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Gene: F2rl3 (F2R like thrombin or trypsin receptor 3) Rattus norvegicus

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Symbol:

F2rl3

Name:

F2R like thrombin or trypsin receptor 3

RGD ID:

620872

Description:

Predicted to enable G protein-coupled receptor activity and protease binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; platelet activation; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within platelet aggregation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human F2RL3 (F2R like thrombin or trypsin receptor 3); PARTICIPATES IN protease mediated signaling via protease-activated receptor 4; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; C60 fullerene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

coagulation factor II (thrombin) receptor-like 3; coagulation factor II receptor-like 3; F2R like thrombin/trypsin receptor 3; PAR-4; PAR4; protease-activated receptor 4; proteinase-activated receptor 4; thrombin receptor-like 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	F2RL3 (F2R like thrombin or trypsin receptor 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-132p1.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gnrr-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	f2rl3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	f2rl3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,151,516 - 17,153,509 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	17,151,516 - 17,153,823 (-)	Ensembl				GRCr8
mRatBN7.2	16	17,117,441 - 17,119,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,117,441 - 17,119,472 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	17,185,458 - 17,187,486 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,317,104 - 18,319,112 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,238,362 - 17,240,390 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,817,797 - 18,819,790 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,814,622 - 18,819,833 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	18,687,984 - 18,689,977 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	16	17,341,816 - 17,343,823 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

peliosis hepatis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3',5'-cyclic AMP (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

bivalirudin (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

calcium atom (ISO)

calcium(0) (ISO)

chromium(6+) (ISO)

colforsin daropate hydrochloride (ISO)

copper atom (EXP)

copper(0) (EXP)

cyclophosphamide (EXP)

Dibutyl phosphate (ISO)

diquat (ISO)

fluorene (ISO)

flusilazole (EXP)

GSK-J4 (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

methimazole (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

potassium dichromate (ISO)

progesterone (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

Thrombin (ISO)

topotecan (EXP)

triadimefon (EXP)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

Triptolide (ISO)

triptonide (ISO)

valproic acid (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

G protein-coupled receptor signaling pathway (IBA,IEA)

hemostasis (IEA)

platelet activation (IEA,ISO)

platelet aggregation (ISO)

positive regulation of release of sequestered calcium ion into cytosol (ISO)

signal transduction (IEA)

thrombin-activated receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IBA,IEA,TAS)

protease binding (ISO)

thrombin-activated receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

protease mediated signaling via protease-activated receptor 4 (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cross Talk Pathways Between Coagulation and Inflammation.	Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Molecular cloning of the rat proteinase-activated receptor 4 (PAR4).	Hoogerwerf WA, etal., BMC Mol Biol 2002;3(1):2.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15145074	PMID:16403464	PMID:17136598	PMID:18480058	PMID:19889854	PMID:20875131	PMID:24105611	PMID:25931468	PMID:35093640

Genomics

Comparative Map Data

F2rl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,151,516 - 17,153,509 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	17,151,516 - 17,153,823 (-)	Ensembl				GRCr8
mRatBN7.2	16	17,117,441 - 17,119,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,117,441 - 17,119,472 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	17,185,458 - 17,187,486 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,317,104 - 18,319,112 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,238,362 - 17,240,390 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,817,797 - 18,819,790 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,814,622 - 18,819,833 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	18,687,984 - 18,689,977 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	16	17,341,816 - 17,343,823 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

F2RL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,888,999 - 16,892,606 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,888,999 - 16,892,606 (+)	Ensembl			hg38	GRCh38
GRCh37	19	16,999,810 - 17,003,417 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,860,826 - 16,863,830 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	16,860,825 - 16,870,516	NCBI
Celera	19	16,901,357 - 16,904,361 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	16,568,368 - 16,571,379 (+)	NCBI		HuRef
CHM1_1	19	16,999,569 - 17,002,573 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	17,023,836 - 17,027,443 (+)	NCBI		T2T-CHM13v2.0

F2rl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	73,488,287 - 73,490,526 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	73,488,508 - 73,490,502 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	72,761,659 - 72,763,898 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,761,880 - 72,763,874 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	75,285,779 - 75,287,784 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,657,952 - 75,659,957 (+)	NCBI		MGSCv36	mm8
Celera	8	77,077,985 - 77,079,990 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	35.08	NCBI

F2rl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,044,792 - 1,047,819 (-)	Ensembl
ChiLan1.0	NW_004955524	1,045,493 - 1,047,924 (-)	NCBI	ChiLan1.0	ChiLan1.0

