Sdha (succinate dehydrogenase complex flavoprotein subunit A) - Rat Genome Database

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Gene: Sdha (succinate dehydrogenase complex flavoprotein subunit A) Rattus norvegicus
Analyze
Symbol: Sdha
Name: succinate dehydrogenase complex flavoprotein subunit A
RGD ID: 621557
Description: Enables succinate dehydrogenase (quinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A); PARTICIPATES IN citric acid cycle pathway; electron transport chain pathway; fumaric aciduria pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: flavoprotein subunit of complex II; fp; malate dehydrogenase [quinone] flavoprotein subunit; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,764,553 - 30,789,523 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl130,764,590 - 30,790,121 (+)EnsemblGRCr8
mRatBN7.2128,935,965 - 28,960,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx128,737,137 - 28,762,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,736,999 - 34,762,123 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,937,767 - 28,962,889 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,545,631 - 31,570,601 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)Ensemblrn6Rnor6.0
Rnor_5.0132,971,779 - 32,996,749 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,739,359 - 29,764,329 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,587,801 - 27,612,771 (+)NCBICelera
RGSC_v3.1129,742,303 - 29,767,274 (+)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-pantothenic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
apigenin  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Bufotalin  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Diosbulbin B  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
imisopasem manganese  (EXP)
indometacin  (EXP,ISO)
isoniazide  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
morphine  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
nitrates  (ISO)
nobiletin  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
phlorizin  (ISO)
poly(guanylic acid)  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
Pseudolaric acid B  (ISO)
pyrogallol  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (ISO)
quinoxyfen  (ISO)
rac-1,2-dichloropropane  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
taurine  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichloroacetic acid  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Bourgeron T, etal., Nat Genet 1995 Oct;11(2):144-9.
2. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons. Grünewald A, etal., Ann Neurol. 2016 Mar;79(3):366-78. doi: 10.1002/ana.24571. Epub 2016 Jan 28.
6. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Lashin OM, etal., Free Radic Biol Med. 2006 Mar 1;40(5):886-96. Epub 2005 Nov 2.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Information Derived from GenBank Report RGD, Sept. 2003
19. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
20. Intraabdominal adhesion formation is associated with differential mRNA expression of metabolic genes PDHb and SDHa. Wallwiener M, etal., Arch Gynecol Obstet. 2012 Sep;286(3):683-6. doi: 10.1007/s00404-012-2364-9. Epub 2012 May 9.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15989954   PMID:16120479   PMID:16361598   PMID:16751257   PMID:16826196   PMID:17480203   PMID:17634366   PMID:18252725   PMID:18614015   PMID:19723079  
PMID:19808025   PMID:19837698   PMID:21700703   PMID:23602810   PMID:24781757   PMID:25483313   PMID:26316108   PMID:31904090   PMID:32357304   PMID:36005845  


