Mcpt1 (mast cell protease 1) - Rat Genome Database

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Gene: Mcpt1 (mast cell protease 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt1
Name: mast cell protease 1
RGD ID: 621058
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: group-specific protease; mast cell peptidase 1; mast cell peptidase 2; mast cell protease 2; mast cell protease I; mast cell protease II; Mcpt2; rMCP-1; rMCP-2; rMCP-I; rMCP-II
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,841,606 - 33,844,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,841,606 - 33,844,174 (+)EnsemblGRCr8
mRatBN7.21529,871,360 - 29,873,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,871,335 - 29,873,926 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,717,373 - 31,719,707 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,864,574 - 32,866,908 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,122,707 - 31,125,041 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,032,078 - 35,034,412 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,862,266 - 35,034,622 (+)Ensemblrn6Rnor6.0
Rnor_5.01538,920,069 - 38,922,403 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,556,079 - 34,558,413 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,446,088 - 29,448,422 (+)NCBICelera
RGSC_v3.11534,571,778 - 34,574,113 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. Benfey PN, etal., J Biol Chem 1987 Apr 15;262(11):5377-84.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:629933   PMID:3233198   PMID:19812197   PMID:25923134   PMID:26114959  


Genomics

Variants

.
Variants in Mcpt1
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000027988
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH137187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,873,663 - 29,873,853 (+)MAPPERmRatBN7.2
Rnor_6.01535,034,351 - 35,034,540NCBIRnor6.0
Rnor_5.01538,922,342 - 38,922,531UniSTSRnor5.0
RGSC_v3.41534,558,352 - 34,558,541UniSTSRGSC3.4
Celera1529,448,361 - 29,448,550UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
16 1 46 69 82 89 59 85 59 3 285 151 11 53 59 52 30

Sequence


Ensembl Acc Id: ENSRNOT00000027931   ⟹   ENSRNOP00000027931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,862,266 - 34,865,100 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000027988   ⟹   ENSRNOP00000027988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,862,281 - 35,034,412 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091757   ⟹   ENSRNOP00000069470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,841,606 - 33,844,174 (+)Ensembl
mRatBN7.2 Ensembl1529,871,335 - 29,873,926 (+)Ensembl
Rnor_6.0 Ensembl1535,032,049 - 35,034,622 (+)Ensembl
RefSeq Acc Id: NM_172044   ⟹   NP_742041
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,841,606 - 33,844,174 (+)NCBI
mRatBN7.21529,871,360 - 29,873,928 (+)NCBI
Rnor_6.01535,032,078 - 35,034,412 (+)NCBI
Rnor_5.01538,920,069 - 38,922,403 (+)NCBI
RGSC_v3.41534,556,079 - 34,558,413 (+)RGD
Celera1529,446,088 - 29,448,422 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_742041 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66284 (Get FASTA)   NCBI Sequence Viewer  
  AAA66285 (Get FASTA)   NCBI Sequence Viewer  
  AAN86617 (Get FASTA)   NCBI Sequence Viewer  
  EDM14309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069470
  ENSRNOP00000069470.1
GenBank Protein P00770 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742041   ⟸   NM_172044
- Peptide Label: precursor
- UniProtKB: P00770 (UniProtKB/Swiss-Prot),   A6KH80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027988   ⟸   ENSRNOT00000027988
Ensembl Acc Id: ENSRNOP00000027931   ⟸   ENSRNOT00000027931
Ensembl Acc Id: ENSRNOP00000069470   ⟸   ENSRNOT00000091757
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00770-F1-model_v2 AlphaFold P00770 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699703
Promoter ID:EPDNEW_R10227
Type:single initiation site
Name:Mcpt1_2
Description:mast cell protease 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10225  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01535,032,046 - 35,032,106EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621058 AgrOrtholog
BioCyc Gene G2FUF-13665 BioCyc
Ensembl Genes ENSRNOG00000020625 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091757 ENTREZGENE
  ENSRNOT00000091757.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:29266 UniProtKB/Swiss-Prot
NCBI Gene 29266 ENTREZGENE
PANTHER CHYMASE 2, MAST CELL-RELATED UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Mcpt1 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020625 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6KH80 ENTREZGENE, UniProtKB/TrEMBL
  MCPT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-25 Mcpt1  mast cell protease 1  Mcpt2  mast cell protease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Mcpt2  mast cell protease 2  Mcpt2  mast cell peptidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mcpt2  mast cell peptidase 2    mast cell protease 2  Name updated 1299863 APPROVED
2002-08-07 Mcpt2  mast cell protease 2      Symbol and Name status set to provisional 70820 PROVISIONAL