Akap8 (A-kinase anchoring protein 8) - Rat Genome Database

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Gene: Akap8 (A-kinase anchoring protein 8) Rattus norvegicus
Analyze
Symbol: Akap8
Name: A-kinase anchoring protein 8
RGD ID: 620832
Description: Enables double-stranded DNA binding activity; protein kinase A regulatory subunit binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cellular response to prostaglandin E stimulus; and negative regulation of tumor necrosis factor production. Located in nuclear matrix. Orthologous to human AKAP8 (A-kinase anchoring protein 8); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AKAP 95; AKAP-8; Akap95
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,966,769 - 11,983,056 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl711,966,772 - 11,982,900 (-)EnsemblGRCr8
mRatBN7.2711,316,224 - 11,332,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,316,228 - 11,332,399 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,134,699 - 14,150,843 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,012,121 - 16,028,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,883,649 - 13,899,780 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,323,298 - 14,339,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)Ensemblrn6Rnor6.0
Rnor_5.0714,477,683 - 14,493,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4712,873,303 - 12,889,333 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera79,427,350 - 9,443,479 (-)NCBICelera
RGSC_v3.1712,873,301 - 12,889,308 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
lead diacetate  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
condensed chromosome  (IEA,ISO)
cytoplasm  (IEA)
female pronucleus  (IEA,ISO)
nuclear matrix  (IBA,IDA,IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. Akileswaran L, etal., J Biol Chem. 2001 May 18;276(20):17448-54. Epub 2001 Feb 22.
2. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
3. Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase. Coghlan VM, etal., J Biol Chem 1994 Mar 11;269(10):7658-65.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
Additional References at PubMed
PMID:12082153   PMID:12477932   PMID:15878851   PMID:16751186   PMID:16980585   PMID:17911601   PMID:19073898   PMID:19531803   PMID:19946888   PMID:22130794   PMID:22658674   PMID:22681889  
PMID:26683827   PMID:33716104  


