Vdac1 (voltage-dependent anion channel 1) - Rat Genome Database

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Gene: Vdac1 (voltage-dependent anion channel 1) Rattus norvegicus
Analyze
Symbol: Vdac1
Name: voltage-dependent anion channel 1
RGD ID: 621575
Description: Enables voltage-gated monoatomic anion channel activity. Involved in calcium import into the mitochondrion. Located in mitochondrial outer membrane and synaptic vesicle. Part of protein-containing complex. Is active in postsynaptic density membrane and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; Huntington's disease pathway; influenza A pathway; INTERACTS WITH (R)-adrenaline; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: non-selective voltage-gated ion channel VDAC1; outer mitochondrial membrane protein porin 1; rVDAC1; VDAC-1; voltage-dependent anion-selective channel protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,029,377 - 37,060,542 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1037,023,145 - 37,060,541 (+)EnsemblGRCr8
mRatBN7.21036,532,306 - 36,559,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,532,244 - 36,559,640 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,225,788 - 41,253,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,715,759 - 40,743,034 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,219,484 - 36,246,760 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,724,915 - 37,752,827 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,724,915 - 37,752,826 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,498,352 - 37,525,819 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,795,721 - 37,823,253 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,886,487 - 35,913,291 (+)NCBICelera
RGSC_v3.11037,802,150 - 37,829,682 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (EXP,ISO)
asiatic acid  (ISO)
ATP  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carnosic acid  (ISO)
CCCP  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
elaidic acid  (EXP)
emodin  (ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP)
flufenoxuron  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melittin  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
microcystin-LR  (EXP)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethylmaleimide  (EXP)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
olesoxime  (EXP)
oxaliplatin  (EXP)
oxidopamine  (ISO)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (EXP)
Pf-06840003  (ISO)
phenethyl caffeate  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (EXP)
Propiverine  (EXP)
pyrazinecarboxamide  (EXP)
pyrogallol  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
saxitoxin  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
staurosporine  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc oxide  (ISO)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Adachi M, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G695-705. Epub 2004 Mar 25.
2. Bax increases the pore size of rat brain mitochondrial voltage-dependent anion channel in the presence of tBid. Banerjee J and Ghosh S, Biochem Biophys Res Commun. 2004 Oct 8;323(1):310-4.
3. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases. Beutner G, etal., Biochim Biophys Acta. 1998 Jan 5;1368(1):7-18.
4. All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain. Cesar Mde C and Wilson JE, Arch Biochem Biophys. 2004 Feb 15;422(2):191-6.
5. Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease. Chu Y, etal., Neurobiol Dis. 2014 Sep;69:1-14. doi: 10.1016/j.nbd.2014.05.003. Epub 2014 May 10.
6. A candidate for the permeability pathway of the outer mitochondrial membrane. Colombini M, Nature. 1979 Jun 14;279(5714):643-5. doi: 10.1038/279643a0.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function. Gincel D, etal., Biochem J. 2001 Aug 15;358(Pt 1):147-55. doi: 10.1042/0264-6021:3580147.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats. Gong D, etal., Proteomics. 2009 Sep;9(18):4309-20. doi: 10.1002/pmic.200900285.
11. Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction. Javadov S, etal., J Mol Cell Cardiol. 2009 Jun;46(6):998-1007. doi: 10.1016/j.yjmcc.2008.12.023. Epub 2009 Jan 20.
12. Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative proteomics. Jiang W, etal., J Neurosci Res. 2007 Nov 1;85(14):3160-70.
13. Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men. Liu T, etal., Oncotarget. 2017 May 22;8(37):61305-61317. doi: 10.18632/oncotarget.18064. eCollection 2017 Sep 22.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Presence of a voltage-dependent anion channel 1 in the rat postsynaptic density fraction. Moon JI, etal., Neuroreport. 1999 Feb 25;10(3):443-7. doi: 10.1097/00001756-199902250-00001.
