Hey2 (hes-related family bHLH transcription factor with YRPW motif 2) - Rat Genome Database

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Gene: Hey2 (hes-related family bHLH transcription factor with YRPW motif 2) Rattus norvegicus
Analyze
Symbol: Hey2
Name: hes-related family bHLH transcription factor with YRPW motif 2
RGD ID: 621405
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including Notch signaling pathway; negative regulation of cardiac vascular smooth muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2; Herp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,641,100 - 28,651,187 (+)NCBIGRCr8
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,573,165 - 26,583,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,572,976 - 32,583,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,773,752 - 26,783,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior axis specification  (ISO)
anterior/posterior pattern specification  (IBA)
aortic valve morphogenesis  (ISO)
arterial endothelial cell differentiation  (ISO)
artery development  (ISO)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve development  (ISO)
blood vessel development  (ISO)
blood vessel endothelial cell differentiation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell apoptotic process  (ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum morphogenesis  (ISO)
cardiac vascular smooth muscle cell development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell fate commitment  (ISO)
circulatory system development  (IBA)
cochlea development  (ISO)
coronary vasculature morphogenesis  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
heart development  (IEP)
heart trabecula formation  (ISO)
labyrinthine layer blood vessel development  (ISO)
mesenchymal cell development  (ISO)
muscular septum morphogenesis  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cardiac vascular smooth muscle cell differentiation  (IDA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of smooth muscle cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription initiation by RNA polymerase II  (ISO)
Notch signaling pathway  (IBA,IDA,ISO)
outflow tract morphogenesis  (ISO)
pattern specification process  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein-DNA complex assembly  (ISO)
pulmonary artery morphogenesis  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of gene expression  (ISO)
regulation of inner ear auditory receptor cell differentiation  (ISO)
regulation of neurogenesis  (IBA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of vasculogenesis  (ISO)
tricuspid valve formation  (ISO)
tricuspid valve morphogenesis  (ISO)
umbilical cord morphogenesis  (ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (ISO)
ventricular cardiac muscle cell development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. Chin MT, etal., J Biol Chem. 2000 Mar 3;275(9):6381-7.
2. HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Doi H, etal., Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2328-34. Epub 2005 Sep 8.
3. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. HERP1 is a cell type-specific primary target of Notch. Iso T, etal., J Biol Chem 2002 Feb 22;277(8):6598-607.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Miloudi K, etal., Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
14. Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. Wang W, etal., J Biol Chem 2002 Jun 28;277(26):23165-71.
Additional References at PubMed
PMID:10964718   PMID:11076679   PMID:11095750   PMID:11486045   PMID:12372254   PMID:12535671   PMID:15107403   PMID:15297376   PMID:15485867   PMID:15680351   PMID:15821257   PMID:16025100  
PMID:16043483   PMID:16199874   PMID:16293227   PMID:16603706   PMID:16953280   PMID:17259303   PMID:17303760   PMID:17332425   PMID:18239137   PMID:18302773   PMID:19154718   PMID:20382855  
PMID:20619341   PMID:20628571   PMID:21290414   PMID:22110751   PMID:22615585  


