Map3k2 (mitogen activated protein kinase kinase kinase 2)

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Gene: Map3k2 (mitogen activated protein kinase kinase kinase 2) Rattus norvegicus

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Symbol:

Map3k2

Name:

mitogen activated protein kinase kinase kinase 2

RGD ID:

620967

Description:

Enables MAP kinase kinase kinase activity. Involved in protein phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human MAP3K2 (mitogen-activated protein kinase kinase kinase 2); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; Erk5 MAPK signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Mekk2; mitogen-activated protein kinase kinase kinase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	24,081,444 - 24,153,940 (+)	NCBI		GRCr8
mRatBN7.2	18	23,807,218 - 23,879,722 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	23,807,218 - 23,871,433 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	23,935,311 - 23,999,520 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	24,692,639 - 24,757,275 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	24,030,296 - 24,094,510 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	24,680,069 - 24,682,550 (+)	NCBI
Celera	18	23,559,225 - 23,623,916 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant thrombophilia due to protein C deficiency (ISO)

autosomal recessive limb-girdle muscular dystrophy type 2W (ISO)

centronuclear myopathy 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3-chloropropane-1,2-diol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

fluoranthene (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

galaxolide (EXP)

gentamycin (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

isoprenaline (EXP)

metformin (ISO)

methimazole (EXP)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

miconazole (ISO)

nickel sulfate (ISO)

paclitaxel (ISO)

paracetamol (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium cyanide (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

torcetrapib (ISO)

troglitazone (ISO)

valproic acid (EXP,ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to mechanical stimulus (ISO)

intracellular signal transduction (ISO)

MAPK cascade (IEA)

protein phosphorylation (IDA)

Cellular Component

cytoplasm (IBA)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

ATP binding (IEA)

MAP kinase kinase kinase activity (IDA)

protein binding (ISO)

protein kinase activity (ISO)

protein kinase binding (ISO)

protein serine/threonine kinase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

Erk5 MAPK signaling pathway (ISO)

gonadotropin-releasing hormone signaling pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

the extracellular signal-regulated Raf/Mek/Erk signaling pathway (NAS)

References

References - curated

#	Reference Title	Reference Citation
1.	MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42.	Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK.	Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
4.	The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.	Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
5.	Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.	Lenz G, etal., J Neurochem 2001 May;77(4):1001-9.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.	Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Regulation of cellular functions by the ERK5 signalling pathway.	Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.

Additional References at PubMed

PMID:14515274	PMID:15001576	PMID:17003042	PMID:17906693	PMID:19593445	PMID:33506923

Genomics

Comparative Map Data

Map3k2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	24,081,444 - 24,153,940 (+)	NCBI		GRCr8
mRatBN7.2	18	23,807,218 - 23,879,722 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	23,807,218 - 23,871,433 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	23,935,311 - 23,999,520 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	24,692,639 - 24,757,275 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	24,030,296 - 24,094,510 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	24,680,069 - 24,682,550 (+)	NCBI
Celera	18	23,559,225 - 23,623,916 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

MAP3K2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	127,298,668 - 127,388,465 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	127,298,668 - 127,388,465 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	128,056,244 - 128,146,041 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	127,778,609 - 127,817,240 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	127,780,007 - 127,817,035	NCBI
Celera	2	121,373,314 - 121,412,005 (-)	NCBI		Celera
Cytogenetic Map	2	q14.3	NCBI
HuRef	2	120,363,448 - 120,407,794 (-)	NCBI		HuRef
CHM1_1	2	128,060,819 - 128,105,372 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	127,733,893 - 127,823,745 (-)	NCBI		T2T-CHM13v2.0

Map3k2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	32,296,142 - 32,369,804 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	32,296,142 - 32,369,804 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	32,163,089 - 32,236,751 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	32,163,089 - 32,236,751 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	32,322,743 - 32,396,405 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	32,306,212 - 32,371,521 (+)	NCBI		MGSCv36	mm8
Celera	18	32,644,790 - 32,718,516 (+)	NCBI		Celera
Cytogenetic Map	18	B1	NCBI
cM Map	18	17.95	NCBI