F2RL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	21,757,541 - 21,762,253 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	20,764,020 - 20,768,733 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,375,572 - 16,379,587 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,355,542 - 17,357,628 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,355,542 - 17,357,628 (+)	Ensembl			panPan2	panpan1.1

F2RL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,738,587 - 45,740,564 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,738,587 - 45,740,473 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,652,073 - 45,655,003 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,224,593 - 46,227,523 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,225,014 - 46,226,479 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,460,781 - 45,463,709 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,871,392 - 45,874,323 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,146,994 - 46,149,271 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

F2RL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,742,996 - 60,744,864 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	60,742,978 - 60,747,014 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	60,307,031 - 60,309,288 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F2RL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,397,552 - 15,400,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	4,036,812 - 4,040,135 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F2rl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	762,356 - 766,563 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624908	761,067 - 764,562 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

F2rl3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	19,761,025 - 19,763,026 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in F2rl3
8 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	219
Count of miRNA genes:	159
Interacting mature miRNAs:	177
Transcripts:	ENSRNOT00000072664
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33425095	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39568015	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15748006	25801629	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	1	26734272	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26734272	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	16278184	27244292	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39568015	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3386790	26128267	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26734272	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4234333	17730812	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	15905802	60905802	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

D8Mit133

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	17,117,370 - 17,117,490 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	18,817,727 - 18,817,846	NCBI	Rnor6.0
Rnor_5.0	16	18,687,914 - 18,688,033	UniSTS	Rnor5.0
Celera	16	17,341,746 - 17,341,865	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	157	87	86	55	92	55	6	331	190	11	131	62	91	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF269246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF310216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY517481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072664 ⟹ ENSRNOP00000065190

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	18,814,622 - 18,819,833 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102959 ⟹ ENSRNOP00000076521

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	17,151,516 - 17,153,823 (-)	Ensembl
mRatBN7.2 Ensembl	16	17,117,441 - 17,119,472 (-)	Ensembl

RefSeq Acc Id:

NM_053808 ⟹ NP_446260

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	17,151,516 - 17,153,509 (-)	NCBI
mRatBN7.2	16	17,117,441 - 17,119,434 (-)	NCBI
Rnor_6.0	16	18,817,797 - 18,819,790 (-)	NCBI
Rnor_5.0	16	18,687,984 - 18,689,977 (-)	NCBI
Celera	16	17,341,816 - 17,343,823 (-)	RGD

Sequence:

show sequence

ATGCTCGGGTTCAGCATCAGCCCGGCGGAATGCCAGACGCCCAGCATCTACGACGATGTAGAGA
GTACCAGGGAAGGCCAAGAAGCCTCTCTGCGTCCCACAGTAGAACTTAATGAGTCGAAGTCCCC
AGACAAGCCTAATCCACGAGGCTTCCCGGGCAAGCCCTGTGCCAACAACAGTGACACGCTGGAG
CTCCCAGCCAGCTCTGAAGCACTGCTTCTGGGGTGGGTCCCCACGAGGCTGGTACCTGCCATCT
ATGGGCTAGTGGTGGTCGTGGGGCTGCCTGCCAATGGGCTAGCGCTGTGGGTGCTGGCCACAAG
GGTCCCACGCTTGCCATCCACCATTCTGCTCATGAACCTGGCAGTGGCTGACTTGCTACTGGCC
CTGGTGCTCCCACCACGACTGGTTTATCACCTGCGTGGCCAGCGCTGGCCGTTTGGGGAGGCTG
CCTGCCGGGTGGCCACAGCTGCCCTCTATGGCCACATGTATGGTTCAGTGTTGCTTCTGGCCGC
AGTCAGCCTGGACAGATACCTGGCCCTGGTGCATCCTTTGCGGGCCCGGGCATTGCGTGGTCAA
CGCCTCACCACCATACTCTGCTTGGTGGCCTGGCTCTCTGCAGCCACTCTAGTCTTGCCACTCA
CGTTTCATCGGCAGACCTTCCTATTGGCTGGCTCCGATCGCATGCTGTGTCATGATGCGCTGCC
ATTGGCGGAGCAGACCTCCCATTGGAGACCGGCCTTCATCTGCCTGGCTGTCCTGGGCTGCTTT
GTGCCACTGCTGGCCATGGTCCTGTGCTATGGGGCCACCCTTCGTGCACTGGCAGCCAATGGTC
AGCGGTACAGCCATGCAGTGAGACTGACAGCCCTGGTCCTGTTCTCAGCAGTGGCCGCTTTCAC
ACCTAGCAATGTGCTTCTGGTGCTGCACTATTCAAACCCAAGCCCTGAGGCCTGGGGCAATCTC
TATGGAGCCTATGTTCCCAGCCTGGCACTCAGCACCCTTAACAGCTGCGTAGACCCTTTCATCT
ACTACTATGTGTCCCACGAGTTCAGGGAGAAGGTACGGGCTATGTTGTGTCGCCAGCTGAAGGC
CAGCAGCTCCTCTCAGGCCTCCAGGGAGGCTGGAAGCCGAGGGACTGCCATTTGCTCCTCTACA
CTTCTGTGACTGTTAGCTGAGTTGGGAAGGGGACGTTCAGACTCGACTGGATCTCCCCTTAAAC
TGTCCCTCCTGAACCCTCAGGACATGACCTTATTTGGATATGCACTTGGCGCGACCTTCATTAG
TGGAGCTGAGGTCCACTGGAAATGCCCTGGTAAAAGGCCTGGGTACCATACACCTGTCACCCCA
GCACTAGGGAGGTGGAGAGGAGGATCAGAAGCCCAGCATTGTCTTTGACTATGTAGTGACTTCG
AAGCTAGGCTGGGCTATGCGAGAGTCCAGAGGTGGAGAGGTATCACGAGGTCACGAGGATGCTG
AGAAAGCAGAATTGAGCCTGTTTCCCACTCAGAGGACCCAGCCCCAGACACCCTGATTTTGTCA
TTGTGCCTCTTAGAACTTCACACTGTTGTGCTTTGCATGTGTCTGCACAGCGTAGATGTGTCTT
CACATGTATATTGTATGTGCCTGTGGGTACTCGAAGAGGCCAAAGGATGATGGGTGTGTACCTC
AATTCCCTCTCTACCTTTAAATTTTGTAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_446260	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK58604	(Get FASTA)	NCBI Sequence Viewer
	AAL26790	(Get FASTA)	NCBI Sequence Viewer
	AAS10196	(Get FASTA)	NCBI Sequence Viewer
	EDL90865	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076521
GenBank Protein	Q920E0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446260 ⟸ NM_053808

