Dao (D-amino-acid oxidase) - Rat Genome Database

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Gene: Dao (D-amino-acid oxidase) Rattus norvegicus
Analyze
Symbol: Dao
Name: D-amino-acid oxidase
RGD ID: 621138
Description: Predicted to enable FAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors. Predicted to be involved in several processes, including alpha-amino acid catabolic process; dopamine biosynthetic process; and neutrophil-mediated killing of gram-negative bacterium. Predicted to act upstream of or within L-leucine metabolic process. Located in peroxisomal matrix and presynaptic active zone. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D-amino acid oxidase; D-amino acid oxidase 1; DAAO; DAMOX; Dao1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,252,900 - 48,275,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1248,252,902 - 48,273,300 (-)EnsemblGRCr8
mRatBN7.21242,592,342 - 42,613,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,592,343 - 42,612,741 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,758,494 - 43,778,668 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,372,084 - 44,392,254 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,432,603 - 43,452,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,353,691 - 48,373,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,354,196 - 48,365,784 (-)Ensemblrn6Rnor6.0
Rnor_5.01250,135,334 - 50,157,417 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,627,593 - 43,648,332 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1244,196,549 - 44,215,768 (-)NCBICelera
RGSC_v3.11243,490,980 - 43,511,720 (-)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methyl-pyrazole-3-carboxylic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium acetate  (EXP)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
diquat  (ISO)
epoxomicin  (ISO)
ethanol  (EXP)
flutamide  (EXP)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (EXP)
hexadecanoic acid  (ISO)
indometacin  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
levetiracetam  (EXP)
methapyrilene  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
Propiverine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium benzoate  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP,ISO)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Heterogenous staining of D-amino acid oxidase in peroxisomes of rat liver and kidney. A light and electron microscopic study. Angermüller S and Fahimi HD, Histochemistry. 1988;88(3-6):277-85.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Hasegawa H, etal., Am J Physiol Endocrinol Metab 2004 Jul;287(1):E160-5. Epub 2004 Mar 16.
4. Rat D-amino-acid oxidase cDNA: rat D-amino-acid oxidase as an intermediate form between mouse and other mammalian D-amino-acid oxidases. Konno R Biochim Biophys Acta 1998 Jan 21;1395(2):165-70.
5. Novel insights into renal D-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo. Luks L, etal., Arch Toxicol. 2017 Jan;91(1):427-437. doi: 10.1007/s00204-016-1685-z. Epub 2016 Mar 9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, etal., J Biol Chem. 2011 Aug 19;286(33):28867-28875. doi: 10.1074/jbc.M111.262063. Epub 2011 Jun 23.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Schumacher J, etal., Mol Psychiatry 2004 Feb;9(2):203-7.
Additional References at PubMed
PMID:2572224   PMID:12364586   PMID:12477932   PMID:15489334   PMID:16616139   PMID:17303072   PMID:18544534   PMID:18716858   PMID:19309736   PMID:19685198   PMID:20178365   PMID:20368421  
PMID:20521334   PMID:20603179   PMID:21110210   PMID:21679769   PMID:24005798   PMID:24138986   PMID:32512180   PMID:33319325   PMID:38044118  


