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Gene: Ptpn12 (protein tyrosine phosphatase, non-receptor type 12) Rattus norvegicus

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Symbol:

Ptpn12

Name:

protein tyrosine phosphatase, non-receptor type 12

RGD ID:

620894

Description:

Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic GMP; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Ptpg1; RKPTP; tyrosine-protein phosphatase non-receptor type 12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,913,071 - 14,985,084 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	14,913,218 - 14,985,284 (+)	Ensembl				GRCr8
mRatBN7.2	4	14,020,997 - 14,092,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	14,021,052 - 14,092,927 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	19,158,307 - 19,230,084 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,960,328 - 15,032,112 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,343,956 - 13,415,737 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,631,129 - 10,702,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,631,073 - 10,702,386 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	10,623,632 - 10,695,128 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	9,517,642 - 9,589,954 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	9,582,368 - 9,654,126 (+)	NCBI		Celera
RGSC_v3.1	4	9,517,585 - 9,574,832 (+)	NCBI
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colon carcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-butoxyethanol (ISO)

3',5'-cyclic GMP (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

caffeine (ISO)

calcium atom (EXP)

calcium(0) (EXP)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

enzyme inhibitor (ISO)

flavonoids (EXP)

folic acid (ISO)

FR900359 (ISO)

geldanamycin (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

hypochlorous acid (ISO)

indometacin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

lead diacetate (ISO)

leflunomide (ISO)

mercury dichloride (ISO)

methimazole (EXP)

methotrexate (ISO)

N(6)-dimethylallyladenine (ISO)

nitrates (ISO)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tebufenpyrad (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc protoporphyrin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to epidermal growth factor stimulus (IEA,ISO)

peptidyl-tyrosine dephosphorylation (ISO)

protein dephosphorylation (ISO)

regulation of epidermal growth factor receptor signaling pathway (IBA,IEA,ISO)

tissue regeneration (IEP)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (IEA,ISO)

nucleus (IBA)

podosome (IEA,ISO)

Molecular Function

hydrolase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA,ISO)

protein binding (ISO)

protein tyrosine phosphatase activity (IBA,IDA,IEA,ISO)

SH3 domain binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.	Kitamura T, etal., Jpn J Cancer Res. 1995 Sep;86(9):811-8.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney.	Moriyama T, etal., FEBS Lett 1994 Oct 24;353(3):305-8.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:7772023	PMID:9285683	PMID:12674328	PMID:16354758	PMID:21376233	PMID:24791697	PMID:27061092	PMID:27134172

Genomics

Comparative Map Data

Ptpn12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,913,071 - 14,985,084 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	14,913,218 - 14,985,284 (+)	Ensembl				GRCr8
mRatBN7.2	4	14,020,997 - 14,092,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	14,021,052 - 14,092,927 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	19,158,307 - 19,230,084 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,960,328 - 15,032,112 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,343,956 - 13,415,737 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,631,129 - 10,702,390 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,631,073 - 10,702,386 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	10,623,632 - 10,695,128 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	9,517,642 - 9,589,954 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	9,582,368 - 9,654,126 (+)	NCBI		Celera
RGSC_v3.1	4	9,517,585 - 9,574,832 (+)	NCBI
Cytogenetic Map	4	q11	NCBI

PTPN12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	77,537,295 - 77,640,069 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	77,537,295 - 77,640,072 (+)	Ensembl			hg38	GRCh38
GRCh37	7	77,166,612 - 77,269,386 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	77,004,771 - 77,107,322 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	76,811,485 - 76,914,037	NCBI
Celera	7	71,867,421 - 71,970,039 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,768,818 - 71,871,494 (+)	NCBI		HuRef
CHM1_1	7	77,097,083 - 77,199,758 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	78,789,201 - 78,891,996 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,499,836 - 76,602,451 (+)	NCBI

Ptpn12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,191,643 - 21,261,009 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,191,643 - 21,260,909 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	20,986,645 - 21,055,911 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	20,986,645 - 21,055,911 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	20,492,463 - 20,561,615 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,498,469 - 20,567,621 (-)	NCBI		MGSCv36	mm8
Celera	5	17,944,646 - 18,014,696 (-)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

