Rab5a (RAB5A, member RAS oncogene family) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Rab5a (RAB5A, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab5a (Ensembl: Rab5al1)
Name: RAB5A, member RAS oncogene family (Ensembl:Rab5a, member RAS oncogene family-like 1)
RGD ID: 620936
Description: Enables GDP-dissociation inhibitor binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and vesicle-mediated transport in synapse. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynaptic endocytic zone membrane. Orthologous to human RAB5A (RAB5A, member RAS oncogene family); PARTICIPATES IN autophagy pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ras-related protein Rab-5A; small GTP-binding protein rab5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,720,057 - 6,749,456 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl96,721,122 - 6,749,447 (+)EnsemblGRCr8
mRatBN7.296,483,906 - 6,512,877 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,484,469 - 6,512,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx97,630,486 - 7,658,751 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0912,788,023 - 12,816,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0911,952,310 - 11,980,643 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.095,910 - 6,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.095,572 - 5,722 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.491,492,864 - 1,516,405NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.191,492,865 - 1,516,405NCBI
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
chromium(6+)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
haloperidol  (ISO)
ivermectin  (ISO)
melittin  (ISO)
Mesaconitine  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
propiconazole  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, etal., Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629.
2. NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. Brown TC, etal., Neuron. 2005 Jan 6;45(1):81-94. doi: 10.1016/j.neuron.2004.12.023.
3. The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. de Hoop MJ, etal., Neuron. 1994 Jul;13(1):11-22.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Endosomal sorting of readily releasable synaptic vesicles. Hoopmann P, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19055-60. doi: 10.1073/pnas.1007037107. Epub 2010 Oct 18.
6. Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression. Huang CC, etal., J Biol Chem 2004 Mar 26;279(13):12286-92. Epub 2004 Jan 6.
7. Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. Ikin AF, etal., J Biol Chem. 1996 Dec 13;271(50):31783-6.
8. Rab proteins in endocytosis and Glut4 trafficking. Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
9. The proteins of synaptic vesicle membranes are affected during ageing of rat brain. Lee SR, etal., Exp Mol Med 2001 Dec 31;33(4):220-5.
10. RNAi-mediated Rab5a suppression inhibits proliferation and migration of vascular smooth muscle cells. Ma Z, etal., Acta Cardiol. 2010 Oct;65(5):507-14.
11. Overview of macroautophagy regulation in mammalian cells. Mehrpour M, etal., Cell Res. 2010 Jul;20(7):748-62. Epub 2010 Jun 15.
12. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Nashida T, etal., Arch Histol Cytol. 2003 Mar;66(1):45-52.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. EARP is a multisubunit tethering complex involved in endocytic recycling. Schindler C, etal., Nat Cell Biol. 2015 May;17(5):639-50. doi: 10.1038/ncb3129. Epub 2015 Mar 23.
19. Endocytosis-dominated membrane area decrease requires Rab5 protein in rat melanotrophs. Sedej S, etal., Ann N Y Acad Sci. 2005 Jun;1048:272-80.
20. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
21. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
22. Identification of Rab 5 but not Rab 3A in rat pancreatic zymogen granule membranes. Wagner AC, etal., Biochem Biophys Res Commun. 1994 Apr 15;200(1):542-8.
23. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
24. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
25. EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. Wilson JM, etal., Mol Biol Cell. 2000 Aug;11(8):2657-71.
26. Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells. Wolff NA, etal., Toxicol Appl Pharmacol. 2008 Jul 1;230(1):78-85. Epub 2008 Feb 20.
27. Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. Zhong P, etal., J Physiol. 2008 Sep 15;586(Pt 18):4465-79. Epub 2008 Jul 24.
