Macroh2a1 (macroH2A.1 histone) - Rat Genome Database

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Gene: Macroh2a1 (macroH2A.1 histone) Rattus norvegicus
Analyze
Symbol: Macroh2a1
Name: macroH2A.1 histone
RGD ID: 621462
Description: Predicted to enable several functions, including ADP-D-ribose binding activity; DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of gene expression; and regulation of response to oxidative stress. Predicted to act upstream of or within dosage compensation by inactivation of X chromosome and protein poly-ADP-ribosylation. Located in chromatin. Part of nucleosome. Orthologous to human MACROH2A1 (macroH2A.1 histone); PARTICIPATES IN histone modification pathway; systemic lupus erythematosus pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: core histone macro-H2A.1; H2A histone family, member Y; H2A.y; H2A/y; H2afy; histone macroH2A1; MGC105515; mH2A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,484,340 - 8,547,268 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,484,246 - 8,547,257 (+)EnsemblGRCr8
mRatBN7.2178,479,331 - 8,542,071 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,479,372 - 8,542,072 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx178,494,921 - 8,557,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,028,056 - 10,089,627 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,491,302 - 8,553,426 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,282,109 - 9,344,698 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,282,675 - 9,344,678 (+)Ensemblrn6Rnor6.0
Rnor_5.01711,440,567 - 11,502,758 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41714,457,307 - 14,520,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,563,234 - 8,625,826 (+)NCBICelera
RGSC_v3.11714,457,306 - 14,520,963 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomipramine  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydroquinone  (ISO)
imipramine  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Barr body  (IEA,ISO)
chromatin  (IDA,IEA,ISO)
chromosome  (IEA)
condensed chromosome  (IEA,ISO)
nuclear chromosome  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleosome  (IBA,IDA,IEA)
nucleus  (IBA,IEA,ISO,ISS)
pericentric heterochromatin  (IEA,ISO)
site of DNA damage  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Gaspar-Maia A, etal., Nat Commun. 2013;4:1565. doi: 10.1038/ncomms2582.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. MacroH2A, a core histone containing a large nonhistone region. Pehrson JR and Fried VA, Science 1992 Sep 4;257(5075):1398-400.
7. Developmental and tissue expression patterns of histone macroH2A1 subtypes. Pehrson JR, etal., J Cell Biochem. 1997 Apr;65(1):107-13.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Histone variants: dynamic punctuation in transcription. Weber CM and Henikoff S, Genes Dev. 2014 Apr 1;28(7):672-82. doi: 10.1101/gad.238873.114.
Additional References at PubMed
PMID:11331621   PMID:12082075   PMID:12419249   PMID:12477932   PMID:15053874   PMID:15489334   PMID:16107708   PMID:18936163   PMID:19135898   PMID:19486527   PMID:19734898   PMID:20008927  
PMID:21630459   PMID:22194607   PMID:23022728   PMID:23376485   PMID:23533145   PMID:23595991   PMID:24071584   PMID:25526730   PMID:25931508   PMID:26373281   PMID:29476059  


Genomics

Comparative Map Data
Macroh2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,484,340 - 8,547,268 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,484,246 - 8,547,257 (+)EnsemblGRCr8
mRatBN7.2178,479,331 - 8,542,071 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,479,372 - 8,542,072 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx178,494,921 - 8,557,042 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,028,056 - 10,089,627 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,491,302 - 8,553,426 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,282,109 - 9,344,698 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,282,675 - 9,344,678 (+)Ensemblrn6Rnor6.0
Rnor_5.01711,440,567 - 11,502,758 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41714,457,307 - 14,520,963 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,563,234 - 8,625,826 (+)NCBICelera
RGSC_v3.11714,457,306 - 14,520,963 (+)NCBI
Cytogenetic Map17p14NCBI
MACROH2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,334,381 - 135,399,887 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,333,609 - 135,400,023 (-)Ensemblhg38GRCh38
GRCh375134,670,071 - 134,735,577 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365134,697,970 - 134,763,476 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345134,697,969 - 134,762,802NCBI
Celera5130,793,877 - 130,859,396 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5129,857,754 - 129,923,276 (-)NCBIHuRef
CHM1_15134,102,741 - 134,168,247 (-)NCBICHM1_1
