Dad1 (defender against cell death 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Dad1 (defender against cell death 1) Rattus norvegicus
Analyze
Symbol: Dad1
Name: defender against cell death 1
RGD ID: 621028
Description: Predicted to enable enzyme activator activity. Involved in response to nutrient and response to xenobiotic stimulus. Predicted to be part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. Orthologous to human DAD1 (defender against cell death 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; oligosaccharyl transferase subunit DAD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,647,326 - 31,667,159 (-)NCBIGRCr8
mRatBN7.21527,677,286 - 27,697,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,677,268 - 27,697,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,518,815 - 29,538,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,665,754 - 30,685,523 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01528,915,796 - 28,935,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01532,868,136 - 32,887,933 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1532,868,087 - 32,888,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,679,088 - 36,699,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,285,592 - 32,305,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,301,291 - 32,321,585 (-)NCBI
Celera1527,259,040 - 27,278,828 (-)NCBICelera
Cytogenetic Map15p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1RatBrain-Lung-Thyroid Syndrome  ISODAD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868

1 to 20 of 111 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1Rat1,2-dimethylhydrazine multiple interactionsISODad1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DAD1 mRNACTDPMID:22206623
Dad1Rat17beta-estradiol increases expressionISODAD1 (Homo sapiens)6480464Estradiol results in increased expression of DAD1 mRNACTDPMID:16474171
Dad1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of DAD1 mRNACTDPMID:32145629
Dad1Rat17beta-estradiol affects expressionISODad1 (Mus musculus)6480464Estradiol affects the expression of DAD1 mRNACTDPMID:15598610
Dad1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISODad1 (Mus musculus)64804642 more ...CTDPMID:30294300
Dad1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DAD1 mRNACTDPMID:19520675
Dad1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of DAD1 mRNACTDPMID:34747641
Dad1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODad1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DAD1 mRNACTDPMID:21570461 and PMID:24680724
Dad1Rat2-bromohexadecanoic acid multiple interactionsISODAD1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of DAD1 protein]CTDPMID:38195004
Dad1Rat2-hydroxypropanoic acid decreases expressionISODAD1 (Homo sapiens)6480464Lactic Acid results in decreased expression of DAD1 mRNACTDPMID:30851411
Dad1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISODAD1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAD1 mRNACTDPMID:28628672
Dad1Rat4,4'-diaminodiphenylmethane decreases expressionISODad1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of DAD1 mRNACTDPMID:18648102
Dad1Rat4,4'-sulfonyldiphenol multiple interactionsISODad1 (Mus musculus)6480464[bisphenol S co-treated with Tretinoin] results in decreased expression of DAD1 mRNACTDPMID:30951980
Dad1Rat4,4'-sulfonyldiphenol increases expressionISODAD1 (Homo sapiens)6480464bisphenol S results in increased expression of DAD1 proteinCTDPMID:34186270
Dad1Rat4,4'-sulfonyldiphenol increases expressionISODad1 (Mus musculus)6480464bisphenol S results in increased expression of DAD1 mRNACTDPMID:39298647
Dad1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of DAD1 mRNACTDPMID:30047161
Dad1Ratacrylamide affects expressionEXP 6480464Acrylamide affects the expression of DAD1 mRNACTDPMID:28959563
Dad1Rataflatoxin B1 increases expressionISODAD1 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of DAD1 mRNACTDPMID:27153756
Dad1Rataflatoxin B1 increases methylationISODAD1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of DAD1 geneCTDPMID:27153756
Dad1Ratall-trans-retinoic acid multiple interactionsISODad1 (Mus musculus)6480464[bisphenol A co-treated with Tretinoin] results in decreased expression of DAD1 mRNA more ...CTDPMID:30951980