Genomics

Comparative Map Data
Hey2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,641,100 - 28,651,187 (+)NCBIGRCr8
mRatBN7.2126,822,131 - 26,832,218 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,573,165 - 26,583,262 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0132,572,976 - 32,583,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,773,752 - 26,783,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,191,170 - 29,201,257 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0130,633,675 - 30,643,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,505,117 - 27,515,204 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,516,255 - 27,516,788 (+)NCBI
Celera125,500,527 - 25,510,614 (+)NCBICelera
Cytogenetic Map1p11NCBI
HEY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386125,749,632 - 125,761,269 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6125,747,664 - 125,761,269 (+)EnsemblGRCh38hg38GRCh38
GRCh376126,070,778 - 126,082,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366126,112,425 - 126,124,108 (+)NCBINCBI36Build 36hg18NCBI36
Build 346126,112,565 - 126,124,110NCBI
Celera6126,813,087 - 126,824,769 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6123,645,968 - 123,657,653 (+)NCBIHuRef
CHM1_16126,334,804 - 126,346,479 (+)NCBICHM1_1
T2T-CHM13v2.06126,938,147 - 126,949,784 (+)NCBIT2T-CHM13v2.0
Hey2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391030,708,355 - 30,718,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1030,708,355 - 30,718,797 (-)EnsemblGRCm39 Ensembl
GRCm381030,832,359 - 30,842,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1030,832,359 - 30,842,801 (-)EnsemblGRCm38mm10GRCm38
MGSCv371030,552,165 - 30,562,589 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361030,521,775 - 30,532,199 (-)NCBIMGSCv36mm8
Celera1031,757,027 - 31,767,443 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.19NCBI
Hey2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554367,060,930 - 7,070,030 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554367,060,930 - 7,070,610 (+)NCBIChiLan1.0ChiLan1.0
HEY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25145,733,083 - 145,744,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16143,638,233 - 143,649,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06123,527,180 - 123,538,794 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16127,647,547 - 127,659,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6127,647,547 - 127,659,056 (+)Ensemblpanpan1.1panPan2
HEY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1164,630,656 - 64,646,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha165,440,361 - 65,450,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0164,840,402 - 64,850,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl164,839,247 - 64,850,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1164,769,017 - 64,778,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,556,353 - 64,566,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,207,272 - 65,217,212 (+)NCBIUU_Cfam_GSD_1.0
Hey2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946114,704,470 - 114,715,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366393,703,447 - 3,716,820 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366393,705,225 - 3,714,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl137,219,883 - 37,231,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1137,219,887 - 37,231,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2140,989,466 - 41,000,901 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11347,965,808 - 47,977,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1347,964,847 - 47,977,346 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604020,275,597 - 20,288,250 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hey2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624753375,279 - 384,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624753375,163 - 394,402 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hey2
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:636
Count of miRNA genes:273
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000018718
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 2 4 7 8
Low 2 15 42 26 19 26 8 10 72 31 34 3 8
Below cutoff 1 15 15 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018718   ⟹   ENSRNOP00000018718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl126,822,131 - 26,832,218 (+)Ensembl
Rnor_6.0 Ensembl129,191,192 - 29,201,531 (+)Ensembl
RefSeq Acc Id: NM_130417   ⟹   NP_569101
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8128,641,100 - 28,651,187 (+)NCBI
mRatBN7.2126,822,131 - 26,832,218 (+)NCBI
Rnor_6.0129,191,170 - 29,201,257 (+)NCBI
Rnor_5.0130,633,675 - 30,643,762 (+)NCBI
RGSC_v3.4127,505,117 - 27,515,204 (+)RGD
Celera125,500,527 - 25,510,614 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569101 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL30105 (Get FASTA)   NCBI Sequence Viewer  
  EDL87708 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018718
  ENSRNOP00000018718.3
Reference Protein Sequences
RefSeq Acc Id: NP_569101   ⟸   NM_130417
- UniProtKB: G3V7S6 (UniProtKB/TrEMBL),   A6JUS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018718   ⟸   ENSRNOT00000018718
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7S6-F1-model_v2 AlphaFold G3V7S6 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689543
Promoter ID:EPDNEW_R67
Type:multiple initiation site
Name:Hey2_1
Description:hes-related family bHLH transcription factor with YRPW motif2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0129,191,116 - 29,191,176EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621405 AgrOrtholog
BioCyc Gene G2FUF-61981 BioCyc
Ensembl Genes ENSRNOG00000013364 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018718 ENTREZGENE
  ENSRNOT00000018718.7 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  6.10.250.980 UniProtKB/TrEMBL
InterPro HLH_DNA-bd_sf UniProtKB/TrEMBL
  HLH_dom UniProtKB/TrEMBL
  Orange UniProtKB/TrEMBL
KEGG Report rno:155430 UniProtKB/TrEMBL
NCBI Gene 155430 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/TrEMBL
  HAIRY/ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2 UniProtKB/TrEMBL
Pfam Hairy_orange UniProtKB/TrEMBL
  HLH UniProtKB/TrEMBL
PhenoGen Hey2 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013364 RatGTEx
SMART HLH UniProtKB/TrEMBL
  ORANGE UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
  Orange domain-like UniProtKB/TrEMBL
UniProt A6JUS1 ENTREZGENE, UniProtKB/TrEMBL
  G3V7S6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hey2  hes-related family bHLH transcription factor with YRPW motif 2  Hey2  hairy/enhancer-of-split related with YRPW motif 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hey2  hairy/enhancer-of-split related with YRPW motif 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hey2  hairy/enhancer-of-split related with YRPW motif 2      Symbol and Name status set to provisional 70820 PROVISIONAL