Cdx2 (caudal type homeo box 2) - Rat Genome Database

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Gene: Cdx2 (caudal type homeo box 2) Rattus norvegicus
Analyze
Symbol: Cdx2
Name: caudal type homeo box 2
RGD ID: 621234
Description: Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of cell population proliferation. Located in nucleus. Orthologous to human CDX2 (caudal type homeobox 2); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; beta-naphthoflavone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homeobox protein CDX-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,762,769 - 12,769,246 (+)NCBIGRCr8
mRatBN7.2127,726,798 - 7,733,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,726,798 - 7,733,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,411,731 - 8,418,073 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0129,034,882 - 9,041,224 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,062,897 - 8,069,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,464,026 - 9,470,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,464,026 - 9,470,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,578,762 - 11,585,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,296,103 - 8,303,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1128,326,030 - 8,333,571 (+)NCBI
Celera129,464,881 - 9,471,223 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Homeosis and intestinal tumours in Cdx2 mutant mice. Chawengsaksophak K, etal., Nature 1997 Mar 6;386(6620):84-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. AGR2 gene function requires a unique endoplasmic reticulum localization motif. Gupta A, etal., J Biol Chem. 2012 Feb 10;287(7):4773-82. doi: 10.1074/jbc.M111.301531. Epub 2011 Dec 19.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia? Turkmen IC, etal., Turk Patoloji Derg. 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132.
10. Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium. Uesaka T, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G840-7.
Additional References at PubMed
PMID:11959827   PMID:15019784   PMID:15509711   PMID:15677472   PMID:15788452   PMID:16239403   PMID:16325584   PMID:16396910   PMID:17138661   PMID:17212918   PMID:17347684   PMID:17404613  
PMID:17417665   PMID:18313392   PMID:18423437   PMID:19664209   PMID:19796622   PMID:19853565   PMID:20404091   PMID:20551175   PMID:20676102   PMID:21530438   PMID:22015720   PMID:22190642  
PMID:22529382   PMID:22573614   PMID:22948967   PMID:23824537   PMID:24036311   PMID:24268575   PMID:24315442   PMID:25397698   PMID:26268420   PMID:28473536  


Genomics

Comparative Map Data
Cdx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,762,769 - 12,769,246 (+)NCBIGRCr8
mRatBN7.2127,726,798 - 7,733,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,726,798 - 7,733,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx128,411,731 - 8,418,073 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0129,034,882 - 9,041,224 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0128,062,897 - 8,069,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,464,026 - 9,470,565 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,464,026 - 9,470,565 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,578,762 - 11,585,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,296,103 - 8,303,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1128,326,030 - 8,333,571 (+)NCBI
Celera129,464,881 - 9,471,223 (+)NCBICelera
Cytogenetic Map12p11NCBI
CDX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381327,960,918 - 27,969,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1327,960,918 - 27,969,315 (-)EnsemblGRCh38hg38GRCh38
GRCh371328,535,055 - 28,543,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,434,278 - 27,441,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 341327,434,278 - 27,441,317NCBI
Celera139,611,324 - 9,618,360 (-)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,356,889 - 9,364,186 (-)NCBIHuRef
CHM1_11328,504,663 - 28,511,974 (-)NCBICHM1_1
T2T-CHM13v2.01327,182,310 - 27,190,703 (-)NCBIT2T-CHM13v2.0
Cdx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,237,710 - 147,244,059 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,237,615 - 147,244,080 (-)EnsemblGRCm39 Ensembl
GRCm385147,300,900 - 147,307,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,300,805 - 147,307,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,112,476 - 148,118,825 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,611,249 - 147,617,598 (-)NCBIMGSCv36mm8
Celera5145,292,162 - 145,298,512 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.86NCBI
Cdx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554977,316,372 - 7,321,627 (-)NCBIChiLan1.0ChiLan1.0
CDX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,548,318 - 27,556,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,652,989 - 18,661,365 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,241,856 - 9,250,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,585,194 - 27,593,632 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1327,586,340 - 27,593,632 (-)Ensemblpanpan1.1panPan2
CDX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,701,134 - 11,707,883 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,700,779 - 11,707,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,764,347 - 11,771,858 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,830,047 - 11,837,557 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,830,188 - 11,836,088 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,724,391 - 11,732,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,716,837 - 11,724,610 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,761,010 - 11,768,541 (+)NCBIUU_Cfam_GSD_1.0
Cdx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,810,950 - 172,815,170 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647223,137,936 - 23,141,205 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,339,716 - 5,346,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,339,727 - 5,346,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,113,685 - 5,120,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,080,142 - 7,088,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,078,503 - 7,087,285 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605737,301,589 - 37,309,900 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,551,503 - 10,556,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,551,503 - 10,556,987 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdx2
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:99
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000048188
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 21 44 41 24 23 24 6 84 37 10 14 27 17

