Pdxk (pyridoxal kinase) - Rat Genome Database

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Gene: Pdxk (pyridoxal kinase) Rattus norvegicus
Analyze
Symbol: Pdxk
Name: pyridoxal kinase
RGD ID: 621324
Description: Enables pyridoxal binding activity and pyridoxal kinase activity. Involved in several processes, including pyridoxal phosphate biosynthetic process; response to X-ray; and response to progesterone. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human PDXK (pyridoxal kinase); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909742; pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase-like; pyridoxine kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,209,975 - 10,232,012 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,209,832 - 10,233,780 (+)EnsemblGRCr8
mRatBN7.22010,210,276 - 10,232,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,210,289 - 10,232,110 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,909,956 - 10,931,608 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,270,865 - 10,292,517 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,742,295 - 10,763,997 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,930,651 - 10,952,194 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,930,518 - 10,952,391 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,102,429 - 13,123,972 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,541,656 - 10,563,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,721,159 - 11,742,702 (+)NCBICelera
RGSC_v3.12010,541,882 - 10,563,426 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
choline  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
dibutyl phthalate  (ISO)
dimethoate  (EXP,ISO)
diquat  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
inulin  (ISO)
L-methionine  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
metronidazole  (EXP)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
pyridoxal 5'-phosphate  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Roscovitine targets, protein kinases and pyridoxal kinase. Bach S, etal., J Biol Chem. 2005 Sep 2;280(35):31208-19. Epub 2005 Jun 23.
2. Rapid purification by affinity chromatography of rat brain pyridoxal kinase and pyridoxamine-5-phosphate oxidase. Cash CD, etal., Biochem Biophys Res Commun. 1980 Oct 31;96(4):1755-60.
3. Glutamate decarboxylase inhibition and vitamin B6 metabolism in brain of cirrhotic rats chronically treated with carbon tetrachloride. Diaz-Munoz M and Tapia R, J Neurosci Res. 1988 Jul;20(3):376-82.
4. Levodopa-mediated alteration in the activity of pyridoxal kinase in rat basal ganglia. Ebadi M, etal., Pharmacology. 1978;17(3):149-56.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor. Hanna MC, etal., J Biol Chem 1997 Apr 18;272(16):10756-60.
7. Effects of some insecticides on several enzymes of tryptophan metabolism in rats. Hassan AA, etal., J Environ Sci Health B. 1990 Jun;25(3):333-46.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Azo dye-induced alterations in vitamin B-6 metabolism and in pyridoxal 5'-phosphate-binding proteins in rat liver. Kittler JM, etal., J Nutr. 1986 Apr;116(4):588-98.
10. A novel role of circadian transcription factor DBP in hippocampal plasticity. Klugmann M, etal., Mol Cell Neurosci. 2006 Feb;31(2):303-14. Epub 2005 Oct 27.
11. Vitamin B6 metabolism in McA-RH7777 cells. Meisler NT and Thanassi JW, Cancer Res. 1988 Mar 1;48(5):1080-5.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. [The content of pyridoxal coenzymes in the brain and liver of rats exposed to a single irradiation with x-rays] Pikulev AT, etal., Radiobiologiia. 1989 Jan-Feb;29(1):70-3.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Repression of anti-apoptotic genes via AP-1 as a mechanism of apoptosis induction in ventricular cardiomyocytes. Schlieper A, etal., Pflugers Arch. 2007 Apr;454(1):53-61. Epub 2006 Nov 18.
20. Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro. Takeuchi F, etal., Biochem J. 1985 Apr 15;227(2):537-44.
21. Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores. Van den Berg H and Bogaards JJ, J Nutr. 1987 Nov;117(11):1866-74.
22. The influence of dietary restriction on vitamin B-6 vitamer distribution and on vitamin B-6 metabolizing enzymes in rats. Wei IL J Am Coll Nutr. 1999 Apr;18(2):144-51.
Additional References at PubMed
PMID:9252787   PMID:10930737   PMID:10987144   PMID:16600635   PMID:16780588   PMID:17766369   PMID:19056867   PMID:21630459   PMID:23376485   PMID:31187503  