Map3k2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	3,136,010 - 3,196,971 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955459	3,135,959 - 3,196,971 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	48,257,665 - 48,347,308 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	48,272,647 - 48,362,285 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	32,889,499 - 32,979,077 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	127,963,999 - 128,008,773 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	127,972,900 - 128,008,766 (-)	Ensembl	panpan1.1		panPan2

MAP3K2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	23,210,106 - 23,303,426 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	23,210,714 - 23,294,586 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	23,457,614 - 23,550,900 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	24,536,705 - 24,630,042 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	24,519,123 - 24,622,032 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	23,240,311 - 23,333,600 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	23,434,707 - 23,529,263 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	24,567,169 - 24,660,474 (+)	NCBI		UU_Cfam_GSD_1.0

Map3k2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	97,654,640 - 97,736,974 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	43,880,468 - 43,958,556 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	43,880,816 - 43,958,556 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	25,087,738 - 25,178,060 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	25,087,479 - 25,184,106 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	28,766,719 - 28,864,185 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	2,831,265 - 2,921,782 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	2,831,270 - 2,912,897 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	19,831,765 - 19,921,903 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map3k2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	13,790,080 - 13,877,598 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	13,790,088 - 13,877,641 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Map3k2
224 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	84
Interacting mature miRNAs:	90
Transcripts:	ENSRNOT00000060996
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944273	26548295	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	18234564	31359530	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25758124	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	11944299	24797117	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	18234564	31359530	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	11944273	26548295	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	11944273	26548295	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	11944273	26548295	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	11944273	26548295	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	11944273	26548295	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	11944273	26548295	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25758124	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Markers in Region

RH138636

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	23,859,604 - 23,859,745 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	25,013,660 - 25,013,800	NCBI	Rnor6.0
Rnor_5.0	18	24,728,903 - 24,729,043	UniSTS	Rnor5.0
RGSC_v3.4	18	24,660,910 - 24,661,050	UniSTS	RGSC3.4
Celera	18	23,612,079 - 23,612,219	UniSTS
RH 3.4 Map	18	302.3	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC126902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF487544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060996 ⟹ ENSRNOP00000057715

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	23,807,218 - 23,871,433 (+)	Ensembl
Rnor_6.0 Ensembl	18	24,961,245 - 25,025,897 (+)	Ensembl

RefSeq Acc Id:

NM_138503 ⟹ NP_612512

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,081,444 - 24,145,651 (+)	NCBI
mRatBN7.2	18	23,807,218 - 23,871,433 (+)	NCBI
Rnor_6.0	18	24,961,250 - 25,025,488 (+)	NCBI
Rnor_5.0	18	24,676,280 - 24,740,723 (+)	NCBI
RGSC_v3.4	18	24,606,219 - 24,672,732 (+)	RGD
Celera	18	23,559,225 - 23,623,916 (+)	RGD

Sequence:

show sequence

AGACATCACGGGTCTGTGTGTAGTGGCGGCCCGGCTGTCCTCAGCCGCATCGCCTGGCGAGGGT
GGCGCGGCGTTCCTGGGTTGCGGGACCGGCGACAAAGAGGACCGACAGAGAACGATCTGGTCGC
AGAGTCGCCGCTTCCGCTTAGCTGCTTCTCCGGTCACCCGCGACGCGGGCCCGGGGCTTCCTCC
TCGTCGGCCCAGTTTACTCGGCGGGCCCCGGGGCTGCATCTACCCAGAAGCAGCGAAGAGGCCC
CGGGCTGCGCGCCCGCTGTCCCATGTGAAGCAGGTTGGGCCTGGTTTCTGCTGCGGCCCTTCAG
GCCTCGGGGACCCCGCGAGGCGCTGCTCCTGGGGGGCGCGGTGACAGGCCGTGCGGGGGCGGAG
GGGTCAGCTCCGTGGCCTCCTCTCGGCCCTCCGCTCCACGATCCCCGCCCAGAGGCCGGGCAAT
AAAGAATGTTGATGGGAGAACTGTTTTCCTAATTTTAAAATTATTGAGCTGGACGCCATAATGG
ATGATCAGCAAGCTTTGAATTCAATCATGCAAGATTTGGCTGTCCTTCATAAGGCCAGTCGGCC
AGCATTATCTTTACAAGAAACCAGAAAAGCAAAACCCTCTTCACCAAAAAAACAGAATGATGTC
CGAGTCAAATTTGAACATAGAGGAGAAAAAAGAATCTTGCAGGTTACTAGACCAGTTAAACTAG
AAGATCTGAGGTCTAAGTCTAAAATTGCCTTTGGACAGTCTATGGATCTACACTATACCAACAA
CGAGTTGGTAATTCCGTTAACTACCCAAGATGACTTGGACAAAGCTGTGGAACTGCTGGATCGC
AGTATCCACATGAAGAGTCTCAAGATATTACTTGTTCTAAATGGGAGTACACAGGCTACTAATT
TAGAGCCGTCACCATCACCAGACGATCTGAATAATACACCACTCGGTGCGGAGAGGAAAAAGCG
GCTATCTGTAGTAGGTCCCCCTAATAGGGATAGAAGTTCTCCACCCCCAGGATACATTCCAGAT
GAACTGCACCAGATTGCCCGGAACGGGTCTTTCACCAGCATCAACAGTGAAGGAGAGTTCATCC
CAGAGAGCATGGACCAAATGCTGGATCCACTGTCTTTAAGCAGCCCTGAAAACTCTGGCTCAGG
AAGCTGCCCGTCACTGGATAGTCCTTTGGATGGAGAAAGCTACCCAAAATCACGGATGCCTAGG
GCACAGAGCTACCCAGATAATCATCAGGAGTTTTCAGACTATGATAACCCCATTTTTGAGAAAT
TTGGAAAAGGAGGAACATATCCAAGAAGGTATCATGTTTCATACCATCATCAAGAGTATAATGA
TGGTCGGAAGACTTTTCCAAGAGCCAGAAGGACCCAGGGCACCAGTTTCCGGTCTCCTGTGAGT
TTCAGTCCTACTGATCACTCCTTAAGCACTAGTAGTGGGAGCAGCATCTTTACCCCAGAGTATG
AAGACAGTCGGATAAGAAGACGGGGGAGTGACATAGACAATCCTACTTTGACTGTCACAGACAT
CAGCCCACCCAGCCGTTCACCTCGAGCTCCAACCAACTGGAGATTGGGCAAACTGCTTGGCCAA
GGAGCTTTTGGAAGGGTCTACCTCTGTTATGATGTTGATACCGGACGAGAACTGGCTGTTAAAC
AAGTTCAGTTTAACCCTGACAGCCCCGAGACCAGCAAGGAAGTAAATGCACTTGAGTGTGAAAT
TCAGTTGTTGAAAAACTTGTTGCATGAGCGAATTGTTCAGTATTATGGCTGTCTGAGGGATCCT
CAGGAGAAAACACTTTCCATCTTTATGGAGTACATGCCAGGGGGCTCAATTAAGGACCAACTCA
AAGCATATGGAGCCCTTACTGAGAATGTGACGAGGAAATACACCCGTCAGATTCTGGAGGGGGT
CCATTACCTGCATAGTAATATGATTGTCCATAGAGACATCAAAGGAGCGAATATCTTAAGGGAT
TCCACGGGCAATATCAAGCTAGGAGACTTTGGAGCTAGCAAACGACTTCAGACCATCTGTCTCT
CAGGCACAGGGATGAAGTCTGTCACAGGCACGCCATATTGGATGAGTCCTGAGGTCATTAGTGG
AGAAGGCTATGGCAGAAAAGCAGATATCTGGAGCGTAGCATGTACGGTGGTGGAGATGCTAACT
GAAAAGCCACCTTGGGCTGAATTTGAAGCAATGGCTGCCATCTTTAAGATCGCCACTCAGCCAA
CAAACCCAAAGCTGCCACCTCATGTCTCAGACTATACTCGGGACTTTCTCAAACGGATTTTTGT
AGAGGCCAAACTCCGACCTTCAGCCGAGGAGCTCCTGCGGCACCTGTTCGTGCATTGCCACTAG
CAGCCAGCGTCCTCCACCCGCCCGCCGCCACCGCCACCTTCTCTCTTACTGCACTTTCCTTTTT
TATAAAAAGAGAGATGGGGAGAAAAAGACAAGAGGGAAAAATATTTCTCTTGATTCTTGGTTAA
ATTTGTTTAATAATAATAGTAAACTAAA