Ptpn12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	7,557,103 - 7,599,139 (-)	Ensembl
ChiLan1.0	NW_004955410	7,556,283 - 7,599,170 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTPN12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	95,387,345 - 95,490,209 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	143,651,984 - 143,754,849 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	69,457,158 - 69,560,111 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	83,268,834 - 83,371,120 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	83,268,834 - 83,371,120 (+)	Ensembl			panPan2	panpan1.1

PTPN12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	17,608,665 - 17,692,543 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	17,607,936 - 17,692,219 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	17,266,233 - 17,315,593 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	17,927,205 - 18,011,994 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	17,927,265 - 18,011,993 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	17,677,847 - 17,762,567 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	17,617,247 - 17,702,020 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	17,886,436 - 17,971,250 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ptpn12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	59,785,782 - 59,892,793 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	20,909,551 - 21,016,606 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	20,909,557 - 21,016,562 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTPN12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	102,480,924 - 102,563,751 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	102,480,914 - 102,563,969 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	112,920,939 - 112,961,308 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTPN12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	71,285,917 - 71,389,645 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	71,285,736 - 71,389,926 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	32,533,869 - 32,637,803 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptpn12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624739	26,747,830 - 26,828,535 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ptpn12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	150,291,963 - 150,359,885 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ptpn12
603 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	282
Count of miRNA genes:	188
Interacting mature miRNAs:	212
Transcripts:	ENSRNOT00000017907
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	13080146	58080146	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	32668025	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	28392287	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	32668025	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	34142783	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	34142783	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	31106810	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	28392287	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	32668025	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	28392287	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	8428551	30449094	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	33538816	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	32668025	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10758701	40490708	Rat

Markers in Region

RH143589

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	14,067,650 - 14,067,779 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	10,677,559 - 10,677,687	NCBI	Rnor6.0
Rnor_5.0	4	10,670,289 - 10,670,417	UniSTS	Rnor5.0
RGSC_v3.4	4	9,564,180 - 9,564,308	UniSTS	RGSC3.4
Celera	4	9,628,900 - 9,629,028	UniSTS
RH 3.4 Map	4	59.2	UniSTS
Cytogenetic Map	4	q11	UniSTS

PTPN12_1837

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	14,092,075 - 14,092,706 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	10,701,535 - 10,702,165	NCBI	Rnor6.0
Rnor_5.0	4	10,694,273 - 10,694,903	UniSTS	Rnor5.0
RGSC_v3.4	4	9,589,103 - 9,589,733	UniSTS	RGSC3.4
Celera	4	9,653,275 - 9,653,905	UniSTS
Cytogenetic Map	4	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BP489229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK367675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV102923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CX570435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D38072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY560717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017907 ⟹ ENSRNOP00000017907

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	14,913,219 - 14,985,083 (+)	Ensembl
mRatBN7.2 Ensembl	4	14,021,108 - 14,092,927 (+)	Ensembl
Rnor_6.0 Ensembl	4	10,631,129 - 10,702,386 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081939 ⟹ ENSRNOP00000075346

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	14,913,218 - 14,971,865 (+)	Ensembl
mRatBN7.2 Ensembl	4	14,021,052 - 14,079,703 (+)	Ensembl
Rnor_6.0 Ensembl	4	10,631,073 - 10,688,211 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106350 ⟹ ENSRNOP00000079518

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	14,913,274 - 14,985,080 (+)	Ensembl
mRatBN7.2 Ensembl	4	14,021,108 - 14,092,927 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122000 ⟹ ENSRNOP00000102951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	14,913,274 - 14,985,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126039 ⟹ ENSRNOP00000111147

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	14,913,652 - 14,985,083 (+)	Ensembl

RefSeq Acc Id:

NM_057115 ⟹ NP_476456

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,913,274 - 14,985,080 (+)	NCBI
mRatBN7.2	4	14,021,108 - 14,092,927 (+)	NCBI
Rnor_6.0	4	10,631,129 - 10,702,386 (+)	NCBI
Rnor_5.0	4	10,623,632 - 10,695,128 (+)	NCBI
RGSC_v3.4	4	9,517,642 - 9,589,954 (+)	RGD
Celera	4	9,582,368 - 9,654,126 (+)	RGD

