Klf5 (KLF transcription factor 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Klf5 (KLF transcription factor 5) Rattus norvegicus
Analyze
Symbol: Klf5
Name: KLF transcription factor 5
RGD ID: 621446
Description: Enables sequence-specific DNA binding activity. Involved in cellular response to endothelin and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Used to study transient cerebral ischemia. Biomarker of metabolic dysfunction and alcohol associated liver disease. Orthologous to human KLF5 (KLF transcription factor 5); INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Bteb2; IKLF; Krueppel-like factor 5; Kruppel-like factor 5; Kruppel-like factor 5 (intestinal)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Klf5-ps1   Klf5-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,472,081 - 82,487,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1582,472,065 - 82,487,262 (+)EnsemblGRCr8
mRatBN7.21576,060,320 - 76,079,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1580,049,636 - 80,064,848 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,126,239 - 81,141,451 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,073,796 - 78,089,010 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,703,796 - 83,722,921 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,703,791 - 83,722,921 (+)Ensemblrn6Rnor6.0
Rnor_5.01587,212,719 - 87,231,850 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41583,103,177 - 83,118,363 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1575,305,416 - 75,320,302 (+)NCBICelera
RGSC_v3.11583,121,895 - 83,132,620 (+)NCBI
Cytogenetic Map15q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimonite  (ISO)
antimycin A  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
boric acid  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
Curcumol  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
etoposide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pioglitazone  (EXP)
progesterone  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
udenafil  (EXP)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
transcription regulator complex  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Intestinal tumor progression is associated with altered function of KLF5. Bateman NW, etal., J Biol Chem 2004 Mar 26;279(13):12093-101. Epub 2004 Jan 15.
2. microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway. Chang L, etal., Mol Med. 2020 Apr 9;26(1):31. doi: 10.1186/s10020-020-00150-w.
3. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Cheng Y, etal., Circ Res. 2009 Jul 17;105(2):158-66. doi: 10.1161/CIRCRESAHA.109.197517. Epub 2009 Jun 18.
4. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower saponins in rats with metabolic hypertension by inhibiting the activation of the renin-angiotensin-aldosterone system through complement 3. Huang Q, etal., BMC Complement Med Ther. 2023 Jan 18;23(1):13. doi: 10.1186/s12906-022-03828-2.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy. Nagai R, etal., Adv Exp Med Biol 2003;538:57-65; discussion 66.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Inducible expression of BTEB2, a member of the zinc-finger family of transcription factors, in cardiac allograft arteriosclerosis. Ogata T, etal., Transplant Proc. 2000 Nov;32(7):2032-3.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2. Sakamoto H, etal., Cardiology. 2003;100(2):80-5.
14. Intestinal-enriched Kruppel-like factor (Kruppel-like factor 5) is a positive regulator of cellular proliferation. Sun R, etal., J Biol Chem 2001 Mar 9;276(10):6897-900.
15. BTEB2, a Kruppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene. Watanabe N, etal., Circ Res. 1999 Jul 23;85(2):182-91.
16. The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. Xu J, etal., Gene. 2018 Dec 30;679:266-273. doi: 10.1016/j.gene.2018.09.010. Epub 2018 Sep 7.
17. HDAC2 phosphorylation-dependent Klf5 deacetylation and RARalpha acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Zheng B, etal., Cell Res. 2011 Oct;21(10):1487-508. doi: 10.1038/cr.2011.34. Epub 2011 Mar 8.
Additional References at PubMed
PMID:12101409   PMID:12477932   PMID:12568725   PMID:14711826   PMID:15581624   PMID:16595680   PMID:18095165   PMID:18178156   PMID:19628677   PMID:20037604   PMID:20439489   PMID:20719859  
PMID:21468585   PMID:21503901   PMID:22147266   PMID:23266329   PMID:24770868   PMID:25205373   PMID:25323860   PMID:26102029   PMID:26702149   PMID:27743478   PMID:27764756   PMID:29211809  
PMID:30322616   PMID:36135378  


