Pde9a (phosphodiesterase 9A) - Rat Genome Database

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Gene: Pde9a (phosphodiesterase 9A) Rattus norvegicus
Analyze
Symbol: Pde9a
Name: phosphodiesterase 9A
RGD ID: 621035
Description: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and identical protein binding activity. Involved in negative regulation of neural precursor cell proliferation and positive regulation of long-term synaptic potentiation. Located in perikaryon. Used to study Huntington's disease and congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,471,136 - 9,564,286 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,471,167 - 9,564,286 (+)EnsemblGRCr8
mRatBN7.2209,469,809 - 9,562,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,165,615 - 10,257,682 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,526,786 - 9,618,849 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,001,929 - 10,094,704 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,123,624 - 10,216,325 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)Ensemblrn6Rnor6.0
Rnor_5.02012,328,651 - 12,405,855 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,806,117 - 9,901,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,004,465 - 11,077,661 (+)NCBICelera
RGSC_v3.1209,816,126 - 9,901,810 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3',5'-cyclic GMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
gedunin  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptorelin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Almeida CB, etal., Blood. 2012 Oct 4;120(14):2879-88. doi: 10.1182/blood-2012-02-409524. Epub 2012 Jul 25.
2. Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction. Besler C, etal., ESC Heart Fail. 2021 Jun;8(3):1861-1872. doi: 10.1002/ehf2.13327. Epub 2021 Mar 30.
3. Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. Dungan JR, etal., Am Heart J Plus. 2022 May;17:100152. doi: 10.1016/j.ahjo.2022.100152. Epub 2022 Jun 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro. Huan X, etal., Neurochem Int. 2020 Feb;133:104630. doi: 10.1016/j.neuint.2019.104630. Epub 2019 Dec 9.
7. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system. Kruse LS, etal., Brain Res. 2009 Jul 24;1281:25-34. Epub 2009 May 13.
8. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Lee DI, etal., Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. Mishra S, etal., J Clin Invest. 2021 Nov 1;131(21):e148798. doi: 10.1172/JCI148798.
11. Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor. Nagy D, etal., Exp Neurol. 2015 Jan;263:122-31. doi: 10.1016/j.expneurol.2014.10.001. Epub 2014 Oct 12.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure. Richards DA, etal., Circ Heart Fail. 2021 Jan;14(1):e007300. doi: 10.1161/CIRCHEARTFAILURE.120.007300. Epub 2021 Jan 19.
18. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents. Rosenbrock H, etal., J Pharmacol Exp Ther. 2019 Dec;371(3):633-641. doi: 10.1124/jpet.119.260059. Epub 2019 Oct 2.
19. Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain. Van Staveren WC, etal., J Neurocytol 2002 Sep-Oct;31(8-9):729-41.
20. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling. Wang PX, etal., Acta Pharmacol Sin. 2017 Sep;38(9):1257-1268. doi: 10.1038/aps.2017.38. Epub 2017 Jun 26.
21. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Wu Y, etal., J Med Chem. 2019 Apr 25;62(8):4218-4224. doi: 10.1021/acs.jmedchem.8b01041. Epub 2019 Apr 3.
