Kcnn4 (potassium calcium-activated channel subfamily N member 4) - Rat Genome Database

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Gene: Kcnn4 (potassium calcium-activated channel subfamily N member 4) Rattus norvegicus
Analyze
Symbol: Kcnn4
Name: potassium calcium-activated channel subfamily N member 4
RGD ID: 621476
Description: Enables Intermediate conductance calcium-activated potassium channel activity and inward rectifier potassium channel activity. Involved in several processes, including hepatocyte apoptotic process; regulation of cytokine production; and regulation of systemic arterial blood pressure. Located in apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study hypertension; middle cerebral artery infarction; and temporal lobe epilepsy. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IK1; intermediate conductance calcium-activated potassium channel; intermediate conductance calcium-activated potassium channel protein 4; intermediate conductance K channel; intermediate-conductance Ca-activated K channel; KCa3.1; KCa4; MGC156636; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; rKCNN4c; rSK4; SK4; SKCa 4; SKCa4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,084,306 - 89,102,279 (+)NCBIGRCr8
mRatBN7.2179,956,380 - 79,974,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,353,007 - 85,367,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,902,801 - 93,917,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,108,816 - 87,123,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,230,612 - 81,245,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetohydrazide  (ISO)
acetylcysteine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
aurantio-obtusin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorzoxazone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clotrimazole  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
dexamethasone  (EXP)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
insulin  (EXP)
inulin  (ISO)
ionomycin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
lithium chloride  (ISO)
menadione  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium atom  (ISO)
progesterone  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-allylcysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
TRAM-34  (ISO)
trichloroethene  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (IEA,ISO)
cardiac muscle hypertrophy  (IMP)
cell volume homeostasis  (IEA,ISO)
cellular response to hypoxia  (IEP)
establishment of localization in cell  (IEA,ISO)
hepatocyte apoptotic process  (IMP)
monoatomic anion transport  (IDA)
mononuclear cell migration  (IMP)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of cell volume  (IMP)
negative regulation of hepatic stellate cell proliferation  (IMP)
phospholipid translocation  (IEA,ISO)
positive regulation of G0 to G1 transition  (IMP)
positive regulation of microglial cell activation  (IMP)
positive regulation of p38MAPK cascade  (IMP)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
potassium ion export across plasma membrane  (IDA)
potassium ion transmembrane transport  (IBA,IEA)
potassium ion transport  (IDA)
regulation of angiotensin levels in blood  (IMP)
regulation of monocyte chemotactic protein-1 production  (IMP)
regulation of renin secretion into blood stream  (IMP)
regulation of smooth muscle cell proliferation  (IMP)
regulation of tumor necrosis factor production  (IMP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to tetrachloromethane  (IEP)
saliva secretion  (IEA,ISO)
stabilization of membrane potential  (IEA,ISO)
vascular associated smooth muscle cell migration  (IMP)
vascular associated smooth muscle cell proliferation  (IEP)

Cellular Component
apical plasma membrane  (IDA)
basolateral plasma membrane  (IDA)
cytosol  (IEA,ISO)
membrane  (IEA)
neuron projection  (IBA,IEA)
neuronal cell body  (IBA,IDA,IEA)
plasma membrane  (IBA,IEA,ISO)
vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Small-conductance Ca2+-activated K+ channels: form and function. Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2. Ca2+-activated IK1 channels associate with lipid rafts upon cell swelling and mediate volume recovery. Barfod ET, etal., J Biol Chem. 2007 Mar 23;282(12):8984-93. Epub 2007 Jan 30.
3. Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line. Basalingappa KM, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G905-11. doi: 10.1152/ajpgi.00558.2010. Epub 2011 Aug 25.
4. miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma. Chen Y, etal., Oncotarget. 2016 Sep 6;7(36):58148-58161. doi: 10.18632/oncotarget.11252.
5. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. Chen YJ, etal., J Cereb Blood Flow Metab. 2011 Dec;31(12):2363-74. doi: 10.1038/jcbfm.2011.101. Epub 2011 Jul 13.
6. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. Chen YJ, etal., J Cereb Blood Flow Metab. 2016 Dec;36(12):2146-2161. doi: 10.1177/0271678X15611434. Epub 2015 Nov 2.
7. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. Chen YJ, etal., PLoS One. 2013 Nov 29;8(11):e81006. doi: 10.1371/journal.pone.0081006. eCollection 2013.
8. Blood-brain barrier KCa3.1 channels: evidence for a role in brain Na uptake and edema in ischemic stroke. Chen YJ, etal., Stroke. 2015 Jan;46(1):237-44. doi: 10.1161/STROKEAHA.114.007445. Epub 2014 Dec 4.
9. NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia. Choi S, etal., Free Radic Biol Med. 2013 Apr;57:10-21. doi: 10.1016/j.freeradbiomed.2012.12.009. Epub 2012 Dec 20.
10. Exenatide Inhibits the KCa3.1 Channels of Aortic Vascular Smooth Muscle in Diabetic Rats. Dong P, etal., Acta Cardiol Sin. 2017 Nov;33(6):648-655. doi: 10.6515/ACS20170612B.
11. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
12. Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1. Fei YD, etal., Theranostics. 2019 Aug 14;9(22):6396-6411. doi: 10.7150/thno.34801. eCollection 2019.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Glaser N, etal., Pediatr Diabetes. 2017 Aug;18(5):356-366. doi: 10.1111/pedi.12396. Epub 2016 May 13.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Involvement of Ca2+-activated K+ channel 3.1 in hypoxia-induced pulmonary arterial hypertension and therapeutic effects of TRAM-34 in rats. Guo S, etal., Biosci Rep. 2017 Jul 27;37(4):BSR20170763. doi: 10.1042/BSR20170763. Print 2017 Aug 31.
17. TRAM-34 attenuates hypoxia induced pulmonary artery smooth muscle cell proliferation. Guo SJ, etal., Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3515-21.
18. High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channel. Huang C, etal., PLoS One. 2014 Apr 14;9(4):e95173. doi: 10.1371/journal.pone.0095173. eCollection 2014.
19. The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy. Huang C, etal., PLoS One. 2018 Feb 9;13(2):e0192800. doi: 10.1371/journal.pone.0192800. eCollection 2018.
20. Targeting the KCa3.1 channel suppresses diabetes-associated atherosclerosis via the STAT3/CD36 axis. Jiang XX, etal., Diabetes Res Clin Pract. 2022 Mar;185:109776. doi: 10.1016/j.diabres.2022.109776. Epub 2022 Feb 9.
21. Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. Joiner WJ, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G185-96. Epub 2003 Feb 26.
22. Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction. Ju CH, etal., Cell Physiol Biochem. 2015;36(4):1305-15. doi: 10.1159/000430298.
23. Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Kang H, etal., Cell Rep. 2014 Aug 21;8(4):1210-24. doi: 10.1016/j.celrep.2014.07.032. Epub 2014 Aug 14.
24. Modafinil improves monocrotaline-induced pulmonary hypertension rat model. Lee H, etal., Pediatr Res. 2016 Jul;80(1):119-27. doi: 10.1038/pr.2016.38. Epub 2016 Mar 9.
25. Inhibitory effects of candesartan on KCa3.1 potassium channel expression and cell culture and proliferation in peripheral blood CD4+T lymphocytes in Kazakh patients with hypertension from the Xinjiang region. Li H, etal., Clin Exp Hypertens. 2018;40(4):303-311. doi: 10.1080/10641963.2017.1377212. Epub 2018 Feb 1.
26. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. Mauler F, etal., Eur J Neurosci. 2004 Oct;20(7):1761-8. doi: 10.1111/j.1460-9568.2004.03615.x.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Mongan LC, etal., Neuroscience. 2005;131(1):161-75.
29. Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Nanda Kumar NS, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G707-14. Epub 2010 Jul 8.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Molecular cloning and characterization of the intermediate-conductance Ca(2+)-activated K(+) channel in vascular smooth muscle: relationship between K(Ca) channel diversity and smooth muscle cell function. Neylon CB, etal., Circ Res 1999 Oct 29;85(9):e33-43.
32. Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models. Ongerth T, etal., Eur J Pharmacol. 2014 Oct 5;740:72-80. doi: 10.1016/j.ejphar.2014.06.061. Epub 2014 Jul 10.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury. Sevelsted Møller L, etal., Sci Rep. 2016 Jun 29;6:28770. doi: 10.1038/srep28770.