Sequence


Ensembl Acc Id: ENSRNOT00000048188   ⟹   ENSRNOP00000045045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl127,726,798 - 7,733,142 (+)Ensembl
Rnor_6.0 Ensembl129,464,026 - 9,470,565 (+)Ensembl
RefSeq Acc Id: NM_023963   ⟹   NP_076453
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,762,904 - 12,769,246 (+)NCBI
mRatBN7.2127,726,798 - 7,733,142 (+)NCBI
Rnor_6.0129,464,026 - 9,470,565 (+)NCBI
Rnor_5.01211,578,762 - 11,585,434 (+)NCBI
RGSC_v3.4128,296,103 - 8,303,643 (+)RGD
Celera129,464,881 - 9,471,223 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271647   ⟹   XP_063127717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,762,769 - 12,769,240 (+)NCBI
Protein Sequences
Protein RefSeqs NP_076453 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127717 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD17915 (Get FASTA)   NCBI Sequence Viewer  
  CAC03735 (Get FASTA)   NCBI Sequence Viewer  
  EDL89564 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045045.4
RefSeq Acc Id: NP_076453   ⟸   NM_023963
- UniProtKB: Q9ESV7 (UniProtKB/TrEMBL),   F1M7G8 (UniProtKB/TrEMBL),   A0A9K3Y7D3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045045   ⟸   ENSRNOT00000048188
RefSeq Acc Id: XP_063127717   ⟸   XM_063271647
- Peptide Label: isoform X1
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESV7-F1-model_v2 AlphaFold Q9ESV7 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698402
Promoter ID:EPDNEW_R8927
Type:initiation region
Name:Cdx2_1
Description:caudal type homeo box 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0129,463,987 - 9,464,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621234 AgrOrtholog
BioCyc Gene G2FUF-20116 BioCyc
Ensembl Genes ENSRNOG00000032759 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048188.6 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Caudal_activation_dom UniProtKB/TrEMBL
  Caudal_homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
  Homeodomain UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  HTH_motif UniProtKB/TrEMBL
KEGG Report rno:66019 UniProtKB/TrEMBL
NCBI Gene 66019 ENTREZGENE
PANTHER HOMEOBOX PROTEIN CDX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN CDX-2 UniProtKB/TrEMBL
Pfam Caudal_act UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
PhenoGen Cdx2 PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032759 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A9K3Y7D3 ENTREZGENE, UniProtKB/TrEMBL
  F1M7G8 ENTREZGENE
  Q9ESV7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M7G8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cdx2  caudal type homeo box 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cdx2  caudal type homeo box 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is restricted to the intestine 625733
gene_physical_interaction interacts with DNA elements that have an AT-rich consensus sequence (TTTAC/T) 625733
gene_process induces expression of heparin-binding EGF-like growth factor (HB-EGF) 625733
gene_process activates transcription of heparin-binding EGF-like growth factor (HB-EGF) in intestinal epithetial cells (IEC)-6 625733
gene_process activates several genes that are not involved in cell proliferation, including sucrase-isomaltase (SI), lactase-phlorizin hydrolase, lactase, apolipoprotein B, carbonic anhydrase 1, calbindin-D9K, and clusterin 625733
gene_process mediates cell proliferation and migration by activation of gene transcription 625733
gene_product member of the caudal-related homeobox gene family 625733
gene_regulation function inhibited partially by an EGF receptor-specific tyrosine kinase inhibitor, PD-153035 625733