Fbn2 (fibrillin 2) - Rat Genome Database

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Gene: Fbn2 (fibrillin 2) Rattus norvegicus
Analyze
Symbol: Fbn2
Name: fibrillin 2
RGD ID: 620910
Description: Predicted to enable hormone activity. Predicted to be involved in several processes, including bone trabecula formation; eye development; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within embryonic limb morphogenesis. Predicted to be located in extracellular region and microfibril. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital contractural arachnodactyly and scoliosis. Orthologous to human FBN2 (fibrillin 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibrillin-2; fibrillin-2-like; LOC102553271; LOC689008; similar to fibrillin 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81853,696,197 - 53,901,992 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1853,697,708 - 53,902,191 (-)EnsemblGRCr8
mRatBN7.21851,499,670 - 51,703,976 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1851,499,737 - 51,703,976 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1853,530,293 - 53,735,692 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01854,244,849 - 54,450,243 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01852,050,395 - 52,254,717 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01853,068,495 - 53,272,254 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1853,068,495 - 53,181,503 (-)Ensemblrn6Rnor6.0
Rnor_5.01852,284,482 - 52,487,739 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41853,883,011 - 53,914,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1849,628,059 - 49,829,139 (-)NCBICelera
RGSC_v3.11853,946,953 - 54,078,364NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
chlorogenic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
indometacin  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
propanal  (ISO)
puerarin  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis. Buchan JG, etal., Hum Mol Genet. 2014 Oct 1;23(19):5271-82. doi: 10.1093/hmg/ddu224. Epub 2014 May 15.
2. Mutation of the gene encoding fibrillin-2 results in syndactyly in mice. Chaudhry SS, etal., Hum Mol Genet 2001 Apr 1;10(8):835-43.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Ten novel FBN2 mutations in congenital contractural arachnodactyly: delineation of the molecular pathogenesis and clinical phenotype. Gupta PA, etal., Hum Mutat 2002 Jan;19(1):39-48.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning of rat fibrillin-2 cDNA and its role in branching morphogenesis of embryonic lung. Yang Q, etal., Dev Biol 1999 Aug 1;212(1):229-42.
Additional References at PubMed
PMID:8120105   PMID:10700192   PMID:11350121   PMID:14681019   PMID:20855508   PMID:23658023   PMID:24348270   PMID:25406291   PMID:26405179  


Genomics

Comparative Map Data
Fbn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81853,696,197 - 53,901,992 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1853,697,708 - 53,902,191 (-)EnsemblGRCr8
mRatBN7.21851,499,670 - 51,703,976 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1851,499,737 - 51,703,976 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1853,530,293 - 53,735,692 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01854,244,849 - 54,450,243 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01852,050,395 - 52,254,717 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01853,068,495 - 53,272,254 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1853,068,495 - 53,181,503 (-)Ensemblrn6Rnor6.0
Rnor_5.01852,284,482 - 52,487,739 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41853,883,011 - 53,914,001 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1849,628,059 - 49,829,139 (-)NCBICelera
RGSC_v3.11853,946,953 - 54,078,364NCBI
Cytogenetic Map18q12.1NCBI
FBN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385128,257,909 - 128,538,245 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5128,257,909 - 128,659,185 (-)Ensemblhg38GRCh38
GRCh375127,593,601 - 127,873,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365127,621,500 - 127,901,634 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345127,621,627 - 127,901,195NCBI
Celera5123,725,605 - 124,005,813 (-)NCBICelera
Cytogenetic Map5q23.3NCBI
HuRef5122,784,332 - 123,064,311 (-)NCBIHuRef
CHM1_15127,026,171 - 127,306,337 (-)NCBICHM1_1
T2T-CHM13v2.05128,776,747 - 129,057,063 (-)NCBIT2T-CHM13v2.0
Fbn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391858,141,689 - 58,343,200 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1858,141,695 - 58,343,559 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381858,008,623 - 58,210,572 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1858,008,623 - 58,210,487 (-)Ensemblmm10GRCm38
