)1624291 PMID:38065946RGDPMID:38065946
Vdac2Ratporin activity enablesIEAUniProtKB-KW:KW-06261600115GO_REF:0000043UniProtGO_REF:0000043
Vdac2Ratprotein binding enablesISOVDAC2 (Homo sapiens)1624291UniProtKB:A0A6Q8PF08 more ...RGDPMID:15082785 more ...
Vdac2Ratprotein binding enablesISOVdac2 (Mus musculus)1624291PR:Q8C624 more ...RGDPMID:12881569 more ...
Vdac2Ratprotein binding enablesISOVDAC2 (Homo sapiens) and UniProtKB:P45880-31624291UniProtKB:P21754 more ...RGDPMID:23355646
Vdac2Ratvoltage-gated monoatomic anion channel activity enablesIEAInterPro:IPR0019251600115GO_REF:0000002InterProGO_REF:0000002
Vdac2Ratvoltage-gated monoatomic anion channel activity enablesIBAFB:FBgn0004363 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Vdac2Ratvoltage-gated monoatomic anion channel activity enablesISOVDAC2 (Homo sapiens)1624291 PMID:38065946RGDPMID:38065946
Vdac2Ratvoltage-gated monoatomic ion channel activity enablesISOVdac2 (Mus musculus)1624291 PMID:10430654RGDPMID:10430654
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Vdac2Ratcalcium/calcium-mediated signaling pathway   IEA 6907045 KEGGrno:04020
Vdac2RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Vdac2RatParkinson's disease pathway   IEA 6907045 KEGGrno:05012

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Reference Title
Reference Citation
1. Proteomic analysis reveals late exercise effects on cardiac remodeling following myocardial infarction. Bansal A, etal., J Proteomics. 2010 Sep 10;73(10):2041-9. doi: 10.1016/j.jprot.2010.06.009. Epub 2010 Jul 1.
2. All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain. Cesar Mde C and Wilson JE, Arch Biochem Biophys. 2004 Feb 15;422(2):191-6.
3. [Voltage dependent anion channel 2 involved mitochondrial apoptosis and its possible regulatory signal pathway in hearts of rats with severe scalds]. Feng YQ, etal., Zhonghua Yi Xue Za Zhi. 2013 Mar 26;93(12):939-43.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics. Jiang W, etal., J Neurosci Res. 2007 Nov 1;85(14):3160-70.
7. Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy. Liu XY, etal., Proteomics. 2008 Feb;8(3):582-603. doi: 10.1002/pmic.200700514.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels. Morciano M, etal., J Neurochem. 2009 Feb;108(3):662-75. doi: 10.1111/j.1471-4159.2008.05824.x.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Characterization of porin isoforms expressed in tumor cells. Shinohara Y, etal., Eur J Biochem 2000 Oct;267(19):6067-73.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:1373732   PMID:8420959   PMID:12865426   PMID:12881569   PMID:14651853   PMID:15489334   PMID:17634366   PMID:18063578   PMID:18504258   PMID:18614015   PMID:18802025   PMID:19688190  
PMID:20833797   PMID:21605504   PMID:21630459   PMID:22082260   PMID:22867515   PMID:23106098   PMID:23355646   PMID:23376485   PMID:24625528   PMID:25204797   PMID:26316108   PMID:29476059  
PMID:30624982   PMID:32357304   PMID:33450132  



Vdac2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,512,214 - 2,526,105 (-)NCBIGRCr8
mRatBN7.2152,462,877 - 2,476,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,463,056 - 2,476,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,470,328 - 2,484,006 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,856,774 - 3,870,452 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,469,123 - 2,482,800 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,634,622 - 2,648,548 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,634,624 - 2,648,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,615,635 - 2,629,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4152,515,297 - 2,528,969 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1152,515,298 - 2,528,969 (-)NCBI
Celera152,105,517 - 2,119,199 (+)NCBICelera
Cytogenetic Map15p16NCBI
VDAC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381075,210,170 - 75,231,448 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1075,210,154 - 75,231,448 (+)EnsemblGRCh38hg38GRCh38
GRCh371076,969,928 - 76,991,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,640,569 - 76,661,212 (+)NCBINCBI36Build 36hg18NCBI36
Build 341076,640,568 - 76,661,210NCBI
Celera1070,258,168 - 70,279,465 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,968,331 - 70,989,598 (+)NCBIHuRef
CHM1_11077,251,734 - 77,273,028 (+)NCBICHM1_1
T2T-CHM13v2.01076,083,655 - 76,104,942 (+)NCBIT2T-CHM13v2.0
Vdac2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,881,629 - 21,895,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,875,306 - 21,895,947 (+)EnsemblGRCm39 Ensembl
GRCm381421,831,561 - 21,845,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,825,238 - 21,845,879 (+)EnsemblGRCm38mm10GRCm38
MGSCv371422,650,783 - 22,665,101 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361420,620,113 - 20,634,431 (+)NCBIMGSCv36mm8
Celera1418,214,291 - 18,228,576 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.91NCBI
Vdac2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543716,853,433 - 16,872,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543716,857,715 - 16,871,717 (-)NCBIChiLan1.0ChiLan1.0
VDAC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2887,366,329 - 87,391,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11087,372,155 - 87,397,048 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,739,395 - 71,763,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,403,221 - 74,411,762 (+)NCBIpanpan1.1PanPan1.1panPan2
VDAC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,449,926 - 25,462,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl425,449,442 - 25,462,335 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha425,585,079 - 25,597,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0425,732,572 - 25,744,990 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,732,597 - 25,753,031 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,627,631 - 25,640,037 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,828,227 - 25,840,628 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0426,184,477 - 26,196,904 (+)NCBIUU_Cfam_GSD_1.0
Vdac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,629,722 - 55,643,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,122,270 - 4,136,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,122,447 - 4,136,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VDAC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,766,686 - 77,782,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11477,767,165 - 77,782,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VDAC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,141,153 - 56,160,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,136,756 - 56,157,173 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604816,628,451 - 16,649,525 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vdac2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,587,920 - 8,602,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247548,587,698 - 8,601,757 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Vdac2
50 total Variants

