Stx3 (syntaxin 3) - Rat Genome Database

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Gene: Stx3 (syntaxin 3) Rattus norvegicus
Analyze
Symbol: Stx3
Name: syntaxin 3
RGD ID: 621005
Description: Enables SNAP receptor activity and arachidonate binding activity. Involved in membrane fusion and neuron projection development. Located in growth cone and plasma membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human STX3 (syntaxin 3); INTERACTS WITH 1-benzylpiperazine; 17beta-estradiol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Stx3a; syntaxin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,940,697 - 218,114,865 (-)NCBIGRCr8
mRatBN7.21208,617,018 - 208,686,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,639,115 - 208,685,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,017,514 - 217,060,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,004,990 - 224,047,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,771,951 - 216,814,831 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01228,137,781 - 228,195,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1228,149,867 - 228,194,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,205,648 - 235,262,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,554,512 - 214,597,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,712,944 - 214,755,826 (-)NCBI
Celera1206,113,799 - 206,156,646 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stx3RatBardet-Biedl syndrome 1  ISOStx3 (Mus musculus)11532386 RGD 
Stx3RatBardet-Biedl syndrome 17  ISOStx3 (Mus musculus)11532386protein:increased expression:photoreceptor outer segment layer RGD 
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stx3Ratgenetic disease  ISOSTX3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Stx3Ratintellectual disability  ISOSTX3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Stx3Ratleukocyte adhesion deficiency 3  ISOSTX3 (Homo sapiens)8554872ClinVar Annotator: match by term: Leukocyte adhesion deficiency 3ClinVarPMID:28492532
Stx3RatMicrovillus Inclusion Disease 2  ISOSTX3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24726755 more ...
Stx3RatRetinal Dystrophy and Microvillus Inclusion Disease  ISOSTX3 (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophy and microvillus inclusion diseaseClinVar 
Object Symbol
Species
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Reference
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Original Reference(s)
Stx3RatMicrovillus Inclusion Disease 2  ISOSTX3 (Homo sapiens)7240710 OMIM 
Stx3RatRetinal Dystrophy and Microvillus Inclusion Disease  ISOSTX3 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
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Qualifier
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Reference
Notes
Source
Original Reference(s)
Stx3Rat(1->4)-beta-D-glucan multiple interactionsISOStx3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of STX3 mRNACTDPMID:36331819
Stx3Rat1,2-dimethylhydrazine multiple interactionsISOStx3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of STX3 mRNACTDPMID:22206623
Stx3Rat1,2-dimethylhydrazine affects expressionISOStx3 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of STX3 mRNACTDPMID:22206623
Stx3Rat1-benzylpiperazine increases expressionEXP 6480464N-benzylpiperazine results in increased expression of STX3 mRNACTDPMID:26821219
Stx3Rat14-Deoxy-11,12-didehydroandrographolide increases expressionISOSTX3 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in increased expression of STX3 mRNACTDPMID:22101062
Stx3Rat17alpha-ethynylestradiol increases expressionISOStx3 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of STX3 mRNACTDPMID:17942748
Stx3Rat17alpha-ethynylestradiol multiple interactionsISOStx3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX3 mRNACTDPMID:17942748
Stx3Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of STX3 mRNACTDPMID:26496021
Stx3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOSTX3 (Homo sapiens)64804642 more ...CTDPMID:19095052
Stx3Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOStx3 (Mus musculus)64804642 more ...CTDPMID:30294300
Stx3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOStx3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX3 mRNACTDPMID:17942748
Stx3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOStx3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of STX3 mRNACTDPMID:21570461 and PMID:26377647
Stx3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOStx3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of STX3 mRNACTDPMID:19465110
Stx3Rat2-palmitoylglycerol increases expressionISOSTX3 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of STX3 mRNACTDPMID:37199045
Stx3Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOStx3 (Mus musculus)6480464tetrabromobisphenol A results in increased expression of STX3 mRNACTDPMID:25172293
Stx3Rat3,4-methylenedioxymethamphetamine increases expressionISOStx3 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of STX3 mRNACTDPMID:20188158
Stx3Rat4-hydroxyphenyl retinamide increases expressionISOStx3 (Mus musculus)6480464Fenretinide results in increased expression of STX3 mRNACTDPMID:28973697
Stx3Rat5-aza-2'-deoxycytidine affects expressionISOSTX3 (Homo sapiens)6480464Decitabine affects the expression of STX3 mRNACTDPMID:23300844
Stx3Rat8-Br-cAMP decreases expressionISOSTX3 (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in decreased expression of STX3 mRNACTDPMID:22079614
Stx3Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of STX3 mRNACTDPMID:31881176

