Adgrl4 (adhesion G protein-coupled receptor L4) - Rat Genome Database

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Gene: Adgrl4 (adhesion G protein-coupled receptor L4) Rattus norvegicus
Analyze
Symbol: Adgrl4
Name: adhesion G protein-coupled receptor L4
RGD ID: 621136
Description: Predicted to enable G protein-coupled receptor activity. Involved in protein-containing complex assembly. Located in cytoplasmic vesicle and plasma membrane. Biomarker of glioblastoma. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EGF, latrophilin and seven transmembrane domain containing 1; EGF, latrophilin and seven transmembrane domain-containing protein 1; EGF, latrophilin seven transmembrane domain containing 1; EGF,latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; Eltd1; Etl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,014,927 - 243,117,226 (+)NCBIGRCr8
mRatBN7.22240,354,909 - 240,457,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,354,941 - 240,457,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2248,150,182 - 248,254,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02246,037,208 - 246,141,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02240,908,297 - 241,010,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02256,609,787 - 256,724,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2256,609,787 - 256,724,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,293,988 - 275,408,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42249,764,600 - 249,866,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12249,779,206 - 249,881,437 (+)NCBI
Celera2232,295,578 - 232,396,733 (+)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasmic vesicle  (IDA)
plasma membrane  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. Nechiporuk T, etal., J Biol Chem 2001 Feb 9;276(6):4150-7.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. ELTD1, a potential new biomarker for gliomas. Towner RA, etal., Neurosurgery. 2013 Jan;72(1):77-90; discussion 91. doi: 10.1227/NEU.0b013e318276b29d.
9. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. Xiao J, etal., PLoS One. 2012;7(5):e35779. doi: 10.1371/journal.pone.0035779. Epub 2012 May 11.
10. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Ziegler J, etal., Neuro Oncol. 2017 Feb 1;19(2):175-185. doi: 10.1093/neuonc/now147.

Genomics

Comparative Map Data
Adgrl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,014,927 - 243,117,226 (+)NCBIGRCr8
mRatBN7.22240,354,909 - 240,457,231 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,354,941 - 240,457,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2248,150,182 - 248,254,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02246,037,208 - 246,141,984 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02240,908,297 - 241,010,524 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02256,609,787 - 256,724,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2256,609,787 - 256,724,641 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,293,988 - 275,408,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42249,764,600 - 249,866,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12249,779,206 - 249,881,437 (+)NCBI
Celera2232,295,578 - 232,396,733 (+)NCBICelera
Cytogenetic Map2q45NCBI
ADGRL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,889,764 - 79,006,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,889,764 - 79,282,124 (-)EnsemblGRCh38hg38GRCh38
GRCh37179,355,449 - 79,472,415 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36179,128,037 - 79,245,083 (-)NCBINCBI36Build 36hg18NCBI36
Celera177,595,032 - 77,712,073 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef177,487,868 - 77,604,946 (-)NCBIHuRef
CHM1_1179,471,875 - 79,588,556 (-)NCBICHM1_1
T2T-CHM13v2.0178,728,626 - 78,845,196 (-)NCBIT2T-CHM13v2.0
Adgrl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,143,519 - 151,250,718 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,143,524 - 151,250,723 (+)EnsemblGRCm39 Ensembl
GRCm383151,437,882 - 151,545,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3151,437,887 - 151,545,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv373151,100,846 - 151,208,045 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363151,375,268 - 151,482,467 (+)NCBIMGSCv36mm8
Celera3157,902,449 - 158,009,462 (+)NCBICelera
Cytogenetic Map3H3NCBI
cM Map376.76NCBI
Adgrl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542314,395,558 - 14,487,856 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542314,395,712 - 14,487,803 (+)NCBIChiLan1.0ChiLan1.0
ADGRL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21147,892,334 - 148,008,807 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11147,048,791 - 147,165,268 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,099,504 - 78,216,060 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1180,236,721 - 80,353,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl180,236,040 - 80,353,157 (-)Ensemblpanpan1.1panPan2
ADGRL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1668,078,481 - 68,189,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,078,246 - 68,220,743 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha670,736,971 - 70,847,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0668,665,910 - 68,775,602 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl668,665,865 - 68,803,027 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1668,170,982 - 68,281,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0668,116,156 - 68,227,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0668,602,665 - 68,712,408 (+)NCBIUU_Cfam_GSD_1.0
Adgrl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505890,076,709 - 90,181,473 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365715,587,059 - 5,691,670 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365715,587,077 - 5,691,623 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADGRL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6134,362,901 - 134,462,694 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16134,362,714 - 134,462,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26124,520,112 - 124,620,447 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADGRL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12054,208,073 - 54,325,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2054,208,321 - 54,327,545 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603363,213,110 - 63,333,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adgrl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474218,306,871 - 18,396,342 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474218,306,809 - 18,397,683 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adgrl4
833 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000047564
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat

Markers in Region
BF404923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22240,357,127 - 240,357,237 (+)MAPPERmRatBN7.2
Rnor_6.02256,611,974 - 256,612,083NCBIRnor6.0
Rnor_5.02275,296,175 - 275,296,284UniSTSRnor5.0
RGSC_v3.42249,766,787 - 249,766,896UniSTSRGSC3.4
Celera2232,297,760 - 232,297,869UniSTS
RH 3.4 Map21653.81UniSTS
Cytogenetic Map2q45UniSTS
AI237194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22240,456,851 - 240,457,036 (+)MAPPERmRatBN7.2
Rnor_6.02256,724,268 - 256,724,452NCBIRnor6.0
Rnor_5.02275,408,521 - 275,408,705UniSTSRnor5.0
RGSC_v3.42249,866,457 - 249,866,641UniSTSRGSC3.4
Celera2232,396,359 - 232,396,543UniSTS
RH 3.4 Map21654.81UniSTS
Cytogenetic Map2q45UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000047564   ⟹   ENSRNOP00000045890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2240,354,941 - 240,457,225 (+)Ensembl
Rnor_6.0 Ensembl2256,609,787 - 256,724,641 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088437   ⟹   ENSRNOP00000071560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2240,354,968 - 240,457,225 (+)Ensembl
Rnor_6.0 Ensembl2256,609,787 - 256,724,641 (+)Ensembl
RefSeq Acc Id: NM_022294   ⟹   NP_071630
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,014,939 - 243,117,221 (+)NCBI
mRatBN7.22240,354,941 - 240,457,226 (+)NCBI
Rnor_6.02256,609,787 - 256,724,642 (+)NCBI
Rnor_5.02275,293,988 - 275,408,900 (+)NCBI
RGSC_v3.42249,764,600 - 249,866,831 (+)RGD
Celera2232,295,578 - 232,396,733 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103036   ⟹   XP_038958964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,014,927 - 243,117,226 (+)NCBI
mRatBN7.22240,354,912 - 240,457,231 (+)NCBI
RefSeq Acc Id: NP_071630   ⟸   NM_022294
- Peptide Label: precursor
- UniProtKB: Q9ESC0 (UniProtKB/Swiss-Prot),   Q9ESC1 (UniProtKB/Swiss-Prot),   A6HWI6 (UniProtKB/TrEMBL),   A0A8L2R476 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045890   ⟸   ENSRNOT00000047564
Ensembl Acc Id: ENSRNOP00000071560   ⟸   ENSRNOT00000088437
RefSeq Acc Id: XP_038958964   ⟸   XM_039103036
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R476 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   G-protein coupled receptors family 2 profile   GAIN-B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESC1-F1-model_v2 AlphaFold Q9ESC1 1-738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691820
Promoter ID:EPDNEW_R2344
Type:initiation region
Name:Adgrl4_1
Description:adhesion G protein-coupled receptor L4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02256,609,964 - 256,610,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621136 AgrOrtholog
BioCyc Gene G2FUF-50830 BioCyc
Ensembl Genes ENSRNOG00000033940 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024722 UniProtKB/Swiss-Prot
  ENSRNOG00060001374 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047564.5 UniProtKB/Swiss-Prot
  ENSRNOT00000088437.2 UniProtKB/TrEMBL
  ENSRNOT00055042646 UniProtKB/Swiss-Prot
  ENSRNOT00060002017 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.220.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64124 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64124 ENTREZGENE
PANTHER ADHESION G PROTEIN-COUPLED RECEPTOR L4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADHESION G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adgrl4 PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033940 RatGTEx
  ENSRNOG00055024722 RatGTEx
  ENSRNOG00060001374 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R476 ENTREZGENE, UniProtKB/TrEMBL
  A6HWI6 ENTREZGENE, UniProtKB/TrEMBL
  AGRL4_RAT UniProtKB/Swiss-Prot
  Q9ESC0 ENTREZGENE
  Q9ESC1 ENTREZGENE
UniProt Secondary Q9ESC0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Adgrl4  adhesion G protein-coupled receptor L4  Eltd1  EGF, latrophilin and seven transmembrane domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Eltd1  EGF, latrophilin and seven transmembrane domain containing 1    EGF, latrophilin seven transmembrane domain containing 1  Name updated 1299863 APPROVED
2004-12-14 Eltd1  EGF, latrophilin seven transmembrane domain containing 1  Etl  ETL protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Etl  ETL protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization associated with cell membranes; localized in cytoplasmic vesicles 632805
gene_domains contains a large extracellular domain with epidermal growth factor (EGF)-like repeats and a seven-transmembrane domain 632805
gene_expression expressed in cardiomyocytes, enriched in vascular and bronchiolar smooth muscle cells 632805
gene_product member of the secretin family of G-protein-coupled peptide hormone receptors and the EGF-TM7 subfamily of receptors 632805
gene_protein 738 amino acids 632805