16. The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels. Morciano M, etal., J Neurochem. 2009 Feb;108(3):662-75. doi: 10.1111/j.1471-4159.2008.05824.x.
17. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Narita M, etal., Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14681-6.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. Rapizzi E, etal., J Cell Biol 2002 Nov 25;159(4):613-24.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Characterization of porin isoforms expressed in tumor cells. Shinohara Y, etal., Eur J Biochem 2000 Oct;267(19):6067-73.
25. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. Szabadkai G, etal., J Cell Biol. 2006 Dec 18;175(6):901-11. doi: 10.1083/jcb.200608073.
26. The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. Zhang X, etal., PLoS One. 2014 Dec 1;9(12):e113642. doi: 10.1371/journal.pone.0113642. eCollection 2014.
Additional References at PubMed
PMID:8420959   PMID:9714728   PMID:11907043   PMID:12118373   PMID:12477932   PMID:12560326   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16527372   PMID:17008324   PMID:17376863  
PMID:17634366   PMID:18063578   PMID:18504258   PMID:18614015   PMID:18832158   PMID:18988731   PMID:19056867   PMID:19646951   PMID:19688190   PMID:19717555   PMID:19822599   PMID:20420578  
PMID:20458337   PMID:20833797   PMID:21370995   PMID:21492153   PMID:21605504   PMID:21630459   PMID:21951169   PMID:22082260   PMID:22117062   PMID:22164227   PMID:22871113   PMID:23028046  
PMID:23291291   PMID:23376485   PMID:23533145   PMID:24625528   PMID:24945955   PMID:25244949   PMID:25296756   PMID:25470454   PMID:26306046   PMID:26316108   PMID:26387735   PMID:26767982  
PMID:27064145   PMID:27738100   PMID:27796346   PMID:29253592   PMID:29476059   PMID:30188326   PMID:30287344   PMID:30391711   PMID:31575916   PMID:31618500   PMID:31686426   PMID:32047033  
PMID:32901466   PMID:33328613   PMID:33675282   PMID:35352799   PMID:35449127   PMID:36755387   PMID:36816741  


Genomics

Comparative Map Data
Vdac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,029,377 - 37,060,542 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1037,023,145 - 37,060,541 (+)EnsemblGRCr8
mRatBN7.21036,532,306 - 36,559,642 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,532,244 - 36,559,640 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,225,788 - 41,253,064 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,715,759 - 40,743,034 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,219,484 - 36,246,760 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,724,915 - 37,752,827 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,724,915 - 37,752,826 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,498,352 - 37,525,819 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,795,721 - 37,823,253 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,886,487 - 35,913,291 (+)NCBICelera
RGSC_v3.11037,802,150 - 37,829,682 (+)NCBI
Cytogenetic Map10q22NCBI
VDAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,971,871 - 134,114,540 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,971,871 - 134,005,360 (-)Ensemblhg38GRCh38
GRCh375133,307,562 - 133,450,231 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,335,506 - 133,368,332 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345133,335,505 - 133,368,332NCBI
Celera5129,431,292 - 129,464,120 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,492,511 - 128,525,784 (-)NCBIHuRef
CHM1_15132,740,167 - 132,773,436 (-)NCBICHM1_1
T2T-CHM13v2.05134,495,517 - 134,638,169 (-)NCBIT2T-CHM13v2.0
Vdac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,251,905 - 52,280,224 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,251,687 - 52,280,224 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,360,851 - 52,389,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,360,860 - 52,389,397 (+)Ensemblmm10GRCm38
MGSCv371152,174,617 - 52,202,898 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361152,204,538 - 52,232,819 (+)NCBIMGSCv36mm8
