Anxa6 (annexin A6) - Rat Genome Database

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Gene: Anxa6 (annexin A6) Rattus norvegicus
Analyze
Symbol: Anxa6
Name: annexin A6
RGD ID: 621172
Description: Enables calcium-dependent phospholipid binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; mitochondrial calcium ion homeostasis; and negative regulation of sequestering of calcium ion. Predicted to act upstream of or within regulation of muscle contraction. Located in apical plasma membrane; intercalated disc; and sarcolemma. Part of protein-containing complex. Orthologous to human ANXA6 (annexin A6); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 67 kDa calelectrin; annexin VI; annexin-6; Anx6; calcium-binding protein 65/67; calcium-binding protein CATA 65/67; calphobindin-II; CBP 65/67; chromobindin-20; CPB-II; lipocortin VI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,602,106 - 39,657,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,602,106 - 39,657,359 (-)EnsemblGRCr8
mRatBN7.21039,101,395 - 39,156,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,097,109 - 39,156,433 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,789,578 - 43,844,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,279,657 - 43,334,764 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,783,353 - 38,838,463 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,320,581 - 40,375,605 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,320,581 - 40,375,605 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,092,956 - 40,148,308 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,383,975 - 40,439,683 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,439,076 - 38,494,023 (-)NCBICelera
RGSC_v3.11040,397,765 - 40,453,266 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
genistein  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
GSK-J4  (ISO)
heparin  (EXP)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (ISO)
N-nitrosomorpholine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. Alvares K, etal., J Biol Chem. 2013 May 3;288(18):13036-45. doi: 10.1074/jbc.M112.389627. Epub 2013 Mar 22.
2. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
3. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. Chow A, etal., FEBS Lett. 2000 Mar 3;469(1):88-92.
4. Identification and immunolocalisation of annexins V and VI, the major cardiac annexins, in rat heart. Doubell AF, etal., Cardiovasc Res. 1993 Jul;27(7):1359-67.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells. Thomas DD, etal., J Biol Chem 2002 Sep 20;277(38):35496-502.
Additional References at PubMed
PMID:1618851   PMID:2138016   PMID:7607247   PMID:11919174   PMID:12477932   PMID:15078881   PMID:15226301   PMID:16605264   PMID:19056867   PMID:19946888   PMID:20387083   PMID:20458337  
PMID:20506562   PMID:21272378   PMID:21362503   PMID:21423176   PMID:22871113   PMID:23341998   PMID:23360953   PMID:23376485   PMID:23533145   PMID:24403064   PMID:28369848  


Genomics

Comparative Map Data
Anxa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,602,106 - 39,657,183 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1039,602,106 - 39,657,359 (-)EnsemblGRCr8
mRatBN7.21039,101,395 - 39,156,483 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,097,109 - 39,156,433 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,789,578 - 43,844,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,279,657 - 43,334,764 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,783,353 - 38,838,463 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,320,581 - 40,375,605 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,320,581 - 40,375,605 (-)Ensemblrn6Rnor6.0
Rnor_5.01040,092,956 - 40,148,308 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41040,383,975 - 40,439,683 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1038,439,076 - 38,494,023 (-)NCBICelera
RGSC_v3.11040,397,765 - 40,453,266 (-)NCBI
Cytogenetic Map10q22NCBI
ANXA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,100,706 - 151,157,779 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,100,706 - 151,157,815 (-)Ensemblhg38GRCh38
GRCh375150,480,267 - 150,537,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,460,461 - 150,517,560 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345150,460,862 - 150,517,585NCBI
Celera5146,561,624 - 146,618,767 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,626,078 - 145,683,049 (-)NCBIHuRef