T2T-CHM13v2.05135,861,569 - 135,927,059 (-)NCBIT2T-CHM13v2.0
Macroh2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,221,435 - 56,283,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,221,432 - 56,284,174 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381356,073,622 - 56,135,626 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,073,619 - 56,136,361 (-)Ensemblmm10GRCm38
MGSCv371356,174,983 - 56,236,911 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361356,083,796 - 56,145,137 (-)NCBIMGSCv36mm8
Celera1357,128,470 - 57,190,557 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
LOC102008188
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540830,497,531 - 30,550,118 (-)Ensembl
ChiLan1.0NW_00495540830,497,531 - 30,550,095 (-)NCBIChiLan1.0ChiLan1.0
LOC100974858
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24130,622,460 - 130,690,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15128,762,020 - 128,826,904 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05130,727,065 - 130,791,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15136,868,521 - 136,933,834 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5136,868,521 - 136,933,834 (-)EnsemblpanPan2panpan1.1
MACROH2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,369,957 - 23,448,235 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,370,300 - 23,438,219 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1122,118,904 - 22,197,335 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01124,196,790 - 24,265,246 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,205,586 - 24,264,536 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,875,051 - 22,953,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01122,740,600 - 22,819,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,384,272 - 23,469,034 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971629
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213123,471,582 - 123,531,449 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365972,495,862 - 2,556,603 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365972,496,489 - 2,556,352 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MACROH2A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2137,534,138 - 137,623,886 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12137,535,128 - 137,623,886 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,054,432 - 143,135,657 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MACROH2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,113,212 - 38,178,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,113,195 - 38,168,382 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603439,737,224 - 39,802,999 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101706296
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473311,650,537 - 11,715,999 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473311,650,067 - 11,714,399 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116883258
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11474,405,158 - 74,441,548 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Macroh2a1
336 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:386
Count of miRNA genes:189
Interacting mature miRNAs:223
Transcripts:ENSRNOT00000015632, ENSRNOT00000051702
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M99065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M99066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015632   ⟹   ENSRNOP00000015632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,484,246 - 8,547,256 (+)Ensembl
mRatBN7.2 Ensembl178,485,886 - 8,541,561 (+)Ensembl
Rnor_6.0 Ensembl179,289,189 - 9,344,188 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051702   ⟹   ENSRNOP00000049143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,484,554 - 8,547,257 (+)Ensembl
mRatBN7.2 Ensembl178,479,372 - 8,542,051 (+)Ensembl
Rnor_6.0 Ensembl179,282,675 - 9,344,678 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099134   ⟹   ENSRNOP00000076427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,479,372 - 8,542,072 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117731   ⟹   ENSRNOP00000083083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,484,550 - 8,524,860 (+)Ensembl
mRatBN7.2 Ensembl178,479,372 - 8,518,785 (+)Ensembl
RefSeq Acc Id: NM_017182   ⟹   NP_058878
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,550 - 8,547,268 (+)NCBI
mRatBN7.2178,479,352 - 8,542,071 (+)NCBI
Rnor_6.0179,282,675 - 9,344,698 (+)NCBI
Rnor_5.01711,440,567 - 11,502,758 (+)NCBI
RGSC_v3.41714,457,307 - 14,520,963 (+)RGD
Celera178,563,234 - 8,625,826 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253573   ⟹   XP_006253635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,547,207 (+)NCBI
mRatBN7.2178,479,334 - 8,542,071 (+)NCBI
