Prom2 (prominin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prom2 (prominin 2) Rattus norvegicus
Analyze
Symbol: Prom2
Name: prominin 2
RGD ID: 621435
Description: Enables cholesterol binding activity. Predicted to be involved in negative regulation of caveolin-mediated endocytosis; negative regulation of pinocytosis; and positive regulation of cell projection organization. Located in several cellular components, including microspike; microvillus; and prominosome. Colocalizes with membrane raft. Orthologous to human PROM2 (prominin 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PROM-2; Prom-rp; prominin-2; prominin-like protein 2; prominin-related protein; Promrp; rPROML2; testosterone-regulated prominin-related protein; Trprp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,200,944 - 135,215,130 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,200,944 - 135,215,077 (-)EnsemblGRCr8
mRatBN7.23114,747,654 - 114,761,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,747,654 - 114,761,787 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,636,941 - 118,651,057 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,232,493 - 127,246,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,892,871 - 124,906,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,087,633 - 120,107,495 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,092,582 - 120,106,697 (-)Ensemblrn6Rnor6.0
Rnor_5.03127,225,616 - 127,239,978 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43115,030,864 - 115,044,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,584,551 - 113,598,660 (-)NCBICelera
RGSC_v3.13114,936,437 - 114,950,560 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. Fargeas CA, etal., J Biol Chem 2003 Mar 7;278(10):8586-96.
2. Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine. Florek M, etal., Cell Tissue Res. 2007 Apr;328(1):31-47. Epub 2006 Nov 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification and characterization of a novel testosterone-regulated prominin-like gene in the rat ventral prostate. Zhang Q, etal., Endocrinology 2002 Dec;143(12):4788-96.
Additional References at PubMed
PMID:12832703   PMID:19056867   PMID:19199708   PMID:23376485   PMID:23533145   PMID:23583380   PMID:29113580  


Genomics

Comparative Map Data
Prom2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,200,944 - 135,215,130 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,200,944 - 135,215,077 (-)EnsemblGRCr8
mRatBN7.23114,747,654 - 114,761,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,747,654 - 114,761,787 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,636,941 - 118,651,057 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,232,493 - 127,246,609 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,892,871 - 124,906,989 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,087,633 - 120,107,495 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,092,582 - 120,106,697 (-)Ensemblrn6Rnor6.0
Rnor_5.03127,225,616 - 127,239,978 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43115,030,864 - 115,044,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,584,551 - 113,598,660 (-)NCBICelera
RGSC_v3.13114,936,437 - 114,950,560 (-)NCBI
Cytogenetic Map3q36NCBI
PROM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38295,274,449 - 95,291,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl295,274,444 - 95,302,296 (+)Ensemblhg38GRCh38
GRCh37295,940,197 - 95,957,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36295,303,928 - 95,320,781 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34295,362,074 - 95,378,928NCBI
Celera290,293,346 - 90,310,195 (+)NCBICelera
Cytogenetic Map2q11.1NCBI
HuRef289,967,276 - 89,984,207 (+)NCBIHuRef
CHM1_1295,944,554 - 95,961,410 (+)NCBICHM1_1
T2T-CHM13v2.0295,780,925 - 95,797,779 (+)NCBIT2T-CHM13v2.0
Prom2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,368,873 - 127,383,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,368,393 - 127,383,387 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382127,526,953 - 127,541,417 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,526,473 - 127,541,467 (-)Ensemblmm10GRCm38
MGSCv372127,352,689 - 127,367,153 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362127,217,914 - 127,232,908 (-)NCBIMGSCv36mm8
Celera2128,771,840 - 128,786,259 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.04NCBI
Prom2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,524,805 - 3,538,935 (+)Ensembl
ChiLan1.0NW_0049554703,524,900 - 3,538,882 (+)NCBIChiLan1.0ChiLan1.0
PROM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21233,000,900 - 33,034,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A33,007,160 - 33,034,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A104,117,086 - 104,138,298 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A96,177,524 - 96,194,382 (+)NCBIPanPan1.1PanPan1.1panPan2
