Sec14l3 (SEC14-like lipid binding 3)

Gene: Sec14l3 (SEC14-like lipid binding 3) Rattus norvegicus

Analyze

Symbol:

Sec14l3

Name:

SEC14-like lipid binding 3

RGD ID:

620812

Description:

Predicted to enable lipid binding activity. Predicted to be active in cytoplasm. Orthologous to human SEC14L3 (SEC14 like lipid binding 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

45 kDa secretory protein; AJ132352; rsec45; SEC14-like 3; SEC14-like 3 (S. cerevisiae); SEC14-like protein 3; secretory protein, 45kD; Spf2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SEC14L3 (SEC14 like lipid binding 3)	HGNC	EggNOG, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Sec14l3 (SEC14-like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sec14l3 (SEC14 like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SEC14L3 (SEC14 like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC477540 (SEC14-like protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sec14l3 (SEC14 like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100156470 (SEC14-like protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SEC14L3 (SEC14 like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sec14l3 (SEC14 like lipid binding 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SEC14L4 (SEC14 like lipid binding 4)	HGNC	Ensembl, Inparanoid, OrthoDB, Treefam
Homo sapiens (human):	SEC14L6 (SEC14 like lipid binding 6)	HGNC	OrthoDB, Treefam
Homo sapiens (human):	SEC14L2 (SEC14 like lipid binding 2)	HGNC	OrthoDB
Homo sapiens (human):	POGK (pogo transposable element derived with KRAB domain)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SEC14L3 (SEC14 like lipid binding 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sec14l3 (SEC14-like lipid binding 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sec14l8 (SEC14-like lipid binding 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sec14l7 (SEC14-like lipid binding 7)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG13893	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SEC14	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	YKL091C	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector)
Caenorhabditis elegans (roundworm):	ctg-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ctg-2	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sec14l3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	83,168,154 - 83,181,240 (+)	NCBI		GRCr8
mRatBN7.2	14	78,944,568 - 78,955,608 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	78,912,750 - 78,956,099 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,385,674 - 83,410,373 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	84,625,753 - 84,650,452 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	81,071,560 - 81,081,953 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	84,306,466 - 84,317,241 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,274,550 - 84,319,449 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	84,987,892 - 84,998,667 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	84,699,356 - 84,710,131 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	84,718,487 - 84,729,238 (+)	NCBI
Celera	14	77,855,680 - 77,866,455 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aldehydo-D-glucose (ISO)

amitrole (EXP)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

bleomycin A2 (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

D-glucose (ISO)

diazinon (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

methimazole (EXP)

naphthalene (ISO)

paracetamol (ISO)

pentane-2,3-dione (EXP)

potassium dichromate (ISO)

quercetin (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tebuconazole (ISO)

tetrachloroethene (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IBA,IEA)

nuclear speck (IEA)

Molecular Function

lipid binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation.	Merkulova MI, etal., FEBS Lett 1999 Apr 30;450(1-2):126-30.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15033454	PMID:16262698	PMID:19577556	PMID:23533145

Genomics

Comparative Map Data

Sec14l3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	83,168,154 - 83,181,240 (+)	NCBI		GRCr8
mRatBN7.2	14	78,944,568 - 78,955,608 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	78,912,750 - 78,956,099 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,385,674 - 83,410,373 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	84,625,753 - 84,650,452 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	81,071,560 - 81,081,953 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	84,306,466 - 84,317,241 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,274,550 - 84,319,449 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	84,987,892 - 84,998,667 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	84,699,356 - 84,710,131 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	84,718,487 - 84,729,238 (+)	NCBI
Celera	14	77,855,680 - 77,866,455 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

SEC14L3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	30,447,661 - 30,472,017 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	30,447,959 - 30,472,017 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	30,843,648 - 30,868,004 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	29,185,219 - 29,198,017 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	29,179,772 - 29,192,571	NCBI
Celera	22	14,654,929 - 14,667,748 (-)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	13,816,449 - 13,829,268 (-)	NCBI		HuRef
CHM1_1	22	30,814,641 - 30,827,457 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	30,911,006 - 30,935,427 (-)	NCBI		T2T-CHM13v2.0

Sec14l3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	4,014,853 - 4,028,990 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	4,014,841 - 4,027,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	4,064,853 - 4,078,990 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	4,064,841 - 4,077,736 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	3,964,844 - 3,976,619 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	3,964,844 - 3,976,619 (+)	NCBI		MGSCv36	mm8
Celera	11	4,560,723 - 4,572,545 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	2.86	NCBI

Sec14l3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	4,681,026 - 4,692,490 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	4,681,026 - 4,692,277 (-)	NCBI	ChiLan1.0	ChiLan1.0

SEC14L3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	40,417,578 - 40,430,349 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	43,116,217 - 43,128,987 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	11,486,937 - 11,499,251 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	29,287,254 - 29,299,776 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	29,287,254 - 29,299,776 (-)	Ensembl	panpan1.1		panPan2

