Pde9a (phosphodiesterase 9A) - Rat Genome Database

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Gene: Pde9a (phosphodiesterase 9A) Rattus norvegicus
Analyze
Symbol: Pde9a
Name: phosphodiesterase 9A
RGD ID: 621035
Description: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and identical protein binding activity. Involved in negative regulation of neural precursor cell proliferation and positive regulation of long-term synaptic potentiation. Located in perikaryon. Used to study Huntington's disease and congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,471,136 - 9,564,286 (+)NCBIGRCr8
mRatBN7.2209,469,809 - 9,562,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,165,615 - 10,257,682 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,526,786 - 9,618,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,001,929 - 10,094,704 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,123,624 - 10,216,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,328,651 - 12,405,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,806,117 - 9,901,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,816,126 - 9,901,810 (+)NCBI
Celera2011,004,465 - 11,077,661 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3',5'-cyclic GMP  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
gedunin  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptorelin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Almeida CB, etal., Blood. 2012 Oct 4;120(14):2879-88. doi: 10.1182/blood-2012-02-409524. Epub 2012 Jul 25.
2. Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction. Besler C, etal., ESC Heart Fail. 2021 Jun;8(3):1861-1872. doi: 10.1002/ehf2.13327. Epub 2021 Mar 30.
3. Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. Dungan JR, etal., Am Heart J Plus. 2022 May;17:100152. doi: 10.1016/j.ahjo.2022.100152. Epub 2022 Jun 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro. Huan X, etal., Neurochem Int. 2020 Feb;133:104630. doi: 10.1016/j.neuint.2019.104630. Epub 2019 Dec 9.
7. PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system. Kruse LS, etal., Brain Res. 2009 Jul 24;1281:25-34. Epub 2009 May 13.
8. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Lee DI, etal., Nature. 2015 Mar 26;519(7544):472-6. doi: 10.1038/nature14332. Epub 2015 Mar 18.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice. Mishra S, etal., J Clin Invest. 2021 Nov 1;131(21):e148798. doi: 10.1172/JCI148798.
11. Application of neurophysiological biomarkers for Huntington's disease: evaluating a phosphodiesterase 9A inhibitor. Nagy D, etal., Exp Neurol. 2015 Jan;263:122-31. doi: 10.1016/j.expneurol.2014.10.001. Epub 2014 Oct 12.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure. Richards DA, etal., Circ Heart Fail. 2021 Jan;14(1):e007300. doi: 10.1161/CIRCHEARTFAILURE.120.007300. Epub 2021 Jan 19.
18. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents. Rosenbrock H, etal., J Pharmacol Exp Ther. 2019 Dec;371(3):633-641. doi: 10.1124/jpet.119.260059. Epub 2019 Oct 2.
19. Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain. Van Staveren WC, etal., J Neurocytol 2002 Sep-Oct;31(8-9):729-41.
20. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling. Wang PX, etal., Acta Pharmacol Sin. 2017 Sep;38(9):1257-1268. doi: 10.1038/aps.2017.38. Epub 2017 Jun 26.
21. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Wu Y, etal., J Med Chem. 2019 Apr 25;62(8):4218-4224. doi: 10.1021/acs.jmedchem.8b01041. Epub 2019 Apr 3.