Sequence:

show sequence

CGGAGCGAGCTGGGGAAGACGGAGCGGGCGCTGCGGCGCGCGGGCGGGCGGCGGGGGGGACGCG
GGAGGATGGAGCAAGTGGAGATTCTGAGGAGGTTCATCCAGAGGGTCCAGGCCATGAAAAGTCC
GGACCACAATGGGGAGGACAACTTCGCCCGGGACTTCATGCGATTGAGAAGATTGTCTACCAAA
TATAGAACAGAAAAGATTTATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAACA
GATATAAGGACATACTGCCATTTGATCACAGCCGAGTTAAGTTGACTTTGAAGACACCATCCCA
AGATTCAGATTATATCAATGCAAATTTTATTAAGGGTGTATATGGGCCGAGAGCATACGTGGCA
ACCCAAGGGCCTTTGGCGAATACAGTCATAGACTTCTGGAGGATGATATGGGAGTACAATGTGG
TGATCATTGTAATGGCCTGTCGTGAATTTGAGATGGGAAGGAAAAAGTGTGAGCGCTATTGGCC
TTTGTATGGAGAAGATCCTATAACATTTGCACCATTTAAAATTTCTTGTGAAAATGAACAAGCA
AGAACAGACTACTTCATTCGAACACTTTTACTTGAATTTCAAAATGAATCCCGTCGACTCTATC
AGTTTCATTACGTGAACTGGCCAGACCATGATGTCCCTTCGTCATTCGATTCTATCCTGGACAT
GATAAGTCTAATGAGGAAGTACCAAGAGCACGAAGATGTGCCTATTTGTATCCATTGCAGTGCA
GGCTGTGGACGGACAGGTGCTATTTGTGCCATCGACTACACGTGGAACTTACTGAAAGCAGGGA
AAATTCCAGAGGAATTTAATGTATTTAATTTAATACAAGAAATGAGAACACAAAGGCACTCTGC
AGTACAAACGAAGGAGCAGTATGAACTCGTCCATAGAGCTATTGCCCAACTGTTTGAAAAACAG
CTACAACTGTATGAAATCCACGGAGCCCAGAAAATCACTGATGGTAATGAAATTAGCACTGGAA
ACATGGTCAGTTCCATTGATAGTGAAAAACAAGATTCTCCTCCTCCAAAGCCACCACGGACTCG
AAGTTGTCTTGTAGAGGGGGATGCCAAGGAAGAAATCCTCCAGCCACCAGAGCCTCACCCGGTG
CCGCCCATCCTGACACCGTCGCCTCCTTCAGCATTCCCAACCGTTACCACTGTGTGGCAAGACA
GTGACAGGTACCACCCAAAGCCAGTGCTGCACATGGCTTCCCCAGAGCAGCCCCCAACGGACCT
CAACAGAAACTATGATAAGTCAGCGGACCTAATGGGGAGAAGCGAATCTGCTGTTGAGCACACA
GATAAAAAGTTAGAACAAAATTTAAGTTTTGAGATTAAGAAAGTCCCTCTCCAAGAAGGGCCCA
AAAGTTTTGATGGGAACACACTCTTGAATAGGGGACATGCGATTAAAATTAAGTCTGCTTCATC
TTCTGTAGTTGACAAAAGCTCTAAGCCACAGGAGTTAAGTTCAGGTGATCTAAAGGTTCACGAT
GTGTCTCAGAATTCCTGTGCGGACTGCAGTGCCTCACACTTAGACAACGCTCCTGAGTCTTCAG
AAGAGTCCCAGAACTCACACACACCTCCACGGCCAGACTGCTTGCCCCTTGATAAGAAAGGACA
TGTGACATGGTCACTTCATGGACCTGAAAATGCCACACCTGTATCTGACTCACCAGATAATCAT
TCTCAAACTCTAAAAACTGTGAGTTCCACACCAAACTCGACAGCAGAAGAGGAATCCCACGATC
TCACAGAGCACCATAACAGCTCCCCTCTGCCGAGAGCTCCTCTCAGCTTTACCAACCCTCTTCA
CTCTGACGACTCCGACTCAGACGAAGGGAACTCCGATGGTGCTGTGACCAAGAACAAAACTAGC
ATTTCAACAGCAAGTGCCACCGTGTCTCCTGCCAGTAGTACCGAGAGTGCTTGCACTAGGAGAG
TACTGCCCATGTCCATTGCCAGGCAGGAAATGGCAGGAAGGCGGCATTCAGGTGCTGAGAAAGA
TGCTGACGTTAGTGAAGAGTCGCCTCCTCCCTTACCTGAAAGAACTCCCGAGTCTTTTGTATTA
GCAGATATGCCCATAAGATCTGATTGGCATGAACTTCCAAGTCAGGAGTGCTCGGAGCACAGGG
AATCTGAAGGCTTGATAACCTCTGGAAATGACAAACACGATGCAGGGGTTTCCCACACAGCGGC
TTGTTCACCCACTTTCAGTGACAAGAAAGAGGAAATAACAGAAAGTCTAACAGAAGTCACAGAC
ATTGGTTTTGGTAATCGCTGTGGAAAACCTAAAGGACCAAGAGATCCACCTTCAGAATGGACAT
GATTCAGGGAGTTAAAAGACACTTTAAATTATACTGGAAAATTCAAGTGCCACTGAAAGCCAGA
TTTATAGTATTCCATCTTTAAAATGTGGGACTGATAGCAGTGTAGATTGTTACCTTAATATTTT
TTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAGAAAGTATTACATATTGTTTATTTT
GTAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACAAGCTGCTTGTAGACCTGTT
AATATAGTAATACTTTTATGATAAACTGAGTTAAAGGACTACTCTTTTGCTGTTTTATCATGTA
TGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATAATTTGATAAAGTTGAAGTCCTAAAA
TATTATTAACAGAAGATGTAAGAATTTCTGCATGGTTTAAGTCTTTGTGTATCTTACTTGTAAA
TTATTTGCCCTGAAATTTTAGAAAACTGTTTCTGAATTTTAAACTTGCTGGATTCGTGTAGCCA
GCATTGCAGGTTATCAGAGATCAAAGAGTGTAATAATAATACCTTTTGTAAATTGTAAGCAAAA
AGTTATTTTTATATTATATACTGTCTAATTGTTCACCCTAATGGTTCTTGTTTTCGTCTAGTCA
TGGAGATTCAGTAAGTGCCTTGGAACAACATTGACTTCCCTTAGCTCGAGTGTGTTACTTTCAA
GTTTGAATTCAACTGGGGTTAGAAGACTATCAGAATCTATGTATGTTTCAGGATATTTGTTGAC
CTGCCATTAAAAAAACAAACAGTTTTACACT

