Ptpn12 (protein tyrosine phosphatase, non-receptor type 12) - Rat Genome Database

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Gene: Ptpn12 (protein tyrosine phosphatase, non-receptor type 12) Rattus norvegicus
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Symbol: Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
RGD ID: 620894
Description: Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ptpg1; RKPTP; tyrosine-protein phosphatase non-receptor type 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,913,071 - 14,985,084 (+)NCBIGRCr8
mRatBN7.2414,020,997 - 14,092,931 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,021,052 - 14,092,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,158,307 - 19,230,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,960,328 - 15,032,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,343,956 - 13,415,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,631,129 - 10,702,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,631,073 - 10,702,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,623,632 - 10,695,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,517,642 - 9,589,954 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.149,517,585 - 9,574,832 (+)NCBI
Celera49,582,368 - 9,654,126 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptpn12RatChromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB  ISOPTPN12 (Homo sapiens)8554872ClinVar Annotator: match by term: DISTAL CHROMOSOME 7q11.23 DELETION SYNDROMEClinVar 
Ptpn12Ratcolon carcinoma  ISOPTPN12 (Homo sapiens)8554872ClinVar Annotator: match by term: Carcinoma of colonClinVarPMID:7509295
Ptpn12Ratcolorectal cancer  ISOPTPN12 (Homo sapiens)8554872ClinVar Annotator: match by term: PTPN12-related conditionClinVarPMID:25741868
Ptpn12Ratpleomorphic xanthoastrocytoma  ISOPTPN12 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptpn12RatColorectal Neoplasms  ISOPTPN12 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ptpn12Ratcolorectal cancer  ISOPTPN12 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Term
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Source
Original Reference(s)
Ptpn12Rat(-)-epigallocatechin 3-gallate multiple interactionsISOPTPN12 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTPN12 mRNACTDPMID:22079256
Ptpn12Rat1,2-dimethylhydrazine decreases expressionISOPtpn12 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PTPN12 mRNACTDPMID:22206623
Ptpn12Rat1,2-dimethylhydrazine multiple interactionsISOPtpn12 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTPN12 mRNACTDPMID:22206623
Ptpn12Rat17beta-estradiol affects expressionISOPTPN12 (Homo sapiens)6480464Estradiol affects the expression of PTPN12 mRNACTDPMID:22574217
Ptpn12Rat17beta-estradiol multiple interactionsISOPTPN12 (Homo sapiens)6480464[Estradiol co-treated with Norethindrone Acetate] results in increased expression of PTPN12 mRNACTDPMID:22217510
Ptpn12Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOPTPN12 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPtpn12 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PTPN12 mRNACTDPMID:19770486
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PTPN12 mRNACTDPMID:34747641
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPtpn12 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PTPN12 mRNACTDPMID:25975270
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPtpn12 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PTPN12 mRNACTDPMID:21570461
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPtpn12 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PTPN12 mRNACTDPMID:21354282
Ptpn12Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PTPN12 mRNACTDPMID:21215274 and PMID:33387578