36. KCa3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats. She G, etal., J Am Heart Assoc. 2019 Jan 8;8(1):e010418. doi: 10.1161/JAHA.118.010418.
37. Insulin-mediated upregulation of K(Ca)3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle. Su XL, etal., J Mol Cell Cardiol. 2011 Jul;51(1):51-7. doi: 10.1016/j.yjmcc.2011.03.014. Epub 2011 Apr 2.
38. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. Toyama K, etal., J Clin Invest. 2008 Sep;118(9):3025-37. doi: 10.1172/JCI30836.
39. Oxidative stress promotes myocardial fibrosis by upregulating KCa3.1 channel expression in AGT-REN double transgenic hypertensive mice. Wang LP, etal., Pflugers Arch. 2017 Sep;469(9):1061-1071. doi: 10.1007/s00424-017-1984-0. Epub 2017 Apr 28.
40. [Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats]. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
41. Molecular and functional characterization of the small Ca(2+)-regulated K+ channel (rSK4) of colonic crypts. Warth R, etal., Pflugers Arch 1999 Sep;438(4):437-44.
42. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
43. Relationship between haplotypes of KCNN4 gene and susceptibility to human vascular diseases in Japanese. Yamaguchi M, etal., Med Sci Monit. 2009 Aug;15(8):CR389-97.
44. The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke. Yi M, etal., J Neuroinflammation. 2017 Oct 16;14(1):203. doi: 10.1186/s12974-017-0973-8.
45. Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway. Yu Z, etal., J Neurochem. 2014 Jul;130(1):41-49. doi: 10.1111/jnc.12710. Epub 2014 Mar 27.
46. Potassium channel changes of peripheral blood T-lymphocytes from Kazakh hypertensive patients in Northwest China and the inhibition effect towards potassium channels by telmisartan. Zhang Q, etal., Kardiol Pol. 2016;74(5):476-488. doi: 10.5603/KP.a2015.0210. Epub 2015 Oct 27.
47. [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh]. Zhang QB, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1020-4.
48. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Zhao LM, etal., Pflugers Arch. 2015 Nov;467(11):2275-85. doi: 10.1007/s00424-015-1694-4. Epub 2015 Feb 27.
Additional References at PubMed
PMID:11724775   PMID:12388098   PMID:12477932   PMID:14602578   PMID:15615695   PMID:16873365   PMID:17202491   PMID:18097031   PMID:18403729   PMID:18796614   PMID:20364152   PMID:20445171  
PMID:20501432   PMID:21345794   PMID:22168445   PMID:22322970   PMID:22414869   PMID:22555847   PMID:22646737   PMID:22815978   PMID:23053478   PMID:23212096   PMID:23488860   PMID:23620825  
PMID:23656217   PMID:24420768   PMID:24901797   PMID:25212242   PMID:25468996   PMID:26148990   PMID:26335442   PMID:26824610   PMID:26950800   PMID:27486024   PMID:28248292   PMID:29038048  
PMID:29558628   PMID:29952429   PMID:31432175   PMID:31638180   PMID:32065503   PMID:32879404   PMID:33331347   PMID:34313357   PMID:35732494  


Genomics

Comparative Map Data
Kcnn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,084,306 - 89,102,279 (+)NCBIGRCr8
mRatBN7.2179,956,380 - 79,974,354 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,353,007 - 85,367,886 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,902,801 - 93,917,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,108,816 - 87,123,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,227,855 - 81,245,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,230,612 - 81,245,996 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,490,768 - 82,508,502 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,613,736 - 79,628,887 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,691,846 - 79,706,998 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBICelera
Cytogenetic Map1q21NCBI
KCNN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,766,533 - 43,780,973 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,766,533 - 43,780,976 (-)EnsemblGRCh38hg38GRCh38
GRCh371944,270,685 - 44,285,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,962,525 - 48,977,249 (-)NCBINCBI36Build 36hg18NCBI36
Build 341948,962,524 - 48,977,249NCBI
Celera1941,074,253 - 41,088,976 (-)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,702,891 - 40,717,615 (-)NCBIHuRef
CHM1_11944,272,786 - 44,287,492 (-)NCBICHM1_1
T2T-CHM13v2.01946,589,266 - 46,619,926 (-)NCBIT2T-CHM13v2.0
Kcnn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,069,750 - 24,084,635 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,069,688 - 24,086,115 (+)EnsemblGRCm39 Ensembl