Genomics

Comparative Map Data
Klf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,472,081 - 82,487,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1582,472,065 - 82,487,262 (+)EnsemblGRCr8
mRatBN7.21576,060,320 - 76,079,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1580,049,636 - 80,064,848 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01581,126,239 - 81,141,451 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01578,073,796 - 78,089,010 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,703,796 - 83,722,921 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,703,791 - 83,722,921 (+)Ensemblrn6Rnor6.0
Rnor_5.01587,212,719 - 87,231,850 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41583,103,177 - 83,118,363 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1575,305,416 - 75,320,302 (+)NCBICelera
RGSC_v3.11583,121,895 - 83,132,620 (+)NCBI
Cytogenetic Map15q21NCBI
KLF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381373,054,976 - 73,077,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1373,054,976 - 73,077,541 (+)Ensemblhg38GRCh38
GRCh371373,629,114 - 73,651,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,531,143 - 72,549,677 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341372,531,142 - 72,549,677NCBI
Celera1354,531,627 - 54,550,162 (+)NCBICelera
Cytogenetic Map13q22.1NCBI
HuRef1354,330,388 - 54,348,922 (+)NCBIHuRef
CHM1_11373,600,752 - 73,619,289 (+)NCBICHM1_1
T2T-CHM13v2.01372,276,491 - 72,299,055 (+)NCBIT2T-CHM13v2.0
Klf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,536,127 - 99,550,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,536,127 - 99,552,472 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381499,298,691 - 99,313,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,298,691 - 99,315,036 (+)Ensemblmm10GRCm38
MGSCv371499,697,910 - 99,712,631 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361498,181,825 - 98,196,546 (+)NCBIMGSCv36mm8
Celera1497,974,632 - 97,989,357 (+)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.43NCBI
Klf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,644,077 - 33,658,094 (-)Ensembl
ChiLan1.0NW_00495540433,642,604 - 33,665,445 (-)NCBIChiLan1.0ChiLan1.0
KLF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,642,536 - 74,661,347 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11373,233,936 - 73,252,670 (+)NCBINHGRI_mPanPan1
KLF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12227,163,179 - 27,185,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2227,162,397 - 27,200,871 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2227,019,480 - 27,041,542 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02227,495,564 - 27,517,646 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,495,481 - 27,517,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12227,157,251 - 27,179,316 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02227,200,989 - 27,218,613 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,268,194 - 27,290,288 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,390,448 - 132,412,071 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365117,806,708 - 7,824,992 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365117,806,714 - 7,824,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,369,810 - 45,388,314 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11145,370,009 - 45,386,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,866,834 - 49,870,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11q13-q14NCBI
KLF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1352,188,139 - 52,210,882 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660468,300,637 - 8,319,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,489,535 - 27,505,494 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475127,488,434 - 27,509,871 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11225,189,489 - 25,204,823 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf5
113 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir31rno-miR-31a-5pMirtarbaseexternal_infoReporter assayFunctional MTI19542014
Mir145rno-miR-145-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19542014

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:121
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000057843
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
UniSTS:237237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21576,067,436 - 76,067,606 (+)MAPPERmRatBN7.2
mRatBN7.2319,788,432 - 19,788,601 (+)MAPPERmRatBN7.2
Rnor_6.0315,772,895 - 15,773,063NCBIRnor6.0
Rnor_6.01583,710,914 - 83,711,083NCBIRnor6.0
Rnor_5.01587,219,842 - 87,220,011UniSTSRnor5.0
Rnor_5.0321,067,659 - 21,067,827UniSTSRnor5.0
RGSC_v3.4315,671,010 - 15,671,178UniSTSRGSC3.4
RGSC_v3.41583,106,356 - 83,106,525UniSTSRGSC3.4
Celera1575,308,294 - 75,308,463UniSTS
Celera314,499,987 - 14,500,155UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 148 91 90 59 84 59 6 348 184 11 127 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000057843   ⟹   ENSRNOP00000054653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1582,472,065 - 82,487,262 (+)Ensembl
mRatBN7.2 Ensembl1576,064,258 - 76,079,445 (+)Ensembl
Rnor_6.0 Ensembl1583,707,735 - 83,722,921 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090637   ⟹   ENSRNOP00000075155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1583,703,791 - 83,721,398 (+)Ensembl
RefSeq Acc Id: NM_053394   ⟹   NP_445846
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,472,081 - 82,487,267 (+)NCBI
mRatBN7.21576,064,258 - 76,079,445 (+)NCBI
Rnor_6.01583,707,735 - 83,722,921 (+)NCBI
Rnor_5.01587,212,719 - 87,231,850 (+)NCBI
RGSC_v3.41583,103,177 - 83,118,363 (+)RGD
Celera1575,305,416 - 75,320,302 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445846 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG16894 (Get FASTA)   NCBI Sequence Viewer  
  AAH81758 (Get FASTA)   NCBI Sequence Viewer  
  BAC57493 (Get FASTA)   NCBI Sequence Viewer  
  EDM02422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054653
  ENSRNOP00000054653.2
RefSeq Acc Id: NP_445846   ⟸   NM_053394
- UniProtKB: F1LSL7 (UniProtKB/TrEMBL),   Q66HP1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054653   ⟸   ENSRNOT00000057843
Ensembl Acc Id: ENSRNOP00000075155   ⟸   ENSRNOT00000090637
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LSL7-F1-model_v2 AlphaFold F1LSL7 1-443 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699860
Promoter ID:EPDNEW_R10384
Type:multiple initiation site
Name:Klf5_1
Description:Kruppel-like factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01583,707,722 - 83,707,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621446 AgrOrtholog
BioCyc Gene G2FUF-12785 BioCyc
Ensembl Genes ENSRNOG00000008785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057843 ENTREZGENE
  ENSRNOT00000057843.4 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132572 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:84410 UniProtKB/TrEMBL
MGC_CLONE MGC:93308 IMAGE-MGC_LOAD
NCBI Gene 84410 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  PTHR23235:SF82 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf5 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008785 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt F1LSL7 ENTREZGENE, UniProtKB/TrEMBL
  Q66HP1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf5  KLF transcription factor 5  Klf5  Kruppel-like factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Klf5  Kruppel-like factor 5    Kruppel-like factor 5 (intestinal)  Name updated 1299863 APPROVED
2002-08-07 Klf5  Kruppel-like factor 5 (intestinal)      Symbol and Name status set to provisional 70820 PROVISIONAL