1 to 20 of 111 rows

Biological Process
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1Ratapoptotic process acts_upstream_ofISODad1 (Mus musculus)1624291MGI:2445490 PMID:10748466RGDPMID:10748466
Dad1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Dad1Ratapoptotic process acts_upstream_ofIEAUniProtKB:P61804 and ensembl:ENSMUSP000001223661600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratblastocyst development acts_upstream_of_or_withinISODad1 (Mus musculus)1624291MGI:2445490 PMID:10748466RGDPMID:10748466
Dad1Ratblastocyst development acts_upstream_of_or_withinIEAUniProtKB:P61804 and ensembl:ENSMUSP000001223661600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratnegative regulation of apoptotic process acts_upstream_of_or_withinISODad1 (Mus musculus)1624291MGI:2445490 PMID:10748466RGDPMID:10748466
Dad1Ratnegative regulation of apoptotic process acts_upstream_of_or_withinIEAUniProtKB:P61804 and ensembl:ENSMUSP000001223661600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratprotein glycosylation involved_inISSUniProtKB:E2R4X31600115GO_REF:0000024UniProtGO_REF:0000024
Dad1Ratprotein glycosylation involved_inIEAUniPathway:UPA003781600115GO_REF:0000041UniProtGO_REF:0000041
Dad1Ratprotein glycosylation involved_inISODAD1 (Canis lupus familiaris)1624291 PMID:12887896RGDPMID:12887896
Dad1Ratprotein N-linked glycosylation involved_inIBAFB:FBgn0263852 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dad1Ratprotein N-linked glycosylation via asparagine involved_inIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratprotein N-linked glycosylation via asparagine involved_inISODAD1 (Homo sapiens)1624291 PMID:22467853RGDPMID:22467853
Dad1Ratregulation of protein stability involved_inIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratregulation of protein stability involved_inISODAD1 (Homo sapiens)1624291 PMID:22467853RGDPMID:22467853
Dad1Ratresponse to nutrient  IEP 1601045 RGD 
Dad1Ratresponse to xenobiotic stimulus  IEP 1601040 RGD 
1 to 17 of 17 rows

Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Dad1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Dad1Ratmembrane located_inIEAInterPro:IPR0030381600115GO_REF:0000002InterProGO_REF:0000002
Dad1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Dad1Ratoligosaccharyltransferase complex part_ofISSUniProtKB:E2R4X31600115GO_REF:0000024UniProtGO_REF:0000024
Dad1Ratoligosaccharyltransferase complex part_ofIEAInterPro:IPR0030381600115GO_REF:0000002InterProGO_REF:0000002
Dad1Ratoligosaccharyltransferase complex part_ofIBAPANTHER:PTN000076010 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dad1Ratoligosaccharyltransferase complex part_ofISODAD1 (Homo sapiens)1624291 PMID:22467853 and PMID:31831667RGDPMID:22467853 and PMID:31831667
Dad1Ratoligosaccharyltransferase complex part_ofISODAD1 (Canis lupus familiaris)1624291 PMID:12887896RGDPMID:12887896
Dad1Ratoligosaccharyltransferase complex part_ofIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratoligosaccharyltransferase complex A part_ofISODAD1 (Homo sapiens)1624291 PMID:31831667 more ...RGDPMID:31831667 more ...
Dad1Ratoligosaccharyltransferase complex A part_ofIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratoligosaccharyltransferase complex B part_ofIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratoligosaccharyltransferase complex B part_ofISODAD1 (Homo sapiens)1624291 PMID:31831667RGDPMID:31831667
1 to 14 of 14 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1Ratenzyme activator activity enablesIEAUniProtKB:P61803 and ensembl:ENSP000002504981600115GO_REF:0000107EnsemblGO_REF:0000107
Dad1Ratenzyme activator activity enablesISODAD1 (Homo sapiens)1624291 PMID:22467853RGDPMID:22467853

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dad1RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Dad1RatN-linked glycan biosynthetic pathway  IEA 6907045 KEGGrno:00510

1 to 10 of 10 rows
#
Reference Title
Reference Citation
1. Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Fischer A, etal., Biochem Biophys Res Commun. 2001 Jul 13;285(2):470-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone. Rosen MB, etal., Reprod Toxicol. 2005 Jan-Feb;19(3):367-79.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
1 to 10 of 10 rows
PMID:10748466   PMID:12887896   PMID:15489334   PMID:19946888   PMID:22467853   PMID:23376485  



