Rab27a (RAB27A, member RAS oncogene family) - Rat Genome Database

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Gene: Rab27a (RAB27A, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab27a
Name: RAB27A, member RAS oncogene family
RGD ID: 620918
Description: Enables protein domain specific binding activity. Predicted to be involved in several processes, including complement-dependent cytotoxicity; positive regulation of biosynthetic process; and regulation of vesicle-mediated transport. Predicted to act upstream of or within several processes, including melanocyte differentiation; melanosome transport; and secretion by cell. Located in Weibel-Palade body; apical plasma membrane; and melanosome. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to human RAB27A (RAB27A, member RAS oncogene family); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTP-binding protein Ram; low Mr GTP-binding protein; MGC112618; rab-27; ram; ram p25; ras-related protein Rab-27A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8882,663,373 - 82,717,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl882,663,276 - 82,717,262 (+)EnsemblGRCr8
mRatBN7.2873,782,730 - 73,836,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,782,694 - 73,847,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx879,306,073 - 79,359,615 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,578,681 - 77,632,264 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,416,032 - 75,469,605 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,722,334 - 79,776,228 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,722,334 - 79,776,221 (+)Ensemblrn6Rnor6.0
Rnor_5.0873,311,535 - 73,366,647 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4877,798,830 - 77,861,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera867,919,443 - 67,972,735 (-)NCBICelera
RGSC_v3.1877,817,883 - 77,880,143 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
erianin  (ISO)
ethyl methanesulfonate  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
irinotecan  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenol red  (ISO)
potassium chromate  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IBA,IDA)
cytoplasm  (IEA)
dendrite  (IEA,ISO)
endomembrane system  (IEA)
exocytic vesicle  (IBA,IEA,ISO)
Golgi apparatus  (IBA,IEA,ISO)
late endosome  (IEA,ISO,ISS)
lysosome  (IEA,ISO)
melanosome  (IBA,IDA,IEA,ISO)
membrane  (IEA)
multivesicular body membrane  (IEA,ISO)
photoreceptor outer segment  (IEA,ISO)
secretory granule  (IBA,IDA,IEA,ISO)
Weibel-Palade body  (IDA)

Molecular Function
G protein activity  (IEA,ISO,ISS)
GDP binding  (IEA,ISO,ISS)
GTP binding  (IBA,IEA,ISO,ISS)
GTPase activity  (IBA,IEA,ISO,ISS)
hydrolase activity  (IEA)
metal ion binding  (IEA)
myosin V binding  (IEA,ISO)
nucleotide binding  (IEA)
protein binding  (IPI,ISO)
protein domain specific binding  (IPI)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A. Anikster Y, etal., Am J Hum Genet. 2002 Aug;71(2):407-14. Epub 2002 Jun 7.
2. Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. Bahadoran P, etal., J Biol Chem. 2003 Mar 28;278(13):11386-92. Epub 2003 Jan 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells. Goishi K, etal., Biochem Biophys Res Commun. 2004 Nov 5;324(1):294-301.
6. Differential dynamics of Rab3A and Rab27A on secretory granules. Handley MT, etal., J Cell Sci. 2007 Mar 15;120(Pt 6):973-84. doi: 10.1242/jcs.03406. Epub 2007 Feb 20.
7. Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Imai A, etal., Arch Biochem Biophys. 2006 Nov 15;455(2):127-35. Epub 2006 Oct 9.
8. The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Imai A, etal., J Cell Sci. 2004 Apr 15;117(Pt 10):1945-53. Epub 2004 Mar 23.
9. Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets. Kondo H, etal., J Biol Chem. 2006 Sep 29;281(39):28657-65. Epub 2006 Jul 31.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. The ram: a novel low molecular weight GTP-binding protein cDNA from a rat megakaryocyte library. Nagata K, etal., FEBS Lett 1990 Nov 26;275(1-2):29-32.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
18. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. Wasmeier C, etal., J Cell Biol. 2006 Oct 23;175(2):271-81. doi: 10.1083/jcb.200606050. Epub 2006 Oct 16.
19. A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis. Zografou S, etal., J Cell Sci. 2012 Oct 15;125(Pt 20):4780-90. doi: 10.1242/jcs.104174. Epub 2012 Aug 16.
Additional References at PubMed
PMID:1527078   PMID:2379821   PMID:9066979   PMID:10859366   PMID:11266470   PMID:11266473   PMID:11266474   PMID:11887186   PMID:11964381   PMID:11980908   PMID:12477932   PMID:14722103  
PMID:14724135   PMID:14978221   PMID:15357836   PMID:15548590   PMID:15572405   PMID:17237785   PMID:18573236   PMID:18812475   PMID:18940603   PMID:19056867   PMID:19717423   PMID:19966785  
PMID:20937701   PMID:22157766   PMID:22275436   PMID:23092844   PMID:23533145   PMID:23702376   PMID:24404184   PMID:25051489   PMID:30771381  