Ptpn12Rat2,4,6-tribromophenol decreases expressionISOPTPN12 (Homo sapiens)64804642 more ...CTDPMID:31675489
Ptpn12Rat2-butoxyethanol increases expressionISOPtpn12 (Mus musculus)6480464n-butoxyethanol results in increased expression of PTPN12 mRNACTDPMID:19812364
Ptpn12Rat3',5'-cyclic GMP increases activityEXP 6480464Cyclic GMP results in increased activity of PTPN12 proteinCTDPMID:12714323
Ptpn12Rat4,4'-sulfonyldiphenol increases expressionISOPtpn12 (Mus musculus)6480464bisphenol S results in increased expression of PTPN12 mRNACTDPMID:39298647
Ptpn12Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of PTPN12 mRNACTDPMID:30047161
Ptpn12Ratafimoxifene multiple interactionsISOPTPN12 (Homo sapiens)6480464afimoxifene inhibits the reaction [Estrogens results in decreased expression of PTPN12 mRNA]CTDPMID:21233418
Ptpn12Rataflatoxin B1 increases expressionISOPtpn12 (Mus musculus)6480464Aflatoxin B1 results in increased expression of PTPN12 mRNACTDPMID:19770486
Ptpn12Rataflatoxin B1 increases expressionISOPTPN12 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of PTPN12 mRNACTDPMID:27153756

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Biological Process
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Cellular Component
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Object Symbol
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Original Reference(s)
Ptpn12Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Ptpn12Ratcytoplasm is_active_inIBAMGI:104673 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ptpn12Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Ptpn12Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Ptpn12Ratcytoplasm located_inIEAUniRule:UR0000013731600115GO_REF:0000104UniProtGO_REF:0000104
Ptpn12Ratcytosol located_inISOPtpn12 (Mus musculus)1624291 PMID:7772023RGDPMID:7772023
Ptpn12Ratcytosol located_inIEAUniProtKB:P35831 and ensembl:ENSMUSP000000305561600115GO_REF:0000107EnsemblGO_REF:0000107
Ptpn12Ratnucleus is_active_inIBAMGI:107170 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ptpn12Ratpodosome located_inISOPtpn12 (Mus musculus)1624291 PMID:12674328RGDPMID:12674328
Ptpn12Ratpodosome located_inIEAUniProtKB:P35831 and ensembl:ENSMUSP000000305561600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Object Symbol
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Reference
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Original Reference(s)
Ptpn12Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Ptpn12Ratnon-membrane spanning protein tyrosine phosphatase activity enablesIEAInterPro:IPR0471701600115GO_REF:0000002InterProGO_REF:0000002
Ptpn12Ratphosphoprotein phosphatase activity enablesISOPTPN12 (Homo sapiens)1624291 PMID:27134172RGDPMID:27134172
Ptpn12Ratphosphoprotein phosphatase activity enablesIEAUniProtKB:Q05209 and ensembl:ENSP000002485941600115GO_REF:0000107EnsemblGO_REF:0000107
Ptpn12Ratphosphoprotein phosphatase activity enablesIEAUniProtKB:P35831 and ensembl:ENSMUSP000000305561600115GO_REF:0000107EnsemblGO_REF:0000107
Ptpn12Ratphosphoprotein phosphatase activity enablesIEAUniRule:UR0000013731600115GO_REF:0000104UniProtGO_REF:0000104
Ptpn12Ratphosphoprotein phosphatase activity enablesIEAARBA:ARBA000276511600115GO_REF:0000117UniProtGO_REF:0000117
Ptpn12Ratphosphoprotein phosphatase activity enablesISOPtpn12 (Mus musculus)1624291 PMID:7772023RGDPMID:7772023
Ptpn12Ratphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Ptpn12Ratprotein binding enablesISOPTPN12 (Homo sapiens)1624291UniProtKB:O43586 more ...RGDPMID:11971877 more ...
Ptpn12Ratprotein binding enablesISOPtpn12 (Mus musculus)1624291PR:Q8VI36 more ...RGDPMID:11711533 more ...
