Eml2 (EMAP like 2) - Rat Genome Database

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Gene: Eml2 (EMAP like 2) Rattus norvegicus
Analyze
Symbol: Eml2
Name: EMAP like 2
RGD ID: 621066
Description: Enables ionotropic glutamate receptor binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm; microtubule; and spindle. Predicted to colocalize with mitotic spindle. Orthologous to human EML2 (EMAP like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: echinoderm microtubule associated protein like 2; echinoderm microtubule-associated protein-like 2; Emap; Emap-2; Eml1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,955,924 - 87,987,366 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,955,606 - 87,987,366 (+)EnsemblGRCr8
mRatBN7.2178,827,595 - 78,859,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,828,080 - 78,859,341 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,217,266 - 84,248,461 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,774,855 - 92,806,025 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,972,357 - 86,003,550 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,087,684 - 80,118,784 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,087,684 - 80,119,012 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,353,763 - 81,386,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,539,321 - 78,570,125 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,293,805 - 73,321,834 (+)NCBICelera
RGSC_v3.1178,617,431 - 78,648,236 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoskeleton  (IEA)
microtubule  (IEA)
mitotic spindle  (IBA,IEA,ISO,ISS)
spindle  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of rat EMAP, a delta-glutamate receptor binding protein. Ly CD, etal., Biochem Biophys Res Commun 2002 Feb 15;291(1):85-90.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11694528   PMID:21647708   PMID:24625528   PMID:24706829   PMID:33416103  


Genomics

Comparative Map Data
Eml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,955,924 - 87,987,366 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl187,955,606 - 87,987,366 (+)EnsemblGRCr8
mRatBN7.2178,827,595 - 78,859,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,828,080 - 78,859,341 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,217,266 - 84,248,461 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,774,855 - 92,806,025 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,972,357 - 86,003,550 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,087,684 - 80,118,784 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,087,684 - 80,119,012 (+)Ensemblrn6Rnor6.0
Rnor_5.0181,353,763 - 81,386,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4178,539,321 - 78,570,125 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,293,805 - 73,321,834 (+)NCBICelera
RGSC_v3.1178,617,431 - 78,648,236 (+)NCBI
Cytogenetic Map1q21NCBI
EML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,609,400 - 45,645,629 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,606,994 - 45,645,602 (-)Ensemblhg38GRCh38
GRCh371946,112,658 - 46,148,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,804,498 - 50,834,509 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341950,804,499 - 50,834,509NCBI
Celera1942,918,762 - 42,954,890 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,541,781 - 42,577,903 (-)NCBIHuRef
CHM1_11946,115,925 - 46,152,046 (-)NCBICHM1_1
T2T-CHM13v2.01948,436,666 - 48,472,895 (-)NCBIT2T-CHM13v2.0
Eml2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,910,322 - 18,940,407 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,910,346 - 18,940,407 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,176,421 - 19,206,482 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,176,421 - 19,206,482 (+)Ensemblmm10GRCm38
MGSCv37719,766,519 - 19,791,831 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36718,334,943 - 18,365,002 (+)NCBIMGSCv36mm8
Celera716,593,020 - 16,618,880 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.46NCBI
Eml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574106,253 - 135,289 (-)Ensembl
ChiLan1.0NW_004955574106,788 - 135,289 (-)NCBIChiLan1.0ChiLan1.0
EML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,770,742 - 51,809,081 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,642,173 - 53,680,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,614,590 - 42,652,956 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,155,635 - 51,190,088 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,153,241 - 51,191,754 (-)EnsemblpanPan2panpan1.1
EML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,916,358 - 109,942,344 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,916,766 - 110,054,505 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1109,401,730 - 109,427,249 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01110,449,858 - 110,475,420 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,450,037 - 110,587,109 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,125,434 - 110,150,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,760,067 - 109,785,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,628,943 - 110,654,484 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,671,609 - 17,697,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,018,934 - 2,044,739 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,018,951 - 2,044,695 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,984,433 - 52,013,393 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1651,988,084 - 52,013,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,057,327 - 39,092,642 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607318,680,664 - 18,717,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,521,690 - 7,556,229 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248327,521,700 - 7,555,641 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Eml2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12171,412,261 - 171,443,791 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eml2
286 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:133
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000041215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041215   ⟹   ENSRNOP00000046691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,955,924 - 87,987,366 (+)Ensembl
mRatBN7.2 Ensembl178,828,080 - 78,859,113 (+)Ensembl
Rnor_6.0 Ensembl180,087,684 - 80,118,784 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078336   ⟹   ENSRNOP00000075212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,960,919 - 87,987,366 (+)Ensembl
mRatBN7.2 Ensembl178,832,900 - 78,859,341 (+)Ensembl
Rnor_6.0 Ensembl180,092,403 - 80,119,012 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107022   ⟹   ENSRNOP00000097902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,957,703 - 87,987,365 (+)Ensembl
mRatBN7.2 Ensembl178,829,650 - 78,859,317 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111912   ⟹   ENSRNOP00000096567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,955,606 - 87,987,364 (+)Ensembl
mRatBN7.2 Ensembl178,830,449 - 78,859,320 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113449   ⟹   ENSRNOP00000096394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,957,681 - 87,987,364 (+)Ensembl
mRatBN7.2 Ensembl178,829,627 - 78,859,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115540   ⟹   ENSRNOP00000090007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl187,961,423 - 87,987,366 (+)Ensembl
mRatBN7.2 Ensembl178,833,275 - 78,859,341 (+)Ensembl
RefSeq Acc Id: NM_001414650   ⟹   NP_001401579
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,960,919 - 87,987,366 (+)NCBI
mRatBN7.2178,832,890 - 78,859,342 (+)NCBI
RefSeq Acc Id: NM_138921   ⟹   NP_620276
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,955,924 - 87,987,366 (+)NCBI
mRatBN7.2178,827,893 - 78,859,342 (+)NCBI
Rnor_6.0180,087,684 - 80,118,784 (+)NCBI
Rnor_5.0181,353,763 - 81,386,605 (+)NCBI
RGSC_v3.4178,539,321 - 78,570,125 (+)RGD
Celera173,293,805 - 73,321,834 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093491   ⟹   XP_038949419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,956,098 - 87,987,366 (+)NCBI
mRatBN7.2178,827,598 - 78,859,342 (+)NCBI
RefSeq Acc Id: XM_039093526   ⟹   XP_038949454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,957,657 - 87,987,366 (+)NCBI
mRatBN7.2178,829,627 - 78,859,342 (+)NCBI
RefSeq Acc Id: XM_039093551   ⟹   XP_038949479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,957,659 - 87,987,366 (+)NCBI
mRatBN7.2178,829,627 - 78,859,342 (+)NCBI
RefSeq Acc Id: XM_039093638   ⟹   XP_038949566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,956,098 - 87,978,743 (+)NCBI
mRatBN7.2178,827,595 - 78,850,718 (+)NCBI
RefSeq Acc Id: XR_010061162
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,956,098 - 87,984,941 (+)NCBI
RefSeq Acc Id: NP_620276   ⟸   NM_138921
- Peptide Label: isoform 2
- UniProtKB: A0A8L2QPN8 (UniProtKB/TrEMBL),   A0A8I6B6G9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046691   ⟸   ENSRNOT00000041215
Ensembl Acc Id: ENSRNOP00000075212   ⟸   ENSRNOT00000078336
RefSeq Acc Id: XP_038949566   ⟸   XM_039093638
- Peptide Label: isoform X4
- UniProtKB: A6J8K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949419   ⟸   XM_039093491
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B6G9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949454   ⟸   XM_039093526
- Peptide Label: isoform X2
- UniProtKB: A0A8I6B6G9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949479   ⟸   XM_039093551
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AQQ2 (UniProtKB/TrEMBL),   A0A8I6B6G9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096567   ⟸   ENSRNOT00000111912
Ensembl Acc Id: ENSRNOP00000096394   ⟸   ENSRNOT00000113449
Ensembl Acc Id: ENSRNOP00000090007   ⟸   ENSRNOT00000115540
Ensembl Acc Id: ENSRNOP00000097902   ⟸   ENSRNOT00000107022
RefSeq Acc Id: NP_001401579   ⟸   NM_001414650
- Peptide Label: isoform 1
- UniProtKB: Q6P6T4 (UniProtKB/Swiss-Prot),   Q8VIM8 (UniProtKB/Swiss-Prot),   A0A8I6ACZ3 (UniProtKB/TrEMBL)
Protein Domains
Echinoderm microtubule-associated protein-like first   EML-like second beta-propeller