Celera1156,932,845 - 56,961,186 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Vdac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,260,353 - 5,275,990 (-)Ensembl
ChiLan1.0NW_0049554085,260,444 - 5,275,972 (-)NCBIChiLan1.0ChiLan1.0
VDAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,270,460 - 129,303,316 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,410,021 - 127,443,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,375,267 - 129,408,230 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,529,173 - 135,663,570 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,529,173 - 135,560,005 (-)EnsemblpanPan2panpan1.1
VDAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,197,814 - 22,212,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,197,949 - 22,212,924 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1120,943,845 - 20,970,964 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01122,998,225 - 23,025,442 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,998,225 - 23,025,663 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,698,673 - 21,725,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,563,273 - 21,590,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,206,295 - 22,233,311 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vdac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,217,313 - 114,246,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,230,450 - 1,249,814 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,220,075 - 1,249,579 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VDAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,302,191 - 136,396,301 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12136,302,188 - 136,334,461 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,876,797 - 141,909,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VDAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,783,670 - 36,817,071 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603441,120,091 - 41,153,374 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vdac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,184,016 - 38,210,478 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473338,183,376 - 38,210,368 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Vdac1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,860,037 - 34,886,634 (+)NCBIRrattus_CSIRO_v1

Variants

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Variants in Vdac1
358 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:188
Interacting mature miRNAs:226
Transcripts:ENSRNOT00000008477
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
U30840  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81852,201,965 - 52,202,069 (+)Marker Load Pipeline
mRatBN7.2X146,383,339 - 146,383,444 (-)MAPPERmRatBN7.2
mRatBN7.21036,558,923 - 36,559,028 (+)MAPPERmRatBN7.2
Rnor_6.01037,752,110 - 37,752,214NCBIRnor6.0
Rnor_6.0X155,630,333 - 155,630,437NCBIRnor6.0
Rnor_5.01151,348,138 - 151,348,242UniSTSRnor5.0
Rnor_5.01037,525,102 - 37,525,206UniSTSRnor5.0
RGSC_v3.41037,822,536 - 37,822,640UniSTSRGSC3.4
Celera1035,912,574 - 35,912,678UniSTS
Celera1134,979,166 - 134,979,270UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic MapXq37UniSTS
Cytogenetic Map6q24UniSTS
RH137996  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,543,325 - 36,543,495 (+)MAPPERmRatBN7.2
Rnor_6.01037,736,903 - 37,737,072NCBIRnor6.0
Rnor_5.01037,509,372 - 37,509,541UniSTSRnor5.0
RGSC_v3.41037,806,741 - 37,806,910UniSTSRGSC3.4
Celera1035,897,492 - 35,897,661UniSTS
RH 3.4 Map10389.0UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008477   ⟹   ENSRNOP00000008477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1037,045,646 - 37,060,541 (+)Ensembl
mRatBN7.2 Ensembl1036,532,244 - 36,559,640 (+)Ensembl
Rnor_6.0 Ensembl1037,724,915 - 37,752,826 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095488   ⟹   ENSRNOP00000083811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,541,592 - 36,559,620 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103029   ⟹   ENSRNOP00000093638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1037,023,145 - 37,060,541 (+)Ensembl