CHM1_15149,913,062 - 149,970,211 (-)NCBICHM1_1
T2T-CHM13v2.05151,637,192 - 151,694,982 (-)NCBIT2T-CHM13v2.0
Anxa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,869,779 - 54,924,297 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,869,934 - 54,924,271 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381154,978,953 - 55,033,471 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,979,108 - 55,033,445 (-)Ensemblmm10GRCm38
MGSCv371154,792,464 - 54,846,973 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,822,534 - 54,876,837 (-)NCBIMGSCv36mm8
Celera1159,568,328 - 59,623,325 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Anxa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,522,027 - 2,570,426 (+)Ensembl
ChiLan1.0NW_0049554082,522,027 - 2,565,862 (+)NCBIChiLan1.0ChiLan1.0
ANXA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,332,836 - 146,389,613 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,470,664 - 144,529,116 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,528,446 - 146,585,186 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,530,545 - 152,587,152 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,530,445 - 152,652,231 (-)EnsemblpanPan2panpan1.1
ANXA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,091,186 - 58,140,102 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,091,251 - 58,139,372 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0458,529,305 - 58,578,378 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,528,478 - 58,578,372 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,347,153 - 58,396,255 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,445,645 - 58,494,709 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,949,170 - 58,998,237 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Anxa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,975,286 - 117,026,700 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,976,903 - 4,029,485 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,978,047 - 4,029,485 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,857,249 - 71,913,723 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11671,857,229 - 71,913,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,135,702 - 78,147,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,657,377 - 53,714,828 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2353,657,718 - 53,714,850 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603423,999,800 - 24,057,882 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473341,024,514 - 41,071,353 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473341,024,503 - 41,071,390 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Anxa6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1937,412,647 - 37,464,825 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Anxa6
483 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:57
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000014464
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AW525206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,101,412 - 39,101,607 (+)MAPPERmRatBN7.2
Rnor_6.01040,320,599 - 40,320,793NCBIRnor6.0
Rnor_5.01040,092,974 - 40,093,168UniSTSRnor5.0
RGSC_v3.41040,383,993 - 40,384,187UniSTSRGSC3.4
Celera1038,439,094 - 38,439,288UniSTS
RH 3.4 Map10406.0UniSTS
Cytogenetic Map10q22UniSTS
RH136640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,114,255 - 39,114,462 (+)MAPPERmRatBN7.2
Rnor_6.01040,333,439 - 40,333,645NCBIRnor6.0
Rnor_5.01040,106,123 - 40,106,329UniSTSRnor5.0
RGSC_v3.41040,397,518 - 40,397,724UniSTSRGSC3.4
Celera1038,451,848 - 38,452,054UniSTS
RH 3.4 Map10411.4UniSTS
Cytogenetic Map10q22UniSTS
BE118744  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21039,154,008 - 39,154,184 (+)MAPPERmRatBN7.2
Rnor_6.01040,373,190 - 40,373,365NCBIRnor6.0
Rnor_5.01040,145,875 - 40,146,050UniSTSRnor5.0
RGSC_v3.41040,437,268 - 40,437,443UniSTSRGSC3.4
Celera1038,491,608 - 38,491,783UniSTS
RH 3.4 Map10411.1UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014464   ⟹   ENSRNOP00000014464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,602,106 - 39,657,130 (-)Ensembl
mRatBN7.2 Ensembl1039,101,398 - 39,156,420 (-)Ensembl
Rnor_6.0 Ensembl1040,320,581 - 40,375,605 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096029   ⟹   ENSRNOP00000091681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,602,106 - 39,657,359 (-)Ensembl
