Cry2 (cryptochrome circadian regulator 2) - Rat Genome Database

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Gene: Cry2 (cryptochrome circadian regulator 2) Rattus norvegicus
Analyze
Symbol: Cry2
Name: cryptochrome circadian regulator 2
RGD ID: 620935
Description: Predicted to enable several functions, including DNA binding activity; FAD binding activity; and enzyme binding activity. Involved in circadian rhythm. Predicted to be located in extracellular region and mitochondrion. Predicted to be part of Cry-Per complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CRY2 (cryptochrome circadian regulator 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,830,479 - 98,860,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,830,483 - 98,860,447 (-)EnsemblGRCr8
mRatBN7.2378,374,995 - 78,405,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl378,374,995 - 78,404,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,850,766 - 81,880,732 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0390,449,805 - 90,479,779 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0388,300,907 - 88,330,825 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0381,314,151 - 81,344,143 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl381,314,149 - 81,344,110 (-)Ensemblrn6Rnor6.0
Rnor_5.0388,018,201 - 88,048,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,802,782 - 76,830,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,577,028 - 77,606,933 (-)NCBICelera
RGSC_v3.1376,699,209 - 76,727,330 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
cocaine hydrochloride  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
melatonin  (EXP)
methamphetamine  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (EXP)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Cry-Per complex  (ISO)
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
extracellular region  (IEA,ISO)
mitochondrion  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of cryptochrome2 cDNA in the rat. Eun BK, etal., Mol Cells 2001 Dec 31;12(3):286-91.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Reduced expression of circadian clock genes in male alcoholic patients. Huang MC, etal., Alcohol Clin Exp Res. 2010 Nov;34(11):1899-904. doi: 10.1111/j.1530-0277.2010.01278.x. Epub 2010 Aug 24.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
8. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. van der Horst GT, etal., Nature 1999 Apr 15;398(6728):627-30.
Additional References at PubMed
PMID:8909283   PMID:9383998   PMID:9753616   PMID:9801304   PMID:12024206   PMID:12397359   PMID:12477932   PMID:12627958   PMID:12738229   PMID:14645221   PMID:14672706   PMID:15147242  
PMID:15689618   PMID:15751956   PMID:17264215   PMID:17310242   PMID:19299583   PMID:19605937   PMID:20123978   PMID:20424134   PMID:20840750   PMID:21680841   PMID:22170608   PMID:22871113  
PMID:23503662   PMID:23531614   PMID:23575670   PMID:23616524   PMID:24158435   PMID:24549704   PMID:24619734   PMID:24736997   PMID:28683290   PMID:28751364   PMID:29561690   PMID:33070440  