mRatBN7.2 Ensembl1036,539,649 - 36,559,620 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108882   ⟹   ENSRNOP00000088882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,541,592 - 36,559,620 (+)Ensembl
RefSeq Acc Id: NM_031353   ⟹   NP_112643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81037,033,209 - 37,060,542 (+)NCBI
mRatBN7.21036,532,306 - 36,559,642 (+)NCBI
Rnor_6.01037,724,915 - 37,752,827 (+)NCBI
Rnor_5.01037,498,352 - 37,525,819 (+)NCBI
RGSC_v3.41037,795,721 - 37,823,253 (+)RGD
Celera1035,886,487 - 35,913,291 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269961   ⟹   XP_063126031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81037,036,827 - 37,060,542 (+)NCBI
RefSeq Acc Id: XM_063269962   ⟹   XP_063126032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81037,029,377 - 37,060,542 (+)NCBI
RefSeq Acc Id: NP_112643   ⟸   NM_031353
- UniProtKB: Q6IN28 (UniProtKB/Swiss-Prot),   Q5M972 (UniProtKB/Swiss-Prot),   Q5M944 (UniProtKB/Swiss-Prot),   Q3MHT8 (UniProtKB/Swiss-Prot),   A1L125 (UniProtKB/Swiss-Prot),   Q6P9W9 (UniProtKB/Swiss-Prot),   Q9Z2L0 (UniProtKB/Swiss-Prot),   A6HEA9 (UniProtKB/TrEMBL),   A0A8I6GGP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008477   ⟸   ENSRNOT00000008477
Ensembl Acc Id: ENSRNOP00000083811   ⟸   ENSRNOT00000095488
Ensembl Acc Id: ENSRNOP00000088882   ⟸   ENSRNOT00000108882
Ensembl Acc Id: ENSRNOP00000093638   ⟸   ENSRNOT00000103029
RefSeq Acc Id: XP_063126032   ⟸   XM_063269962
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GGP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126031   ⟸   XM_063269961
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGP1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2L0-F1-model_v2 AlphaFold Q9Z2L0 1-283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697170
Promoter ID:EPDNEW_R7694
Type:initiation region
Name:Vdac1_1
Description:voltage-dependent anion channel 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01037,724,924 - 37,724,984EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621575 AgrOrtholog
BioCyc Gene G2FUF-25171 BioCyc
Ensembl Genes ENSRNOG00000006375 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008477 ENTREZGENE
  ENSRNOT00000008477.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.160.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889983 IMAGE-MGC_LOAD
  IMAGE:7105146 IMAGE-MGC_LOAD
  IMAGE:7304939 IMAGE-MGC_LOAD
  IMAGE:7312189 IMAGE-MGC_LOAD
  IMAGE:7462139 IMAGE-MGC_LOAD
  IMAGE:8370617 IMAGE-MGC_LOAD
InterPro Porin_dom_sf UniProtKB/Swiss-Prot
  Porin_Euk UniProtKB/Swiss-Prot
  Porin_Euk/Tom40 UniProtKB/Swiss-Prot
KEGG Report rno:83529 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105403 IMAGE-MGC_LOAD
  MGC:105404 IMAGE-MGC_LOAD
  MGC:124959 IMAGE-MGC_LOAD
  MGC:156627 IMAGE-MGC_LOAD
  MGC:72775 IMAGE-MGC_LOAD
  MGC:91640 IMAGE-MGC_LOAD
NCBI Gene 83529 ENTREZGENE
PANTHER PTHR11743 UniProtKB/Swiss-Prot
  PTHR11743:SF13 UniProtKB/Swiss-Prot
Pfam Porin_3 UniProtKB/Swiss-Prot
PhenoGen Vdac1 PhenoGen
PRINTS EUKARYTPORIN UniProtKB/Swiss-Prot
PROSITE EUKARYOTIC_PORIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006375 RatGTEx
UniProt A0A8I6AKF7_RAT UniProtKB/TrEMBL
  A0A8I6GGP1 ENTREZGENE
  A1L125 ENTREZGENE
  A6HEA9 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHT8 ENTREZGENE
  Q5M944 ENTREZGENE
  Q5M972 ENTREZGENE
  Q6IN28 ENTREZGENE
  Q6P9W9 ENTREZGENE
  Q9Z2L0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A1L125 UniProtKB/Swiss-Prot
  Q3MHT8 UniProtKB/Swiss-Prot
  Q5M944 UniProtKB/Swiss-Prot
  Q5M972 UniProtKB/Swiss-Prot
  Q6IN28 UniProtKB/Swiss-Prot
  Q6P9W9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Vdac1  voltage-dependent anion channel 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vdac1  voltage-dependent anion channel 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process positive regulator of mitochondrial Ca2+ accumulation 634413