Ptpn12Ratprotein tyrosine phosphatase activity  IDA 633766 RGD 
Ptpn12Ratprotein tyrosine phosphatase activity enablesIEAEC:3.1.3.481600115GO_REF:0000003UniProtGO_REF:0000003
Ptpn12Ratprotein tyrosine phosphatase activity enablesIEAInterPro:IPR0002421600115GO_REF:0000002InterProGO_REF:0000002
Ptpn12Ratprotein tyrosine phosphatase activity enablesIBAMGI:107170 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ptpn12Ratprotein tyrosine phosphatase activity enablesIEAInterPro:IPR000242 and InterPro:IPR0122661600115GO_REF:0000002InterProGO_REF:0000002
Ptpn12Ratprotein tyrosine phosphatase activity enablesISOPTPN12 (Homo sapiens)1624291 PMID:21376233RGDPMID:21376233
Ptpn12RatSH3 domain binding enablesISOPTPN12 (Homo sapiens)1624291UniProtKB:P56945 and PMID:9285683RGDPMID:9285683
Ptpn12RatSH3 domain binding enablesIEAUniProtKB:Q05209 and ensembl:ENSP000002485941600115GO_REF:0000107EnsemblGO_REF:0000107
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells. Kitamura T, etal., Jpn J Cancer Res. 1995 Sep;86(9):811-8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney. Moriyama T, etal., FEBS Lett 1994 Oct 24;353(3):305-8.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:7772023   PMID:9285683   PMID:12674328   PMID:16354758   PMID:21376233   PMID:24791697   PMID:27061092   PMID:27134172  



Ptpn12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,913,071 - 14,985,084 (+)NCBIGRCr8
mRatBN7.2414,020,997 - 14,092,931 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl414,021,052 - 14,092,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx419,158,307 - 19,230,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,960,328 - 15,032,112 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0413,343,956 - 13,415,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0410,631,129 - 10,702,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl410,631,073 - 10,702,386 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0410,623,632 - 10,695,128 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.449,517,642 - 9,589,954 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.149,517,585 - 9,574,832 (+)NCBI
Celera49,582,368 - 9,654,126 (+)NCBICelera
Cytogenetic Map4q11NCBI
PTPN12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38777,537,295 - 77,640,069 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl777,537,295 - 77,640,069 (+)EnsemblGRCh38hg38GRCh38
GRCh37777,166,612 - 77,269,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36777,004,771 - 77,107,322 (+)NCBINCBI36Build 36hg18NCBI36
Build 34776,811,485 - 76,914,037NCBI
Celera771,867,421 - 71,970,039 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef771,768,818 - 71,871,494 (+)NCBIHuRef
CHM1_1777,097,083 - 77,199,758 (+)NCBICHM1_1
T2T-CHM13v2.0778,789,201 - 78,891,996 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2776,499,836 - 76,602,451 (+)NCBI
Ptpn12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,191,643 - 21,261,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,191,643 - 21,260,909 (-)EnsemblGRCm39 Ensembl
GRCm38520,986,645 - 21,055,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl520,986,645 - 21,055,911 (-)EnsemblGRCm38mm10GRCm38
MGSCv37520,492,463 - 20,561,615 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36520,498,469 - 20,567,621 (-)NCBIMGSCv36mm8
Celera517,944,646 - 18,014,696 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.83NCBI
Ptpn12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554107,557,103 - 7,599,139 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554107,556,283 - 7,599,170 (-)NCBIChiLan1.0ChiLan1.0
PTPN12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2695,387,345 - 95,490,209 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17143,651,984 - 143,754,849 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0769,457,158 - 69,560,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1783,268,834 - 83,371,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl783,268,834 - 83,371,120 (+)Ensemblpanpan1.1panPan2
PTPN12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11817,608,665 - 17,692,543 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1817,607,936 - 17,692,219 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1817,266,233 - 17,315,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01817,927,205 - 18,011,994 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,927,265 - 18,011,993 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11817,677,847 - 17,762,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01817,617,247 - 17,702,020 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,886,436 - 17,971,250 (+)NCBIUU_Cfam_GSD_1.0
Ptpn12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,785,782 - 59,892,793 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,909,551 - 21,016,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,909,557 - 21,016,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9102,480,924 - 102,563,751 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19102,480,914 - 102,563,969 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29112,920,939 - 112,961,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12171,285,917 - 71,389,645 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2171,285,736 - 71,389,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604232,533,869 - 32,637,803 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473926,747,830 - 26,828,535 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ptpn12