Additional References at PubMed
PMID:9624145   PMID:9624146   PMID:12477932   PMID:16780588   PMID:24746365   PMID:26871637  


Genomics

Comparative Map Data
Pde9a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,471,136 - 9,564,286 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl209,471,167 - 9,564,286 (+)EnsemblGRCr8
mRatBN7.2209,469,809 - 9,562,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2010,165,615 - 10,257,682 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,526,786 - 9,618,849 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,001,929 - 10,094,704 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,123,624 - 10,216,325 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)Ensemblrn6Rnor6.0
Rnor_5.02012,328,651 - 12,405,855 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4209,806,117 - 9,901,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2011,004,465 - 11,077,661 (+)NCBICelera
RGSC_v3.1209,816,126 - 9,901,810 (+)NCBI
Cytogenetic Map20p12NCBI
PDE9A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,653,621 - 42,775,509 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,653,591 - 42,775,513 (+)Ensemblhg38GRCh38
GRCh372144,073,731 - 44,195,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,946,931 - 43,068,688 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342142,946,930 - 43,068,685NCBI
Celera2129,223,477 - 29,345,213 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,521,492 - 29,610,642 (+)NCBIHuRef
CHM1_12143,634,707 - 43,756,559 (+)NCBICHM1_1
T2T-CHM13v2.02141,042,071 - 41,163,988 (+)NCBIT2T-CHM13v2.0
Pde9a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,605,079 - 31,695,284 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,605,184 - 31,695,284 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381731,386,105 - 31,476,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,386,210 - 31,476,310 (+)Ensemblmm10GRCm38
MGSCv371731,523,179 - 31,613,254 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361731,114,961 - 31,205,019 (+)NCBIMGSCv36mm8
Celera1732,303,547 - 32,393,926 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1716.23NCBI
Pde9a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,087,952 - 39,165,370 (-)Ensembl
ChiLan1.0NW_00495540739,090,718 - 39,165,363 (-)NCBIChiLan1.0ChiLan1.0
PDE9A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,711,809 - 38,837,021 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,563,380 - 33,688,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,963,181 - 29,088,395 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12142,275,697 - 42,398,681 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2142,275,697 - 42,398,681 (+)EnsemblpanPan2panpan1.1
PDE9A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,949,777 - 37,036,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,949,723 - 37,035,809 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3136,100,337 - 36,186,877 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03136,466,402 - 36,554,549 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,466,337 - 36,577,183 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,358,954 - 36,446,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,339,084 - 36,425,881 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,835,440 - 36,922,397 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde9a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,199,186 - 36,265,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365001,203,437 - 1,267,095 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365001,201,843 - 1,266,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE9A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,938,348 - 206,034,976 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113205,938,342 - 206,034,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,378,700 - 216,446,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE9A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,541,151 - 86,656,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,541,326 - 86,658,157 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605414,513,801 - 14,630,144 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde9a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474527,839,682 - 27,919,299 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474527,834,814 - 27,919,264 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde9a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1182,400,586 - 2,493,988 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde9a
959 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:177
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000001559
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
AI169470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,562,673 - 9,562,876 (+)MAPPERmRatBN7.2
Rnor_6.02010,216,050 - 10,216,252NCBIRnor6.0
Rnor_5.02012,405,580 - 12,405,782UniSTSRnor5.0
RGSC_v3.4209,901,309 - 9,901,511UniSTSRGSC3.4
Celera2011,077,386 - 11,077,588UniSTS
RH 3.4 Map20116.59UniSTS
Cytogenetic Map20p12UniSTS
MARC_20758-20759:1025103834:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8209,558,191 - 9,559,037 (+)Marker Load Pipeline
mRatBN7.2209,556,853 - 9,557,699 (+)MAPPERmRatBN7.2
Rnor_6.02010,210,231 - 10,211,076NCBIRnor6.0
Rnor_5.02012,399,526 - 12,400,371UniSTSRnor5.0
