Evl (Enah/Vasp-like) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Evl (Enah/Vasp-like) Rattus norvegicus
Analyze
Symbol: Evl
Name: Enah/Vasp-like
RGD ID: 621150
Description: Predicted to enable SH3 domain binding activity and profilin binding activity. Predicted to be involved in several processes, including negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of supramolecular fiber organization. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in lamellipodium and phagocytic vesicle. Predicted to be active in focal adhesion and plasma membrane. Orthologous to human EVL (Enah/Vasp-like); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ena-vasodilator stimulated phosphoprotein; ena/vasodilator-stimulated phosphoprotein-like; ena/VASP-like protein; Rnb6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,238,547 - 133,358,730 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,238,547 - 133,358,729 (+)EnsemblGRCr8
mRatBN7.26127,473,119 - 127,594,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,474,543 - 127,594,344 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,598,518 - 127,718,462 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,893,578 - 128,013,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,251,788 - 127,371,660 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,470,283 - 132,590,242 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,510,757 - 132,590,241 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,693,628 - 141,760,318 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,952,804 - 133,019,870 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6125,029,592 - 125,149,350 (+)NCBICelera
RGSC_v3.16132,987,208 - 133,026,056 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium dichloride  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
linsidomine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA)
focal adhesion  (IBA,ISO,ISS)
lamellipodium  (IEA,ISO,ISS)
phagocytic vesicle  (ISO)
plasma membrane  (IBA)
stress fiber  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Differential display cloning of a novel rat cDNA (RNB6) that shows high expression in the neonatal brain revealed a member of Ena/VASP family. Ohta S, etal., Biochem Biophys Res Commun 1997 Aug 18;237(2):307-12.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10945997   PMID:15174098   PMID:16336193   PMID:19144319   PMID:19946888   PMID:23153535   PMID:28242260   PMID:30053369  


Genomics

Comparative Map Data
Evl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86133,238,547 - 133,358,730 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6133,238,547 - 133,358,729 (+)EnsemblGRCr8
mRatBN7.26127,473,119 - 127,594,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,474,543 - 127,594,344 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6127,598,518 - 127,718,462 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,893,578 - 128,013,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,251,788 - 127,371,660 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,470,283 - 132,590,242 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,510,757 - 132,590,241 (+)Ensemblrn6Rnor6.0
Rnor_5.06141,693,628 - 141,760,318 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46132,952,804 - 133,019,870 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6125,029,592 - 125,149,350 (+)NCBICelera
RGSC_v3.16132,987,208 - 133,026,056 (+)NCBI
Cytogenetic Map6q32NCBI
EVL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,971,422 - 100,144,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,971,449 - 100,144,236 (+)Ensemblhg38GRCh38
GRCh3714100,437,759 - 100,610,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,601,504 - 99,680,326 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1480,586,599 - 80,665,405 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,713,940 - 80,792,633 (+)NCBIHuRef
CHM1_114100,469,494 - 100,548,295 (+)NCBICHM1_1
T2T-CHM13v2.01494,204,463 - 94,377,284 (+)NCBIT2T-CHM13v2.0
Evl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,520,942 - 108,654,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,520,979 - 108,654,775 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812108,554,681 - 108,688,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,554,720 - 108,688,516 (+)Ensemblmm10GRCm38
MGSCv3712109,792,930 - 109,926,726 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612109,002,527 - 109,136,323 (+)NCBIMGSCv36mm8
Celera12109,790,151 - 109,924,702 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.46NCBI
Evl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543821,198,763 - 21,298,657 (+)Ensembl
ChiLan1.0NW_00495543821,198,761 - 21,298,657 (+)NCBIChiLan1.0ChiLan1.0