Additional References at PubMed
PMID:8197185   PMID:9034150   PMID:11092755   PMID:12388596   PMID:12446704   PMID:12477932   PMID:14668490   PMID:14741744   PMID:14978216   PMID:15016378   PMID:15039456   PMID:15078902  
PMID:15128739   PMID:15378032   PMID:16141272   PMID:16380373   PMID:16880210   PMID:16890161   PMID:16902405   PMID:17267689   PMID:17562788   PMID:17716972   PMID:17765678   PMID:18034774  
PMID:18504258   PMID:18656450   PMID:18767904   PMID:18794329   PMID:19013132   PMID:19376974   PMID:19509052   PMID:19549681   PMID:19966785   PMID:20458337   PMID:21266579   PMID:21419809  
PMID:21645192   PMID:22279005   PMID:22431521   PMID:22493499   PMID:22783020   PMID:23382462   PMID:23416069   PMID:23687301   PMID:24029230   PMID:24035762   PMID:24334765   PMID:24891604  
PMID:25161316   PMID:25568335   PMID:25592972   PMID:25869668   PMID:26005850   PMID:26582200   PMID:27390154   PMID:27559088   PMID:29476059   PMID:30988348   PMID:36062786  


Genomics

Comparative Map Data
Rab5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr896,720,057 - 6,749,456 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl96,721,122 - 6,749,447 (+)EnsemblGRCr8
mRatBN7.296,483,906 - 6,512,877 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl96,484,469 - 6,512,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx97,630,486 - 7,658,751 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0912,788,023 - 12,816,289 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0911,952,310 - 11,980,643 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.095,910 - 6,065 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.095,572 - 5,722 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.491,492,864 - 1,516,405NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.191,492,865 - 1,516,405NCBI
Cytogenetic Map9q11NCBI
RAB5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38319,947,097 - 19,985,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl319,947,097 - 19,985,178 (+)Ensemblhg38GRCh38
GRCh37319,988,589 - 20,026,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36319,963,760 - 20,001,647 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34319,963,762 - 20,001,647NCBI
Celera319,929,100 - 19,967,199 (+)NCBICelera
Cytogenetic Map3p24.3NCBI
HuRef319,928,511 - 19,966,511 (+)NCBIHuRef
CHM1_1319,940,747 - 19,978,758 (+)NCBICHM1_1
T2T-CHM13v2.0319,951,230 - 19,989,247 (+)NCBIT2T-CHM13v2.0
Rab5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391753,786,262 - 53,814,706 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1753,786,262 - 53,814,708 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381753,479,234 - 53,507,678 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1753,479,234 - 53,507,680 (+)Ensemblmm10GRCm38
MGSCv371753,618,559 - 53,647,003 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361752,944,163 - 52,972,607 (+)NCBIMGSCv36mm8
Celera1756,925,059 - 56,953,192 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1727.82NCBI
Rab5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543011,992,449 - 12,040,003 (+)Ensembl
ChiLan1.0NW_00495543011,991,548 - 12,040,003 (+)NCBIChiLan1.0ChiLan1.0
RAB5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2219,913,592 - 19,951,348 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1319,918,359 - 19,956,115 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0319,866,110 - 19,903,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1320,197,067 - 20,234,579 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl320,197,067 - 20,234,579 (+)EnsemblpanPan2panpan1.1
RAB5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12323,303,650 - 23,333,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2323,304,940 - 23,332,206 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2323,330,152 - 23,357,439 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02323,790,486 - 23,820,520 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2323,788,850 - 23,819,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12323,503,982 - 23,531,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02323,569,385 - 23,596,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02323,815,500 - 23,842,853 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118179,099,612 - 179,128,766 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647312,238,156 - 12,269,089 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647312,238,226 - 12,267,339 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl136,905,390 - 6,941,423 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1136,905,302 - 6,940,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAB5A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11564,678,910 - 64,715,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1564,682,723 - 64,713,928 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604137,700,148 - 37,736,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab5a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248215,271,246 - 5,311,469 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rab5a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1490,508,209 - 90,539,230 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab5a