hide sequence

RefSeq Acc Id:

XM_006235868 ⟹ XP_006235930

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,913,071 - 14,985,084 (+)	NCBI
mRatBN7.2	4	14,020,997 - 14,092,931 (+)	NCBI
Rnor_6.0	4	10,631,139 - 10,702,390 (+)	NCBI
Rnor_5.0	4	10,623,632 - 10,695,128 (+)	NCBI

Sequence:

show sequence

TGGGGAAGACGGAGCGGGCGCTGCGGCGCGCGGGCGGGCGGCGGGGGGGACGCGGGAGGATGGA
GCAAGTGGAGATTCTGAGGAGGTTCATCCAGAGGGTCCAGGCCATGAAAAGTCCGGACCACAAT
GGGGAGGACAACTTCGCCCGGGACTTCATGCGATTGAGAAGATTGTCTACCAAATATAGAACAG
AAAAGATTTATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAACAGATATAAGGA
CATACTGCCATTTGATCACAGCCGAGTTAAGTTGACTTTGAAGACACCATCCCAAGATTCAGAT
TATATCAATGCAAATTTTATTAAGGGTGTATATGGGCCGAGAGCATACGTGGCAACCCAAGGGC
CTTTGGCGAATACAGTCATAGACTTCTGGAGGATGATATGGGAGTACAATGTGGTGATCATTGT
AATGGCCTGTCGTGAATTTGAGATGGGAAGGAAAAAGTGTGAGCGCTATTGGCCTTTGTATGGA
GAAGATCCTATAACATTTGCACCATTTAAAATTTCTTGTGAAAATGAACAAGCAAGAACAGACT
ACTTCATTCGAACACTTTTACTTGAATTTCAAAATGAATCCCGTCGACTCTATCAGTTTCATTA
CGTGAACTGGCCAGACCATGATGTCCCTTCGTCATTCGATTCTATCCTGGACATGATAAGTCTA
ATGAGGAAGTACCAAGAGCACGAAGATGTGCCTATTTGTATCCATTGCAGTGCAGGCTGTGGAC
GGACAGGTGCTATTTGTGCCATCGACTACACGTGGAACTTACTGAAAGCAGGGAAAATTCCAGA
GGAATTTAATGTATTTAATTTAATACAAGAAATGAGAACACAAAGGCACTCTGCAGTACAAACG
AAGGAGCAGTATGAACTCGTCCATAGAGCTATTGCCCAACTGTTTGAAAAACAGCTACAACTGT
ATGAAATCCACGGAGCCCAGAAAATCACTGATGGTAATGAAATTAGCACTGGAAACATGGTCAG
TTCCATTGATAGTGAAAAACAAGATTCTCCTCCTCCAAAGCCACCACGGACTCGAAGTTGTCTT
GTAGAGGGGGATGCCAAGGAAGAAATCCTCCAGCCACCAGAGCCTCACCCGGTGCCGCCCATCC
TGACACCGTCGCCTCCTTCAGCATTCCCAACCGTTACCACTGTGTGGCAAGACAGTGACAGGTA
CCACCCAAAGCCAGTGCTGCACATGGCTTCCCCAGAGCAGCCCCCAACGGACCTCAACAGAAAC
TATGATAAGTCAGCGGACCTAATGGGGAGAAGCGAATCTGCTGTTGAGCACACAGATAAAAAGT
TAGAACAAAATTTAAGTTTTGAGATTAAGAAAGTCCCTCTCCAAGAAGGGCCCAAAAGTTTTGA