GRCm38724,369,826 - 24,385,212 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,370,263 - 24,386,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,155,282 - 25,170,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,079,023 - 24,093,969 (+)NCBIMGSCv36mm8
Celera718,994,758 - 19,009,501 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.37NCBI
Kcnn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,490,052 - 1,509,113 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,493,600 - 1,509,113 (-)NCBIChiLan1.0ChiLan1.0
KCNN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,929,192 - 49,945,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,801,737 - 51,819,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,715,621 - 40,735,025 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,321,403 - 49,335,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,321,403 - 49,335,900 (-)Ensemblpanpan1.1panPan2
KCNN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,391,464 - 111,407,612 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,391,159 - 111,407,701 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,871,521 - 110,887,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01111,964,804 - 111,980,983 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,968,172 - 111,980,026 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,590,240 - 111,606,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,224,067 - 111,240,036 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,107,905 - 112,124,068 (+)NCBIUU_Cfam_GSD_1.0
Kcnn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,593,227 - 16,605,448 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936706940,585 - 952,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,580,022 - 50,593,544 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,580,016 - 50,593,518 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,440,884 - 46,454,405 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,289,088 - 37,316,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607316,833,196 - 16,851,561 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,266,348 - 1,278,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,266,348 - 1,279,258 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnn4
151 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:50
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000026489
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat

Markers in Region
D1Got82  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,969,446 - 79,969,559 (+)MAPPERmRatBN7.2
Rnor_6.0181,241,080 - 81,241,192NCBIRnor6.0
Rnor_5.0182,503,596 - 82,503,708UniSTSRnor5.0
RGSC_v3.4179,624,016 - 79,624,129RGDRGSC3.4
RGSC_v3.4179,624,017 - 79,624,129UniSTSRGSC3.4
RGSC_v3.1179,702,128 - 79,702,240RGD
Celera174,423,915 - 74,424,027UniSTS
RH 3.4 Map1787.0UniSTS
RH 3.4 Map1787.0RGD
RH 2.0 Map1501.1RGD
Cytogenetic Map1q21UniSTS
RH131024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,973,983 - 79,974,178 (+)MAPPERmRatBN7.2
Rnor_6.0181,245,616 - 81,245,810NCBIRnor6.0
Rnor_5.0182,508,132 - 82,508,326UniSTSRnor5.0
RGSC_v3.4179,628,554 - 79,628,748UniSTSRGSC3.4
Celera174,428,451 - 74,428,645UniSTS
RH 3.4 Map1786.99UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 28 20 19 20 1
Low 33 25 18 18 7 10 58 33 33 10 7
Below cutoff 4 3 3 1 1 16 2 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010057357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB292802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB292803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF149250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF156554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ133438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ137429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU872449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU872450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU872451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC874397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026489   ⟹   ENSRNOP00000026489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)Ensembl
Rnor_6.0 Ensembl181,230,612 - 81,245,996 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077952   ⟹   ENSRNOP00000073190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,959,322 - 79,974,340 (+)Ensembl
Rnor_6.0 Ensembl181,230,989 - 81,245,580 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098055   ⟹   ENSRNOP00000083641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,959,741 - 79,974,340 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107668   ⟹   ENSRNOP00000084392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,959,464 - 79,974,340 (+)Ensembl