Genomics

Comparative Map Data
Pdxk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,209,975 - 10,232,012 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,209,832 - 10,233,780 (+)EnsemblGRCr8
mRatBN7.22010,210,276 - 10,232,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,210,289 - 10,232,110 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,909,956 - 10,931,608 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,270,865 - 10,292,517 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,742,295 - 10,763,997 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,930,651 - 10,952,194 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,930,518 - 10,952,391 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,102,429 - 13,123,972 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,541,656 - 10,563,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,721,159 - 11,742,702 (+)NCBICelera
RGSC_v3.12010,541,882 - 10,563,426 (+)NCBI
Cytogenetic Map20p12NCBI
PDXK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,737,000 - 43,738,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,719,094 - 43,762,307 (+)Ensemblhg38GRCh38
GRCh372145,138,978 - 45,182,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,963,406 - 44,006,616 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342143,963,405 - 44,006,608NCBI
Celera2130,244,819 - 30,287,780 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,506,765 - 30,550,585 (+)NCBIHuRef
CHM1_12144,717,696 - 44,718,791 (+)NCBICHM1_1
T2T-CHM13v2.02142,092,543 - 42,093,640 (+)NCBIT2T-CHM13v2.0
Pdxk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,272,581 - 78,300,782 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,272,578 - 78,300,809 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381078,436,747 - 78,464,948 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,436,744 - 78,464,975 (-)Ensemblmm10GRCm38
MGSCv371077,899,492 - 77,927,693 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361077,842,099 - 77,868,104 (-)NCBIMGSCv36mm8
Celera1079,458,844 - 79,487,046 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Pdxk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,482,216 - 41,494,177 (-)Ensembl
ChiLan1.0NW_00495540741,482,216 - 41,494,174 (-)NCBIChiLan1.0ChiLan1.0
PDXK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,727,200 - 39,771,206 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,577,814 - 34,621,766 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02129,977,286 - 30,021,266 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,276,660 - 43,319,866 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,273,237 - 43,313,637 (+)EnsemblpanPan2panpan1.1
Pdxk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,928,712 - 36,956,834 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500509,510 - 529,455 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936500510,977 - 539,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDXK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,489,249 - 87,534,376 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,489,315 - 87,531,621 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605415,561,891 - 15,606,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdxk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,157,446 - 30,175,803 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474530,157,446 - 30,175,905 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdxk
259 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000001589
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH126288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22010,168,469 - 10,168,922 (+)MAPPERmRatBN7.2
mRatBN7.22010,231,575 - 10,232,021 (+)MAPPERmRatBN7.2
Rnor_6.02010,951,833 - 10,952,278NCBIRnor6.0
Rnor_6.02010,889,488 - 10,889,941NCBIRnor6.0
Rnor_5.02013,123,611 - 13,124,056UniSTSRnor5.0
Rnor_5.02013,061,266 - 13,061,719UniSTSRnor5.0
RGSC_v3.42010,562,838 - 10,563,283UniSTSRGSC3.4
RGSC_v3.42010,499,734 - 10,500,186UniSTSRGSC3.4
Celera2011,679,528 - 11,679,980UniSTS
Celera2011,742,341 - 11,742,786UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001589   ⟹   ENSRNOP00000001589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,209,988 - 10,233,780 (+)Ensembl
mRatBN7.2 Ensembl2010,210,289 - 10,232,110 (+)Ensembl
Rnor_6.0 Ensembl2010,930,518 - 10,952,391 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121560   ⟹   ENSRNOP00000108691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,209,832 - 10,233,780 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156821   ⟹   ENSRNOP00000107660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,217,812 - 10,233,780 (+)Ensembl
RefSeq Acc Id: NM_031769   ⟹   NP_113957
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,209,975 - 10,232,012 (+)NCBI
mRatBN7.22010,210,276 - 10,232,314 (+)NCBI
Rnor_6.02010,930,651 - 10,952,194 (+)NCBI
Rnor_5.02013,102,429 - 13,123,972 (+)NCBI
RGSC_v3.42010,541,656 - 10,563,199 (+)RGD
Celera2011,721,159 - 11,742,702 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113957 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB71400 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001589
GenBank Protein O35331 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113957   ⟸   NM_031769
- UniProtKB: O35331 (UniProtKB/Swiss-Prot),   G3V647 (UniProtKB/TrEMBL),   A6JK21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001589   ⟸   ENSRNOT00000001589
Ensembl Acc Id: ENSRNOP00000108691   ⟸   ENSRNOT00000121560
Ensembl Acc Id: ENSRNOP00000107660   ⟸   ENSRNOT00000156821
Protein Domains
Pyridoxamine kinase/Phosphomethylpyrimidine kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35331-F1-model_v2 AlphaFold O35331 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701483
Promoter ID:EPDNEW_R12007
Type:multiple initiation site
Name:Pdxk_1
Description:pyridoxal kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,930,590 - 10,930,650EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621324 AgrOrtholog
BioCyc Gene G2FUF-4286 BioCyc
BioCyc Pathway PLPSAL-PWY [pyridoxal 5'-phosphate salvage I] BioCyc
BioCyc Pathway Image PLPSAL-PWY BioCyc
Ensembl Genes ENSRNOG00000049937 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001589 ENTREZGENE
Gene3D-CATH 3.40.1190.20 UniProtKB/Swiss-Prot
InterPro PM/HMP-P_kinase-1 UniProtKB/Swiss-Prot
  PyrdxlKinase UniProtKB/Swiss-Prot
  Ribokinase-like UniProtKB/Swiss-Prot
KEGG Report rno:83578 UniProtKB/Swiss-Prot
NCBI Gene 83578 ENTREZGENE
PANTHER PTHR10534 UniProtKB/Swiss-Prot
  PYRIDOXAL KINASE UniProtKB/Swiss-Prot
Pfam Phos_pyr_kin UniProtKB/Swiss-Prot
PhenoGen Pdxk PhenoGen
RatGTEx ENSRNOG00000049937 RatGTEx
Superfamily-SCOP SSF53613 UniProtKB/Swiss-Prot
UniProt A0ABK0LS97_RAT UniProtKB/TrEMBL
  A0ABK0M1I1_RAT UniProtKB/TrEMBL
  A6JK21 ENTREZGENE, UniProtKB/TrEMBL
  G3V647 ENTREZGENE, UniProtKB/TrEMBL
  O35331 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pdxk  pyridoxal kinase  LOC100909742  pyridoxal kinase-like  Data merged from RGD:6502017 737654 PROVISIONAL
2017-02-01 Pdxk  pyridoxal kinase  Pdxk  pyridoxal (pyridoxine, vitamin B6) kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909742  pyridoxal kinase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Pdxk  pyridoxal (pyridoxine, vitamin B6) kinase    pyridoxal kinase  Name updated 1299863 APPROVED
2002-08-07 Pdxk  pyridoxal kinase      Symbol and Name status set to provisional 70820 PROVISIONAL