TGGGAACACACTCTTGAATAGGGGACATGCGATTAAAATTAAGTCTGCTTCATCTTCTGTAGTT
GACAAAAGCTCTAAGCCACAGGAGTTAAGTTCAGGTGATCTAAAGGTTCACGATGTGTCTCAGA
ATTCCTGTGCGGACTGCAGTGCCTCACACTTAGACAACGCTCCTGAGTCTTCAGAAGAGTCCCA
GAACTCACACACACCTCCACGGCCAGACTGCTTGCCCCTTGATAAGAAAGGACATGTGACATGG
TCACTTCATGGACCTGAAAATGCCACACCTGTATCTGACTCACCAGATAATCATTCTCAAACTC
TAAAAACTGTGAGTTCCACACCAAACTCGACAGCAGAAGAGGAATCCCACGATCTCACAGAGCA
CCATAACAGCTCCCCTCTGCCGAGAGCTCCTCTCAGCTTTACCAACCCTCTTCACTCTGACGAC
TCCGACTCAGACGAAGGGAACTCCGATGGTGCTGTGACCAAGAACAAAACTAGCATTTCAACAG
CAAGTGCCACCGTGTCTCCTGCCAGTAGTACCGAGAGTGCTTGCACTAGGAGAGTACTGCCCAT
GTCCATTGCCAGGCAGGAAATGGCAGGAAGGCGGCATTCAGGTGCTGAGAAAGATGCTGACGTT
AGTGAAGAGTCGCCTCCTCCCTTACCTGAAAGAACTCCCGAGTCTTTTGTATTAGCAGATATGC
CCATAAGATCTGATTGGCATGAACTTCCAAGTCAGGAGTGCTCGGAGCACAGGGAATCTGAAGG
CTTGATAACCTCTGGAAATGACAAACACGGTTTTGGTAATCGCTGTGGAAAACCTAAAGGACCA
AGAGATCCACCTTCAGAATGGACATGATTCAGGGAGTTAAAAGACACTTTAAATTATACTGGAA
AATTCAAGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAAAATGTGGGACTGATAGCA
GTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGA
GAAAGTATTACATATTGTTTATTTTGTAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCT
GTTACAAGCTGCTTGTAGACCTGTTAATATAGTAATACTTTTATGATAAACTGAGTTAAAGGAC
TACTCTTTTGCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATA
ATTTGATAAAGTTGAAGTCCTAAAATATTATTAACAGAAGATGTAAGAATTTCTGCATGGTTTA
AGTCTTTGTGTATCTTACTTGTAAATTATTTGCCCTGAAATTTTAGAAAACTGTTTCTGAATTT
TAAACTTGCTGGATTCGTGTAGCCAGCATTGCAGGTTATCAGAGATCAAAGAGTGTAATAATAA
TACCTTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACTGTCTAATTGTTCACCCT
AATGGTTCTTGTTTTCGTCTAGTCATGGAGATTCAGTAAGTGCCTTGGAACAACATTGACTTCC
CTTAGCTCGAGTGTGTTACTTTCAAGTTTGAATTCAACTGGGGTTAGAAGACTATCAGAATCTA
TGTATGTTTCAGGATATTTGTTGACCTGCCATTAAAAAAACAAACAGTTTTACACTGCTA

hide sequence

RefSeq Acc Id:

XM_006235870 ⟹ XP_006235932

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,913,187 - 14,985,084 (+)	NCBI
mRatBN7.2	4	14,021,021 - 14,092,931 (+)	NCBI
Rnor_6.0	4	10,631,253 - 10,702,390 (+)	NCBI
Rnor_5.0	4	10,623,632 - 10,695,128 (+)	NCBI

Sequence:

show sequence

GTCCGGACCACAATGGGGAGGACAACTTCGCCCGGGACTTCATGTTGATCACAGCCGAGTTAAG
TTGACTTTGAAGACACCATCCCAAGATTCAGATTATATCAATGCAAATTTTATTAAGGGTGTAT
ATGGGCCGAGAGCATACGTGGCAACCCAAGGGCCTTTGGCGAATACAGTCATAGACTTCTGGAG
GATGATATGGGAGTACAATGTGGTGATCATTGTAATGGCCTGTCGTGAATTTGAGATGGGAAGG
AAAAAGTGTGAGCGCTATTGGCCTTTGTATGGAGAAGATCCTATAACATTTGCACCATTTAAAA
TTTCTTGTGAAAATGAACAAGCAAGAACAGACTACTTCATTCGAACACTTTTACTTGAATTTCA
AAATGAATCCCGTCGACTCTATCAGTTTCATTACGTGAACTGGCCAGACCATGATGTCCCTTCG
TCATTCGATTCTATCCTGGACATGATAAGTCTAATGAGGAAGTACCAAGAGCACGAAGATGTGC
CTATTTGTATCCATTGCAGTGCAGGCTGTGGACGGACAGGTGCTATTTGTGCCATCGACTACAC
GTGGAACTTACTGAAAGCAGGGAAAATTCCAGAGGAATTTAATGTATTTAATTTAATACAAGAA
ATGAGAACACAAAGGCACTCTGCAGTACAAACGAAGGAGCAGTATGAACTCGTCCATAGAGCTA
TTGCCCAACTGTTTGAAAAACAGCTACAACTGTATGAAATCCACGGAGCCCAGAAAATCACTGA
TGGTAATGAAATTAGCACTGGAAACATGGTCAGTTCCATTGATAGTGAAAAACAAGATTCTCCT
CCTCCAAAGCCACCACGGACTCGAAGTTGTCTTGTAGAGGGGGATGCCAAGGAAGAAATCCTCC
AGCCACCAGAGCCTCACCCGGTGCCGCCCATCCTGACACCGTCGCCTCCTTCAGCATTCCCAAC
CGTTACCACTGTGTGGCAAGACAGTGACAGGTACCACCCAAAGCCAGTGCTGCACATGGCTTCC
CCAGAGCAGCCCCCAACGGACCTCAACAGAAACTATGATAAGTCAGCGGACCTAATGGGGAGAA
GCGAATCTGCTGTTGAGCACACAGATAAAAAGTTAGAACAAAATTTAAGTTTTGAGATTAAGAA
AGTCCCTCTCCAAGAAGGGCCCAAAAGTTTTGATGGGAACACACTCTTGAATAGGGGACATGCG
ATTAAAATTAAGTCTGCTTCATCTTCTGTAGTTGACAAAAGCTCTAAGCCACAGGAGTTAAGTT
CAGGTGATCTAAAGGTTCACGATGTGTCTCAGAATTCCTGTGCGGACTGCAGTGCCTCACACTT
AGACAACGCTCCTGAGTCTTCAGAAGAGTCCCAGAACTCACACACACCTCCACGGCCAGACTGC
TTGCCCCTTGATAAGAAAGGACATGTGACATGGTCACTTCATGGACCTGAAAATGCCACACCTG
TATCTGACTCACCAGATAATCATTCTCAAACTCTAAAAACTGTGAGTTCCACACCAAACTCGAC
AGCAGAAGAGGAATCCCACGATCTCACAGAGCACCATAACAGCTCCCCTCTGCCGAGAGCTCCT
CTCAGCTTTACCAACCCTCTTCACTCTGACGACTCCGACTCAGACGAAGGGAACTCCGATGGTG
CTGTGACCAAGAACAAAACTAGCATTTCAACAGCAAGTGCCACCGTGTCTCCTGCCAGTAGTAC
CGAGAGTGCTTGCACTAGGAGAGTACTGCCCATGTCCATTGCCAGGCAGGAAATGGCAGGAAGG
CGGCATTCAGGTGCTGAGAAAGATGCTGACGTTAGTGAAGAGTCGCCTCCTCCCTTACCTGAAA
GAACTCCCGAGTCTTTTGTATTAGCAGATATGCCCATAAGATCTGATTGGCATGAACTTCCAAG
TCAGGAGTGCTCGGAGCACAGGGAATCTGAAGGCTTGATAACCTCTGGAAATGACAAACACGAT
GCAGGGGTTTCCCACACAGCGGCTTGTTCACCCACTTTCAGTGACAAGAAAGAGGAAATAACAG
AAAGTCTAACAGAAGTCACAGACATTGGTTTTGGTAATCGCTGTGGAAAACCTAAAGGACCAAG
AGATCCACCTTCAGAATGGACATGATTCAGGGAGTTAAAAGACACTTTAAATTATACTGGAAAA
TTCAAGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAAAATGTGGGACTGATAGCAGT
GTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAGA
AAGTATTACATATTGTTTATTTTGTAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGT
TACAAGCTGCTTGTAGACCTGTTAATATAGTAATACTTTTATGATAAACTGAGTTAAAGGACTA
CTCTTTTGCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATAAT
TTGATAAAGTTGAAGTCCTAAAATATTATTAACAGAAGATGTAAGAATTTCTGCATGGTTTAAG
TCTTTGTGTATCTTACTTGTAAATTATTTGCCCTGAAATTTTAGAAAACTGTTTCTGAATTTTA
AACTTGCTGGATTCGTGTAGCCAGCATTGCAGGTTATCAGAGATCAAAGAGTGTAATAATAATA
CCTTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACTGTCTAATTGTTCACCCTAA
TGGTTCTTGTTTTCGTCTAGTCATGGAGATTCAGTAAGTGCCTTGGAACAACATTGACTTCCCT
TAGCTCGAGTGTGTTACTTTCAAGTTTGAATTCAACTGGGGTTAGAAGACTATCAGAATCTATG
TATGTTTCAGGATATTTGTTGACCTGCCATTAAAAAAACAAACAGTTTTACACTGCTA