MGSCv371858,168,277 - 58,369,580 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361858,135,627 - 58,335,174 (-)NCBIMGSCv36mm8
Celera1859,320,066 - 59,527,555 (-)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1832.15NCBI
Fbn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554151,309,077 - 1,537,052 (-)Ensembl
ChiLan1.0NW_0049554151,307,553 - 1,535,435 (-)NCBIChiLan1.0ChiLan1.0
FBN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24123,567,395 - 123,847,929 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15121,706,955 - 121,987,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05123,673,209 - 123,953,741 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15129,435,248 - 129,715,699 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5129,435,248 - 129,715,711 (-)EnsemblpanPan2panpan1.1
FBN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,311,238 - 17,551,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,311,226 - 17,551,536 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1116,107,059 - 16,346,938 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01118,048,902 - 18,289,161 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,048,887 - 18,289,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,778,944 - 17,018,819 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,618,045 - 16,858,590 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,228,746 - 17,469,482 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213139,961,651 - 140,183,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365041,535,624 - 1,757,435 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365041,535,629 - 1,757,386 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2131,150,667 - 131,370,466 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12131,150,665 - 131,370,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22136,502,442 - 136,602,300 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12331,204,652 - 31,476,677 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2331,204,391 - 31,475,820 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603446,561,539 - 46,838,522 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477412,863,446 - 13,116,545 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477412,863,446 - 13,116,929 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fbn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11573,626,989 - 73,834,050 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbn2
5190 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000066548
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Rat92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,514,825 - 51,515,008 (+)MAPPERmRatBN7.2
Rnor_6.01853,083,584 - 53,083,766NCBIRnor6.0
Rnor_5.01852,299,571 - 52,299,753UniSTSRnor5.0
Rnor_5.01852,255,071 - 52,255,253UniSTSRnor5.0
RGSC_v3.41853,898,100 - 53,898,282UniSTSRGSC3.4
RGSC_v3.41853,898,099 - 53,898,282RGDRGSC3.4
Celera1849,643,148 - 49,643,330UniSTS
RGSC_v3.11853,962,000 - 53,962,432RGD
SHRSP x BN Map1820.5099RGD
SHRSP x BN Map1820.5099UniSTS
Cytogenetic Map18q12.1UniSTS
D18Rat137  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81853,877,240 - 53,877,467 (+)Marker Load Pipeline
mRatBN7.21851,679,218 - 51,679,445 (+)MAPPERmRatBN7.2
Rnor_6.01853,247,504 - 53,247,730NCBIRnor6.0
Rnor_5.01852,462,989 - 52,463,215UniSTSRnor5.0
RGSC_v3.41853,987,908 - 53,988,134UniSTSRGSC3.4
RGSC_v3.41853,987,907 - 53,988,134RGDRGSC3.4
Celera1849,804,377 - 49,804,603UniSTS
RGSC_v3.11854,051,850 - 54,052,077RGD
FHH x ACI Map1829.33RGD
FHH x ACI Map1829.33UniSTS
Cytogenetic Map18q12.1UniSTS
BI282166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,499,785 - 51,499,998 (+)MAPPERmRatBN7.2
Rnor_6.01853,068,544 - 53,068,756NCBIRnor6.0
Rnor_5.01852,284,531 - 52,284,743UniSTSRnor5.0
Rnor_5.01852,240,031 - 52,240,243UniSTSRnor5.0
RGSC_v3.41853,883,060 - 53,883,272UniSTSRGSC3.4
Celera1849,628,108 - 49,628,320UniSTS
Cytogenetic Map18q12.1UniSTS
BE120754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,521,626 - 51,521,785 (+)MAPPERmRatBN7.2
Rnor_6.01853,090,385 - 53,090,543NCBIRnor6.0
Rnor_5.01852,306,372 - 52,306,530UniSTSRnor5.0
Rnor_5.01852,261,872 - 52,262,030UniSTSRnor5.0
RGSC_v3.41853,904,901 - 53,905,059UniSTSRGSC3.4
Celera1849,649,701 - 49,649,859UniSTS
RH 3.4 Map18473.52UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 148 90 89 58 26 58 6 277 125 11 127 70 92 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000066548   ⟹   ENSRNOP00000059245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1853,697,708 - 53,902,191 (-)Ensembl
mRatBN7.2 Ensembl1851,499,737 - 51,703,976 (-)Ensembl