Additional References at PubMed
PMID:9624145   PMID:9624146   PMID:12477932   PMID:16780588   PMID:24746365   PMID:26871637  


Genomics

Comparative Map Data
Pde9a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,471,136 - 9,564,286 (+)NCBIGRCr8
mRatBN7.2209,469,809 - 9,562,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,165,615 - 10,257,682 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,526,786 - 9,618,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,001,929 - 10,094,704 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,123,624 - 10,216,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,328,651 - 12,405,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,806,117 - 9,901,584 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,816,126 - 9,901,810 (+)NCBI
Celera2011,004,465 - 11,077,661 (+)NCBICelera
Cytogenetic Map20p12NCBI
PDE9A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,653,621 - 42,775,509 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,653,621 - 42,775,509 (+)EnsemblGRCh38hg38GRCh38
GRCh372144,073,731 - 44,195,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,946,931 - 43,068,688 (+)NCBINCBI36Build 36hg18NCBI36
Build 342142,946,930 - 43,068,685NCBI
Celera2129,223,477 - 29,345,213 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,521,492 - 29,610,642 (+)NCBIHuRef
CHM1_12143,634,707 - 43,756,559 (+)NCBICHM1_1
T2T-CHM13v2.02141,042,071 - 41,163,988 (+)NCBIT2T-CHM13v2.0
Pde9a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,605,079 - 31,695,284 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,605,184 - 31,695,284 (+)EnsemblGRCm39 Ensembl
GRCm381731,386,105 - 31,476,309 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,386,210 - 31,476,310 (+)EnsemblGRCm38mm10GRCm38
MGSCv371731,523,179 - 31,613,254 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,114,961 - 31,205,019 (+)NCBIMGSCv36mm8
Celera1732,303,547 - 32,393,926 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1716.23NCBI
Pde9a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,087,952 - 39,165,370 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,090,718 - 39,165,363 (-)NCBIChiLan1.0ChiLan1.0
PDE9A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,711,809 - 38,837,021 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,563,380 - 33,688,847 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,963,181 - 29,088,395 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12142,275,697 - 42,398,681 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2142,275,697 - 42,398,681 (+)Ensemblpanpan1.1panPan2
PDE9A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,949,777 - 37,036,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,949,723 - 37,035,809 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3136,100,337 - 36,186,877 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,466,402 - 36,554,549 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13136,358,954 - 36,446,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,339,084 - 36,425,881 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,835,440 - 36,922,397 (+)NCBIUU_Cfam_GSD_1.0
Pde9a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,199,186 - 36,265,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365001,203,437 - 1,267,095 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365001,201,843 - 1,266,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE9A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,938,348 - 206,034,976 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,938,342 - 206,034,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,378,700 - 216,446,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE9A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,541,151 - 86,656,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,541,326 - 86,658,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605414,513,801 - 14,630,144 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde9a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474527,839,682 - 27,919,299 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474527,834,814 - 27,919,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pde9a
815 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:177
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000001559
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
AI169470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,562,673 - 9,562,876 (+)MAPPERmRatBN7.2
Rnor_6.02010,216,050 - 10,216,252NCBIRnor6.0
Rnor_5.02012,405,580 - 12,405,782UniSTSRnor5.0
RGSC_v3.4209,901,309 - 9,901,511UniSTSRGSC3.4
Celera2011,077,386 - 11,077,588UniSTS
RH 3.4 Map20116.59UniSTS
Cytogenetic Map20p12UniSTS
MARC_20758-20759:1025103834:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,556,853 - 9,557,699 (+)MAPPERmRatBN7.2
Rnor_6.02010,210,231 - 10,211,076NCBIRnor6.0
Rnor_5.02012,399,526 - 12,400,371UniSTSRnor5.0
RGSC_v3.4209,895,490 - 9,896,335UniSTSRGSC3.4
Celera2011,071,567 - 11,072,412UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 6 6 73 27 28 11