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:73
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000018462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

1 to 10 of 11 rows
RH135028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,462,675 - 2,462,856 (+)MAPPERmRatBN7.2
Rnor_6.0152,634,421 - 2,634,601NCBIRnor6.0
Rnor_5.0152,615,434 - 2,615,614UniSTSRnor5.0
RGSC_v3.4152,515,096 - 2,515,276UniSTSRGSC3.4
Celera152,119,220 - 2,119,400UniSTS
RH 3.4 Map1544.6UniSTS
Cytogenetic Map15p16UniSTS
AA900297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,463,295 - 2,463,434 (+)MAPPERmRatBN7.2
Rnor_6.0152,635,041 - 2,635,179NCBIRnor6.0
Rnor_5.0152,616,054 - 2,616,192UniSTSRnor5.0
RGSC_v3.4152,515,716 - 2,515,854UniSTSRGSC3.4
Celera152,118,642 - 2,118,780UniSTS
RH 3.4 Map1546.3UniSTS
Cytogenetic Map15p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000018462   ⟹   ENSRNOP00000018462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,467,361 - 2,476,553 (-)Ensembl
Rnor_6.0 Ensembl152,634,624 - 2,648,294 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086864   ⟹   ENSRNOP00000074839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,463,056 - 2,475,565 (-)Ensembl
Rnor_6.0 Ensembl152,634,800 - 2,648,551 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110275   ⟹   ENSRNOP00000083875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,463,056 - 2,476,063 (-)Ensembl
RefSeq Acc Id: NM_031354   ⟹   NP_112644
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,512,214 - 2,525,886 (-)NCBI
mRatBN7.2152,462,877 - 2,476,548 (-)NCBI
Rnor_6.0152,634,622 - 2,648,294 (-)NCBI
Rnor_5.0152,615,635 - 2,629,561 (-)NCBI
RGSC_v3.4152,515,297 - 2,528,969 (-)RGD
Celera152,105,517 - 2,119,199 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251661   ⟹   XP_006251723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,512,393 - 2,526,105 (-)NCBI
mRatBN7.2152,463,052 - 2,476,802 (-)NCBI
Rnor_6.0152,634,801 - 2,648,548 (-)NCBI
Rnor_5.0152,615,635 - 2,629,561 (-)NCBI
Sequence:
Protein RefSeqs NP_112644 (Get FASTA)   NCBI Sequence Viewer  
  XP_006251723 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF80116 (Get FASTA)   NCBI Sequence Viewer  
  AAH63164 (Get FASTA)   NCBI Sequence Viewer  
  BAB13474 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018462
GenBank Protein P81155 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112644   ⟸   NM_031354
- UniProtKB: Q9JI32 (UniProtKB/Swiss-Prot),   P81155 (UniProtKB/Swiss-Prot),   A0A8L2URG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251723   ⟸   XM_006251661
- Peptide Label: isoform X1
- UniProtKB: Q9JI32 (UniProtKB/Swiss-Prot),   P81155 (UniProtKB/Swiss-Prot),   A0A8L2URG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018462   ⟸   ENSRNOT00000018462
Ensembl Acc Id: ENSRNOP00000074839   ⟸   ENSRNOT00000086864
Ensembl Acc Id: ENSRNOP00000083875   ⟸   ENSRNOT00000110275

Name Modeler Protein Id AA Range Protein Structure
AF-P81155-F1-model_v2 AlphaFold P81155 1-295 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699546
Promoter ID:EPDNEW_R10070
Type:initiation region
Name:Vdac2_1
Description:voltage-dependent anion channel 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0152,648,259 - 2,648,319EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-14601 BioCyc
Ensembl Genes ENSRNOG00000013505 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018462 ENTREZGENE
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921675 IMAGE-MGC_LOAD
InterPro Porin_dom_sf UniProtKB/Swiss-Prot
  Porin_Euk UniProtKB/Swiss-Prot
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot
KEGG Report rno:83531 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72774 IMAGE-MGC_LOAD
NCBI Gene 83531 ENTREZGENE
PANTHER PTHR11743 UniProtKB/Swiss-Prot
  PTHR11743:SF12 UniProtKB/Swiss-Prot
Pfam Porin_3 UniProtKB/Swiss-Prot
PhenoGen Vdac2 PhenoGen
PRINTS EUKARYTPORIN UniProtKB/Swiss-Prot
PROSITE EUKARYOTIC_PORIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013505 RatGTEx
UniProt A0A8I6GB84_RAT UniProtKB/TrEMBL
  A0A8L2UJ74_RAT UniProtKB/TrEMBL
  A0A8L2URG2 ENTREZGENE, UniProtKB/TrEMBL
  P81155 ENTREZGENE
  Q9JI32 ENTREZGENE
  VDAC2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9JI32 UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Vdac2  voltage-dependent anion channel 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vdac2  voltage-dependent anion channel 2      Symbol and Name status set to provisional 70820 PROVISIONAL