Rnor_6.0179,282,640 - 9,344,637 (+)NCBI
Rnor_5.01711,440,567 - 11,502,758 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253575   ⟹   XP_006253637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,547,207 (+)NCBI
mRatBN7.2178,479,333 - 8,542,071 (+)NCBI
Rnor_6.0179,282,640 - 9,344,637 (+)NCBI
Rnor_5.01711,440,567 - 11,502,758 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253576   ⟹   XP_006253638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,340 - 8,547,207 (+)NCBI
mRatBN7.2178,479,334 - 8,542,071 (+)NCBI
Rnor_6.0179,282,640 - 9,344,637 (+)NCBI
Rnor_5.01711,440,567 - 11,502,758 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095579   ⟹   XP_038951507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,523,972 (+)NCBI
mRatBN7.2178,479,332 - 8,518,775 (+)NCBI
RefSeq Acc Id: XM_039095580   ⟹   XP_038951508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,523,972 (+)NCBI
mRatBN7.2178,479,334 - 8,518,775 (+)NCBI
RefSeq Acc Id: XR_005495266
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,537,427 (+)NCBI
mRatBN7.2178,479,331 - 8,542,010 (+)NCBI
RefSeq Acc Id: XR_005495267
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,535,443 (+)NCBI
mRatBN7.2178,479,331 - 8,530,214 (+)NCBI
RefSeq Acc Id: XR_010058850
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,537,427 (+)NCBI
RefSeq Acc Id: XR_010058851
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,484,512 - 8,537,427 (+)NCBI
RefSeq Acc Id: NP_058878   ⟸   NM_017182
- UniProtKB: Q63325 (UniProtKB/Swiss-Prot),   O09140 (UniProtKB/Swiss-Prot),   Q02874 (UniProtKB/Swiss-Prot),   A6KAN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253635   ⟸   XM_006253573
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253637   ⟸   XM_006253575
- Peptide Label: isoform X2
- UniProtKB: Q63325 (UniProtKB/Swiss-Prot),   Q02874 (UniProtKB/Swiss-Prot),   O09140 (UniProtKB/Swiss-Prot),   A0A140TAB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253638   ⟸   XM_006253576
- Peptide Label: isoform X3
- UniProtKB: Q63325 (UniProtKB/Swiss-Prot),   O09140 (UniProtKB/Swiss-Prot),   Q02874 (UniProtKB/Swiss-Prot),   A6KAP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049143   ⟸   ENSRNOT00000051702
Ensembl Acc Id: ENSRNOP00000015632   ⟸   ENSRNOT00000015632
RefSeq Acc Id: XP_038951507   ⟸   XM_039095579
- Peptide Label: isoform X4
- UniProtKB: A6KAP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951508   ⟸   XM_039095580
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZW79 (UniProtKB/TrEMBL),   A6KAP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076427   ⟸   ENSRNOT00000099134
Ensembl Acc Id: ENSRNOP00000083083   ⟸   ENSRNOT00000117731
Protein Domains
Histone H2A   Histone H2A C-terminal   Histone H2A/H2B/H3   Macro

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02874-F1-model_v2 AlphaFold Q02874 1-371 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621462 AgrOrtholog
BioCyc Gene G2FUF-10243 BioCyc
Ensembl Genes ENSRNOG00000011523 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015632 ENTREZGENE
  ENSRNOT00000051702 ENTREZGENE
  ENSRNOT00000051702.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
  3.40.220.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126329 IMAGE-MGC_LOAD
InterPro Core_histone_macro-H2A UniProtKB/Swiss-Prot
  Histone-fold UniProtKB/Swiss-Prot
  Histone_H2A UniProtKB/Swiss-Prot
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
  Macro_dom UniProtKB/Swiss-Prot
  Macro_dom-like UniProtKB/Swiss-Prot
  Macro_H2A UniProtKB/Swiss-Prot
KEGG Report rno:29384 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105515 IMAGE-MGC_LOAD
NCBI Gene 29384 ENTREZGENE
PANTHER PTHR23430 UniProtKB/Swiss-Prot
Pfam Histone UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
  Macro UniProtKB/Swiss-Prot
PhenoGen Macroh2a1 PhenoGen
PIRSF Core_histone_macro-H2A UniProtKB/Swiss-Prot
PRINTS HISTONEH2A UniProtKB/Swiss-Prot
PROSITE MACRO UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011523 RatGTEx
SMART A1pp UniProtKB/Swiss-Prot
  H2A UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
  SSF52949 UniProtKB/Swiss-Prot
UniProt A0A140TAB4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZW79 ENTREZGENE, UniProtKB/TrEMBL
  A6KAN9 ENTREZGENE, UniProtKB/TrEMBL
  A6KAP1 ENTREZGENE, UniProtKB/TrEMBL
  A6KAP2 ENTREZGENE, UniProtKB/TrEMBL
  H2AY_RAT UniProtKB/Swiss-Prot
  O09140 ENTREZGENE
  Q02874 ENTREZGENE
  Q63325 ENTREZGENE
UniProt Secondary O09140 UniProtKB/Swiss-Prot
  Q63325 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-20 Macroh2a1  macroH2A.1 histone  H2afy  H2A histone family, member Y  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 H2afy  H2A histone family, member Y      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 H2afy  H2A histone family, member Y      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nucleosomes 728409