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Biological Process
1 to 20 of 28 rows

  
Object Symbol
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Original Reference(s)
Stx3Ratexocytic insertion of neurotransmitter receptor to postsynaptic membrane involved_inISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratexocytic insertion of neurotransmitter receptor to postsynaptic membrane involved_inIBAMGI:103077 and PANTHER:PTN0027170401600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx3Ratexocytosis acts_upstream_of_or_withinISOStx3 (Mus musculus)1624291 PMID:18505797RGDPMID:18505797
Stx3Ratintracellular protein transport involved_inIBAPANTHER:PTN000461349 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx3Ratintracellular protein transport involved_inIEAInterPro:IPR0060121600115GO_REF:0000002InterProGO_REF:0000002
Stx3Ratintracellular transport  TAS 68313 RGD 
Stx3Ratlong-term synaptic potentiation acts_upstream_of_or_withinISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratmembrane fusion  IDA 2306549 RGD 
Stx3Ratmembrane fusion involved_inIEAGO:00054841600115GO_REF:0000108GOCGO_REF:0000108
Stx3Ratmodulation of chemical synaptic transmission involved_inISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratneuron projection development involved_inIDA 8553500PMID:16598260HGNC-UCL 
Stx3Ratneurotransmitter transport involved_inIEAUniProtKB-KW:KW-05321600115GO_REF:0000043UniProtGO_REF:0000043
Stx3Ratorganelle membrane fusion involved_inISSUniProtKB:Q132771600115GO_REF:0000024UniProtGO_REF:0000024
Stx3Ratorganelle membrane fusion involved_inISOSTX3 (Homo sapiens)1624291 PMID:24726755RGDPMID:24726755
Stx3Ratpositive regulation of cell adhesion involved_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratpositive regulation of cell population proliferation involved_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratpositive regulation of chemotaxis involved_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratpositive regulation of protein localization to cell surface involved_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratpositive regulation of protein localization to plasma membrane involved_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratregulation of gene expression involved_inISOSTX3 (Homo sapiens)1624291 PMID:29475951RGDPMID:29475951
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Cellular Component
1 to 20 of 35 rows

  
Object Symbol
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Reference
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Original Reference(s)
Stx3Ratapical plasma membrane located_inISOSTX3 (Homo sapiens)1624291 PMID:16339081RGDPMID:16339081
Stx3Ratapical plasma membrane located_inISOStx3 (Mus musculus)1624291 PMID:10469351 and PMID:18505797RGDPMID:10469351 and PMID:18505797
Stx3Ratazurophil granule located_inISOSTX3 (Homo sapiens)1624291 PMID:18588921RGDPMID:18588921
Stx3Ratcell-cell junction located_inISOSTX3 (Homo sapiens)1624291 PMID:15576373RGDPMID:15576373
Stx3Ratdendrite located_inISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratendomembrane system is_active_inIBAFB:FBgn0011708 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stx3Ratglutamatergic synapse is_active_inISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratgrowth cone located_inIDA 8553500PMID:16598260HGNC-UCL 
Stx3Ratlamellipodium located_inISOSTX3 (Homo sapiens)1624291 PMID:21720706RGDPMID:21720706
Stx3Ratmelanosome located_inISOStx3 (Mus musculus)1624291 PMID:23549422RGDPMID:23549422
Stx3Ratmembrane located_inIEAInterPro:IPR006011 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Stx3Ratmembrane located_inISOStx3 (Mus musculus)1624291 PMID:23395379RGDPMID:23395379
Stx3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Stx3Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Stx3Ratneuron projection located_inIDA 8553500PMID:16598260HGNC-UCL 
Stx3Ratphotoreceptor inner segment located_inISSUniProtKB:Q647041600115GO_REF:0000024UniProtGO_REF:0000024
Stx3Ratphotoreceptor inner segment located_inISOStx3 (Mus musculus)1624291 PMID:33974130RGDPMID:33974130
Stx3Ratphotoreceptor outer segment located_inISSUniProtKB:Q647041600115GO_REF:0000024UniProtGO_REF:0000024
Stx3Ratphotoreceptor outer segment located_inISOStx3 (Mus musculus)1624291 PMID:33974130RGDPMID:33974130
Stx3Ratplasma membrane located_inTAS 8553500PMID:16598260HGNC-UCL 
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Molecular Function
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#
Reference Title
Reference Citation
1. The syntaxin family of vesicular transport receptors. Bennett MK, etal., Cell 1993 Sep 10;74(5):863-73.
2. Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epithelia. Breton S, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F523-9.
3. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Darios F and Davletov B, Nature. 2006 Apr 6;440(7085):813-7.
4. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Datta P, etal., Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4400-9. doi: 10.1073/pnas.1510111112. Epub 2015 Jul 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Hata Y and Sudhof TC, J Biol Chem 1995 Jun 2;270(22):13022-8.
7. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
8. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Li C, etal., Nature 1995 Jun 15;375(6532):594-9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Membrane fusion between liposomes containing SNARE proteins involved in mast cell exocytosis. Sakiyama H, etal., Inflamm Res. 2009 Mar;58(3):139-42.
15. Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Thomas DM, etal., Mol Biol Cell. 1999 Jul;10(7):2285-95.
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PMID:8108429   PMID:8824312   PMID:8996080   PMID:10336434   PMID:10469351   PMID:11487543   PMID:12198139   PMID:12477932   PMID:12828989   PMID:12935901   PMID:15576373   PMID:15943887  
PMID:16186111   PMID:16339081   PMID:17408745   PMID:17693260   PMID:18321981   PMID:18505797   PMID:18535671   PMID:18588921   PMID:18683220   PMID:19056867   PMID:19515809   PMID:19932892  
PMID:20829354   PMID:20844248   PMID:21720706   PMID:23376485   PMID:23395379   PMID:23549422   PMID:24323579   PMID:24680688   PMID:29549124   PMID:31962145  



