Pmpcb (peptidase, mitochondrial processing subunit beta) - Rat Genome Database

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Gene: Pmpcb (peptidase, mitochondrial processing subunit beta) Rattus norvegicus
Analyze
Symbol: Pmpcb
Name: peptidase, mitochondrial processing subunit beta
RGD ID: 621297
Description: Enables metalloendopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH (R)-noradrenaline; 1,2,4-trimethylbenzene; 1-bromopropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-MPP; mitochondrial processing peptidase beta; mitochondrial processing peptidase beta subunit; mitochondrial-processing peptidase subunit beta; Mppb; P-52; peptidase (mitochondrial processing) beta; peptidase, mitochondrial processing beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,189,807 - 14,202,584 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,165,844 - 14,202,615 (-)EnsemblGRCr8
mRatBN7.2413,297,583 - 13,310,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,297,559 - 13,310,367 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,442,919 - 18,455,706 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,257,272 - 14,270,040 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,628,556 - 12,641,349 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,908,838 - 9,921,615 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,908,831 - 9,921,610 (-)Ensemblrn6Rnor6.0
Rnor_5.049,909,996 - 9,922,773 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,746,904 - 8,759,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,888,496 - 8,901,273 (-)NCBICelera
RGSC_v3.148,746,903 - 8,759,681 (-)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
CGP 52608  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. Greene AW, etal., EMBO Rep. 2012 Apr;13(4):378-85. doi: 10.1038/embor.2012.14.
3. Molecular cloning of the smaller subunit(P52) of rat liver mitochondrial processing protease. Kitada S, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):289-93.
4. Glu(191) and Asp(195) in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginine. Kitada S, etal., Biochem Biophys Res Commun. 2001 Sep 28;287(3):594-9. doi: 10.1006/bbrc.2001.5641.
5. A putative metal-binding site in the beta subunit of rat mitochondrial processing peptidase is essential for its catalytic activity. Kitada S, etal., J Biochem. 1995 Jun;117(6):1148-50.
6. Determination of the cleavage site of the presequence by mitochondrial processing peptidase on the substrate binding scaffold and the multiple subsites inside a molecular cavity. Kitada S, etal., J Biol Chem. 2003 Jan 17;278(3):1879-85. doi: 10.1074/jbc.M209263200. Epub 2002 Nov 13.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Processing of mitochondrial presequences. Mossmann D, etal., Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):1098-106. doi: 10.1016/j.bbagrm.2011.11.007. Epub 2011 Dec 7.
9. Glycine-rich region of mitochondrial processing peptidase alpha-subunit is essential for binding and cleavage of the precursor proteins. Nagao Y, etal., J Biol Chem. 2000 Nov 3;275(44):34552-6. doi: 10.1074/jbc.M003110200.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The beta subunit of the mitochondrial processing peptidase from rat liver: cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases. Paces V, etal., Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5355-8.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Pmpcb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,189,807 - 14,202,584 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,165,844 - 14,202,615 (-)EnsemblGRCr8
mRatBN7.2413,297,583 - 13,310,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,297,559 - 13,310,367 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,442,919 - 18,455,706 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,257,272 - 14,270,040 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,628,556 - 12,641,349 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,908,838 - 9,921,615 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,908,831 - 9,921,610 (-)Ensemblrn6Rnor6.0
Rnor_5.049,909,996 - 9,922,773 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,746,904 - 8,759,681 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,888,496 - 8,901,273 (-)NCBICelera
RGSC_v3.148,746,903 - 8,759,681 (-)NCBI
Cytogenetic Map4q11NCBI
PMPCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,297,435 - 103,347,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,295,717 - 103,331,818 (+)Ensemblhg38GRCh38
GRCh377102,937,882 - 102,955,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,725,109 - 102,742,369 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347102,531,849 - 102,546,957NCBI
Celera797,745,096 - 97,762,356 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,300,090 - 97,317,351 (+)NCBIHuRef
CHM1_17102,870,874 - 102,888,137 (+)NCBICHM1_1
T2T-CHM13v2.07104,611,886 - 104,661,980 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,298,239 - 102,315,499 (+)NCBI
Pmpcb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,942,158 - 21,962,150 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,942,139 - 21,962,150 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38521,737,160 - 21,757,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,737,141 - 21,757,152 (+)Ensemblmm10GRCm38
MGSCv37521,242,978 - 21,262,970 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36521,248,972 - 21,268,978 (+)NCBIMGSCv36mm8
Celera518,708,080 - 18,728,070 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Pmpcb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,303,901 - 8,317,447 (+)Ensembl
ChiLan1.0NW_0049554108,304,088 - 8,317,639 (+)NCBIChiLan1.0ChiLan1.0
PMPCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,156,553 - 140,193,141 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,426,523 - 188,458,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,288,747 - 95,320,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,033,235 - 108,048,291 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,033,235 - 108,050,302 (+)EnsemblpanPan2panpan1.1
PMPCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,894,240 - 16,906,988 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,894,276 - 16,906,979 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1816,541,779 - 16,554,661 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01817,189,094 - 17,201,917 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,189,094 - 17,201,922 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,954,255 - 16,967,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,893,175 - 16,906,045 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,161,401 - 17,174,292 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pmpcb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,074,586 - 59,086,415 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,198,417 - 20,210,202 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,198,417 - 20,210,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMPCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,316,190 - 103,330,290 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19103,316,161 - 103,329,653 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,924,688 - 113,938,159 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMPCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,271,390 - 72,286,559 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,271,429 - 72,286,265 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604231,716,546 - 31,731,588 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmpcb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473926,045,982 - 26,061,465 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473926,045,745 - 26,061,509 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pmpcb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16151,049,015 - 151,061,854 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pmpcb
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000017018
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH128128  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8414,189,896 - 14,190,326 (+)Marker Load Pipeline
mRatBN7.2413,297,672 - 13,298,102 (+)MAPPERmRatBN7.2
Rnor_6.049,908,928 - 9,909,357NCBIRnor6.0
Rnor_5.049,910,086 - 9,910,515UniSTSRnor5.0
RGSC_v3.448,746,994 - 8,747,423UniSTSRGSC3.4
Celera48,888,586 - 8,889,015UniSTS
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017018   ⟹   ENSRNOP00000017017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,189,784 - 14,202,615 (-)Ensembl
mRatBN7.2 Ensembl413,297,559 - 13,310,367 (-)Ensembl
Rnor_6.0 Ensembl49,908,831 - 9,921,610 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099923   ⟹   ENSRNOP00000080244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl413,297,559 - 13,307,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101407   ⟹   ENSRNOP00000085389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,165,844 - 14,202,584 (-)Ensembl
mRatBN7.2 Ensembl413,297,585 - 13,310,367 (-)Ensembl
RefSeq Acc Id: NM_022395   ⟹   NP_071790
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,189,807 - 14,202,584 (-)NCBI
mRatBN7.2413,297,583 - 13,310,363 (-)NCBI
Rnor_6.049,908,838 - 9,921,615 (-)NCBI
Rnor_5.049,909,996 - 9,922,773 (-)NCBI
RGSC_v3.448,746,904 - 8,759,681 (-)RGD
Celera48,888,496 - 8,901,273 (-)RGD
Sequence:
RefSeq Acc Id: NP_071790   ⟸   NM_022395
- Peptide Label: precursor
- UniProtKB: Q68G08 (UniProtKB/Swiss-Prot),   Q03346 (UniProtKB/Swiss-Prot),   A6K5A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017017   ⟸   ENSRNOT00000017018
Ensembl Acc Id: ENSRNOP00000085389   ⟸   ENSRNOT00000101407
Ensembl Acc Id: ENSRNOP00000080244   ⟸   ENSRNOT00000099923
Protein Domains
Peptidase M16 C-terminal   Peptidase M16 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03346-F1-model_v2 AlphaFold Q03346 1-489 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692806
Promoter ID:EPDNEW_R3331
Type:multiple initiation site
Name:Pmpcb_1
Description:peptidase, mitochondrial processing beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.049,921,612 - 9,921,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621297 AgrOrtholog
BioCyc Gene G2FUF-45984 BioCyc
Ensembl Genes ENSRNOG00000012693 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017018 ENTREZGENE
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7113892 IMAGE-MGC_LOAD
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot
  MPP/UQCRC_Complex UniProtKB/Swiss-Prot
  Pept_M16_N UniProtKB/Swiss-Prot
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_M16_C UniProtKB/Swiss-Prot
KEGG Report rno:64198 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93441 IMAGE-MGC_LOAD
NCBI Gene 64198 ENTREZGENE
PANTHER METALLOPROTEASE UniProtKB/Swiss-Prot
  PTHR11851:SF103 UniProtKB/Swiss-Prot
Pfam Peptidase_M16 UniProtKB/Swiss-Prot
  Peptidase_M16_C UniProtKB/Swiss-Prot
PhenoGen Pmpcb PhenoGen
PROSITE INSULINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012693 RatGTEx
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot
UniProt A0A8I6GCU4_RAT UniProtKB/TrEMBL
  A0A8L2Q9B4_RAT UniProtKB/TrEMBL
  A6K5A6_RAT UniProtKB/TrEMBL
  A6K5A7 ENTREZGENE, UniProtKB/TrEMBL
  A6K5A8_RAT UniProtKB/TrEMBL
  A6K5A9_RAT UniProtKB/TrEMBL
  A6K5B0_RAT UniProtKB/TrEMBL
  A6K5B1_RAT UniProtKB/TrEMBL
  MPPB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q68G08 ENTREZGENE
UniProt Secondary Q68G08 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Pmpcb  peptidase, mitochondrial processing subunit beta  Pmpcb  peptidase, mitochondrial processing beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-22 Pmpcb  peptidase, mitochondrial processing beta subunit  Pmpcb  peptidase (mitochondrial processing) beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pmpcb  peptidase (mitochondrial processing) beta    mitochondrial processing peptidase beta  Name updated 1299863 APPROVED
2002-08-07 Pmpcb  mitochondrial processing peptidase beta      Symbol and Name status set to provisional 70820 PROVISIONAL