RefSeq Acc Id: NM_001270701   ⟹   NP_001257630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,248 - 89,102,273 (+)NCBI
mRatBN7.2179,959,322 - 79,974,348 (+)NCBI
Rnor_6.0181,230,847 - 81,245,980 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270702   ⟹   NP_001257631
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,248 - 89,102,273 (+)NCBI
mRatBN7.2179,959,322 - 79,974,348 (+)NCBI
Rnor_6.0181,230,847 - 81,245,980 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270703   ⟹   NP_001257632
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,248 - 89,102,273 (+)NCBI
mRatBN7.2179,959,322 - 79,974,348 (+)NCBI
Rnor_6.0181,230,847 - 81,245,980 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
Celera174,414,099 - 74,428,815 (+)NCBI
Sequence:
RefSeq Acc Id: NM_023021   ⟹   NP_075410
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,248 - 89,102,273 (+)NCBI
mRatBN7.2179,959,322 - 79,974,348 (+)NCBI
Rnor_6.0181,230,847 - 81,245,980 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
RGSC_v3.4179,613,736 - 79,628,887 (+)RGD
Celera174,414,099 - 74,428,815 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228469   ⟹   XP_006228531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,102,279 (+)NCBI
mRatBN7.2179,959,485 - 79,974,354 (+)NCBI
Rnor_6.0181,231,073 - 81,245,986 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228471   ⟹   XP_006228533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,084,407 - 89,102,279 (+)NCBI
mRatBN7.2179,958,301 - 79,974,354 (+)NCBI
Rnor_6.0181,228,590 - 81,245,986 (+)NCBI
Rnor_5.0182,490,768 - 82,508,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589696   ⟹   XP_017445185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,102,279 (+)NCBI
mRatBN7.2179,959,485 - 79,974,354 (+)NCBI
Rnor_6.0181,231,073 - 81,245,986 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090032   ⟹   XP_038945960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,096,184 (+)NCBI
mRatBN7.2179,959,485 - 79,968,258 (+)NCBI
RefSeq Acc Id: XM_063272991   ⟹   XP_063129061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,084,306 - 89,102,279 (+)NCBI
RefSeq Acc Id: XM_063272995   ⟹   XP_063129065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,084,411 - 89,102,279 (+)NCBI
RefSeq Acc Id: XM_063273000   ⟹   XP_063129070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,098,331 (+)NCBI
RefSeq Acc Id: XM_063273007   ⟹   XP_063129077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,084,412 - 89,102,279 (+)NCBI
RefSeq Acc Id: XR_005491868
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,102,279 (+)NCBI
mRatBN7.2179,959,485 - 79,974,354 (+)NCBI
RefSeq Acc Id: XR_010057357
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,087,412 - 89,102,279 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257630 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257631 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257632 (Get FASTA)   NCBI Sequence Viewer  
  NP_075410 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228531 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228533 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445185 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945960 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129061 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129065 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129070 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD38032 (Get FASTA)   NCBI Sequence Viewer  
  AAD38205 (Get FASTA)   NCBI Sequence Viewer  
  AAF05602 (Get FASTA)   NCBI Sequence Viewer  
  AAI28737 (Get FASTA)   NCBI Sequence Viewer  
  AAZ91675 (Get FASTA)   NCBI Sequence Viewer  
  ACJ61216 (Get FASTA)   NCBI Sequence Viewer  
  ACJ61217 (Get FASTA)   NCBI Sequence Viewer  
  ACJ61218 (Get FASTA)   NCBI Sequence Viewer  
  BAF95911 (Get FASTA)   NCBI Sequence Viewer  
  BAF95912 (Get FASTA)   NCBI Sequence Viewer  
  CAB40141 (Get FASTA)   NCBI Sequence Viewer  
  CBM42813 (Get FASTA)   NCBI Sequence Viewer  
  EDM08097 (Get FASTA)   NCBI Sequence Viewer  
  EDM08098 (Get FASTA)   NCBI Sequence Viewer  
  EDM08099 (Get FASTA)   NCBI Sequence Viewer  
  EDM08100 (Get FASTA)   NCBI Sequence Viewer  
  EDM08101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026489
  ENSRNOP00000026489.6
  ENSRNOP00000073190
  ENSRNOP00000073190.2
  ENSRNOP00000083641.1
  ENSRNOP00000084392
  ENSRNOP00000084392.1
  ENSRNOP00060047342
  ENSRNOP00065047544
GenBank Protein Q9QYW1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_075410   ⟸   NM_023021
- Peptide Label: isoform a
