Timeless (timeless circadian regulator) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Timeless (timeless circadian regulator) Rattus norvegicus
Analyze
Symbol: Timeless
Name: timeless circadian regulator
RGD ID: 620939
Description: Predicted to enable DNA binding activity; enzyme activator activity; and identical protein binding activity. Involved in kidney development; morphogenesis of an epithelium; and positive regulation of circadian rhythm. Acts upstream of or within branching involved in ureteric bud morphogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 4 and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: rTIM; rTLP; Tim; timeless (Drosophila) homolog; timeless circadian clock; timeless homolog; timeless homolog (Drosophila); timeless-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,239,388 - 1,263,344 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,239,450 - 1,263,337 (+)EnsemblGRCr8
mRatBN7.27654,804 - 678,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7654,822 - 678,738 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,413,239 - 3,434,822 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,289,244 - 5,310,791 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,591,124 - 5,613,782 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,643,288 - 2,667,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,643,288 - 2,667,628 (+)Ensemblrn6Rnor6.0
Rnor_5.072,622,164 - 2,646,205 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,516,568 - 1,540,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7533,427 - 554,888 (+)NCBICelera
RGSC_v3.171,516,569 - 1,540,504 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
geraniol  (ISO)
GSK-J4  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
Monobutylphthalate  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Requirement of mammalian Timeless for circadian rhythmicity. Barnes JW, etal., Science 2003 Oct 17;302(5644):439-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1. Koike N, etal., FEBS Lett 1998 Dec 28;441(3):427-31.
4. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
5. A role for Timeless in epithelial morphogenesis during kidney development. Li Z, etal., Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10038-43.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. Sakamoto K, etal., J Biol Chem 1998 Oct 16;273(42):27039-42.
12. Molecular characterization and nuclear localization of rat timeless-like gene product. Sakamoto S, etal., Biochem Biophys Res Commun. 2000 Dec 9;279(1):131-8.
Additional References at PubMed
PMID:9856465   PMID:9988221   PMID:10231394   PMID:10903565   PMID:12477932   PMID:12875843   PMID:12950082   PMID:15094047   PMID:17102137   PMID:23418588   PMID:23797032   PMID:24489120  
PMID:26344098   PMID:30356214  


Genomics

Comparative Map Data
Timeless
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,239,388 - 1,263,344 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,239,450 - 1,263,337 (+)EnsemblGRCr8
mRatBN7.27654,804 - 678,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7654,822 - 678,738 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,413,239 - 3,434,822 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,289,244 - 5,310,791 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,591,124 - 5,613,782 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,643,288 - 2,667,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,643,288 - 2,667,628 (+)Ensemblrn6Rnor6.0
Rnor_5.072,622,164 - 2,646,205 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.471,516,568 - 1,540,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7533,427 - 554,888 (+)NCBICelera
RGSC_v3.171,516,569 - 1,540,504 (+)NCBI
Cytogenetic Map7q11NCBI
TIMELESS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,416,363 - 56,449,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,416,363 - 56,449,445 (-)Ensemblhg38GRCh38
GRCh371256,810,147 - 56,843,210 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,097,174 - 55,129,433 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341255,097,174 - 55,129,433NCBI
Celera1256,463,518 - 56,496,570 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,849,203 - 53,882,241 (-)NCBIHuRef
CHM1_11256,777,536 - 56,810,809 (-)NCBICHM1_1
T2T-CHM13v2.01256,384,058 - 56,417,137 (-)NCBIT2T-CHM13v2.0
Timeless
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,067,932 - 128,088,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,067,934 - 128,088,810 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3810128,232,063 - 128,252,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,232,065 - 128,252,941 (+)Ensemblmm10GRCm38
MGSCv3710127,669,119 - 127,689,997 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610127,641,015 - 127,655,888 (+)NCBIMGSCv36mm8
Celera10133,268,115 - 133,283,209 (+)NCBICelera
Celera10130,632,719 - 130,638,534 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.49NCBI
Timeless
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,997,725 - 4,029,766 (-)Ensembl
ChiLan1.0NW_0049554583,999,143 - 4,029,523 (-)NCBIChiLan1.0ChiLan1.0
TIMELESS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,882,182 - 37,914,254 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,878,947 - 37,911,019 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,465,529 - 32,497,581 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,718,649 - 32,750,728 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,718,649 - 32,750,728 (+)EnsemblpanPan2panpan1.1
TIMELESS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110671,829 - 701,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10671,269 - 687,016 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha10735,035 - 764,351 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.010680,644 - 710,114 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10680,997 - 710,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110657,877 - 687,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010901,025 - 930,299 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,025,061 - 1,054,020 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Timeless
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,077,412 - 58,090,044 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646780,087 - 792,837 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936646780,021 - 792,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMELESS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,371,781 - 52,408,923 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,372,375 - 52,389,284 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037193,573,940 - 193,611,044 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timeless
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480211,605,116 - 11,629,911 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Timeless
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,703,674 - 155,722,672 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Timeless
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:128