EVL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215101,125,411 - 101,298,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114100,341,906 - 100,514,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,594,889 - 80,767,652 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,959,668 - 100,084,598 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14100,005,645 - 100,084,598 (+)EnsemblpanPan2panpan1.1
EVL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,352,717 - 68,461,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,352,853 - 68,484,269 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha867,874,009 - 67,982,868 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0868,637,968 - 68,746,949 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,600,082 - 68,746,947 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,299,395 - 68,409,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,401,299 - 68,474,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,763,019 - 68,872,002 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Evl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,262,540 - 6,362,430 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,719,976 - 3,822,334 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,720,038 - 3,819,928 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EVL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,911,648 - 121,056,555 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17120,911,814 - 121,056,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,577,563 - 128,588,364 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EVL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,937,319 - 78,113,011 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2478,029,684 - 78,112,664 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605365,072,012 - 65,246,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Evl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247343,927,004 - 4,071,621 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247343,926,939 - 4,023,841 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Evl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17126,232,611 - 126,353,336 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Evl
9152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:49
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000019583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH143992  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera6125,028,222 - 125,028,412UniSTS
RH 3.4 Map6793.5UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001414900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019583   ⟹   ENSRNOP00000019584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,308,033 - 133,358,729 (+)Ensembl
mRatBN7.2 Ensembl6127,474,543 - 127,594,341 (+)Ensembl
Rnor_6.0 Ensembl6132,551,394 - 132,590,241 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080230   ⟹   ENSRNOP00000072070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,279,250 - 133,358,729 (+)Ensembl
mRatBN7.2 Ensembl6127,514,742 - 127,594,341 (+)Ensembl
Rnor_6.0 Ensembl6132,510,757 - 132,589,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103365   ⟹   ENSRNOP00000084449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,319,859 - 133,358,729 (+)Ensembl
mRatBN7.2 Ensembl6127,543,439 - 127,594,344 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108816   ⟹   ENSRNOP00000077166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,316,919 - 133,358,729 (+)Ensembl
mRatBN7.2 Ensembl6127,543,121 - 127,594,341 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113728   ⟹   ENSRNOP00000092151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,308,033 - 133,358,729 (+)Ensembl
mRatBN7.2 Ensembl6127,543,439 - 127,594,344 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128429   ⟹   ENSRNOP00000112463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,238,547 - 133,358,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137650   ⟹   ENSRNOP00000101632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,308,033 - 133,358,729 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142269   ⟹   ENSRNOP00000107038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6133,304,456 - 133,358,729 (+)Ensembl
RefSeq Acc Id: NM_001414900   ⟹   NP_001401829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,238,547 - 133,358,728 (+)NCBI
mRatBN7.26127,474,152 - 127,594,342 (+)NCBI
RefSeq Acc Id: NM_024147   ⟹   NP_077061
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,238,547 - 133,358,728 (+)NCBI
mRatBN7.26127,474,152 - 127,594,342 (+)NCBI
Rnor_6.06132,470,283 - 132,590,242 (+)NCBI
Rnor_5.06141,693,628 - 141,760,318 (+)NCBI
RGSC_v3.46132,952,804 - 133,019,870 (+)RGD