- UniProtKB: Q9WVA5 (UniProtKB/Swiss-Prot),   Q9R198 (UniProtKB/Swiss-Prot),   Q9QYW1 (UniProtKB/Swiss-Prot),   A1A5N3 (UniProtKB/TrEMBL),   F1M7L2 (UniProtKB/TrEMBL),   A6J8Y4 (UniProtKB/TrEMBL),   C6ZGH2 (UniProtKB/TrEMBL),   C6ZGH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257630   ⟸   NM_001270701
- Peptide Label: isoform a
- UniProtKB: Q9WVA5 (UniProtKB/Swiss-Prot),   Q9R198 (UniProtKB/Swiss-Prot),   Q9QYW1 (UniProtKB/Swiss-Prot),   A1A5N3 (UniProtKB/TrEMBL),   F1M7L2 (UniProtKB/TrEMBL),   A6J8Y4 (UniProtKB/TrEMBL),   C6ZGH2 (UniProtKB/TrEMBL),   C6ZGH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257632   ⟸   NM_001270703
- Peptide Label: isoform c
- UniProtKB: A9CP48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257631   ⟸   NM_001270702
- Peptide Label: isoform b
- UniProtKB: C6ZGH4 (UniProtKB/TrEMBL),   A0A8I5ZZ67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228533   ⟸   XM_006228471
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K4V7 (UniProtKB/TrEMBL),   A9CP48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228531   ⟸   XM_006228469
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445185   ⟸   XM_017589696
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073190   ⟸   ENSRNOT00000077952
RefSeq Acc Id: ENSRNOP00000026489   ⟸   ENSRNOT00000026489
RefSeq Acc Id: XP_038945960   ⟸   XM_039090032
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000083641   ⟸   ENSRNOT00000098055
RefSeq Acc Id: ENSRNOP00000084392   ⟸   ENSRNOT00000107668
RefSeq Acc Id: XP_063129061   ⟸   XM_063272991
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063129065   ⟸   XM_063272995
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129077   ⟸   XM_063273007
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063129070   ⟸   XM_063273000
- Peptide Label: isoform X4
Protein Domains
Calmodulin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYW1-F1-model_v2 AlphaFold Q9QYW1 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689792
Promoter ID:EPDNEW_R316
Type:initiation region
Name:Kcnn4_1
Description:potassium calcium-activated channel subfamily N member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0181,230,888 - 81,230,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621476 AgrOrtholog
BioCyc Gene G2FUF-60448 BioCyc
Ensembl Genes ENSRNOG00000019440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00060033002 UniProtKB/Swiss-Prot
  ENSRNOG00065033610 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026489 ENTREZGENE
  ENSRNOT00000026489.8 UniProtKB/TrEMBL
  ENSRNOT00000077952.2 UniProtKB/TrEMBL
  ENSRNOT00000098055.1 UniProtKB/TrEMBL
  ENSRNOT00000107668 ENTREZGENE
  ENSRNOT00000107668.1 UniProtKB/TrEMBL
  ENSRNOT00060057264 UniProtKB/Swiss-Prot
  ENSRNOT00065057758 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8372655 IMAGE-MGC_LOAD
InterPro CaM-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65206 UniProtKB/TrEMBL
MGC_CLONE MGC:156636 IMAGE-MGC_LOAD
NCBI Gene 65206 ENTREZGENE
PANTHER INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SK_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnn4 PhenoGen
RatGTEx ENSRNOG00000019440 RatGTEx
  ENSRNOG00060033002 RatGTEx
  ENSRNOG00065033610 RatGTEx
SMART CaMBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4V7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0D8 ENTREZGENE, UniProtKB/TrEMBL
  A1A5N3 ENTREZGENE, UniProtKB/TrEMBL
  A6J8Y3_RAT UniProtKB/TrEMBL
  A6J8Y4 ENTREZGENE
  A6J8Y6_RAT UniProtKB/TrEMBL
  A6J8Y7_RAT UniProtKB/TrEMBL
  A9CP48 ENTREZGENE, UniProtKB/TrEMBL
  C6ZGH2 ENTREZGENE, UniProtKB/TrEMBL
  C6ZGH3 ENTREZGENE, UniProtKB/TrEMBL
  C6ZGH4 ENTREZGENE, UniProtKB/TrEMBL
  F1M7L2 ENTREZGENE
  KCNN4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R198 ENTREZGENE
  Q9WVA5 ENTREZGENE
UniProt Secondary A6J8Y4 UniProtKB/TrEMBL
  F1M7L2 UniProtKB/TrEMBL
  Q9R198 UniProtKB/Swiss-Prot
  Q9WVA5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnn4  potassium calcium-activated channel subfamily N member 4  Kcnn4  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnn4  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4  Kcnn4  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnn4  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4    intermediate conductance calcium-activated potassium channel  Name updated 1299863 APPROVED
2002-08-07 Kcnn4  intermediate conductance calcium-activated potassium channel      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in oocytes 633066
gene_regulation this channel is upregulated in proliferating smooth muscle cells 633066