Genomics

Comparative Map Data
Rab27a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8882,663,373 - 82,717,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl882,663,276 - 82,717,262 (+)EnsemblGRCr8
mRatBN7.2873,782,730 - 73,836,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl873,782,694 - 73,847,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx879,306,073 - 79,359,615 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0877,578,681 - 77,632,264 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0875,416,032 - 75,469,605 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0879,722,334 - 79,776,228 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl879,722,334 - 79,776,221 (+)Ensemblrn6Rnor6.0
Rnor_5.0873,311,535 - 73,366,647 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4877,798,830 - 77,861,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera867,919,443 - 67,972,735 (-)NCBICelera
RGSC_v3.1877,817,883 - 77,880,143 (+)NCBI
Cytogenetic Map8q24NCBI
RAB27A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381555,202,966 - 55,319,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1555,202,966 - 55,319,113 (-)Ensemblhg38GRCh38
GRCh371555,495,164 - 55,582,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361553,283,084 - 53,369,293 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341553,283,093 - 53,349,877NCBI
Celera1532,384,380 - 32,470,592 (-)NCBICelera
Cytogenetic Map15q21.3NCBI
HuRef1532,320,428 - 32,407,649 (-)NCBIHuRef
CHM1_11555,613,105 - 55,700,081 (-)NCBICHM1_1
T2T-CHM13v2.01553,006,127 - 53,122,312 (-)NCBIT2T-CHM13v2.0
Rab27a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39972,952,092 - 73,004,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl972,952,136 - 73,004,911 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38973,044,810 - 73,097,623 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl973,044,854 - 73,097,629 (+)Ensemblmm10GRCm38
MGSCv37972,892,672 - 72,945,399 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36972,841,997 - 72,894,724 (+)NCBIMGSCv36mm8
Celera970,231,031 - 70,283,807 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map940.08NCBI
Rab27a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955409588,254 - 621,874 (+)Ensembl
ChiLan1.0NW_004955409588,725 - 621,874 (+)NCBIChiLan1.0ChiLan1.0
RAB27A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21644,469,463 - 44,561,427 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11548,650,359 - 48,737,460 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01534,174,491 - 34,263,045 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11552,498,202 - 52,584,731 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1552,498,202 - 52,529,984 (-)EnsemblpanPan2panpan1.1
RAB27A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13020,633,576 - 20,706,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3020,635,400 - 20,690,521 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3020,593,848 - 20,654,911 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03020,784,185 - 20,855,234 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3020,784,188 - 20,855,192 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13020,722,265 - 20,783,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03020,812,483 - 20,867,409 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03020,943,977 - 20,999,165 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab27a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864098,890,138 - 98,967,479 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647116,738,230 - 16,815,943 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647116,738,204 - 16,815,561 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB27A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,532,974 - 116,606,474 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11116,532,816 - 116,606,477 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21129,070,103 - 129,144,161 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB27A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12628,140,972 - 28,227,847 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2628,197,464 - 28,227,963 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048113,038,948 - 113,126,658 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab27a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247316,319,092 - 6,355,534 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247316,315,064 - 6,355,431 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rab27a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1867,413,718 - 67,435,525 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab27a
934 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:596
Count of miRNA genes:284
Interacting mature miRNAs:354
Transcripts:ENSRNOT00000010012
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat

Markers in Region
RH130727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2873,835,222 - 73,835,418 (+)MAPPERmRatBN7.2
Rnor_6.0879,774,821 - 79,775,016NCBIRnor6.0
Rnor_5.0873,312,747 - 73,312,942UniSTSRnor5.0
RGSC_v3.4877,859,684 - 77,859,879UniSTSRGSC3.4
Celera867,920,649 - 67,920,844UniSTS
RH 3.4 Map15301.8UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083957   ⟹   ENSRNOP00000068946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl882,663,276 - 82,717,262 (+)Ensembl
mRatBN7.2 Ensembl873,782,694 - 73,847,829 (+)Ensembl
Rnor_6.0 Ensembl879,722,334 - 79,776,221 (+)Ensembl
RefSeq Acc Id: NM_017317   ⟹   NP_059013
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8882,663,373 - 82,717,261 (+)NCBI
mRatBN7.2873,782,730 - 73,836,624 (+)NCBI
Rnor_6.0879,722,334 - 79,776,222 (+)NCBI
Rnor_5.0873,311,535 - 73,366,647 (-)NCBI
RGSC_v3.4877,798,830 - 77,861,090 (+)RGD
Celera867,919,443 - 67,972,735 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082004   ⟹   XP_038937932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8882,681,876 - 82,717,267 (+)NCBI
mRatBN7.2873,801,233 - 73,836,630 (+)NCBI
RefSeq Acc Id: XM_063266033   ⟹   XP_063122103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8882,671,537 - 82,717,267 (+)NCBI
RefSeq Acc Id: XM_063266034   ⟹   XP_063122104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8882,683,517 - 82,717,267 (+)NCBI
RefSeq Acc Id: XM_063266035   ⟹   XP_063122105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8882,685,246 - 82,717,267 (+)NCBI
RefSeq Acc Id: NP_059013   ⟸   NM_017317
- UniProtKB: Q4KMA7 (UniProtKB/Swiss-Prot),   P23640 (UniProtKB/Swiss-Prot),   A6KEK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068946   ⟸   ENSRNOT00000083957
RefSeq Acc Id: XP_038937932   ⟸   XM_039082004
- Peptide Label: isoform X1
- UniProtKB: P23640 (UniProtKB/Swiss-Prot),   Q4KMA7 (UniProtKB/Swiss-Prot),   A6KEK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122103   ⟸   XM_063266033
- Peptide Label: isoform X1
- UniProtKB: Q4KMA7 (UniProtKB/Swiss-Prot),   P23640 (UniProtKB/Swiss-Prot),   A6KEK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122104   ⟸   XM_063266034
- Peptide Label: isoform X1
- UniProtKB: Q4KMA7 (UniProtKB/Swiss-Prot),   P23640 (UniProtKB/Swiss-Prot),   A6KEK7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122105   ⟸   XM_063266035
- Peptide Label: isoform X1
- UniProtKB: Q4KMA7 (UniProtKB/Swiss-Prot),   P23640 (UniProtKB/Swiss-Prot),   A6KEK7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23640-F1-model_v2 AlphaFold P23640 1-221 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696123
Promoter ID:EPDNEW_R6647
Type:initiation region
Name:Rab27a_1
Description:RAB27A, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0879,722,239 - 79,722,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620918 AgrOrtholog
BioCyc Gene G2FUF-29852 BioCyc
Ensembl Genes ENSRNOG00000052499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083957 ENTREZGENE
  ENSRNOT00000083957.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7384913 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rab27a/b UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rab UniProtKB/Swiss-Prot
KEGG Report rno:50645 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112618 IMAGE-MGC_LOAD
NCBI Gene 50645 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab27a PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052499 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6KEK7 ENTREZGENE, UniProtKB/TrEMBL
  P23640 ENTREZGENE
  Q4KMA7 ENTREZGENE
  RB27A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4KMA7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Rab27a  RAB27A, member RAS oncogene family    low Mr GTP-binding protein  Name updated 1299863 APPROVED
2004-09-10 Rab27a  low Mr GTP-binding protein  ram    Symbol and Name updated 1299863 APPROVED
2002-08-07 ram  low Mr GTP-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in megakaryocytes and platelets 633807