Ptprv (protein tyrosine phosphatase, receptor type, V) - Rat Genome Database

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Gene: Ptprv (protein tyrosine phosphatase, receptor type, V) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ptprv
Name: protein tyrosine phosphatase, receptor type, V
RGD ID: 621123
Description: Enables protein tyrosine phosphatase activity. Involved in several processes, including cellular response to cAMP; cellular response to epidermal growth factor stimulus; and cellular response to parathyroid hormone stimulus. Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: embryonic stem cell protein-tyrosine phosphatase; ES cell phosphatase; Esp; OST-PTP; Osteotesticular phosphatase; osteotesticular protein-tyrosine phosphatase; protein tyrosine phosphatase receptor type V; protein tyrosine phosphatase receptor type W; R-PTP-V; receptor-type tyrosine-protein phosphatase V
RGD Orthologs
Alliance Genes
More Info homologs ...
Candidate Gene For: Bp396
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,099,922 - 49,120,247 (-)NCBIGRCr8
mRatBN7.21346,548,125 - 46,569,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,548,128 - 46,568,329 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,154,881 - 49,175,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,442,953 - 50,463,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,709,077 - 47,729,254 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,935,239 - 51,956,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,935,243 - 51,955,735 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,986,598 - 57,006,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,070,488 - 48,090,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,084,530 - 48,104,725 (-)NCBI
Celera1346,873,988 - 46,894,178 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Mauro LJ, etal., Endocrinology. 1996 Mar;137(3):925-33. doi: 10.1210/endo.137.3.8603605.
4. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. Mauro LJ, etal., J Biol Chem 1994 Dec 2;269(48):30659-67.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10087294  


Genomics

Variants

.
Variants in Ptprv
188 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000007597
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 32
Low 2 26 18 10 18 10 2 3 36 35 9 3 2
Below cutoff 1 17 36 28 1 28 6 8 38 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007597   ⟹   ENSRNOP00000007597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,548,132 - 46,568,329 (-)Ensembl
Rnor_6.0 Ensembl1351,935,243 - 51,955,735 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110943   ⟹   ENSRNOP00000095225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1346,548,128 - 46,566,234 (-)Ensembl
RefSeq Acc Id: NM_033099   ⟹   NP_149090
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,925 - 49,120,121 (-)NCBI
mRatBN7.21346,548,132 - 46,568,329 (-)NCBI
Rnor_6.01351,935,246 - 51,955,440 (-)NCBI
Rnor_5.01356,986,598 - 57,006,819 (-)NCBI
RGSC_v3.41348,070,488 - 48,090,682 (-)RGD
Celera1346,873,988 - 46,894,178 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091068   ⟹   XP_038946996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,239 (-)NCBI
mRatBN7.21346,548,125 - 46,569,128 (-)NCBI
RefSeq Acc Id: XM_039091069   ⟹   XP_038946997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,239 (-)NCBI
mRatBN7.21346,548,125 - 46,569,128 (-)NCBI
RefSeq Acc Id: XM_039091070   ⟹   XP_038946998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,241 (-)NCBI
mRatBN7.21346,548,125 - 46,569,129 (-)NCBI
RefSeq Acc Id: XM_039091071   ⟹   XP_038946999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,102,466 - 49,120,247 (-)NCBI
mRatBN7.21346,550,670 - 46,569,131 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_149090   ⟸   NM_033099
- Peptide Label: precursor
- UniProtKB: Q64612 (UniProtKB/Swiss-Prot),   A0A8I6AM78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007597   ⟸   ENSRNOT00000007597
RefSeq Acc Id: XP_038946998   ⟸   XM_039091070
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946996   ⟸   XM_039091068
- Peptide Label: isoform X1
- UniProtKB: F1M8J3 (UniProtKB/TrEMBL),   A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946997   ⟸   XM_039091069
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946999   ⟸   XM_039091071
- Peptide Label: isoform X4
- UniProtKB: A6ICD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095225   ⟸   ENSRNOT00000110943
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64612-F1-model_v2 AlphaFold Q64612 1-1711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698837
Promoter ID:EPDNEW_R9361
Type:single initiation site
Name:Ptprv_1
Description:protein tyrosine phosphatase, receptor type, V
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01351,955,399 - 51,955,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621123 AgrOrtholog
BioCyc Gene G2FUF-18219 BioCyc
Ensembl Genes ENSRNOG00000005277 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007597 ENTREZGENE
  ENSRNOT00000007597.6 UniProtKB/TrEMBL
  ENSRNOT00000110943.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64576 UniProtKB/Swiss-Prot
NCBI Gene 64576 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-TYROSINE-PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_tm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprv PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005277 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AM78 ENTREZGENE, UniProtKB/TrEMBL
  A6ICD7 ENTREZGENE, UniProtKB/TrEMBL
  F1M8J3 ENTREZGENE, UniProtKB/TrEMBL
  PTPRV_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ptprv  protein tyrosine phosphatase, receptor type, V  Esp  Osteotesticular phosphatase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Esp        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an extracellular domain with 10 fibronectin type III repeats and a cytoplasmic region with two catalytic domains 632779
gene_protein 1711 amino acids 632779
gene_regulation induced by parathyroid hormone and cyclic AMP analogues 632779