Bard1 (BRCA1 associated RING domain 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bard1 (BRCA1 associated RING domain 1) Rattus norvegicus
Analyze
Symbol: Bard1
Name: BRCA1 associated RING domain 1
RGD ID: 621072
Description: Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to testosterone stimulus; and response to aldosterone. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nucleus. Biomarker of retinal degeneration. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BARD-1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,069,960 - 80,144,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl980,069,960 - 80,176,873 (-)EnsemblGRCr8
mRatBN7.2972,616,070 - 72,694,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx981,082,647 - 81,149,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,211,538 - 86,278,825 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0984,594,537 - 84,662,040 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,297,723 - 78,368,777 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)Ensemblrn6Rnor6.0
Rnor_5.0978,074,908 - 78,145,962 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4970,120,151 - 70,198,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera970,040,784 - 70,110,644 (-)NCBICelera
RGSC_v3.1970,267,132 - 70,345,573 (-)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
Abemaciclib  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cisplatin  (ISO)
citalopram  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
dibenzofuran  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
escitalopram  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
gallic acid  (ISO)
Lasiocarpine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
piroxicam  (ISO)
pravastatin  (EXP,ISO)
propanal  (ISO)
purine-6-thiol  (EXP)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
BRCA1-A complex  (IBA,IEA,ISO)
BRCA1-B complex  (IEA,ISO)
BRCA1-BARD1 complex  (IBA,IEA,ISO,ISS)
BRCA1-C complex  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
nuclear speck  (IEA,ISO)
nuclear ubiquitin ligase complex  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated. Feki A, etal., Biol Reprod. 2004 Nov;71(5):1614-24. Epub 2004 Jul 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies. Gautier F, etal., Cancer Res 2000 Dec 15;60(24):6895-900.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer. Gorringe KL, etal., Breast Cancer Res Treat. 2008 Oct;111(3):505-9. Epub 2007 Oct 31.
6. Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping. Gratas C, etal., Cytogenet Cell Genet 2001;94(3-4):250-1.
7. Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis. Huo X, etal., Breast Cancer Res Treat. 2007 May;102(3):329-37. Epub 2006 Sep 21.
8. BARD1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing rats. Irminger-Finger I, etal., Oncol Rep. 2006 Jun;15(6):1425-8.
9. Mutational analysis of BARD1 in familial breast cancer patients in Japan. Ishitobi M, etal., Cancer Lett. 2003 Oct 8;200(1):1-7.
10. BARD1 and breast cancer in Poland. Jakubowska A, etal., Breast Cancer Res Treat. 2008 Jan;107(1):119-22. Epub 2007 Feb 27.
11. Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart. Kim YJ, etal., Korean J Anesthesiol. 2010 Feb;58(2):153-61. doi: 10.4097/kjae.2010.58.2.153. Epub 2010 Feb 28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Sakka L, etal., Oncotarget. 2017 Jun 27;8(26):42789-42807. doi: 10.18632/oncotarget.17050.
21. The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Shakya R, etal., Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. Epub 2008 Apr 28.
22. miR-21 enhances the protective effect of loperamide on rat cardiomyocytes against hypoxia/reoxygenation, reactive oxygen species production and apoptosis via regulating Akap8 and Bard1 expression. Shen H, etal., Exp Ther Med. 2019 Feb;17(2):1312-1320. doi: 10.3892/etm.2018.7047. Epub 2018 Dec 5.
23. The BARD1 Cys557Ser variant and breast cancer risk in Iceland. Stacey SN, etal., PLoS Med. 2006 Jul;3(7):e217.
24. BARD1 variants Cys557Ser and Val507Met in breast cancer predisposition. Vahteristo P, etal., Eur J Hum Genet. 2006 Feb;14(2):167-72.
25. Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Wu JY, etal., Int J Cancer. 2006 Mar 1;118(5):1215-26.
26. BARD1: an independent predictor of survival in non-small cell lung cancer. Zhang YQ, etal., Int J Cancer. 2012 Jul 1;131(1):83-94. doi: 10.1002/ijc.26346. Epub 2011 Dec 21.