280 total Variants

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:188
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000017907
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat

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RH143589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,067,650 - 14,067,779 (+)MAPPERmRatBN7.2
Rnor_6.0410,677,559 - 10,677,687NCBIRnor6.0
Rnor_5.0410,670,289 - 10,670,417UniSTSRnor5.0
RGSC_v3.449,564,180 - 9,564,308UniSTSRGSC3.4
Celera49,628,900 - 9,629,028UniSTS
RH 3.4 Map459.2UniSTS
Cytogenetic Map4q11UniSTS
PTPN12_1837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2414,092,075 - 14,092,706 (+)MAPPERmRatBN7.2
Rnor_6.0410,701,535 - 10,702,165NCBIRnor6.0
Rnor_5.0410,694,273 - 10,694,903UniSTSRnor5.0
RGSC_v3.449,589,103 - 9,589,733UniSTSRGSC3.4
Celera49,653,275 - 9,653,905UniSTS
Cytogenetic Map4q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017907   ⟹   ENSRNOP00000017907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,108 - 14,092,927 (+)Ensembl
Rnor_6.0 Ensembl410,631,129 - 10,702,386 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081939   ⟹   ENSRNOP00000075346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,052 - 14,079,703 (+)Ensembl
Rnor_6.0 Ensembl410,631,073 - 10,688,211 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106350   ⟹   ENSRNOP00000079518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl414,021,108 - 14,092,927 (+)Ensembl
RefSeq Acc Id: NM_057115   ⟹   NP_476456
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,274 - 14,985,080 (+)NCBI
mRatBN7.2414,021,108 - 14,092,927 (+)NCBI
Rnor_6.0410,631,129 - 10,702,386 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
RGSC_v3.449,517,642 - 9,589,954 (+)RGD
Celera49,582,368 - 9,654,126 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235868   ⟹   XP_006235930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,071 - 14,985,084 (+)NCBI
mRatBN7.2414,020,997 - 14,092,931 (+)NCBI
Rnor_6.0410,631,139 - 10,702,390 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235870   ⟹   XP_006235932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,187 - 14,985,084 (+)NCBI
mRatBN7.2414,021,021 - 14,092,931 (+)NCBI
Rnor_6.0410,631,253 - 10,702,390 (+)NCBI
Rnor_5.0410,623,632 - 10,695,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285423   ⟹   XP_063141493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,176 - 14,985,084 (+)NCBI
RefSeq Acc Id: XM_063285424   ⟹   XP_063141494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,913,667 - 14,985,084 (+)NCBI
RefSeq Acc Id: NP_476456   ⟸   NM_057115
- UniProtKB: G3V7Q4 (UniProtKB/TrEMBL),   A6K5C4 (UniProtKB/TrEMBL),   A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235930   ⟸   XM_006235868
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235932   ⟸   XM_006235870
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075346   ⟸   ENSRNOT00000081939
Ensembl Acc Id: ENSRNOP00000017907   ⟸   ENSRNOT00000017907
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Name Modeler Protein Id AA Range Protein Structure
AF-G3V7Q4-F1-model_v2 AlphaFold G3V7Q4 1-766 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692813
Promoter ID:EPDNEW_R3337
Type:initiation region
Name:Ptpn12_1
Description:protein tyrosine phosphatase, non-receptor type 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0410,631,133 - 10,631,193EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-45963 BioCyc
Ensembl Genes ENSRNOG00000013135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017907 ENTREZGENE
  ENSRNOT00000017907.6 UniProtKB/TrEMBL
  ENSRNOT00000081939.2 UniProtKB/TrEMBL
  ENSRNOT00000106350 ENTREZGENE
  ENSRNOT00000106350.1 UniProtKB/TrEMBL
  ENSRNOT00000122000 ENTREZGENE
  ENSRNOT00000126039 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTN12/18/22 UniProtKB/TrEMBL
  PTN12_cat UniProtKB/TrEMBL
  Tyr/Dual-specificity_Pase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_non-rcpt_typ-12 UniProtKB/TrEMBL
  Tyr_Pase_rcpt/non-rcpt UniProtKB/TrEMBL
KEGG Report rno:117255 UniProtKB/TrEMBL
NCBI Gene 117255 ENTREZGENE
PANTHER TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptpn12 PhenoGen
PIRSF Tyr-Ptase_nr12 UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013135 RatGTEx
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A0G2KAC5_RAT UniProtKB/TrEMBL
  A0A8I5ZN71 ENTREZGENE, UniProtKB/TrEMBL
  A6K5C4 ENTREZGENE, UniProtKB/TrEMBL
  G3V7Q4 ENTREZGENE, UniProtKB/TrEMBL
  Q63745_RAT UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ptpn12  protein tyrosine phosphatase, non-receptor type 12      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ptpn12  protein tyrosine phosphatase, non-receptor type 12      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_protein a 382 amino acid protein with a M(r) of 44,438 633766