hide sequence

RefSeq Acc Id:

XM_063285423 ⟹ XP_063141493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,913,176 - 14,985,084 (+)	NCBI

RefSeq Acc Id:

XM_063285424 ⟹ XP_063141494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	14,913,667 - 14,985,084 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_476456	(Get FASTA)	NCBI Sequence Viewer
	XP_006235930	(Get FASTA)	NCBI Sequence Viewer
	XP_006235932	(Get FASTA)	NCBI Sequence Viewer
	XP_063141493	(Get FASTA)	NCBI Sequence Viewer
	XP_063141494	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA07266	(Get FASTA)	NCBI Sequence Viewer
	EDL99433	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017907
	ENSRNOP00000017907.6
	ENSRNOP00000075346.2
	ENSRNOP00000079518
	ENSRNOP00000079518.1
	ENSRNOP00000102951
	ENSRNOP00000102951.1
	ENSRNOP00000111147
	ENSRNOP00000111147.1

RefSeq Acc Id:

NP_476456 ⟸ NM_057115

- UniProtKB:

G3V7Q4 (UniProtKB/TrEMBL), A6K5C4 (UniProtKB/TrEMBL), A0A8I5ZN71 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRY
KDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVI
IVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQF
HYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKI
PEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNM
VSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSD
RYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKS
FDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEE
SQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLT
EHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVL
PMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRES
EGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPRDPPSEWT

hide sequence

RefSeq Acc Id:	XP_006235930 ⟸ XM_006235868
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRY KDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVI IVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQF HYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKI PEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITDGNEISTGNM VSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSD RYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKS FDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHLDNAPESSEE SQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNSTAEEESHDLT EHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASSTESACTRRVL PMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPSQECSEHRES EGLITSGNDKHGFGNRCGKPKGPRDPPSEWT hide sequence