Stx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,940,697 - 218,114,865 (-)NCBIGRCr8
mRatBN7.21208,617,018 - 208,686,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,639,115 - 208,685,805 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,017,514 - 217,060,397 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,004,990 - 224,047,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,771,951 - 216,814,831 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01228,137,781 - 228,195,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1228,149,867 - 228,194,977 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,205,648 - 235,262,820 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,554,512 - 214,597,396 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,712,944 - 214,755,826 (-)NCBI
Celera1206,113,799 - 206,156,646 (-)NCBICelera
Cytogenetic Map1q43NCBI
STX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,754,188 - 59,805,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,713,456 - 59,805,882 (+)EnsemblGRCh38hg38GRCh38
GRCh371159,522,849 - 59,573,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,279,465 - 59,326,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,279,464 - 59,326,752NCBI
Celera1156,885,275 - 56,936,097 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1155,870,047 - 55,920,737 (+)NCBIHuRef
CHM1_11159,388,526 - 59,439,344 (+)NCBICHM1_1
T2T-CHM13v2.01159,706,662 - 59,757,169 (+)NCBIT2T-CHM13v2.0
Stx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,752,482 - 11,798,933 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,752,482 - 11,796,767 (-)EnsemblGRCm39 Ensembl
GRCm381911,775,118 - 11,821,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,775,118 - 11,819,403 (-)EnsemblGRCm38mm10GRCm38
MGSCv371911,849,608 - 11,893,893 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,842,163 - 11,886,448 (-)NCBIMGSCv36mm8
Celera1912,449,207 - 12,493,664 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.52NCBI
Stx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555114,196,114 - 4,218,961 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555114,183,210 - 4,219,528 (+)NCBIChiLan1.0ChiLan1.0
STX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2960,883,565 - 60,933,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11161,924,031 - 61,976,699 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,976,575 - 55,027,638 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,426,888 - 58,476,417 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,426,894 - 58,476,417 (+)Ensemblpanpan1.1panPan2
STX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,298,040 - 50,322,773 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2150,298,158 - 50,318,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,740,398 - 49,762,866 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,472,780 - 51,495,160 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2151,472,484 - 51,524,620 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12150,518,990 - 50,541,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,618,082 - 50,640,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,243,359 - 51,264,997 (+)NCBIUU_Cfam_GSD_1.0
Stx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,830,408 - 12,863,135 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,941,953 - 2,971,405 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,944,230 - 2,976,957 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl211,696,913 - 11,740,744 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1211,694,788 - 11,739,858 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2211,061,370 - 11,088,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,866,853 - 13,916,803 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,874,526 - 13,916,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038111,197,172 - 111,247,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,054,284 - 1,090,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,054,130 - 1,091,071 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Stx3
477 total Variants