RGSC_v3.4209,895,490 - 9,896,335UniSTSRGSC3.4
Celera2011,071,567 - 11,072,412UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 88 87 56 81 56 6 342 181 11 135 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001559   ⟹   ENSRNOP00000001559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,471,170 - 9,564,285 (+)Ensembl
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095394   ⟹   ENSRNOP00000095194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,530,957 - 9,564,285 (+)Ensembl
mRatBN7.2 Ensembl209,529,619 - 9,562,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107659   ⟹   ENSRNOP00000094685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,471,170 - 9,564,285 (+)Ensembl
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110944   ⟹   ENSRNOP00000097325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,497,613 - 9,564,285 (+)Ensembl
mRatBN7.2 Ensembl209,496,280 - 9,562,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114987   ⟹   ENSRNOP00000080744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,471,170 - 9,564,285 (+)Ensembl
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131269   ⟹   ENSRNOP00000110403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,471,171 - 9,564,286 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165087   ⟹   ENSRNOP00000100376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl209,471,167 - 9,560,559 (+)Ensembl
RefSeq Acc Id: NM_138543   ⟹   NP_612552
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,181 - 9,564,286 (+)NCBI
mRatBN7.2209,469,848 - 9,562,949 (+)NCBI
Rnor_6.02010,123,640 - 10,216,325 (+)NCBI
Rnor_5.02012,328,651 - 12,405,855 (+)NCBI
RGSC_v3.4209,806,117 - 9,901,584 (+)RGD
Celera2011,004,465 - 11,077,661 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772793   ⟹   XP_008771015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772794   ⟹   XP_008771016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772795   ⟹   XP_008771017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098410   ⟹   XP_038954338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,528,635 - 9,564,286 (+)NCBI
mRatBN7.2209,527,179 - 9,562,949 (+)NCBI
RefSeq Acc Id: XM_039098411   ⟹   XP_038954339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,136 - 9,554,270 (+)NCBI
mRatBN7.2209,469,809 - 9,552,932 (+)NCBI
RefSeq Acc Id: XM_063278948   ⟹   XP_063135018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,517,863 - 9,564,286 (+)NCBI
RefSeq Acc Id: NP_612552   ⟸   NM_138543
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771015   ⟸   XM_008772793
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771016   ⟸   XM_008772794
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771017   ⟸   XM_008772795
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001559   ⟸   ENSRNOT00000001559
RefSeq Acc Id: XP_038954339   ⟸   XM_039098411
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954338   ⟸   XM_039098410
- Peptide Label: isoform X2
- UniProtKB: A6JJZ6 (UniProtKB/TrEMBL),   A0A8I6AL01 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097325   ⟸   ENSRNOT00000110944
Ensembl Acc Id: ENSRNOP00000095194   ⟸   ENSRNOT00000095394
Ensembl Acc Id: ENSRNOP00000094685   ⟸   ENSRNOT00000107659
Ensembl Acc Id: ENSRNOP00000080744   ⟸   ENSRNOT00000114987
RefSeq Acc Id: XP_063135018   ⟸   XM_063278948
- Peptide Label: isoform X2
- UniProtKB: A6JJZ6 (UniProtKB/TrEMBL),   A0A8I6AL01 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100376   ⟸   ENSRNOT00000165087
Ensembl Acc Id: ENSRNOP00000110403   ⟸   ENSRNOT00000131269
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZV1-F1-model_v2 AlphaFold Q8QZV1 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701475
Promoter ID:EPDNEW_R11999
Type:single initiation site
Name:Pde9a_1
Description:phosphodiesterase 9A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,123,648 - 10,123,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621035 AgrOrtholog
BioCyc Gene G2FUF-4314 BioCyc
Ensembl Genes ENSRNOG00000001174 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001559 ENTREZGENE
  ENSRNOT00000001559.8 UniProtKB/Swiss-Prot
  ENSRNOT00000095394 ENTREZGENE
  ENSRNOT00000131269 ENTREZGENE
  ENSRNOT00000165087 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131665 IMAGE-MGC_LOAD
  IMAGE:9029236 IMAGE-MGC_LOAD
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
KEGG Report rno:191569 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187334 IMAGE-MGC_LOAD
  MGC:93182 IMAGE-MGC_LOAD
NCBI Gene 191569 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde9a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001174 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZRE7_RAT UniProtKB/TrEMBL
  A0A8I6AL01 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASG7_RAT UniProtKB/TrEMBL
  A0ABK0L6T9_RAT UniProtKB/TrEMBL
  A0ABK0LVR9_RAT UniProtKB/TrEMBL
  A6JJZ5_RAT UniProtKB/TrEMBL
  A6JJZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LRG6 ENTREZGENE
  PDE9A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LRG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pde9a  phosphodiesterase 9A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pde9a  phosphodiesterase 9A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression widely present throughout the brain 724613
gene_homology 97.6% and 92.1% amino acid identity to mouse and human homologs, respectively 724613