Additional References at PubMed
PMID:11555636   PMID:12419249   PMID:12890688   PMID:15265711   PMID:15632137   PMID:15782130   PMID:17525342   PMID:19117993   PMID:19261748   PMID:19261749   PMID:20351172  


Genomics

Comparative Map Data
Bard1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,069,960 - 80,144,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl980,069,960 - 80,176,873 (-)EnsemblGRCr8
mRatBN7.2972,616,070 - 72,694,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx981,082,647 - 81,149,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,211,538 - 86,278,825 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0984,594,537 - 84,662,040 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,297,723 - 78,368,777 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)Ensemblrn6Rnor6.0
Rnor_5.0978,074,908 - 78,145,962 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4970,120,151 - 70,198,591 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera970,040,784 - 70,110,644 (-)NCBICelera
RGSC_v3.1970,267,132 - 70,345,573 (-)NCBI
Cytogenetic Map9q33NCBI
BARD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382214,725,646 - 214,809,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2214,725,646 - 214,809,707 (-)Ensemblhg38GRCh38
GRCh372215,590,370 - 215,674,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,301,507 - 215,382,673 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342215,418,782 - 215,499,872NCBI
Celera2209,361,498 - 209,442,679 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2207,449,412 - 207,530,541 (-)NCBIHuRef
CHM1_12215,599,651 - 215,680,793 (-)NCBICHM1_1
T2T-CHM13v2.02215,210,222 - 215,294,294 (-)NCBIT2T-CHM13v2.0
Bard1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,066,694 - 71,142,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,066,657 - 71,142,305 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38171,027,535 - 71,103,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,027,498 - 71,103,146 (-)Ensemblmm10GRCm38
MGSCv37171,074,109 - 71,149,546 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36170,963,575 - 71,036,126 (-)NCBIMGSCv36mm8
Celera171,583,694 - 71,658,621 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map135.67NCBI
Bard1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554571,187,942 - 1,253,803 (+)Ensembl
ChiLan1.0NW_0049554571,187,942 - 1,258,475 (+)NCBIChiLan1.0ChiLan1.0
BARD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213117,351,232 - 117,435,613 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B117,366,194 - 117,450,575 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B101,984,287 - 102,068,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B220,456,972 - 220,541,145 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B220,456,972 - 220,541,145 (-)EnsemblpanPan2panpan1.1
LOC102156002
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.182,420,559 - 2,423,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha82,362,772 - 2,365,405 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.082,529,629 - 2,532,157 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UNSW_CanFamBas_1.082,279,602 - 2,282,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.082,546,112 - 2,548,640 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bard1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,353,079 - 170,425,653 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365862,200,205 - 2,273,307 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365862,200,211 - 2,272,781 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BARD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,047,845 - 117,175,851 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115117,049,483 - 117,135,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215129,595,080 - 129,678,129 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BARD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110100,539,827 - 100,627,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10100,539,527 - 100,627,675 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604098,755,214 - 98,840,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bard1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247651,351,273 - 1,422,587 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247651,354,511 - 1,419,364 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bard1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14144,480,608 - 144,545,664 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bard1
472 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000020414
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Rat155  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8980,074,851 - 80,075,066 (+)Marker Load Pipeline
mRatBN7.2972,625,378 - 72,625,593 (+)MAPPERmRatBN7.2
Rnor_6.0978,299,947 - 78,300,161NCBIRnor6.0
Rnor_5.0978,077,132 - 78,077,346UniSTSRnor5.0
RGSC_v3.4970,122,374 - 70,122,589RGDRGSC3.4
RGSC_v3.4970,122,375 - 70,122,589UniSTSRGSC3.4
Celera970,043,008 - 70,043,222UniSTS
RGSC_v3.1970,269,356 - 70,269,571RGD
SHRSP x BN Map950.0498UniSTS
SHRSP x BN Map950.0498RGD