RefSeq Acc Id:	XP_006235932 ⟸ XM_006235870
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZN71 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQ NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYT WNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKITD GNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPT VTTVWQDSDRYHPKPVLHMASPEQPPTDLNRNYDKSADLMGRSESAVEHTDKKLEQNLSFEIKK VPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDKSSKPQELSSGDLKVHDVSQNSCADCSASHL DNAPESSEESQNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVSDSPDNHSQTLKTVSSTPNST AEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPASST ESACTRRVLPMSIARQEMAGRRHSGAEKDADVSEESPPPLPERTPESFVLADMPIRSDWHELPS QECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTEVTDIGFGNRCGKPKGPR DPPSEWT hide sequence

Ensembl Acc Id:

ENSRNOP00000075346 ⟸ ENSRNOT00000081939

Ensembl Acc Id:

ENSRNOP00000017907 ⟸ ENSRNOT00000017907

Ensembl Acc Id:

ENSRNOP00000079518 ⟸ ENSRNOT00000106350

RefSeq Acc Id:	XP_063141493 ⟸ XM_063285423
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5ZN71 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063141494 ⟸ XM_063285424
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZN71 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000111147 ⟸ ENSRNOT00000126039

Ensembl Acc Id:

ENSRNOP00000102951 ⟸ ENSRNOT00000122000

Protein Domains

Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7Q4-F1-model_v2	AlphaFold	G3V7Q4	1-766	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692813

Promoter ID:

EPDNEW_R3337

Type:

initiation region

Name:

Ptpn12_1

Description:

protein tyrosine phosphatase, non-receptor type 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	10,631,133 - 10,631,193	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620894	AgrOrtholog
BioCyc Gene	G2FUF-45963	BioCyc
Ensembl Genes	ENSRNOG00000013135	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017907	ENTREZGENE
	ENSRNOT00000017907.7	UniProtKB/TrEMBL
	ENSRNOT00000081939.3	UniProtKB/TrEMBL
	ENSRNOT00000106350	ENTREZGENE
	ENSRNOT00000106350.2	UniProtKB/TrEMBL
	ENSRNOT00000122000	ENTREZGENE
	ENSRNOT00000122000.1	UniProtKB/TrEMBL
	ENSRNOT00000126039	ENTREZGENE
	ENSRNOT00000126039.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/TrEMBL
InterPro	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	PTN12/18/22	UniProtKB/TrEMBL
	PTN12_cat	UniProtKB/TrEMBL
	Tyr/Dual-specificity_Pase	UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/TrEMBL
	Tyr_Pase_cat	UniProtKB/TrEMBL
	Tyr_Pase_non-rcpt_typ-12	UniProtKB/TrEMBL
	Tyr_Pase_rcpt/non-rcpt	UniProtKB/TrEMBL
KEGG Report	rno:117255	UniProtKB/TrEMBL
NCBI Gene	117255	ENTREZGENE
PANTHER	TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED	UniProtKB/TrEMBL
	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12	UniProtKB/TrEMBL
Pfam	Y_phosphatase	UniProtKB/TrEMBL
PhenoGen	Ptpn12	PhenoGen
PIRSF	Tyr-Ptase_nr12	UniProtKB/TrEMBL
PRINTS	PRTYPHPHTASE	UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_PTP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013135	RatGTEx
SMART	PTPc	UniProtKB/TrEMBL
	PTPc_motif	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/TrEMBL
UniProt	A0A0G2KAC5_RAT	UniProtKB/TrEMBL
	A0A8I5ZN71	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LPC1_RAT	UniProtKB/TrEMBL
	A0ABK0M671_RAT	UniProtKB/TrEMBL
	A6K5C4	ENTREZGENE, UniProtKB/TrEMBL
	G3V7Q4	ENTREZGENE, UniProtKB/TrEMBL
	Q63745_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Ptpn12	protein tyrosine phosphatase, non-receptor type 12			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Ptpn12	protein tyrosine phosphatase, non-receptor type 12			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_protein	a 382 amino acid protein with a M(r) of 44,438	633766

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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