Genomics

Comparative Map Data
Sdha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8130,764,553 - 30,789,523 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl130,764,590 - 30,790,121 (+)EnsemblGRCr8
mRatBN7.2128,935,965 - 28,960,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx128,737,137 - 28,762,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0134,736,999 - 34,762,123 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,937,767 - 28,962,889 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0131,545,631 - 31,570,601 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)Ensemblrn6Rnor6.0
Rnor_5.0132,971,779 - 32,996,749 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,739,359 - 29,764,329 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera127,587,801 - 27,612,771 (+)NCBICelera
RGSC_v3.1129,742,303 - 29,767,274 (+)NCBI
Cytogenetic Map1p11NCBI
SDHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385218,320 - 268,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5218,274 - 257,083 (+)Ensemblhg38GRCh38
GRCh375218,435 - 257,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365271,356 - 309,815 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345271,446 - 309,792NCBI
Celera5317,918 - 356,377 (+)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef5208,246 - 246,713 (+)NCBIHuRef
CHM1_15215,731 - 254,186 (+)NCBICHM1_1
T2T-CHM13v2.05209,363 - 254,841 (+)NCBIT2T-CHM13v2.0
Sdha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391374,470,374 - 74,498,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1374,470,373 - 74,498,399 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381374,322,255 - 74,350,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1374,322,254 - 74,350,280 (-)Ensemblmm10GRCm38
MGSCv371374,459,703 - 74,487,688 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361374,788,257 - 74,816,242 (-)NCBIMGSCv36mm8
Celera1376,651,719 - 76,679,576 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.15NCBI
Sdha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495550436,911 - 70,494 (+)Ensembl
ChiLan1.0NW_00495550436,939 - 66,507 (+)NCBIChiLan1.0ChiLan1.0
SDHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24434,053 - 476,070 (+)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl5356,087 - 399,923 (+)EnsemblpanPan2panpan1.1
SDHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,935,684 - 11,965,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,935,941 - 11,965,189 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3416,448,897 - 16,478,318 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03411,837,397 - 11,866,790 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,835,625 - 11,866,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,890,237 - 11,900,823 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,876,342 - 11,905,771 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03412,078,358 - 12,107,796 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sdha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,987,678 - 245,006,149 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368151,148,963 - 1,167,568 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368151,148,963 - 1,167,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,834,044 - 79,862,524 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11679,838,442 - 79,862,956 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SDHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14163,726 - 190,145 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605435,952,891 - 35,986,376 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475154,779 - 90,447 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475154,778 - 90,457 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sdha
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12203,749,670 - 203,772,776 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sdha
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000018336
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
RH134400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2128,961,194 - 28,961,380 (+)MAPPERmRatBN7.2
Rnor_6.0131,570,860 - 31,571,045NCBIRnor6.0
Rnor_5.0132,997,008 - 32,997,193UniSTSRnor5.0
RGSC_v3.4129,764,588 - 29,764,773UniSTSRGSC3.4
Celera127,613,030 - 27,613,215UniSTS
RH 3.4 Map1315.51UniSTS
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018336   ⟹   ENSRNOP00000018336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl130,764,590 - 30,790,121 (+)Ensembl
mRatBN7.2 Ensembl128,940,164 - 28,961,535 (+)Ensembl
Rnor_6.0 Ensembl131,545,631 - 31,570,601 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114225   ⟹   ENSRNOP00000078837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,940,698 - 28,961,535 (+)Ensembl
RefSeq Acc Id: NM_130428   ⟹   NP_569112
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8130,764,553 - 30,789,523 (+)NCBI
mRatBN7.2128,935,965 - 28,960,936 (+)NCBI
Rnor_6.0131,545,631 - 31,570,601 (+)NCBI
Rnor_5.0132,971,779 - 32,996,749 (+)NCBI
RGSC_v3.4129,739,359 - 29,764,329 (+)RGD
Celera127,587,801 - 27,612,771 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD77309 (Get FASTA)   NCBI Sequence Viewer  
  BAB69818 (Get FASTA)   NCBI Sequence Viewer  
  EDL87684 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018336
GenBank Protein Q920L2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_569112   ⟸   NM_130428
- Peptide Label: precursor
- UniProtKB: Q920L2 (UniProtKB/Swiss-Prot),   A6JUU5 (UniProtKB/TrEMBL),   A0A8L2Q9A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018336   ⟸   ENSRNOT00000018336
Ensembl Acc Id: ENSRNOP00000078837   ⟸   ENSRNOT00000114225
Protein Domains
FAD-dependent oxidoreductase 2 FAD-binding   Fumarate reductase/succinate dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920L2-F1-model_v2 AlphaFold Q920L2 1-656 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689554
Promoter ID:EPDNEW_R79
Type:multiple initiation site
Name:Sdha_1
Description:succinate dehydrogenase complex flavoprotein subunit A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0131,545,640 - 31,545,700EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621557 AgrOrtholog
BioCyc Gene G2FUF-61946 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000013331 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018336 ENTREZGENE
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
  3.90.700.10 UniProtKB/Swiss-Prot
  Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain UniProtKB/Swiss-Prot
  succinate dehydrogenase protein domain UniProtKB/Swiss-Prot
InterPro FAD-binding_2 UniProtKB/Swiss-Prot
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FRD_SDH_FAD_BS UniProtKB/Swiss-Prot
  Fum_R/Succ_DH_flav-like_C_sf UniProtKB/Swiss-Prot
  Fum_Rdtase/Succ_DH_flav-like_C UniProtKB/Swiss-Prot
  SdhA/FrdA/AprA UniProtKB/Swiss-Prot
  Succ_DH/fumarate_Rdtase_cat_sf UniProtKB/Swiss-Prot
  Succ_DH_flav_su_fwd UniProtKB/Swiss-Prot
  Succ_Dhase_FrdA_Gneg UniProtKB/Swiss-Prot
KEGG Report rno:157074 UniProtKB/Swiss-Prot
NCBI Gene 157074 ENTREZGENE
PANTHER PTHR11632 UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam FAD_binding_2 UniProtKB/Swiss-Prot
  Succ_DH_flav_C UniProtKB/Swiss-Prot
PhenoGen Sdha PhenoGen
PIRSF SDHA_APRA_LASPO UniProtKB/Swiss-Prot
PROSITE FRD_SDH_FAD_BINDING UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013331 RatGTEx
Superfamily-SCOP SSF46977 UniProtKB/Swiss-Prot
  SSF51905 UniProtKB/Swiss-Prot
  SSF56425 UniProtKB/Swiss-Prot
UniProt A0A8L2Q9A7 ENTREZGENE, UniProtKB/TrEMBL
  A6JUU5 ENTREZGENE, UniProtKB/TrEMBL
  Q0QF18_RAT UniProtKB/TrEMBL
  Q920L2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Sdha  succinate dehydrogenase complex flavoprotein subunit A  Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sdha  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)      Symbol and Name status set to provisional 70820 PROVISIONAL