mRatBN7.2 Ensembl1039,101,397 - 39,156,433 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106165   ⟹   ENSRNOP00000079087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,602,106 - 39,657,359 (-)Ensembl
mRatBN7.2 Ensembl1039,097,109 - 39,156,412 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111975   ⟹   ENSRNOP00000080378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1039,602,106 - 39,655,747 (-)Ensembl
mRatBN7.2 Ensembl1039,101,387 - 39,156,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119845   ⟹   ENSRNOP00000076795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,101,387 - 39,156,397 (-)Ensembl
RefSeq Acc Id: NM_024156   ⟹   NP_077070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,602,106 - 39,657,130 (-)NCBI
mRatBN7.21039,101,395 - 39,156,424 (-)NCBI
Rnor_6.01040,320,581 - 40,375,605 (-)NCBI
Rnor_5.01040,092,956 - 40,148,308 (-)NCBI
RGSC_v3.41040,383,975 - 40,439,683 (-)RGD
Celera1038,439,076 - 38,494,023 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246340   ⟹   XP_006246402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,602,258 - 39,655,890 (-)NCBI
mRatBN7.21039,101,395 - 39,154,801 (-)NCBI
Rnor_6.01040,320,581 - 40,374,137 (-)NCBI
Rnor_5.01040,092,956 - 40,148,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246341   ⟹   XP_006246403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,602,258 - 39,655,612 (-)NCBI
mRatBN7.21039,101,395 - 39,154,802 (-)NCBI
Rnor_6.01040,320,581 - 40,374,139 (-)NCBI
Rnor_5.01040,092,956 - 40,148,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086912   ⟹   XP_038942840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81039,602,258 - 39,657,183 (-)NCBI
mRatBN7.21039,101,395 - 39,156,483 (-)NCBI
RefSeq Acc Id: NP_077070   ⟸   NM_024156
- UniProtKB: P48037 (UniProtKB/Swiss-Prot),   Q6IMZ3 (UniProtKB/TrEMBL),   D4ABR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246403   ⟸   XM_006246341
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMD4 (UniProtKB/TrEMBL),   A0A8J8XVA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246402   ⟸   XM_006246340
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G4G4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014464   ⟸   ENSRNOT00000014464
RefSeq Acc Id: XP_038942840   ⟸   XM_039086912
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMD4 (UniProtKB/TrEMBL),   A0A8J8XVA7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080378   ⟸   ENSRNOT00000111975
Ensembl Acc Id: ENSRNOP00000091681   ⟸   ENSRNOT00000096029
Ensembl Acc Id: ENSRNOP00000076795   ⟸   ENSRNOT00000119845
Ensembl Acc Id: ENSRNOP00000079087   ⟸   ENSRNOT00000106165

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48037-F1-model_v2 AlphaFold P48037 1-673 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697194
Promoter ID:EPDNEW_R7719
Type:initiation region
Name:Anxa6_1
Description:annexin A6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01040,375,581 - 40,375,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621172 AgrOrtholog
BioCyc Gene G2FUF-25095 BioCyc
Ensembl Genes ENSRNOG00000010668 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000096029 ENTREZGENE
  ENSRNOT00000106165 ENTREZGENE
  ENSRNOT00000111975 ENTREZGENE
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105847 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot
  Annexin_repeat UniProtKB/Swiss-Prot
  Annexin_repeat_CS UniProtKB/Swiss-Prot
  Annexin_sf UniProtKB/Swiss-Prot
  ANX6 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91612 IMAGE-MGC_LOAD
NCBI Gene 79125 ENTREZGENE
PANTHER ANNEXIN UniProtKB/Swiss-Prot
  ANNEXIN A6 UniProtKB/Swiss-Prot
Pfam Annexin UniProtKB/Swiss-Prot
PhenoGen Anxa6 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot
  ANNEXINVI UniProtKB/Swiss-Prot
PROSITE ANNEXIN UniProtKB/Swiss-Prot
  ANNEXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010668 RatGTEx
SMART ANX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AE49_RAT UniProtKB/TrEMBL
  A0A8I6G4G4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XVA7 ENTREZGENE, UniProtKB/TrEMBL
  ANXA6_RAT UniProtKB/Swiss-Prot
  D4ABR6 ENTREZGENE
  P48037 ENTREZGENE
  Q6IMZ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa6  annexin A6    annexin VI  Name updated 1299863 APPROVED
2002-08-07 Anxa6  annexin VI      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may associate with cd21 724707
gene_process may regulate the release of ca(2+) from intracellular stores 724707