Dad1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81531,647,326 - 31,667,159 (-)NCBIGRCr8
mRatBN7.21527,677,286 - 27,697,120 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1527,677,268 - 27,697,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,518,815 - 29,538,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01530,665,754 - 30,685,523 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01528,915,796 - 28,935,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01532,868,136 - 32,887,933 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1532,868,087 - 32,888,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01536,679,088 - 36,699,062 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,285,592 - 32,305,885 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,301,291 - 32,321,585 (-)NCBI
Celera1527,259,040 - 27,278,828 (-)NCBICelera
Cytogenetic Map15p13NCBI
DAD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381422,564,907 - 22,589,224 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1422,564,907 - 22,589,224 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,033,807 - 23,058,130 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,103,647 - 22,127,969 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,103,646 - 22,127,969NCBI
Celera142,896,859 - 2,921,191 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,152,065 - 3,176,551 (-)NCBIHuRef
CHM1_11423,032,809 - 23,057,139 (-)NCBICHM1_1
T2T-CHM13v2.01416,762,628 - 16,786,951 (-)NCBIT2T-CHM13v2.0
Dad1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,472,942 - 54,491,386 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,472,936 - 54,491,561 (-)EnsemblGRCm39 Ensembl
GRCm381454,235,485 - 54,253,929 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,235,479 - 54,254,104 (-)EnsemblGRCm38mm10GRCm38
MGSCv371454,855,160 - 54,873,604 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,193,491 - 53,211,877 (-)NCBIMGSCv36mm8
Celera1452,031,369 - 52,050,171 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.7NCBI
Dad1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,670,274 - 37,688,391 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,670,266 - 37,688,226 (+)NCBIChiLan1.0ChiLan1.0
DAD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,013,115 - 24,044,990 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,229,601 - 23,254,008 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,401,048 - 3,425,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,502,618 - 21,526,793 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,502,618 - 21,526,793 (-)Ensemblpanpan1.1panPan2
DAD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.182,963,719 - 2,984,978 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha82,913,614 - 2,934,653 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,071,124 - 3,092,393 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,070,735 - 3,092,373 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.182,763,845 - 2,785,098 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.082,825,279 - 2,846,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,087,258 - 3,108,519 (-)NCBIUU_Cfam_GSD_1.0
Dad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864034,690,409 - 34,710,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,678,862 - 1,698,579 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,678,952 - 1,698,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl776,432,051 - 76,457,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1776,432,040 - 76,457,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,668,608 - 81,693,971 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DAD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12922,935,231 - 22,958,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2922,935,005 - 22,958,414 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,465,308 - 23,488,458 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dad1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248259,045,163 - 9,082,634 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248259,062,984 - 9,081,939 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Dad1
89 total Variants

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:40
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000012233
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat

1 to 10 of 25 rows
AW557067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,685,287 - 27,685,437 (+)MAPPERmRatBN7.2
Rnor_6.01532,876,138 - 32,876,287NCBIRnor6.0
Rnor_5.01536,687,267 - 36,687,416UniSTSRnor5.0
RGSC_v3.41532,294,087 - 32,294,236UniSTSRGSC3.4
Celera1527,267,033 - 27,267,182UniSTS
Cytogenetic Map15p13UniSTS
RH133381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2224,859,980 - 24,860,177 (+)MAPPERmRatBN7.2
mRatBN7.21527,691,609 - 27,691,806 (+)MAPPERmRatBN7.2
Rnor_6.01532,882,459 - 32,882,655NCBIRnor6.0
Rnor_6.0223,236,683 - 23,236,879NCBIRnor6.0
Rnor_5.01536,693,588 - 36,693,784UniSTSRnor5.0
Rnor_5.0242,418,108 - 42,418,304UniSTSRnor5.0
RGSC_v3.4223,923,761 - 23,923,957UniSTSRGSC3.4
RGSC_v3.41532,300,411 - 32,300,607UniSTSRGSC3.4
Celera1527,273,354 - 27,273,550UniSTS
Celera220,935,169 - 20,935,365UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map15p13UniSTS
UniSTS:99121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21527,696,876 - 27,696,986 (+)MAPPERmRatBN7.2
Rnor_6.01532,887,726 - 32,887,835NCBIRnor6.0
Rnor_5.01536,698,855 - 36,698,964UniSTSRnor5.0
RGSC_v3.41532,305,678 - 32,305,787UniSTSRGSC3.4
Celera1527,278,621 - 27,278,730UniSTS
Cytogenetic Map15p13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012233   ⟹   ENSRNOP00000012233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,677,268 - 27,697,347 (-)Ensembl
Rnor_6.0 Ensembl1532,868,087 - 32,888,095 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098684   ⟹   ENSRNOP00000092852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1527,677,289 - 27,697,136 (-)Ensembl
RefSeq Acc Id: NM_001393807   ⟹   NP_001380736
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,647,326 - 31,667,159 (-)NCBI
mRatBN7.21527,677,286 - 27,697,120 (-)NCBI
RefSeq Acc Id: NM_138910   ⟹   NP_620265
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81531,647,326 - 31,667,159 (-)NCBI
mRatBN7.21527,677,286 - 27,697,120 (-)NCBI
Rnor_6.01532,868,136 - 32,887,933 (-)NCBI
Rnor_5.01536,679,088 - 36,699,062 (-)NCBI
RGSC_v3.41532,285,592 - 32,305,885 (-)RGD
Celera1527,259,040 - 27,278,828 (-)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001380736 (Get FASTA)   NCBI Sequence Viewer  
  NP_620265 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61530 (Get FASTA)   NCBI Sequence Viewer  
  CAA73780 (Get FASTA)   NCBI Sequence Viewer  
  EDM14147 (Get FASTA)   NCBI Sequence Viewer  
  EDM14148 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012233
  ENSRNOP00000092852
  ENSRNOP00000092852.1
GenBank Protein P61805 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_620265   ⟸   NM_138910
- Peptide Label: isoform 2
- UniProtKB: P61805 (UniProtKB/Swiss-Prot),   A6KGR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012233   ⟸   ENSRNOT00000012233
Ensembl Acc Id: ENSRNOP00000092852   ⟸   ENSRNOT00000098684
RefSeq Acc Id: NP_001380736   ⟸   NM_001393807
- Peptide Label: isoform 1
- UniProtKB: A0A8L2Q6I7 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P61805-F1-model_v2 AlphaFold P61805 1-113 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699646
Promoter ID:EPDNEW_R10169
Type:initiation region
Name:Dad1_1
Description:defender against cell death 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01532,887,933 - 32,887,993EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-13816 BioCyc
BioCyc Pathway MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS [protein N-glycosylation initial phase (eukaryotic)] BioCyc
BioCyc Pathway Image MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS BioCyc
Ensembl Genes ENSRNOG00000009090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012233 ENTREZGENE
  ENSRNOT00000098684 ENTREZGENE
  ENSRNOT00000098684.1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6917861 IMAGE-MGC_LOAD
InterPro DAD/Ost2 UniProtKB/Swiss-Prot
KEGG Report rno:192275 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72685 IMAGE-MGC_LOAD
NCBI Gene 192275 ENTREZGENE
PANTHER DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 UniProtKB/Swiss-Prot
  PTHR10705 UniProtKB/Swiss-Prot
Pfam DAD UniProtKB/Swiss-Prot
PhenoGen Dad1 PhenoGen
PIRSF DAD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009090 RatGTEx
UniProt A0A8L2Q6I7 ENTREZGENE, UniProtKB/TrEMBL
  A6KGR8 ENTREZGENE, UniProtKB/TrEMBL
  A6KGR9_RAT UniProtKB/TrEMBL
  DAD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O08552 UniProtKB/Swiss-Prot
  O70364 UniProtKB/Swiss-Prot
  P46966 UniProtKB/Swiss-Prot
  P46968 UniProtKB/Swiss-Prot
  Q96GB7 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dad1  defender against cell death 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dad1  defender against cell death 1      Symbol and Name status set to provisional 70820 PROVISIONAL