Mk1 (Mk1 protein) - Rat Genome Database

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Gene: Mk1 (Mk1 protein) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mk1
Name: Mk1 protein
RGD ID: 621165
Description: Predicted to enable actin binding activity. Predicted to be involved in positive regulation of actin filament bundle assembly and regulation of actin filament polymerization. Predicted to be active in cytoplasm; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,814,804 - 18,817,293 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21618,780,819 - 18,783,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,779,115 - 18,786,547 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,822,530 - 18,825,019 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,955,478 - 19,957,967 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,875,485 - 18,877,974 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1618,952,290 - 18,954,779 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1618,825,246 - 18,827,735 (-)NCBILyon_Normotensive
Lyon_Hypertensive1618,819,194 - 18,821,683 (-)NCBILyon_Hypertensive
F344_StmMcwi1618,960,608 - 18,963,097 (-)NCBIF344_StmMcwi
Rnor_6.01620,531,720 - 20,534,209 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,531,720 - 20,534,209 (-)Ensemblrn6Rnor6.0
Rnor_5.01620,388,551 - 20,391,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41619,286,294 - 19,288,783 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,972,446 - 18,974,935 (-)NCBICelera
RGSC_v3.11619,286,291 - 19,288,781 (-)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Axons regulate the expression of Shaker-like potassium channel genes in Schwann cells in peripheral nerve. Chiu SY, etal., Glia 1994 Sep;12(1):1-11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mk1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:104
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000026601
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
RH129930  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,782,620 - 18,782,831 (+)MAPPERmRatBN7.2
Rnor_6.01620,533,522 - 20,533,732NCBIRnor6.0
Rnor_5.01620,390,353 - 20,390,563UniSTSRnor5.0
RGSC_v3.41619,288,096 - 19,288,306UniSTSRGSC3.4
Celera1618,974,248 - 18,974,458UniSTS
RH 3.4 Map16180.7UniSTS
Cytogenetic Map16p14UniSTS
AI232612  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81618,816,049 - 18,816,862 (+)Marker Load Pipeline
mRatBN7.21618,782,064 - 18,782,877 (+)MAPPERmRatBN7.2
Rnor_6.01620,532,966 - 20,533,778NCBIRnor6.0
Rnor_5.01620,389,797 - 20,390,609UniSTSRnor5.0
RGSC_v3.41619,287,540 - 19,288,352UniSTSRGSC3.4
Celera1618,973,692 - 18,974,504UniSTS
RH 3.4 Map16182.8UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 39 159 73 72 41 87 41 6 299 159 11 138 75 87 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026601   ⟹   ENSRNOP00000026601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,805,009 - 18,817,462 (+)Ensembl
mRatBN7.2 Ensembl1618,779,115 - 18,786,547 (-)Ensembl
Rnor_6.0 Ensembl1620,531,720 - 20,534,209 (-)Ensembl
RefSeq Acc Id: NM_134399   ⟹   NP_599226
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,814,804 - 18,817,293 (-)NCBI
mRatBN7.21618,780,819 - 18,783,308 (-)NCBI
Dahl_SR_JrHsd1618,952,290 - 18,954,779 (-)NCBI
Lyon_Normotensive1618,825,246 - 18,827,735 (-)NCBI
Lyon_Hypertensive1618,819,194 - 18,821,683 (-)NCBI
F344_StmMcwi1618,960,608 - 18,963,097 (-)NCBI
Rnor_6.01620,531,720 - 20,534,209 (-)NCBI
Rnor_5.01620,388,551 - 20,391,040 (-)NCBI
RGSC_v3.41619,286,294 - 19,288,783 (-)RGD
Celera1618,972,446 - 18,974,935 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90720 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026601.2
RefSeq Acc Id: NP_599226   ⟸   NM_134399
- UniProtKB: Q8VHI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026601   ⟸   ENSRNOT00000026601

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHI2-F1-model_v2 AlphaFold Q8VHI2 1-125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-11795 BioCyc
Ensembl Genes ENSRNOG00000019657 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026601.4 UniProtKB/TrEMBL
Gene3D-CATH Dynein light chain 2a, cytoplasmic UniProtKB/TrEMBL
InterPro PFN_sf UniProtKB/TrEMBL
  Profilin_mammal UniProtKB/TrEMBL
KEGG Report rno:171436 UniProtKB/TrEMBL
NCBI Gene 171436 ENTREZGENE
PANTHER PROFILIN UniProtKB/TrEMBL
  PTHR13936:SF14 UniProtKB/TrEMBL
PhenoGen Mk1 PhenoGen
PRINTS PROFILINMAML UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019657 RatGTEx
Superfamily-SCOP Profilin UniProtKB/TrEMBL
UniProt F7FNJ2_RAT UniProtKB/TrEMBL
  Q8VHI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-08-07 Mk1  Mk1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression regulated by axons 724428