- UniProtKB:

A6K9M2 (UniProtKB/TrEMBL), M0R6X7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLGFSISPAECQTPSIYDDVESTREGQEASLRPTVELNESKSPDKPNPRGFPGKPCANNSDTLE
LPASSEALLLGWVPTRLVPAIYGLVVVVGLPANGLALWVLATRVPRLPSTILLMNLAVADLLLA
LVLPPRLVYHLRGQRWPFGEAACRVATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGQ
RLTTILCLVAWLSAATLVLPLTFHRQTFLLAGSDRMLCHDALPLAEQTSHWRPAFICLAVLGCF
VPLLAMVLCYGATLRALAANGQRYSHAVRLTALVLFSAVAAFTPSNVLLVLHYSNPSPEAWGNL
YGAYVPSLALSTLNSCVDPFIYYYVSHEFREKVRAMLCRQLKASSSSQASREAGSRGTAICSST
LL

hide sequence

Ensembl Acc Id:

ENSRNOP00000065190 ⟸ ENSRNOT00000072664

Ensembl Acc Id:

ENSRNOP00000076521 ⟸ ENSRNOT00000102959

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q920E0-F1-model_v2	AlphaFold	Q920E0	1-395	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620872	AgrOrtholog
BioCyc Gene	G2FUF-11900	BioCyc
Ensembl Genes	ENSRNOG00000048186	Ensembl
	ENSRNOG00000068093	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000102959	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	Prot_act_rcpt_4	UniProtKB/Swiss-Prot
	Protea_act_rcpt	UniProtKB/Swiss-Prot
KEGG Report	rno:116498	UniProtKB/Swiss-Prot
NCBI Gene	116498	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	PROTEINASE-ACTIVATED RECEPTOR 4	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	F2rl3	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	PROTEASEAR	UniProtKB/Swiss-Prot
	PROTEASEAR4	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000048186	RatGTEx
	ENSRNOG00000068093	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A6K9M2	ENTREZGENE, UniProtKB/TrEMBL
	M0R6X7	ENTREZGENE, UniProtKB/TrEMBL
	PAR4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-12	F2rl3	F2R like thrombin or trypsin receptor 3	F2rl3	F2R like thrombin/trypsin receptor 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-01-27	F2rl3	F2R like thrombin/trypsin receptor 3	F2rl3	coagulation factor II (thrombin) receptor-like 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	F2rl3	coagulation factor II (thrombin) receptor-like 3			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	F2rl3	coagulation factor II (thrombin) receptor-like 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	enriched in upper gastrointestinal tract	727352

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations