Fcna (ficolin A) - Rat Genome Database

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Gene: Fcna (ficolin A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Fcna
Name: ficolin A
RGD ID: 621221
Description: Predicted to enable several functions, including antigen binding activity; pattern recognition receptor activity; and sialic acid binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; activation of immune response; and positive regulation of interleukin-8 production. Predicted to be located in plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix; extracellular space; and symbiont cell surface; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: collagen/fibrinogen domain-containing protein 1; Fcn1; ficolin (collagen/fibrinogen domain containing) 1; ficolin-1; ficolin-A; ficolin-alpha; M-ficolin; MGC108660
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,844,036 - 28,847,441 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,844,039 - 28,847,237 (-)EnsemblGRCr8
mRatBN7.238,445,904 - 8,449,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,445,907 - 8,449,105 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,551,092 - 11,554,307 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,137,318 - 20,140,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,327,168 - 18,330,381 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd326,407,096 - 26,410,297 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive333,355,973 - 33,359,174 (-)NCBILyon_Normotensive
Lyon_Hypertensive325,255,460 - 25,258,661 (-)NCBILyon_Hypertensive
F344_StmMcwi36,458,110 - 6,461,311 (-)NCBIF344_StmMcwi
Rnor_6.032,850,006 - 2,853,230 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,849,984 - 2,853,272 (-)Ensemblrn6Rnor6.0
Rnor_5.032,831,419 - 2,834,620 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,797,916 - 3,801,117 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,270,846 - 3,274,047 (-)NCBICelera
RGSC_v3.133,797,915 - 3,801,117 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11907111   PMID:12477932   PMID:15804047   PMID:16328467   PMID:17579066   PMID:22516433   PMID:22789560   PMID:22851708  


Genomics

Variants

.
Variants in Fcna
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:130
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000023022
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH131611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,446,086 - 8,446,305 (+)MAPPERmRatBN7.2
Rnor_6.032,850,189 - 2,850,407NCBIRnor6.0
Rnor_5.032,831,602 - 2,831,820UniSTSRnor5.0
RGSC_v3.433,798,099 - 3,798,317UniSTSRGSC3.4
Celera33,271,029 - 3,271,247UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 91 59 6 353 191 11 130 79 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000023022   ⟹   ENSRNOP00000023022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,844,039 - 28,847,237 (-)Ensembl
mRatBN7.2 Ensembl38,445,907 - 8,449,105 (-)Ensembl
Rnor_6.0 Ensembl32,849,984 - 2,853,272 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106409   ⟹   ENSRNOP00000091955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,844,039 - 28,847,237 (-)Ensembl
mRatBN7.2 Ensembl38,445,907 - 8,449,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166289   ⟹   ENSRNOP00000112361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl328,844,039 - 28,847,237 (-)Ensembl
RefSeq Acc Id: NM_031348   ⟹   NP_112638
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,844,036 - 28,847,237 (-)NCBI
mRatBN7.238,445,904 - 8,449,105 (-)NCBI
Dahl_SR_JrHsd326,407,096 - 26,410,297 (-)NCBI
Lyon_Normotensive333,355,973 - 33,359,174 (-)NCBI
Lyon_Hypertensive325,255,460 - 25,258,661 (-)NCBI
F344_StmMcwi36,458,110 - 6,461,311 (-)NCBI
Rnor_6.032,850,006 - 2,853,207 (-)NCBI
Rnor_5.032,831,419 - 2,834,620 (-)NCBI
RGSC_v3.433,797,916 - 3,801,117 (-)RGD
Celera33,270,846 - 3,274,047 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761614   ⟹   XP_008759836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,844,036 - 28,847,260 (-)NCBI
mRatBN7.238,445,904 - 8,449,128 (-)NCBI
Rnor_6.032,850,006 - 2,853,230 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284644   ⟹   XP_063140714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,844,036 - 28,847,441 (-)NCBI
RefSeq Acc Id: NP_112638   ⟸   NM_031348
- Peptide Label: precursor
- UniProtKB: Q9WTS8 (UniProtKB/Swiss-Prot),   Q5M8B4 (UniProtKB/TrEMBL),   F7FL15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759836   ⟸   XM_008761614
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000023022   ⟸   ENSRNOT00000023022
Ensembl Acc Id: ENSRNOP00000091955   ⟸   ENSRNOT00000106409
RefSeq Acc Id: XP_063140714   ⟸   XM_063284644
- Peptide Label: isoform X1
- UniProtKB: Q9WTS8 (UniProtKB/Swiss-Prot),   F7FL15 (UniProtKB/TrEMBL),   Q5M8B4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112361   ⟸   ENSRNOT00000166289
Protein Domains
Collagen-like   Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTS8-F1-model_v2 AlphaFold Q9WTS8 1-335 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691888
Promoter ID:EPDNEW_R2412
Type:multiple initiation site
Name:Fcna_1
Description:ficolin A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,853,220 - 2,853,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621221 AgrOrtholog
BioCyc Gene G2FUF-50434 BioCyc
Ensembl Genes ENSRNOG00000017063 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023022 ENTREZGENE
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7376326 IMAGE-MGC_LOAD
InterPro Collagen UniProtKB/Swiss-Prot
  Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_C-term_domain UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:108660 IMAGE-MGC_LOAD
NCBI Gene 83517 ENTREZGENE
PANTHER FIBRINOGEN/TENASCIN/ANGIOPOEITIN UniProtKB/Swiss-Prot
  FICOLIN-1 UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Fcna PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017063 RatGTEx
SMART FBG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot
UniProt A0A8I6AG88_RAT UniProtKB/TrEMBL
  A0ABK0M0J2_RAT UniProtKB/TrEMBL
  A6JT93_RAT UniProtKB/TrEMBL
  F7FL15 ENTREZGENE, UniProtKB/TrEMBL
  FCN1_RAT UniProtKB/Swiss-Prot
  Q5M8B4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTS8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-09 Fcna  ficolin A  Fcn1  ficolin (collagen/fibrinogen domain containing) 1  Name and Symbol changed 629549 APPROVED
2008-09-25 Fcn1  ficolin (collagen/fibrinogen domain containing) 1  Fcna  ficolin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fcna  ficolin A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fcna  ficolin A      Symbol and Name status set to provisional 70820 PROVISIONAL