898 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:18
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000006677
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH136188  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21468,333,239 - 68,333,446 (+)MAPPERmRatBN7.2
mRatBN7.296,511,654 - 6,511,861 (+)MAPPERmRatBN7.2
Rnor_6.01472,948,353 - 72,948,559NCBIRnor6.0
Rnor_6.01472,889,928 - 72,890,134NCBIRnor6.0
Rnor_5.01472,908,844 - 72,909,050UniSTSRnor5.0
Rnor_5.01472,967,269 - 72,967,475UniSTSRnor5.0
RGSC_v3.41473,515,685 - 73,515,891UniSTSRGSC3.4
RGSC_v3.491,492,623 - 1,492,829UniSTSRGSC3.4
Celera1467,269,820 - 67,270,026UniSTS
Cytogenetic Map9q11UniSTS
RH136456  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21468,333,239 - 68,333,429 (+)MAPPERmRatBN7.2
mRatBN7.296,511,654 - 6,511,844 (+)MAPPERmRatBN7.2
Rnor_6.01472,948,353 - 72,948,542NCBIRnor6.0
Rnor_5.01472,967,269 - 72,967,458UniSTSRnor5.0
RGSC_v3.491,492,640 - 1,492,829UniSTSRGSC3.4
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084261   ⟹   ENSRNOP00000070031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl96,721,142 - 6,749,188 (+)Ensembl
mRatBN7.2 Ensembl96,484,561 - 6,512,609 (+)Ensembl
Rnor_6.0 Ensembl1472,889,038 - 72,949,307 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105898   ⟹   ENSRNOP00000087406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl96,484,469 - 6,512,872 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108726   ⟹   ENSRNOP00000080027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl96,721,122 - 6,749,447 (+)Ensembl
mRatBN7.2 Ensembl96,484,543 - 6,512,873 (+)Ensembl
RefSeq Acc Id: NM_022692   ⟹   NP_073183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,721,127 - 6,749,456 (+)NCBI
mRatBN7.296,484,546 - 6,512,877 (+)NCBI
Rnor_6.095,910 - 6,065 (-)NCBI
Rnor_5.095,572 - 5,722 (-)NCBI
RGSC_v3.491,492,864 - 1,516,405 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084178   ⟹   XP_038940106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,720,057 - 6,749,456 (+)NCBI
mRatBN7.296,483,958 - 6,512,877 (+)NCBI
RefSeq Acc Id: XM_039084181   ⟹   XP_038940109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,720,057 - 6,738,792 (+)NCBI
mRatBN7.296,483,908 - 6,502,211 (+)NCBI
RefSeq Acc Id: XM_063267691   ⟹   XP_063123761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,722,340 - 6,749,456 (+)NCBI
RefSeq Acc Id: XM_063267692   ⟹   XP_063123762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr896,733,567 - 6,749,456 (+)NCBI
RefSeq Acc Id: NP_073183   ⟸   NM_022692
- UniProtKB: A0A8I5ZS76 (UniProtKB/TrEMBL),   A0A8I6A5S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038940109   ⟸   XM_039084181
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038940106   ⟸   XM_039084178
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS76 (UniProtKB/TrEMBL),   A0A8I6A5S3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080027   ⟸   ENSRNOT00000108726
Ensembl Acc Id: ENSRNOP00000087406   ⟸   ENSRNOT00000105898
Ensembl Acc Id: ENSRNOP00000070031   ⟸   ENSRNOT00000084261
RefSeq Acc Id: XP_063123761   ⟸   XM_063267691
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS76 (UniProtKB/TrEMBL),   A0A8I6A5S3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123762   ⟸   XM_063267692
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RC99-F1-model_v2 AlphaFold M0RC99 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620936 AgrOrtholog
BioCyc Gene G2FUF-28397 BioCyc
Ensembl Genes ENSRNOG00000057056 Ensembl, ENTREZGENE
  ENSRNOG00000062595 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000100183.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108726 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9025210 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:100361891 UniProtKB/Swiss-Prot
  rno:64633 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187370 IMAGE-MGC_LOAD
NCBI Gene 64633 ENTREZGENE
PANTHER PTHR47978 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab5a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057056 RatGTEx
  ENSRNOG00000062595 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZS76 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5S3 ENTREZGENE
  M0RC99 ENTREZGENE
  Q6IN17_RAT UniProtKB/TrEMBL
  RAB5A_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88565 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab5a  RAB5A, member RAS oncogene family    small GTP-binding protein rab5  Name updated 1299863 APPROVED
2002-08-07 Rab5a  small GTP-binding protein rab5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the synaptosome and to synaptic vesicles 704358