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T4-F1-model_v2 AlphaFold Q6P6T4 1-649 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689767
Promoter ID:EPDNEW_R288
Type:multiple initiation site
Name:Eml2_1
Description:echinoderm microtubule associated protein like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,092,393 - 80,092,453EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621066 AgrOrtholog
BioCyc Gene G2FUF-60526 BioCyc
Ensembl Genes ENSRNOG00000030127 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041215 ENTREZGENE
  ENSRNOT00000078336 ENTREZGENE
  ENSRNOT00000107022 ENTREZGENE
  ENSRNOT00000113449 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598497 IMAGE-MGC_LOAD
InterPro Beta-prop_EML-like_2nd UniProtKB/Swiss-Prot
  Beta-prop_EML_1st UniProtKB/Swiss-Prot
  HELP UniProtKB/Swiss-Prot
  Quinoprot_gluc/sorb_DH UniProtKB/Swiss-Prot
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD_repeat_EMAP UniProtKB/Swiss-Prot
KEGG Report rno:192360 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72297 IMAGE-MGC_LOAD
NCBI Gene 192360 ENTREZGENE
PANTHER PTHR13720:SF50 UniProtKB/Swiss-Prot
  WD-40 REPEAT PROTEIN UniProtKB/Swiss-Prot
Pfam Beta-prop_EML UniProtKB/Swiss-Prot
  Beta-prop_EML_2 UniProtKB/Swiss-Prot
  HELP UniProtKB/Swiss-Prot
PhenoGen Eml2 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030127 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50952 UniProtKB/Swiss-Prot
  SSF50998 UniProtKB/Swiss-Prot
UniProt A0A8I6ACZ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6API3_RAT UniProtKB/TrEMBL
  A0A8I6AQQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B6G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QPN8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RA46_RAT UniProtKB/TrEMBL
  A6J8K6 ENTREZGENE, UniProtKB/TrEMBL
  A6J8K7_RAT UniProtKB/TrEMBL
  A6J8K9_RAT UniProtKB/TrEMBL
  EMAL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VIM8 ENTREZGENE
UniProt Secondary Q8VIM8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Eml2  EMAP like 2  Eml2  echinoderm microtubule associated protein like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Eml2  echinoderm microtubule associated protein like 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Eml2  echinoderm microtubule associated protein like 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the postsynaptic density 70319
gene_domains contains 10 WD-repeats 70319