Predicted Target Of
Summary Value
Count of predictions:757
Count of miRNA genes:310
Interacting mature miRNAs:395
Transcripts:ENSRNOT00000028535
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1207987464234238494Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat

1 to 10 of 92 rows
D1Got205  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81218,074,855 - 218,075,013 (+)Marker Load Pipeline
mRatBN7.21208,650,087 - 208,650,245 (+)MAPPERmRatBN7.2
Rnor_6.01228,159,195 - 228,159,348NCBIRnor6.0
Rnor_5.01235,227,047 - 235,227,200UniSTSRnor5.0
RGSC_v3.41214,561,786 - 214,561,939RGDRGSC3.4
RGSC_v3.41214,561,787 - 214,561,940UniSTSRGSC3.4
RGSC_v3.11214,720,216 - 214,720,369RGD
Celera1206,121,068 - 206,121,221UniSTS
RH 3.4 Map11502.0UniSTS
RH 3.4 Map11502.0RGD
Cytogenetic Map1q43UniSTS
BE121305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21208,663,072 - 208,663,246 (+)MAPPERmRatBN7.2
Rnor_6.01228,172,174 - 228,172,347NCBIRnor6.0
Rnor_5.01235,240,026 - 235,240,199UniSTSRnor5.0
RGSC_v3.41214,574,766 - 214,574,939UniSTSRGSC3.4
Celera1206,134,047 - 206,134,220UniSTS
RH 3.4 Map11502.1UniSTS
Cytogenetic Map1q43UniSTS
RH138992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21208,641,923 - 208,642,127 (+)MAPPERmRatBN7.2
Rnor_6.01228,151,031 - 228,151,234NCBIRnor6.0
Rnor_5.01235,218,883 - 235,219,086UniSTSRnor5.0
RGSC_v3.41214,553,622 - 214,553,825UniSTSRGSC3.4
Celera1206,112,909 - 206,113,112UniSTS
RH 3.4 Map11505.9UniSTS
Cytogenetic Map1q43UniSTS
RH139783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21208,641,269 - 208,641,475 (+)MAPPERmRatBN7.2
Rnor_6.01228,150,377 - 228,150,582NCBIRnor6.0
Rnor_5.01235,218,229 - 235,218,434UniSTSRnor5.0
RGSC_v3.41214,552,968 - 214,553,173UniSTSRGSC3.4
Celera1206,112,255 - 206,112,460UniSTS
RH 3.4 Map11505.9UniSTS
Cytogenetic Map1q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 59 31


1 to 20 of 20 rows
RefSeq Transcripts NM_031124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC168246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000028535   ⟹   ENSRNOP00000028535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,641,192 - 208,685,781 (-)Ensembl
Rnor_6.0 Ensembl1228,149,867 - 228,194,977 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094739   ⟹   ENSRNOP00000092371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,645,167 - 208,667,262 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102678   ⟹   ENSRNOP00000097210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,641,191 - 208,685,805 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112820   ⟹   ENSRNOP00000079624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,639,115 - 208,685,805 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119247   ⟹   ENSRNOP00000078489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,641,192 - 208,685,781 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120182   ⟹   ENSRNOP00000097922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1208,639,115 - 208,685,805 (-)Ensembl
RefSeq Acc Id: NM_031124   ⟹   NP_112386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,067,582 - 218,110,466 (-)NCBI
mRatBN7.21208,642,814 - 208,685,700 (-)NCBI
Rnor_6.01228,151,921 - 228,194,905 (-)NCBI
Rnor_5.01235,205,648 - 235,262,820 (-)NCBI
RGSC_v3.41214,554,512 - 214,597,396 (-)RGD
Celera1206,113,799 - 206,156,646 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231097   ⟹   XP_006231159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,063,415 - 218,114,865 (-)NCBI
mRatBN7.21208,639,534 - 208,686,224 (-)NCBI
Rnor_6.01228,147,754 - 228,195,004 (-)NCBI
Rnor_5.01235,205,648 - 235,262,820 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760262   ⟹   XP_008758484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,069,407 - 218,114,865 (-)NCBI
mRatBN7.21208,644,639 - 208,686,240 (-)NCBI
Rnor_6.01228,153,646 - 228,195,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760263   ⟹   XP_008758485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,065,956 - 218,114,865 (-)NCBI
mRatBN7.21208,641,188 - 208,686,211 (-)NCBI
Rnor_6.01228,150,281 - 228,195,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589775   ⟹   XP_017445264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,063,415 - 218,091,306 (-)NCBI
mRatBN7.21208,639,534 - 208,686,237 (-)NCBI
Rnor_6.01228,147,754 - 228,195,004 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092292   ⟹   XP_038948220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,041,791 - 218,114,865 (-)NCBI
mRatBN7.21208,617,018 - 208,686,215 (-)NCBI
RefSeq Acc Id: XM_063275258   ⟹   XP_063131328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81217,940,697 - 218,114,865 (-)NCBI
RefSeq Acc Id: XM_063275266   ⟹   XP_063131336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,065,956 - 218,114,865 (-)NCBI
RefSeq Acc Id: XM_063275275   ⟹   XP_063131345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81217,963,568 - 218,114,865 (-)NCBI
RefSeq Acc Id: XR_005492999
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81218,041,791 - 218,114,865 (-)NCBI
mRatBN7.21208,617,018 - 208,686,209 (-)NCBI
RefSeq Acc Id: XR_010058289
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81217,963,567 - 218,114,865 (-)NCBI
RefSeq Acc Id: XR_010058290
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81217,963,567 - 218,114,865 (-)NCBI
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_112386   ⟸   NM_031124
- UniProtKB: Q08849 (UniProtKB/Swiss-Prot),   B4F7E6 (UniProtKB/TrEMBL),   A0A8I5ZL11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231159   ⟸   XM_006231097
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZRD1 (UniProtKB/TrEMBL),   A6I0B2 (UniProtKB/TrEMBL),   A6I0B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758485   ⟸   XM_008760263
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AS91 (UniProtKB/TrEMBL),   A0A8I6AGY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758484   ⟸   XM_008760262
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445264   ⟸   XM_017589775
- Peptide Label: isoform X6
- UniProtKB: A6I0B5 (UniProtKB/TrEMBL)
- Sequence:
Name Modeler Protein Id AA Range Protein Structure
AF-Q08849-F1-model_v2 AlphaFold Q08849 1-289 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690795
Promoter ID:EPDNEW_R1319
Type:initiation region
Name:Stx3_1
Description:syntaxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01228,194,960 - 228,195,020EPDNEW


1 to 40 of 46 rows
Database
Acc Id
Source(s)
BIND 130902
  130912
  133977
  134467
  134476
  134480
BioCyc Gene G2FUF-56352 BioCyc
Ensembl Genes ENSRNOG00000021013 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028498 ENTREZGENE
  ENSRNOT00000028535.6 UniProtKB/Swiss-Prot
  ENSRNOT00000094739 ENTREZGENE
  ENSRNOT00000102678 ENTREZGENE
  ENSRNOT00000112820 ENTREZGENE
  ENSRNOT00000142473 ENTREZGENE
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
  1.20.58.70 UniProtKB/Swiss-Prot
InterPro SNARE UniProtKB/Swiss-Prot
  Stx3 UniProtKB/Swiss-Prot
  Syntaxin UniProtKB/Swiss-Prot
  Syntaxin/epimorphin_CS UniProtKB/Swiss-Prot
  Syntaxin_N UniProtKB/Swiss-Prot
  T_SNARE_dom UniProtKB/Swiss-Prot
KEGG Report rno:81802 UniProtKB/Swiss-Prot
NCBI Gene 81802 ENTREZGENE
PANTHER PTHR19957 UniProtKB/Swiss-Prot
  PTHR19957:SF34 UniProtKB/Swiss-Prot
Pfam SNARE UniProtKB/Swiss-Prot
  Syntaxin UniProtKB/Swiss-Prot
PhenoGen Stx3 PhenoGen
PROSITE SYNTAXIN UniProtKB/Swiss-Prot
  T_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021013 RatGTEx
SMART SynN UniProtKB/Swiss-Prot
  t_SNARE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47661 UniProtKB/Swiss-Prot
UniProt A0A8I5ZL11 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRD1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS91 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMR2_RAT UniProtKB/TrEMBL
1 to 40 of 46 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Stx3  syntaxin 3  Stx3a    Symbol updated 1299863 APPROVED
2002-08-07 Stx3a  syntaxin 3      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains C-terminal hydrophobic domain anchors protein on the cytoplasmic side of the membrane 68313
gene_expression protein expressed in neuronal cell types throughout kidney 730051
gene_process important for calcium-dependent exocytosis 68313
gene_protein protein weighs 37 kDa 730051