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 162 90 89 58 92 58 6 353 191 11 141 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020414   ⟹   ENSRNOP00000020414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl980,069,960 - 80,143,589 (-)Ensembl
mRatBN7.2 Ensembl972,623,178 - 72,694,265 (-)Ensembl
Rnor_6.0 Ensembl978,297,871 - 78,368,777 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087870   ⟹   ENSRNOP00000075183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl980,069,960 - 80,143,755 (-)Ensembl
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106928   ⟹   ENSRNOP00000097768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl980,069,960 - 80,176,873 (-)Ensembl
mRatBN7.2 Ensembl972,623,155 - 72,674,328 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116643   ⟹   ENSRNOP00000079501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl980,069,960 - 80,143,755 (-)Ensembl
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119929   ⟹   ENSRNOP00000088768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl980,069,960 - 80,143,755 (-)Ensembl
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
RefSeq Acc Id: NM_022622   ⟹   NP_072144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,960 - 80,143,755 (-)NCBI
mRatBN7.2972,620,487 - 72,694,285 (-)NCBI
Rnor_6.0978,297,723 - 78,368,777 (-)NCBI
Rnor_5.0978,074,908 - 78,145,962 (-)NCBI
RGSC_v3.4970,120,151 - 70,198,591 (-)RGD
Celera970,040,784 - 70,110,644 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084173   ⟹   XP_038940101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,553 (-)NCBI
RefSeq Acc Id: XM_039084174   ⟹   XP_038940102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,552 (-)NCBI
RefSeq Acc Id: XM_039084175   ⟹   XP_038940103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,550 (-)NCBI
RefSeq Acc Id: XM_039084176   ⟹   XP_038940104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,105 (-)NCBI
RefSeq Acc Id: XM_063267688   ⟹   XP_063123758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
RefSeq Acc Id: XM_063267689   ⟹   XP_063123759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,096,410 - 80,144,167 (-)NCBI
RefSeq Acc Id: NP_072144   ⟸   NM_022622
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot),   A0A0G2K9Y6 (UniProtKB/TrEMBL),   A6KFF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075183   ⟸   ENSRNOT00000087870
Ensembl Acc Id: ENSRNOP00000020414   ⟸   ENSRNOT00000020414
RefSeq Acc Id: XP_038940101   ⟸   XM_039084173
- Peptide Label: isoform X1
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038940102   ⟸   XM_039084174
- Peptide Label: isoform X2
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot),   A0A8I6A6U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940103   ⟸   XM_039084175
- Peptide Label: isoform X4
- UniProtKB: Q6J724 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940104   ⟸   XM_039084176
- Peptide Label: isoform X5
- UniProtKB: G3V7X7 (UniProtKB/TrEMBL),   Q6J724 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088768   ⟸   ENSRNOT00000119929
Ensembl Acc Id: ENSRNOP00000079501   ⟸   ENSRNOT00000116643
Ensembl Acc Id: ENSRNOP00000097768   ⟸   ENSRNOT00000106928
RefSeq Acc Id: XP_063123758   ⟸   XM_063267688
- Peptide Label: isoform X3
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063123759   ⟸   XM_063267689
- Peptide Label: isoform X6
Protein Domains
BRCT   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZH2-F1-model_v2 AlphaFold Q9QZH2 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621072 AgrOrtholog
BioCyc Gene G2FUF-27255 BioCyc
Ensembl Genes ENSRNOG00000014960 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020414 ENTREZGENE
  ENSRNOT00000087870 ENTREZGENE
  ENSRNOT00000119929 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.40.50.10190 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  BARD1_Znf-RING UniProtKB/Swiss-Prot
  BRCT_dom UniProtKB/Swiss-Prot
  BRCT_dom_sf UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report rno:64557 UniProtKB/Swiss-Prot
NCBI Gene 64557 ENTREZGENE
PANTHER ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED UniProtKB/Swiss-Prot
  BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  zf-RING_6 UniProtKB/Swiss-Prot
PhenoGen Bard1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  BRCT UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014960 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  BRCT UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF52113 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Y6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNM7_RAT UniProtKB/TrEMBL
  A0A8I6A6U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATK8_RAT UniProtKB/TrEMBL
  A6KFF8 ENTREZGENE, UniProtKB/TrEMBL
  BARD1_RAT UniProtKB/Swiss-Prot
  G3V7X7 ENTREZGENE, UniProtKB/TrEMBL
  Q6J724 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZH2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bard1  BRCA1 associated RING domain 1    BRCA1-associated RING domain protein 1  Name updated 1299863 APPROVED
2002-08-07 Bard1  BRCA1-associated RING domain protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL