Adam4 (a disintegrin and metalloprotease domain 4) - Rat Genome Database

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Gene: Adam4 (a disintegrin and metalloprotease domain 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Adam4
Name: a disintegrin and metalloprotease domain 4
RGD ID: 621470
Description: metalloprotease-disintegrin with high similarity to human metargidin; may participate in dual proteolysis and integrin-mediated cell-cell, cell-matrix interaction
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: a disintegrin and metalloprotease domain (ADAM) 4; MGC125044; tMDC V; tMDCV
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,854,533 - 106,856,979 (-)NCBIGRCr8
mRatBN7.26101,123,284 - 101,125,730 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx6101,285,093 - 101,287,539 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,584,283 - 101,586,729 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,956,797 - 100,959,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06105,158,024 - 105,160,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6105,158,026 - 105,160,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06113,305,123 - 113,307,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46105,283,374 - 105,285,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16105,287,500 - 105,288,108 (-)NCBI
Celera698,967,426 - 98,969,872 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



#
Reference Title
Reference Citation
1. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, etal., Genomics 1996 Jun 15;34(3):413-7.
2. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
PMID:12477932  



.

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000008367
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 35 rows
BF390070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26101,123,649 - 101,123,815 (+)MAPPERmRatBN7.2
Rnor_6.06105,158,390 - 105,158,555NCBIRnor6.0
Rnor_5.06113,305,489 - 113,305,654UniSTSRnor5.0
RGSC_v3.46105,283,740 - 105,283,905UniSTSRGSC3.4
Celera698,967,792 - 98,967,957UniSTS
RH 3.4 Map6728.5UniSTS
Cytogenetic Map6q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 90 89 58 25 58 6 217 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000008367   ⟹   ENSRNOP00000008367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6105,158,026 - 105,160,470 (-)Ensembl
RefSeq Acc Id: NM_020305   ⟹   NP_064701
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,854,533 - 106,856,979 (-)NCBI
mRatBN7.26101,123,284 - 101,125,730 (-)NCBI
Rnor_6.06105,158,024 - 105,160,470 (-)NCBI
Rnor_5.06113,305,123 - 113,307,569 (-)NCBI
RGSC_v3.46105,283,374 - 105,285,820 (-)RGD
Celera698,967,426 - 98,969,872 (-)RGD
Sequence:
Protein RefSeqs NP_064701 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07438 (Get FASTA)   NCBI Sequence Viewer  
  CAA72277 (Get FASTA)   NCBI Sequence Viewer  
  EDL81420 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_064701   ⟸   NM_020305
- Peptide Label: precursor
- UniProtKB: Q3B7V9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008367   ⟸   ENSRNOT00000008367
Disintegrin   EGF-like   Peptidase M12B

Name Modeler Protein Id AA Range Protein Structure
AF-Q3B7V9-F1-model_v2 AlphaFold Q3B7V9 1-755 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694704
Promoter ID:EPDNEW_R5229
Type:single initiation site
Name:Adam4_1
Description:a disintegrin and metalloprotease domain 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06105,160,494 - 105,160,554EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36893 BioCyc
Ensembl Genes ENSRNOG00000038275 Ensembl
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132937 IMAGE-MGC_LOAD
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:57022 UniProtKB/TrEMBL
MGC_CLONE MGC:125044 IMAGE-MGC_LOAD
NCBI Gene 57022 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF167 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam4 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038275 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt Q3B7V9 ENTREZGENE, UniProtKB/TrEMBL
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Adam4  a disintegrin and metalloprotease domain 4    a disintegrin and metalloprotease domain (ADAM) 4  Name updated 1299863 APPROVED
2002-08-07 Adam4  a disintegrin and metalloprotease domain (ADAM) 4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in germ cells and somatic cells 631879
gene_expression expressed in germ cells and somatic cells 632496