Genomics

Comparative Map Data
Akap8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,966,769 - 11,983,056 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl711,966,772 - 11,982,900 (-)EnsemblGRCr8
mRatBN7.2711,316,224 - 11,332,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,316,228 - 11,332,399 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,134,699 - 14,150,843 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,012,121 - 16,028,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,883,649 - 13,899,780 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,323,298 - 14,339,953 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)Ensemblrn6Rnor6.0
Rnor_5.0714,477,683 - 14,493,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4712,873,303 - 12,889,333 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera79,427,350 - 9,443,479 (-)NCBICelera
RGSC_v3.1712,873,301 - 12,889,308 (-)NCBI
Cytogenetic Map7q11NCBI
AKAP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,353,385 - 15,379,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,353,385 - 15,379,829 (-)Ensemblhg38GRCh38
GRCh371915,464,196 - 15,490,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,325,335 - 15,351,603 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341915,325,335 - 15,351,603NCBI
Celera1915,359,984 - 15,386,240 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1915,032,304 - 15,058,582 (-)NCBIHuRef
CHM1_11915,463,860 - 15,490,252 (-)NCBICHM1_1
T2T-CHM13v2.01915,478,331 - 15,504,764 (-)NCBIT2T-CHM13v2.0
Akap8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,522,646 - 32,540,212 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,522,646 - 32,540,212 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381732,303,672 - 32,321,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,303,672 - 32,321,238 (-)Ensemblmm10GRCm38
MGSCv371732,440,621 - 32,458,098 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361732,035,284 - 32,052,761 (-)NCBIMGSCv36mm8
Celera1733,224,515 - 33,241,992 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.48NCBI
Akap8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,874,746 - 7,892,944 (+)Ensembl
ChiLan1.0NW_0049554957,874,655 - 7,893,209 (+)NCBIChiLan1.0ChiLan1.0
AKAP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,269,069 - 20,293,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,271,846 - 19,296,405 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,888,201 - 14,912,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,872,536 - 15,897,661 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,872,536 - 15,897,661 (-)EnsemblpanPan2panpan1.1
AKAP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,800,917 - 46,817,397 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,800,872 - 46,817,397 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2046,648,485 - 46,664,965 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02047,287,578 - 47,304,050 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,287,529 - 47,305,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,522,426 - 46,538,895 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,939,069 - 46,955,544 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,212,596 - 47,229,069 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akap8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,574,820 - 205,593,183 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,124,083 - 5,142,027 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,123,988 - 5,142,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,222,249 - 62,241,611 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1262,222,060 - 62,241,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,797,360 - 61,817,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,965,014 - 13,987,586 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660745,520,384 - 5,543,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,451,369 - 2,487,031 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249012,452,506 - 2,471,714 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap8
221 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:425
Count of miRNA genes:236
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000008827
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH133817  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,332,819 - 11,333,001 (+)MAPPERmRatBN7.2
Rnor_6.0714,340,317 - 14,340,498NCBIRnor6.0
Rnor_5.0714,494,413 - 14,494,594UniSTSRnor5.0
RGSC_v3.4712,889,797 - 12,889,978UniSTSRGSC3.4
Celera79,443,943 - 9,444,124UniSTS
Cytogenetic Map7q11UniSTS
RH124529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,317,380 - 11,317,591 (+)MAPPERmRatBN7.2
Rnor_6.0714,324,455 - 14,324,665NCBIRnor6.0
Rnor_5.0714,478,840 - 14,479,050UniSTSRnor5.0
RGSC_v3.4712,874,458 - 12,874,668UniSTSRGSC3.4
Celera79,428,505 - 9,428,715UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008827   ⟹   ENSRNOP00000008827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl711,966,772 - 11,982,900 (-)Ensembl
mRatBN7.2 Ensembl711,316,228 - 11,332,399 (-)Ensembl
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109363   ⟹   ENSRNOP00000088920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl711,966,772 - 11,980,002 (-)Ensembl
mRatBN7.2 Ensembl711,316,228 - 11,332,373 (-)Ensembl
RefSeq Acc Id: NM_053855   ⟹   NP_446307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,966,771 - 11,982,900 (-)NCBI
mRatBN7.2711,316,226 - 11,332,356 (-)NCBI
Rnor_6.0714,323,300 - 14,339,853 (-)NCBI
Rnor_5.0714,477,683 - 14,493,949 (-)NCBI
RGSC_v3.4712,873,303 - 12,889,333 (-)RGD
Celera79,427,350 - 9,443,479 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241047   ⟹   XP_006241109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,966,769 - 11,982,621 (-)NCBI
mRatBN7.2711,316,224 - 11,332,085 (-)NCBI
Rnor_6.0714,323,298 - 14,339,565 (-)NCBI
Rnor_5.0714,477,683 - 14,493,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594573   ⟹   XP_017450062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,966,769 - 11,982,958 (-)NCBI
mRatBN7.2711,316,224 - 11,332,437 (-)NCBI
Rnor_6.0714,323,298 - 14,339,953 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078250   ⟹   XP_038934178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,975,168 - 11,983,056 (-)NCBI
mRatBN7.2711,324,623 - 11,332,523 (-)NCBI
RefSeq Acc Id: NP_446307   ⟸   NM_053855
- UniProtKB: Q63014 (UniProtKB/Swiss-Prot),   B2GV93 (UniProtKB/TrEMBL),   A0A8I6AAG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241109   ⟸   XM_006241047
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450062   ⟸   XM_017594573
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AAG3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008827   ⟸   ENSRNOT00000008827
RefSeq Acc Id: XP_038934178   ⟸   XM_039078250
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000088920   ⟸   ENSRNOT00000109363
Protein Domains
C2H2 AKAP95-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63014-F1-model_v2 AlphaFold Q63014 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620832 AgrOrtholog
BioCyc Gene G2FUF-34829 BioCyc
Ensembl Genes ENSRNOG00000006559 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008827 ENTREZGENE
  ENSRNOT00000008827.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7317962 IMAGE-MGC_LOAD
  IMAGE:7380301 IMAGE-MGC_LOAD
InterPro AKAP95 UniProtKB/Swiss-Prot
  ZF_C2H2_AKAP95 UniProtKB/Swiss-Prot
KEGG Report rno:116633 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109394 IMAGE-MGC_LOAD
  MGC:188279 IMAGE-MGC_LOAD
NCBI Gene 116633 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 8 UniProtKB/Swiss-Prot
  PTHR12190 UniProtKB/Swiss-Prot
Pfam AKAP95 UniProtKB/Swiss-Prot
PhenoGen Akap8 PhenoGen
PROSITE ZF_C2H2_AKAP95 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006559 RatGTEx
Superfamily-SCOP Porins UniProtKB/Swiss-Prot
UniProt A0A8I6AAG3 ENTREZGENE, UniProtKB/TrEMBL
  AKAP8_RAT UniProtKB/Swiss-Prot
  B2GV93 ENTREZGENE, UniProtKB/TrEMBL
  Q5EB69_RAT UniProtKB/TrEMBL
  Q63014 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap8  A-kinase anchoring protein 8  Akap8  A kinase (PRKA) anchor protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Akap8  A kinase (PRKA) anchor protein 8    A kinase anchor protein 8  Name updated 1299863 APPROVED
2002-08-07 Akap8  A kinase anchor protein 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (pka type II) 724707