Genomics

Comparative Map Data
Dao
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,252,900 - 48,275,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1248,252,902 - 48,273,300 (-)EnsemblGRCr8
mRatBN7.21242,592,342 - 42,613,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,592,343 - 42,612,741 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,758,494 - 43,778,668 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,372,084 - 44,392,254 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,432,603 - 43,452,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,353,691 - 48,373,647 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,354,196 - 48,365,784 (-)Ensemblrn6Rnor6.0
Rnor_5.01250,135,334 - 50,157,417 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41243,627,593 - 43,648,332 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1244,196,549 - 44,215,768 (-)NCBICelera
RGSC_v3.11243,490,980 - 43,511,720 (-)NCBI
Cytogenetic Map12q16NCBI
DAO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,880,092 - 108,901,043 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,858,932 - 108,901,051 (+)Ensemblhg38GRCh38
GRCh3712109,273,868 - 109,294,819 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,797,986 - 107,818,839 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412107,776,332 - 107,797,162NCBI
Celera12108,942,740 - 108,963,590 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12106,338,463 - 106,359,320 (+)NCBIHuRef
CHM1_112109,241,476 - 109,262,347 (+)NCBICHM1_1
T2T-CHM13v2.012108,854,786 - 108,875,798 (+)NCBIT2T-CHM13v2.0
Dao
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,137,696 - 114,163,736 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,141,764 - 114,163,743 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385113,999,635 - 114,025,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,003,703 - 114,025,682 (+)Ensemblmm10GRCm38
MGSCv375114,453,835 - 114,475,469 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365114,270,835 - 114,285,905 (+)NCBIMGSCv36mm8
Celera5111,106,565 - 111,127,023 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.93NCBI
Dao
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,095,300 - 10,127,666 (+)Ensembl
ChiLan1.0NW_00495545510,095,597 - 10,127,244 (+)NCBIChiLan1.0ChiLan1.0
DAO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,932,153 - 116,965,615 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,928,929 - 116,962,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,453,807 - 106,475,409 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,849,995 - 109,870,065 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,849,995 - 109,870,065 (+)EnsemblpanPan2panpan1.1
DAO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,032,663 - 18,057,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,033,392 - 18,057,238 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2617,744,673 - 17,773,938 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02618,371,860 - 18,401,188 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,376,518 - 18,395,445 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,954,290 - 17,983,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,362,722 - 18,391,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,381,507 - 18,410,821 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dao
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,717,426 - 144,736,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769744,864 - 758,452 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936769744,862 - 758,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,931,541 - 41,950,633 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11441,931,549 - 41,950,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,473,515 - 44,492,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q2.1-q2.3NCBI
DAO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,080,915 - 104,104,017 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,081,672 - 104,106,222 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037140,993,522 - 141,016,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dao
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474712,105,133 - 12,116,604 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474712,094,658 - 12,117,000 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dao
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11639,936,946 - 39,957,596 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:93
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000000881
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 46 103 91 90 59 66 59 6 300 136 4 79 81 87 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000077317   ⟹   ENSRNOP00000069135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1248,254,474 - 48,273,300 (-)Ensembl
mRatBN7.2 Ensembl1242,593,915 - 42,612,741 (-)Ensembl
Rnor_6.0 Ensembl1248,354,196 - 48,365,784 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094356   ⟹   ENSRNOP00000079300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1248,252,902 - 48,273,300 (-)Ensembl
mRatBN7.2 Ensembl1242,592,343 - 42,612,741 (-)Ensembl
RefSeq Acc Id: NM_053626   ⟹   NP_446078
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81248,252,902 - 48,273,300 (-)NCBI
mRatBN7.21242,592,343 - 42,612,741 (-)NCBI
Rnor_6.01248,353,691 - 48,373,647 (-)NCBI
Rnor_5.01250,135,334 - 50,157,417 (-)NCBI
RGSC_v3.41243,627,593 - 43,648,332 (-)RGD
Celera1244,196,549 - 44,215,768 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089003   ⟹   XP_038944931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81248,252,900 - 48,273,667 (-)NCBI
mRatBN7.21242,592,342 - 42,613,046 (-)NCBI
RefSeq Acc Id: XM_063270980   ⟹   XP_063127050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81248,252,900 - 48,275,964 (-)NCBI
RefSeq Acc Id: XM_063270981   ⟹   XP_063127051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81248,252,900 - 48,273,614 (-)NCBI
RefSeq Acc Id: NP_446078   ⟸   NM_053626
- UniProtKB: O35078 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069135   ⟸   ENSRNOT00000077317
RefSeq Acc Id: XP_038944931   ⟸   XM_039089003
- Peptide Label: isoform X1
- UniProtKB: O35078 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000079300   ⟸   ENSRNOT00000094356
RefSeq Acc Id: XP_063127050   ⟸   XM_063270980
- Peptide Label: isoform X1
- UniProtKB: O35078 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063127051   ⟸   XM_063270981
- Peptide Label: isoform X1
- UniProtKB: O35078 (UniProtKB/Swiss-Prot)
Protein Domains
FAD dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35078-F1-model_v2 AlphaFold O35078 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621138 AgrOrtholog
BioCyc Gene G2FUF-18935 BioCyc
Ensembl Genes ENSRNOG00000054962 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000094356 ENTREZGENE
  ENSRNOT00000094356.1 UniProtKB/Swiss-Prot
Gene3D-CATH D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110523 IMAGE-MGC_LOAD
InterPro D-amino_acid_oxidase_CS UniProtKB/Swiss-Prot
  DAO UniProtKB/Swiss-Prot
  FAD-dep_OxRdtase UniProtKB/Swiss-Prot
KEGG Report rno:114027 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93293 IMAGE-MGC_LOAD
NCBI Gene 114027 ENTREZGENE
PANTHER D-AMINO-ACID OXIDASE UniProtKB/Swiss-Prot
  PTHR11530 UniProtKB/Swiss-Prot
Pfam DAO UniProtKB/Swiss-Prot
PhenoGen Dao PhenoGen
PIRSF D-aa_oxidase UniProtKB/Swiss-Prot
PROSITE DAO UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054962 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot
  Nucleotide-binding domain UniProtKB/Swiss-Prot
UniProt A0A0G2JUK6_RAT UniProtKB/TrEMBL
  O35078 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Dao  D-amino-acid oxidase  Dao1  D-amino acid oxidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dao1  D-amino acid oxidase 1    D-amino acid oxidase  Name updated 1299863 APPROVED
2005-01-20 Dao1  D-amino acid oxidase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dao1  D-amino acid oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney, liver, and brain 632639
gene_homology 93% amino acid identity to mouse homolog 632639
gene_protein 346 amino acids 632639