PROM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,814,260 - 34,827,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,815,735 - 34,827,740 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1734,583,025 - 34,596,585 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01735,585,103 - 35,598,677 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,586,665 - 35,599,267 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,713,897 - 34,727,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,782,431 - 34,795,991 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,991,754 - 35,005,323 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prom2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,819,249 - 82,832,968 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493674473,004 - 85,911 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl346,003,238 - 46,023,405 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1346,001,949 - 46,025,425 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2348,368,831 - 48,381,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114305,442 - 323,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14306,515 - 323,909 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041167,709,896 - 167,727,720 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prom2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,036,280 - 2,049,909 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247492,036,335 - 2,049,434 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prom2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15106,312,012 - 106,324,893 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prom2
101 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:548
Count of miRNA genes:247
Interacting mature miRNAs:307
Transcripts:ENSRNOT00000020354
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH134252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,747,713 - 114,747,918 (+)MAPPERmRatBN7.2
Rnor_6.03120,092,624 - 120,092,828NCBIRnor6.0
Rnor_5.03127,239,714 - 127,239,918UniSTSRnor5.0
RGSC_v3.43115,030,914 - 115,031,118UniSTSRGSC3.4
Celera3113,584,601 - 113,584,805UniSTS
RH 3.4 Map3997.3UniSTS
Cytogenetic Map3q36UniSTS
BM388274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23114,755,494 - 114,755,677 (+)MAPPERmRatBN7.2
Rnor_6.03120,100,405 - 120,100,587NCBIRnor6.0
Rnor_5.03127,231,955 - 127,232,137UniSTSRnor5.0
RGSC_v3.43115,038,696 - 115,038,878UniSTSRGSC3.4
Celera3113,592,370 - 113,592,552UniSTS
RH 3.4 Map3986.5UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 42 119 72 71 40 72 40 6 291 147 11 95 81 87 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000020354   ⟹   ENSRNOP00000020354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3114,747,654 - 114,761,787 (-)Ensembl
Rnor_6.0 Ensembl3120,092,582 - 120,106,697 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097703   ⟹   ENSRNOP00000094442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,200,944 - 135,215,077 (-)Ensembl
mRatBN7.2 Ensembl3114,747,654 - 114,761,787 (-)Ensembl
RefSeq Acc Id: NM_138857   ⟹   NP_620212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,200,944 - 135,215,077 (-)NCBI
mRatBN7.23114,747,654 - 114,761,787 (-)NCBI
Rnor_6.03120,092,574 - 120,106,697 (-)NCBI
Rnor_5.03127,225,616 - 127,239,978 (+)NCBI
RGSC_v3.43115,030,864 - 115,044,987 (-)RGD
Celera3113,584,551 - 113,598,660 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283056   ⟹   XP_063139126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,200,954 - 135,215,130 (-)NCBI
Protein Sequences
Protein RefSeqs NP_620212 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139126 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM03109 (Get FASTA)   NCBI Sequence Viewer  
  AAN63818 (Get FASTA)   NCBI Sequence Viewer  
  EDL80120 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094442
GenBank Protein Q8CJ52 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620212   ⟸   NM_138857
- Peptide Label: precursor
- UniProtKB: Q8R4B6 (UniProtKB/Swiss-Prot),   Q8CJ52 (UniProtKB/Swiss-Prot),   F1LQW5 (UniProtKB/TrEMBL),   A6HQ19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020354   ⟸   ENSRNOT00000020354
Ensembl Acc Id: ENSRNOP00000094442   ⟸   ENSRNOT00000097703
RefSeq Acc Id: XP_063139126   ⟸   XM_063283056
- Peptide Label: isoform X1
- UniProtKB: Q8R4B6 (UniProtKB/Swiss-Prot),   Q8CJ52 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJ52-F1-model_v2 AlphaFold Q8CJ52 1-834 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621435 AgrOrtholog
BioCyc Gene G2FUF-47988 BioCyc
Ensembl Genes ENSRNOG00000014710 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000097703 ENTREZGENE
InterPro Prominin UniProtKB/Swiss-Prot
KEGG Report rno:192211 UniProtKB/Swiss-Prot
NCBI Gene 192211 ENTREZGENE
PANTHER PROMININ-2 UniProtKB/Swiss-Prot
  PTHR22730 UniProtKB/Swiss-Prot
Pfam Prominin UniProtKB/Swiss-Prot
PhenoGen Prom2 PhenoGen
RatGTEx ENSRNOG00000014710 RatGTEx
UniProt A0A8I6ARL5_RAT UniProtKB/TrEMBL
  A6HQ19 ENTREZGENE, UniProtKB/TrEMBL
  F1LQW5 ENTREZGENE
  PROM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R4B6 ENTREZGENE
UniProt Secondary Q8R4B6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prom2  prominin 2  Promrp  prominin-related protein  Symbol and Name updated 1299863 APPROVED
2003-03-04 Promrp  prominin-related protein  Trprp  testosterone-regulated prominin-related protein  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-08-07 Trprp  testosterone-regulated prominin-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane protein, mainly localized in nuclear envelope and perinuclear region 628421
gene_domains contains five transmembrane segments and two glcosylated extracellular loops 633875
gene_expression not expressed in the eye in contrast to prominin-1 633875
gene_function proapoptotic membrane protein 628421
gene_process may support tumor suppression by inducing cell death in cancer cells and growth suppression in normal cells 628421
gene_process may be involved in growth suppression in prostate 628421
gene_product member of the prominin family of pentaspan membrane proteins 633875
gene_protein 886-amino acids 628421
gene_protein a transmembrane protein with five transmembrane domains; 32% homology with prominin and prominin-like protein from human 628421
gene_regulation may be associated with aggressive phenotype in prostate cancer cells 628421