Low 43 32 16 13 16 8 11 1 8 13 8
Below cutoff 16 16 6 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001559   ⟹   ENSRNOP00000001559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
Rnor_6.0 Ensembl2010,123,651 - 10,216,548 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095394   ⟹   ENSRNOP00000095194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,529,619 - 9,562,948 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107659   ⟹   ENSRNOP00000094685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110944   ⟹   ENSRNOP00000097325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,496,280 - 9,562,948 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114987   ⟹   ENSRNOP00000080744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,469,848 - 9,562,948 (+)Ensembl
RefSeq Acc Id: NM_138543   ⟹   NP_612552
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,181 - 9,564,286 (+)NCBI
mRatBN7.2209,469,848 - 9,562,949 (+)NCBI
Rnor_6.02010,123,640 - 10,216,325 (+)NCBI
Rnor_5.02012,328,651 - 12,405,855 (+)NCBI
RGSC_v3.4209,806,117 - 9,901,584 (+)RGD
Celera2011,004,465 - 11,077,661 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772793   ⟹   XP_008771015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772794   ⟹   XP_008771016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772795   ⟹   XP_008771017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,137 - 9,564,286 (+)NCBI
mRatBN7.2209,469,890 - 9,562,949 (+)NCBI
Rnor_6.02010,123,624 - 10,216,325 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098410   ⟹   XP_038954338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,528,635 - 9,564,286 (+)NCBI
mRatBN7.2209,527,179 - 9,562,949 (+)NCBI
RefSeq Acc Id: XM_039098411   ⟹   XP_038954339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,471,136 - 9,554,270 (+)NCBI
mRatBN7.2209,469,809 - 9,552,932 (+)NCBI
RefSeq Acc Id: XM_063278948   ⟹   XP_063135018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8209,517,863 - 9,564,286 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_612552   ⟸   NM_138543
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771015   ⟸   XM_008772793
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771016   ⟸   XM_008772794
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771017   ⟸   XM_008772795
- Peptide Label: isoform X1
- UniProtKB: F1LRG6 (UniProtKB/Swiss-Prot),   Q8QZV1 (UniProtKB/Swiss-Prot),   A0A8I6ALK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001559   ⟸   ENSRNOT00000001559
RefSeq Acc Id: XP_038954339   ⟸   XM_039098411
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954338   ⟸   XM_039098410
- Peptide Label: isoform X2
- UniProtKB: A6JJZ6 (UniProtKB/TrEMBL),   A0A8I6AL01 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000097325   ⟸   ENSRNOT00000110944
RefSeq Acc Id: ENSRNOP00000095194   ⟸   ENSRNOT00000095394
RefSeq Acc Id: ENSRNOP00000094685   ⟸   ENSRNOT00000107659
RefSeq Acc Id: ENSRNOP00000080744   ⟸   ENSRNOT00000114987
RefSeq Acc Id: XP_063135018   ⟸   XM_063278948
- Peptide Label: isoform X2
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZV1-F1-model_v2 AlphaFold Q8QZV1 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701475
Promoter ID:EPDNEW_R11999
Type:single initiation site
Name:Pde9a_1
Description:phosphodiesterase 9A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,123,648 - 10,123,708EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621035 AgrOrtholog
BioCyc Gene G2FUF-4314 BioCyc
Ensembl Genes ENSRNOG00000001174 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065026086 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001559 ENTREZGENE
  ENSRNOT00000001559.8 UniProtKB/Swiss-Prot
  ENSRNOT00000095394.1 UniProtKB/TrEMBL
  ENSRNOT00000107659.1 UniProtKB/TrEMBL
  ENSRNOT00000110944.1 UniProtKB/TrEMBL
  ENSRNOT00000114987.1 UniProtKB/TrEMBL
  ENSRNOT00065045265 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131665 IMAGE-MGC_LOAD
  IMAGE:9029236 IMAGE-MGC_LOAD
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:191569 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187334 IMAGE-MGC_LOAD
  MGC:93182 IMAGE-MGC_LOAD
NCBI Gene 191569 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDEase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pde9a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001174 RatGTEx
  ENSRNOG00065026086 RatGTEx
SMART HDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRE7_RAT UniProtKB/TrEMBL
  A0A8I6AL01 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASG7_RAT UniProtKB/TrEMBL
  A6JJZ5_RAT UniProtKB/TrEMBL
  A6JJZ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LRG6 ENTREZGENE
  PDE9A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LRG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pde9a  phosphodiesterase 9A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pde9a  phosphodiesterase 9A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression widely present throughout the brain 724613
gene_homology 97.6% and 92.1% amino acid identity to mouse and human homologs, respectively 724613