Rnor_6.0 Ensembl1853,068,495 - 53,181,503 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094362   ⟹   ENSRNOP00000097724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1853,697,708 - 53,902,191 (-)Ensembl
mRatBN7.2 Ensembl1851,499,737 - 51,703,976 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158649   ⟹   ENSRNOP00000109987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1853,697,708 - 53,902,191 (-)Ensembl
RefSeq Acc Id: NM_031826   ⟹   NP_114014
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81853,697,693 - 53,901,992 (-)NCBI
mRatBN7.21851,499,670 - 51,703,976 (-)NCBI
Rnor_6.01853,068,495 - 53,272,254 (-)NCBI
Rnor_5.01852,284,482 - 52,487,739 (-)NCBI
RGSC_v3.41853,883,011 - 53,914,001 (-)RGD
Celera1849,628,059 - 49,829,139 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097130   ⟹   XP_038953058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81853,696,197 - 53,809,761 (-)NCBI
mRatBN7.21851,499,772 - 51,611,742 (-)NCBI
Protein Sequences
Protein RefSeqs NP_114014 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953058 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD34439 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059245
  ENSRNOP00000059245.4
  ENSRNOP00000097724.2
  ENSRNOP00000109987.1
RefSeq Acc Id: NP_114014   ⟸   NM_031826
- Peptide Label: precursor
- UniProtKB: A6IX89 (UniProtKB/TrEMBL),   F1M5Q4 (UniProtKB/TrEMBL),   Q9WUH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059245   ⟸   ENSRNOT00000066548
RefSeq Acc Id: XP_038953058   ⟸   XM_039097130
- Peptide Label: isoform X1
- UniProtKB: A6IX88 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097724   ⟸   ENSRNOT00000094362
Ensembl Acc Id: ENSRNOP00000109987   ⟸   ENSRNOT00000158649
Protein Domains
EGF-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M5Q4-F1-model_v2 AlphaFold F1M5Q4 1-2590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620910 AgrOrtholog
BioCyc Gene G2FUF-7408 BioCyc
Ensembl Genes ENSRNOG00000043219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066548 ENTREZGENE
  ENSRNOT00000066548.5 UniProtKB/TrEMBL
  ENSRNOT00000094362.2 UniProtKB/TrEMBL
  ENSRNOT00000158649.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.290.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro cEGF UniProtKB/TrEMBL
  EGF-like_reg_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EGF_dom UniProtKB/TrEMBL
  FBN_EGF_N UniProtKB/TrEMBL
  Fibrillin_U_N UniProtKB/TrEMBL
  Growth_fac_rcpt UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/TrEMBL
  TFG_b-bd UniProtKB/TrEMBL
  vWF_C/EGF_Fibrillin UniProtKB/TrEMBL
KEGG Report rno:689008 UniProtKB/TrEMBL
NCBI Gene Fbn2 ENTREZGENE
PANTHER EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  FIBRILLIN-3 UniProtKB/TrEMBL
  VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam cEGF UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FBN_EGF_st1 UniProtKB/TrEMBL
  Fibrillin_U_N UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  PF00683 UniProtKB/TrEMBL
PhenoGen Fbn2 PhenoGen
PIRSF Fibrillin UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  PS51364 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043219 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  Fibril-assoc UniProtKB/TrEMBL
  Grow_fac_recept UniProtKB/TrEMBL
UniProt A0A8I6GMN0_RAT UniProtKB/TrEMBL
  A0ABK0LGM3_RAT UniProtKB/TrEMBL
  A6IX88 ENTREZGENE, UniProtKB/TrEMBL
  A6IX89 ENTREZGENE, UniProtKB/TrEMBL
  F1M5Q4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUH9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Fbn2  fibrillin 2  LOC102553271  fibrillin-2-like  Data merged from RGD:7521297 737654 PROVISIONAL
2013-12-17 LOC102553271  fibrillin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2007-10-22 Fbn2  fibrillin 2  LOC689008  similar to fibrillin 2  Data merged from RGD:1597478 737654 APPROVED
2006-11-20 LOC689008  similar to fibrillin 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Fbn2  fibrillin 2    fibrillin-2  Name updated 1299863 APPROVED
2002-08-07 Fbn2  fibrillin-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease treatment with the antisense oligodeoxynucleotide induces dysmorphogenesis of the lung explants 632680
gene_domains has two RGD binding sites, transforming growth factor-beta binding protein motifs and Ca(2+) binding epidermal growth factor-like domains 632680
gene_expression expressed in mesenchyme on the 13th day of gestation and in epithelial:mesenchymal interface from 13th to 19th day, expression decreased during the postnatal period 632680
gene_homology 88% homologous to the human gene 632680
gene_process modulates organogenesis of the lung by epithelial:mesenchymal interactions 632680