Gene:	Plcb2 ( Rattus norvegicus ) phospholipase C, beta 2
Description:	may play a role in inositol mediated signal transduction of bitter taste perception
Synonyms:	PKC beta II; phospholipase C beta 2;
ArrayIDs:	1387717_at; AJ011035_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PLCB2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Plcb2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Plcb2 genome assembly 3.1 3 105099951 - 105119770     Rat Celera Assembly 3 104599222 - 104618601     RGSC genome assembly v3.4 3 105203524 - 105223342     Cytogenetic 3 q35 Mus musculus Plcb2 Mouse genome assembly build 36.1 2 118533253 - 118554174     Cytogenetic 2 2 E5 Homo sapiens PLCB2 human genome assembly 15 38367401 - 38387330     Human genome assembly build 36.2 15 38366448 - 38387330     Cytogenetic 15 q15   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology phospholipid binding,  phospholipase C activity,  phosphoinositide phospholipase C activity ...  (details...)
Biological Process	Gene Ontology detection of chemical stimulus involved in sensory perception of bitter taste,  sensory perception of bitter taste,  lipid catabolic process ...  (details...)
Cellular Component	Gene Ontology plasma membrane,  Golgi apparatus,  cytosol ...  (details...)
Phenotype	Ontology skin lesions,  taste sensitivity (details...)
Expression	Note Reference expressed exclusively in a subset of taste receptor cells of circumvallate papillae 729588
Pathway	Ontology inositol phosphate metabolic pathway,  Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: PLCYc IPI SMART: PLCXc IPI SMART: C2 IPI PROSITE: PIPLC_Y_DOMAIN IPI PROSITE: PIPLC_X_DOMAIN IPI PROSITE: C2 IPI UNIPARC: UPI000021D642 IPI UNIPARC: UPI00000E879E IPI KEGG Report: rno:85240 ENTREZGENE HomoloGene Group ID: 20957 ENTREZGENE Germonline: 621004 Pfam: PI-PLC-Y IPI Pfam: PI-PLC-X IPI Pfam: efhand_like IPI Pfam: PLC-beta_C IPI Pfam: C2 IPI KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04270 ENTREZGENE KEGG Pathway: 04742 ENTREZGENE KEGG Pathway: 04070 ENTREZGENE KEGG Pathway: 01100 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04730 ENTREZGENE KEGG Pathway: 00562 ENTREZGENE KEGG Pathway: 05016 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE InterPro: PLC-like_Pdiesterase_TIM-brl. IPI InterPro: Phospholipase_C_Pinositol-sp_Y. IPI InterPro: Phospholipase_C_Pinositol-sp_X. IPI InterPro: Phospholipase_C_Pinositol-sp_C. IPI InterPro: Phospholipase_C_EF-hand-like. IPI InterPro: EF-Hand_type. IPI InterPro: PLC-beta_C. IPI InterPro: PLC-beta. IPI InterPro: C2_membr_targeting. IPI InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI InterPro: C2_Ca-dep. IPI IPI: IPI00195859 IPI IPI: IPI00203756 IPI Ensembl Protein: ENSRNOP00000011129 IPI Ensembl Protein: ENSRNOP00000011911 IPI Gene3D-CATH: PLC-like_Pdiesterase_TIM-brl IPI Gene3D-CATH: EF-Hand_type IPI Entrez Gene: Plcb2 ENTREZGENE PIRSF: PLC-beta IPI UniProt: Q45QJ6_RAT IPI UniProt: PLCB2_RAT IPI Ensembl Genes: ENSRNOG00000008229 IPI Superfamily-SCOP: PLC-like_Pdiesterase_TIM-brl IPI Superfamily-SCOP: C2_CaLB IPI PRINTS: PHPHLIPASEC. IPI
Sequences	Nucleotide: AJ011035 Get FASTA Search GEO Profiles Nucleotide: DQ120505 Get FASTA Search GEO Profiles Nucleotide: DQ120506 Get FASTA Search GEO Profiles Nucleotide: CH473949 Get FASTA Search GEO Profiles Nucleotide: NM_053478 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: Q45QJ6 Get FASTA Protein: O89040 Get FASTA Protein: AAZ23845 Get FASTA Protein: AAZ23844 Get FASTA Protein: CAA09465 Get FASTA Protein: EDL79871 Get FASTA Protein: EDL79870 Get FASTA Protein: EDL79869 Get FASTA Protein: NP_445930 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 30033
References
Curated References	11 references in RGD related to Plcb2
Other References	6 other references at PubMed related to Plcb2
Database Information
RGD ID	621004
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Plcb2 phospholipase C, beta 2 phospholipase C beta 2 APPROVED Name updated 1299863 07-AUG-02: Plcb2 phospholipase C beta 2 PROVISIONAL Symbol and Name status set to provisional 70820