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000047241
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D7Rat36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr871,248,854 - 1,249,021 (+)Marker Load Pipeline
mRatBN7.27664,270 - 664,437 (+)MAPPERmRatBN7.2
Rnor_6.072,653,138 - 2,653,304NCBIRnor6.0
Rnor_5.072,632,014 - 2,632,180UniSTSRnor5.0
RGSC_v3.471,526,178 - 1,526,344UniSTSRGSC3.4
RGSC_v3.471,526,177 - 1,526,344RGDRGSC3.4
Celera7540,630 - 540,796UniSTS
RGSC_v3.171,525,941 - 1,526,374RGD
SHRSP x BN Map70.04RGD
SHRSP x BN Map70.04UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 90 59 6 354 190 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB019576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047241   ⟹   ENSRNOP00000043366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7654,822 - 678,738 (+)Ensembl
Rnor_6.0 Ensembl72,643,288 - 2,667,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083899   ⟹   ENSRNOP00000070516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,239,450 - 1,263,337 (+)Ensembl
mRatBN7.2 Ensembl7654,822 - 678,738 (+)Ensembl
Rnor_6.0 Ensembl72,645,196 - 2,667,628 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116339   ⟹   ENSRNOP00000085093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,239,450 - 1,263,337 (+)Ensembl
mRatBN7.2 Ensembl7654,822 - 678,738 (+)Ensembl
RefSeq Acc Id: NM_031340   ⟹   NP_112630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,450 - 1,263,343 (+)NCBI
mRatBN7.27654,866 - 678,766 (+)NCBI
Rnor_6.072,643,288 - 2,667,329 (+)NCBI
Rnor_5.072,622,164 - 2,646,205 (+)NCBI
RGSC_v3.471,516,568 - 1,540,512 (+)RGD
Celera7533,427 - 554,888 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079948   ⟹   XP_038935876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,388 - 1,263,344 (+)NCBI
mRatBN7.27654,804 - 678,769 (+)NCBI
RefSeq Acc Id: XM_039079949   ⟹   XP_038935877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,240,837 - 1,263,344 (+)NCBI
mRatBN7.27656,710 - 678,769 (+)NCBI
RefSeq Acc Id: XM_039079950   ⟹   XP_038935878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,423 - 1,263,344 (+)NCBI
mRatBN7.27654,804 - 678,769 (+)NCBI
RefSeq Acc Id: XM_039079954   ⟹   XP_038935882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,423 - 1,263,344 (+)NCBI
mRatBN7.27654,804 - 678,769 (+)NCBI
RefSeq Acc Id: XM_063264304   ⟹   XP_063120374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,991 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264305   ⟹   XP_063120375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,991 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264306   ⟹   XP_063120376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,989 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264307   ⟹   XP_063120377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,989 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264308   ⟹   XP_063120378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,990 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264309   ⟹   XP_063120379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,248,991 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264310   ⟹   XP_063120380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,431 - 1,263,344 (+)NCBI
RefSeq Acc Id: XM_063264311   ⟹   XP_063120381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,239,452 - 1,263,344 (+)NCBI
RefSeq Acc Id: NP_112630   ⟸   NM_031340
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070516   ⟸   ENSRNOT00000083899
Ensembl Acc Id: ENSRNOP00000043366   ⟸   ENSRNOT00000047241
RefSeq Acc Id: XP_038935876   ⟸   XM_039079948
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038935878   ⟸   XM_039079950
- Peptide Label: isoform X2
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot),   A0A0G2JY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935882   ⟸   XM_039079954
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GBL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935877   ⟸   XM_039079949
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000085093   ⟸   ENSRNOT00000116339
RefSeq Acc Id: XP_063120380   ⟸   XM_063264310
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GBL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120381   ⟸   XM_063264311
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GBL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120376   ⟸   XM_063264306
- Peptide Label: isoform X3
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120377   ⟸   XM_063264307
- Peptide Label: isoform X4
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120378   ⟸   XM_063264308
- Peptide Label: isoform X5
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120374   ⟸   XM_063264304
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063120375   ⟸   XM_063264305
- Peptide Label: isoform X2
- UniProtKB: Q9Z2Y1 (UniProtKB/Swiss-Prot),   A0A0G2JY47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120379   ⟸   XM_063264309
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GBL8 (UniProtKB/TrEMBL)
Protein Domains
Timeless C-terminal   Timeless N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Y1-F1-model_v2 AlphaFold Q9Z2Y1 1-1205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694928
Promoter ID:EPDNEW_R5453
Type:multiple initiation site
Name:Timeless_1
Description:timeless circadian regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,643,264 - 2,643,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620939 AgrOrtholog
BioCyc Gene G2FUF-35387 BioCyc
Ensembl Genes ENSRNOG00000031916 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083899 ENTREZGENE
  ENSRNOT00000116339 ENTREZGENE
IMAGE_CLONE IMAGE:9101557 IMAGE-MGC_LOAD
InterPro Timeless UniProtKB/Swiss-Prot
  Timeless UniProtKB/Swiss-Prot
  TIMELESS_C UniProtKB/Swiss-Prot
KEGG Report rno:83508 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187364 IMAGE-MGC_LOAD
NCBI Gene 83508 ENTREZGENE
PANTHER PROTEIN TIMELESS HOMOLOG UniProtKB/Swiss-Prot
  PTHR22940 UniProtKB/Swiss-Prot
Pfam TIMELESS UniProtKB/Swiss-Prot
  TIMELESS_C UniProtKB/Swiss-Prot
PhenoGen Timeless PhenoGen
RatGTEx ENSRNOG00000031916 RatGTEx
UniProt A0A0G2JY47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBL8 ENTREZGENE, UniProtKB/TrEMBL
  A6KSB1_RAT UniProtKB/TrEMBL
  B1WBQ6_RAT UniProtKB/TrEMBL
  Q9Z2Y1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Timeless  timeless circadian regulator  Timeless  timeless circadian clock  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-02 Timeless  timeless circadian clock  Timeless  timeless homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Timeless  timeless homolog (Drosophila)    timeless (Drosophila) homolog  Name updated 1299863 APPROVED
2002-08-07 Timeless  timeless (Drosophila) homolog      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process full-length mammalian timeless protein expression in the suprachiasmatic nucleus disrupts the neuronal activity rhythms and alters the level of known core clock elements 734503
gene_regulation light pulses that induce phase delays cause elevation in mRNA level in mouse 734504