Celera6125,029,592 - 125,149,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262532   ⟹   XP_063118602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,278,677 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262533   ⟹   XP_063118603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,301,308 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262534   ⟹   XP_063118604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,307,867 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262535   ⟹   XP_063118605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,278,677 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262536   ⟹   XP_063118606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,278,677 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262537   ⟹   XP_063118607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,307,965 - 133,358,730 (+)NCBI
RefSeq Acc Id: XM_063262538   ⟹   XP_063118608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86133,307,965 - 133,358,730 (+)NCBI
RefSeq Acc Id: NP_077061   ⟸   NM_024147
- Peptide Label: isoform 2
- UniProtKB: A6KBG4 (UniProtKB/TrEMBL),   A0A8I5Y7H8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072070   ⟸   ENSRNOT00000080230
Ensembl Acc Id: ENSRNOP00000019584   ⟸   ENSRNOT00000019583
Ensembl Acc Id: ENSRNOP00000092151   ⟸   ENSRNOT00000113728
Ensembl Acc Id: ENSRNOP00000077166   ⟸   ENSRNOT00000108816
Ensembl Acc Id: ENSRNOP00000084449   ⟸   ENSRNOT00000103365
RefSeq Acc Id: NP_001401829   ⟸   NM_001414900
- Peptide Label: isoform 1
- UniProtKB: A0A8I5Y7H8 (UniProtKB/TrEMBL),   F1M8I7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118602   ⟸   XM_063262532
- Peptide Label: isoform X1
- UniProtKB: O08719 (UniProtKB/Swiss-Prot),   A0A0G2K217 (UniProtKB/Swiss-Prot),   A0A8L2R521 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118605   ⟸   XM_063262535
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1B6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118606   ⟸   XM_063262536
- Peptide Label: isoform X5
- UniProtKB: A0A8L2R521 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118603   ⟸   XM_063262533
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y7H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118604   ⟸   XM_063262534
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y7H8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118607   ⟸   XM_063262537
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A1B6 (UniProtKB/TrEMBL),   A0A8I6AH17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118608   ⟸   XM_063262538
- Peptide Label: isoform X7
- UniProtKB: A0A8I5Y7H8 (UniProtKB/TrEMBL),   A6KBG7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101632   ⟸   ENSRNOT00000137650
Ensembl Acc Id: ENSRNOP00000107038   ⟸   ENSRNOT00000142269
Ensembl Acc Id: ENSRNOP00000112463   ⟸   ENSRNOT00000128429
Protein Domains
WH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08719-F1-model_v2 AlphaFold O08719 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621150 AgrOrtholog
BioCyc Gene G2FUF-36295 BioCyc
Ensembl Genes ENSRNOG00000014476 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019583 ENTREZGENE
  ENSRNOT00000080230 ENTREZGENE
  ENSRNOT00000113728 ENTREZGENE
  ENSRNOT00000128429 ENTREZGENE
  ENSRNOT00000137650 ENTREZGENE
  ENSRNOT00000142269 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot
  VASP/EVL UniProtKB/Swiss-Prot
  VASP_sf UniProtKB/Swiss-Prot
  VASP_tetra UniProtKB/Swiss-Prot
  WH1/EVH1_dom UniProtKB/Swiss-Prot
KEGG Report rno:79115 UniProtKB/Swiss-Prot
NCBI Gene 79115 ENTREZGENE
PANTHER PTHR11202:SF4 UniProtKB/Swiss-Prot
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam VASP_tetra UniProtKB/Swiss-Prot
  WH1 UniProtKB/Swiss-Prot
PhenoGen Evl PhenoGen
PIRSF Vasodilator_Phospo UniProtKB/Swiss-Prot
PROSITE WH1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014476 RatGTEx
SMART WH1 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF118370 UniProtKB/Swiss-Prot
UniProt A0A0G2K217 ENTREZGENE
  A0A8I5Y7H8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AH17 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R521 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8X5_RAT UniProtKB/TrEMBL
  A0ABK0LMX9_RAT UniProtKB/TrEMBL
  A0ABK0M6H6_RAT UniProtKB/TrEMBL
  A6KBG4 ENTREZGENE, UniProtKB/TrEMBL
  A6KBG7 ENTREZGENE, UniProtKB/TrEMBL
  EVL_RAT UniProtKB/Swiss-Prot
  F1M8I7 ENTREZGENE, UniProtKB/TrEMBL
  O08719 ENTREZGENE
UniProt Secondary A0A0G2K217 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Evl  Enah/Vasp-like  Evl  Ena-vasodilator stimulated phosphoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Evl  Ena-vasodilator stimulated phosphoprotein    RNB6  Name updated 1299863 APPROVED
2002-08-07 Evl  RNB6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression in brain peaks at P1, decreases thereafter, also found in spleen, thymus and testis 728214
gene_expression protein found mainly in neurons 728214
gene_homology shares homology with members of the murine Ena/VASP protein family 728214
gene_protein putative protein has 393 aa residues 728214