hide sequence

RefSeq Acc Id:

XM_039096559 ⟹ XP_038952487

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	24,122,980 - 24,153,940 (+)	NCBI
mRatBN7.2	18	23,848,760 - 23,879,722 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_612512	(Get FASTA)	NCBI Sequence Viewer
	XP_038952487	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL93245	(Get FASTA)	NCBI Sequence Viewer
	EDL76185	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057715.2

RefSeq Acc Id:

NP_612512 ⟸ NM_138503

- UniProtKB:

F1M9D0 (UniProtKB/TrEMBL), A6J2Q3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKPSSPKKQNDVRVKFEHRGEKRILQVTRPVK
LEDLRSKSKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLVLNGSTQAT
NLEPSPSPDDLNNTPLGAERKKRLSVVGPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEF
IPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSYPDNHQEFSDYDNPIFE
KFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSFRSPVSFSPTDHSLSTSSGSSIFTPE
YEDSRIRRRGSDIDNPTLTVTDISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAV
KQVQFNPDSPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQ
LKAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTIC
LSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ
PTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLRHLFVHCH

hide sequence

Ensembl Acc Id:

ENSRNOP00000057715 ⟸ ENSRNOT00000060996

RefSeq Acc Id:	XP_038952487 ⟸ XM_039096559
- Peptide Label:	isoform X1

Protein Domains

PB1 Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M9D0-F1-model_v2	AlphaFold	F1M9D0	1-619	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700683

Promoter ID:

EPDNEW_R11207

Type:

initiation region

Name:

Map3k2_1

Description:

mitogen activated protein kinase kinase kinase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	24,961,250 - 24,961,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620967	AgrOrtholog
BioCyc Gene	G2FUF-8039	BioCyc
Ensembl Genes	ENSRNOG00000014089	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060996.4	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	MAP_kinase_kinase_kinase	UniProtKB/TrEMBL
	OPR_PB1	UniProtKB/TrEMBL
	PB1-like	UniProtKB/TrEMBL
	PB1_MEKK2/3	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
KEGG Report	rno:171492	UniProtKB/TrEMBL
NCBI Gene	171492	ENTREZGENE
PANTHER	MAP KINASE KINASE KINASE SSK2-RELATED-RELATED	UniProtKB/TrEMBL
	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3	UniProtKB/TrEMBL
Pfam	PB1	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PhenoGen	Map3k2	PhenoGen
PROSITE	PB1	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014089	RatGTEx
SMART	PB1	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/TrEMBL
	Kinase_like	UniProtKB/TrEMBL
UniProt	A6J2Q3	ENTREZGENE, UniProtKB/TrEMBL
	F1M9D0	ENTREZGENE, UniProtKB/TrEMBL
	Q8R4A9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Map3k2	mitogen activated protein kinase kinase kinase 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Map3k2	mitogen activated protein kinase kinase kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	may be induced by FGF-2	724475

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)