Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Klc1 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of KLC1 mRNA | CTD | PMID:22206623 | Klc1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of KLC1 mRNA] | CTD | PMID:22206623 | Klc1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Klc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLC1 mRNA | CTD | PMID:21570461 | Klc1 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of KLC1 mRNA | CTD | PMID:21346803 | Klc1 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of KLC1 mRNA | CTD | PMID:21346803 | Klc1 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLC1 mRNA | CTD | PMID:30851411 | Klc1 | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2,6-dinitrotoluene affects the expression of KLC1 mRNA | CTD | PMID:21346803 | Klc1 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of KLC1 mRNA | CTD | PMID:28973697 | Klc1 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of KLC1 mRNA | CTD | PMID:28973697 | Klc1 | Rat | 4-vinylcyclohexene dioxide | affects expression | ISO | Klc1 (Mus musculus) | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of KLC1 mRNA | CTD | PMID:20829426 | Klc1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of KLC1 mRNA | CTD | PMID:36843608 | Klc1 | Rat | acrolein | multiple interactions | ISO | KLC1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268|PMID:32845096 | Klc1 | Rat | afimoxifene | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | afimoxifene results in increased expression of KLC1 mRNA | CTD | PMID:16849584 | Klc1 | Rat | aflatoxin B1 | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of KLC1 mRNA | CTD | PMID:19770486 | Klc1 | Rat | Aflatoxin B2 alpha | decreases methylation | ISO | KLC1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of KLC1 intron | CTD | PMID:30157460 | Klc1 | Rat | alpha-pinene | multiple interactions | ISO | KLC1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268 | Klc1 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KLC1 mRNA | CTD | PMID:16483693 | Klc1 | Rat | antirheumatic drug | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of KLC1 mRNA | CTD | PMID:24449571 | Klc1 | Rat | aristolochic acid A | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KLC1 mRNA | CTD | PMID:33212167 | Klc1 | Rat | Aroclor 1254 | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of KLC1 mRNA | CTD | PMID:23650126 | Klc1 | Rat | arsane | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Arsenic results in decreased expression of KLC1 mRNA | CTD | PMID:19654921 | Klc1 | Rat | arsane | affects methylation | ISO | KLC1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of KLC1 gene | CTD | PMID:25304211 | Klc1 | Rat | arsenic atom | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Arsenic results in decreased expression of KLC1 mRNA | CTD | PMID:19654921 | Klc1 | Rat | arsenic atom | affects methylation | ISO | KLC1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of KLC1 gene | CTD | PMID:25304211 | Klc1 | Rat | benzo[a]pyrene | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KLC1 mRNA | CTD | PMID:22228805 | Klc1 | Rat | benzo[a]pyrene | decreases methylation | ISO | Klc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of KLC1 exon; Benzo(a)pyrene results in decreased methylation of KLC1 more ... | CTD | PMID:27901495 | Klc1 | Rat | benzo[a]pyrene | affects methylation | ISO | KLC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KLC1 intron | CTD | PMID:30157460 | Klc1 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLC1 mRNA | CTD | PMID:19150397 | Klc1 | Rat | beta-naphthoflavone | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | beta-Naphthoflavone results in increased expression of KLC1 protein | CTD | PMID:39638853 | Klc1 | Rat | bisphenol A | affects expression | ISO | Klc1 (Mus musculus) | 6480464 | bisphenol A affects the expression of KLC1 mRNA | CTD | PMID:14967926 | Klc1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KLC1 mRNA | CTD | PMID:34947998 | Klc1 | Rat | bisphenol A | decreases methylation | ISO | Klc1 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of KLC1 promoter | CTD | PMID:27312807 | Klc1 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of KLC1 gene | CTD | PMID:28505145 | Klc1 | Rat | bisphenol AF | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of KLC1 protein | CTD | PMID:34186270 | Klc1 | Rat | bisphenol F | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of KLC1 mRNA | CTD | PMID:38685157 | Klc1 | Rat | Brodifacoum | increases expression | EXP | | 6480464 | bromfenacoum results in increased expression of KLC1 protein | CTD | PMID:28903499 | Klc1 | Rat | Butylbenzyl phthalate | decreases methylation | ISO | Klc1 (Mus musculus) | 6480464 | butylbenzyl phthalate results in decreased methylation of KLC1 intron | CTD | PMID:28392331 | Klc1 | Rat | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of KLC1 mRNA | CTD | PMID:21297351 | Klc1 | Rat | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of KLC1 mRNA | CTD | PMID:33453195 | Klc1 | Rat | calcidiol | decreases expression | EXP | | 6480464 | Calcifediol deficiency results in decreased expression of KLC1 mRNA | CTD | PMID:17293106 | Klc1 | Rat | chlordecone | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | Chlordecone results in increased expression of KLC1 mRNA | CTD | PMID:33711761 | Klc1 | Rat | choline | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992 | Klc1 | Rat | cobalt dichloride | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of KLC1 mRNA | CTD | PMID:19376846 | Klc1 | Rat | cyclosporin A | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of KLC1 mRNA | CTD | PMID:20106945|PMID:25562108 | Klc1 | Rat | enzyme inhibitor | multiple interactions | ISO | KLC1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Klc1 | Rat | ethanol | affects splicing | ISO | Klc1 (Mus musculus) | 6480464 | Ethanol affects the splicing of KLC1 mRNA | CTD | PMID:30319688 | Klc1 | Rat | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of KLC1 mRNA | CTD | PMID:18035473 | Klc1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of KLC1 mRNA | CTD | PMID:24136188 | Klc1 | Rat | folic acid | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992|PMID:22206623 | Klc1 | Rat | FR900359 | affects phosphorylation | ISO | KLC1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KLC1 protein | CTD | PMID:37730182 | Klc1 | Rat | haloperidol | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Haloperidol results in decreased expression of KLC1 mRNA | CTD | PMID:18797397 | Klc1 | Rat | ivermectin | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of KLC1 protein | CTD | PMID:32959892 | Klc1 | Rat | L-methionine | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ... | CTD | PMID:20938992 | Klc1 | Rat | lidocaine | decreases expression | EXP | | 6480464 | Lidocaine results in decreased expression of KLC1 mRNA | CTD | PMID:35283115 | Klc1 | Rat | methoxychlor | affects expression | ISO | Klc1 (Mus musculus) | 6480464 | Methoxychlor affects the expression of KLC1 mRNA | CTD | PMID:20829426 | Klc1 | Rat | methoxychlor | increases methylation | EXP | | 6480464 | Methoxychlor results in increased methylation of KLC1 gene | CTD | PMID:23303685 | Klc1 | Rat | methyl methanesulfonate | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of KLC1 mRNA | CTD | PMID:23649840 | Klc1 | Rat | methylmercury chloride | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of KLC1 mRNA | CTD | PMID:28001369 | Klc1 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of KLC1 gene | CTD | PMID:33148267 | Klc1 | Rat | nitrates | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of KLC1 more ... | CTD | PMID:35964746 | Klc1 | Rat | olanzapine | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | olanzapine results in decreased expression of KLC1 mRNA | CTD | PMID:18797397 | Klc1 | Rat | ozone | multiple interactions | ISO | KLC1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268|PMID:32845096 | Klc1 | Rat | ozone | multiple interactions | ISO | Klc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... | CTD | PMID:34911549 | Klc1 | Rat | paracetamol | affects expression | ISO | Klc1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KLC1 mRNA | CTD | PMID:17562736 | Klc1 | Rat | paracetamol | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KLC1 mRNA | CTD | PMID:29067470 | Klc1 | Rat | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of KLC1 mRNA | CTD | PMID:19162173 | Klc1 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of KLC1 gene | CTD | PMID:33148267 | Klc1 | Rat | pirinixic acid | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of KLC1 mRNA | CTD | PMID:23811191 | Klc1 | Rat | rac-lactic acid | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of KLC1 mRNA | CTD | PMID:30851411 | Klc1 | Rat | resveratrol | multiple interactions | ISO | KLC1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of KLC1 mRNA | CTD | PMID:23557933 | Klc1 | Rat | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of KLC1 protein | CTD | PMID:35544339 | Klc1 | Rat | sodium arsenate | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | sodium arsenate results in decreased expression of KLC1 protein | CTD | PMID:38348393 | Klc1 | Rat | sodium arsenite | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of KLC1 mRNA | CTD | PMID:38568856 | Klc1 | Rat | sodium arsenite | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of KLC1 mRNA | CTD | PMID:36209798 | Klc1 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of KLC1 mRNA | CTD | PMID:19281266 | Klc1 | Rat | temozolomide | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of KLC1 mRNA | CTD | PMID:31758290 | Klc1 | Rat | thapsigargin | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | Thapsigargin results in decreased expression of KLC1 protein | CTD | PMID:24648495 | Klc1 | Rat | titanium dioxide | decreases methylation | ISO | Klc1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of KLC1 gene | CTD | PMID:35295148 | Klc1 | Rat | titanium dioxide | increases methylation | ISO | Klc1 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of KLC1 gene | CTD | PMID:35295148 | Klc1 | Rat | toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of KLC1 mRNA | CTD | PMID:22166486 | Klc1 | Rat | triphenyl phosphate | affects expression | ISO | KLC1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of KLC1 mRNA | CTD | PMID:37042841 | Klc1 | Rat | Triptolide | increases expression | ISO | Klc1 (Mus musculus) | 6480464 | triptolide results in increased expression of KLC1 mRNA | CTD | PMID:32835833 | Klc1 | Rat | triptonide | decreases expression | ISO | Klc1 (Mus musculus) | 6480464 | triptonide results in decreased expression of KLC1 mRNA | CTD | PMID:33045310 | Klc1 | Rat | valproic acid | increases methylation | ISO | KLC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KLC1 gene | CTD | PMID:29154799 | Klc1 | Rat | valproic acid | decreases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of KLC1 mRNA | CTD | PMID:26272509 | Klc1 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of KLC1 gene | CTD | PMID:31079544 | Klc1 | Rat | vitamin E | increases expression | ISO | KLC1 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of KLC1 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