Genomics

Comparative Map Data
Cry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,830,479 - 98,860,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,830,483 - 98,860,447 (-)EnsemblGRCr8
mRatBN7.2378,374,995 - 78,405,001 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl378,374,995 - 78,404,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,850,766 - 81,880,732 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0390,449,805 - 90,479,779 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0388,300,907 - 88,330,825 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0381,314,151 - 81,344,143 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl381,314,149 - 81,344,110 (-)Ensemblrn6Rnor6.0
Rnor_5.0388,018,201 - 88,048,651 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,802,782 - 76,830,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,577,028 - 77,606,933 (-)NCBICelera
RGSC_v3.1376,699,209 - 76,727,330 (-)NCBI
Cytogenetic Map3q24NCBI
CRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,847,118 - 45,883,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,847,118 - 45,883,248 (+)Ensemblhg38GRCh38
GRCh371145,868,669 - 45,904,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,825,605 - 45,861,372 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341145,825,604 - 45,861,372NCBI
Celera1146,016,277 - 46,052,408 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1145,575,511 - 45,611,656 (+)NCBIHuRef
CHM1_11145,866,091 - 45,902,224 (+)NCBICHM1_1
T2T-CHM13v2.01146,003,044 - 46,039,180 (+)NCBIT2T-CHM13v2.0
Cry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39292,233,991 - 92,264,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl292,233,991 - 92,264,388 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38292,403,646 - 92,434,085 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl292,403,646 - 92,434,043 (-)Ensemblmm10GRCm38
MGSCv37292,243,803 - 92,274,226 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36292,204,485 - 92,234,867 (-)NCBIMGSCv36mm8
Celera293,769,997 - 93,827,329 (-)NCBICelera
Cytogenetic Map2E1NCBI
Cry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554222,083,138 - 2,115,072 (-)Ensembl
ChiLan1.0NW_0049554222,084,020 - 2,114,980 (-)NCBIChiLan1.0ChiLan1.0
CRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,055,778 - 48,091,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,062,647 - 48,098,524 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01145,801,504 - 45,837,357 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,293,874 - 46,329,759 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,293,717 - 46,329,759 (+)EnsemblpanPan2panpan1.1
CRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,538,335 - 43,573,651 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,539,612 - 43,573,875 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1842,266,185 - 42,301,504 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01844,194,112 - 44,229,456 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1844,194,116 - 44,229,483 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,678,350 - 43,713,658 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01843,231,326 - 43,266,645 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,963,597 - 43,998,926 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494721,022,207 - 21,056,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365623,133,633 - 3,168,480 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365623,133,849 - 3,168,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,587,109 - 16,620,385 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1216,587,101 - 16,620,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,893,190 - 17,926,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,459,734 - 19,498,807 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,472,231 - 19,498,790 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038116,735,973 - 116,773,999 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,621,311 - 2,653,071 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247672,622,786 - 2,652,663 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cry2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1566,587,706 - 66,616,230 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cry2
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:203
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000010142
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
RH141789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2378,375,284 - 78,375,471 (+)MAPPERmRatBN7.2
Rnor_6.0381,314,441 - 81,314,627NCBIRnor6.0
Rnor_5.0388,018,491 - 88,018,677UniSTSRnor5.0
RGSC_v3.4376,801,225 - 76,801,411UniSTSRGSC3.4
Celera377,577,318 - 77,577,504UniSTS
Cytogenetic Map3q24UniSTS
Cry2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2378,375,148 - 78,376,700 (+)MAPPERmRatBN7.2
Rnor_6.0381,314,305 - 81,315,856NCBIRnor6.0
Rnor_5.0388,018,355 - 88,019,906UniSTSRnor5.0
RGSC_v3.4376,801,089 - 76,802,640UniSTSRGSC3.4
Celera377,577,182 - 77,578,733UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010142   ⟹   ENSRNOP00000010142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,830,483 - 98,860,447 (-)Ensembl
mRatBN7.2 Ensembl378,374,995 - 78,404,965 (-)Ensembl
Rnor_6.0 Ensembl381,314,149 - 81,344,110 (-)Ensembl
RefSeq Acc Id: NM_133405   ⟹   NP_596896
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,830,479 - 98,860,437 (-)NCBI
mRatBN7.2378,374,995 - 78,404,953 (-)NCBI
Rnor_6.0381,314,151 - 81,344,109 (-)NCBI
Rnor_5.0388,018,201 - 88,048,651 (-)NCBI
RGSC_v3.4376,802,782 - 76,830,902 (-)RGD
Celera377,577,028 - 77,606,933 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283037   ⟹   XP_063139107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,830,479 - 98,851,561 (-)NCBI
RefSeq Acc Id: XM_063283038   ⟹   XP_063139108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,830,479 - 98,849,359 (-)NCBI
RefSeq Acc Id: NP_596896   ⟸   NM_133405
- UniProtKB: Q923I8 (UniProtKB/Swiss-Prot),   B2GUU9 (UniProtKB/TrEMBL),   A6HNH4 (UniProtKB/TrEMBL),   A6HNH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010142   ⟸   ENSRNOT00000010142
RefSeq Acc Id: XP_063139107   ⟸   XM_063283037
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139108   ⟸   XM_063283038
- Peptide Label: isoform X2
Protein Domains
Photolyase/cryptochrome alpha/beta

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923I8-F1-model_v2 AlphaFold Q923I8 1-594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692224
Promoter ID:EPDNEW_R2749
Type:multiple initiation site
Name:Cry2_1
Description:cryptochrome circadian regulator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0381,344,120 - 81,344,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620935 AgrOrtholog
BioCyc Gene G2FUF-48698 BioCyc
Ensembl Genes ENSRNOG00000007478 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010142 ENTREZGENE
Gene3D-CATH 1.25.40.80 UniProtKB/Swiss-Prot
  3.40.50.620 UniProtKB/Swiss-Prot
  DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9033484 IMAGE-MGC_LOAD
InterPro Crypto/Photolyase_FAD-like_sf UniProtKB/Swiss-Prot
  Crypto/Photolyase_N_sf UniProtKB/Swiss-Prot
  Cryptochr/Photolyase_FAD-bd UniProtKB/Swiss-Prot
  Cryptochrome/DNA_photolyase_1 UniProtKB/Swiss-Prot
  DNA_photolyase_N UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
MGC_CLONE MGC:187339 IMAGE-MGC_LOAD
NCBI Gene 170917 ENTREZGENE
PANTHER CRYPTOCHROME-2 UniProtKB/Swiss-Prot
  PTHR11455 UniProtKB/Swiss-Prot
Pfam DNA_photolyase UniProtKB/Swiss-Prot
  FAD_binding_7 UniProtKB/Swiss-Prot
PhenoGen Cry2 PhenoGen
PROSITE PHR_CRY_ALPHA_BETA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007478 RatGTEx
Superfamily-SCOP SSF48173 UniProtKB/Swiss-Prot
  SSF52425 UniProtKB/Swiss-Prot
UniProt A6HNH4 ENTREZGENE, UniProtKB/TrEMBL
  A6HNH5 ENTREZGENE, UniProtKB/TrEMBL
  B2GUU9 ENTREZGENE
  CRY2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Cry2  cryptochrome circadian regulator 2  Cry2  cryptochrome circadian clock 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-01-23 Cry2  cryptochrome circadian clock 2  Cry2  cryptochrome 2 (photolyase-like)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cry2  cryptochrome 2 (photolyase-like)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cry2  cryptochrome 2 (photolyase-like)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all of the tissues; expressed higher level in peripheral tissues than in the brain 632584