LOC477540
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	23,580,899 - 23,590,676 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	23,580,901 - 23,590,622 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	23,451,985 - 23,461,733 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	23,965,177 - 23,974,925 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	23,965,175 - 24,030,406 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	23,666,685 - 23,676,433 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	23,929,262 - 23,939,009 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	23,989,690 - 23,999,651 (-)	NCBI		UU_Cfam_GSD_1.0

Sec14l3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	116,494,628 - 116,506,077 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936904	228,148 - 238,935 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936904	228,121 - 239,182 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100156470
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	47,406,939 - 47,417,882 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	47,406,935 - 47,424,502 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	50,491,451 - 50,508,966 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SEC14L3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	13,343,715 - 13,356,774 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	13,343,722 - 13,356,608 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	112,779,681 - 112,802,806 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sec14l3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	6,765,196 - 6,777,195 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	6,765,246 - 6,777,103 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sec14l3
142 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	73
Count of miRNA genes:	64
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000006116
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	73415323	92554092	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	73415323	92554092	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	95876975	Rat

Markers in Region

AA964104

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	78,955,620 - 78,955,848 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	84,317,412 - 84,317,639	NCBI	Rnor6.0
Rnor_5.0	14	84,998,838 - 84,999,065	UniSTS	Rnor5.0
RGSC_v3.4	14	84,710,302 - 84,710,529	UniSTS	RGSC3.4
Celera	14	77,866,626 - 77,866,853	UniSTS
RH 3.4 Map	14	544.8	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			22	21		21			2			11
Low	3	7	33	18	19	18	8	9	13	10	28		8
Below cutoff		8	2	2		2		2	43	7	12

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC119662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ132352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC162038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000006053 ⟹ ENSRNOP00000006053

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,912,750 - 78,928,799 (+)	Ensembl
Rnor_6.0 Ensembl	14	84,274,550 - 84,290,594 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000006116 ⟹ ENSRNOP00000006116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,944,658 - 78,955,415 (+)	Ensembl
Rnor_6.0 Ensembl	14	84,306,466 - 84,317,214 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078271 ⟹ ENSRNOP00000074130

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,912,750 - 78,928,799 (+)	Ensembl
Rnor_6.0 Ensembl	14	84,282,073 - 84,291,435 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087383 ⟹ ENSRNOP00000069897

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,912,750 - 78,955,423 (+)	Ensembl
Rnor_6.0 Ensembl	14	84,274,570 - 84,319,449 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103465 ⟹ ENSRNOP00000089732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,946,201 - 78,955,423 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113444 ⟹ ENSRNOP00000093206

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	78,944,658 - 78,956,099 (+)	Ensembl

RefSeq Acc Id:

NM_022608 ⟹ NP_072130

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	83,168,258 - 83,179,033 (+)	NCBI
mRatBN7.2	14	78,944,673 - 78,955,450 (+)	NCBI
Rnor_6.0	14	84,306,466 - 84,317,241 (+)	NCBI
Rnor_5.0	14	84,987,892 - 84,998,667 (+)	NCBI
RGSC_v3.4	14	84,699,356 - 84,710,131 (+)	RGD
Celera	14	77,855,680 - 77,866,455 (+)	RGD

Sequence:

show sequence

CTTACTGCTCATCAGTCTCAGCACCATGAGTGGCCGAGTTGGAGACCTGAGCCCCAAGCAGGCA
GAGACCCTGGCCAAGTTCCGAGAAAATGTCCAGGATGTGCTGCCCGCCCTGCCAAACCCTGATG
ACTATTTTCTTCTTCGTTGGCTCCGAGCTCGGAACTTTGACCTACAGAAATCAGAGGCCATGCT
CCGCAAGTACATGGAGTTCCGGAAGACCATGGACATTGATCACATCCTTGACTGGCAGCCCCCA
GAGGTGATCCAGAAGTACATGCCCGGAGGCCTGTGTGGCTATGACCGGGACGGCTGCCCTTTGT
GGTATGACATCATCGGGCCACTGGACCCCAAAGGGCTGCTTTTCTCAGTCACCAAGCAGGACCT
GTTGAAGACTAAGATGAGGGACTGTGAACGTATCCTGCACGAGTGTGACCTGCAGACAGAGCGG
CTGGGGAGGAAGATTGAAACCATTGTGATGATATTTGACTGTGAAGGTCTGGGACTGAAGCACT
TCTGGAAACCTCTGGTGGAAGTGTACCAGGAGTTCTTTGGCCTCCTTGAAGAGAATTACCCAGA
GACCCTGAAGTTCATGCTCATTGTGAAAGCCACCAAACTGTTCCCCGTGGGCTACAACCTCATG
AAGCCATTCCTGAGTGAGGACACACGGAGGAAGATTGTAGTGTTGGGAAACAGCTGGAAAGAAG
GTTTGCTGAAACTCATCAGTCCTGAGGAACTGCCTGCCCATTTTGGGGGGACACTCACTGACCC
AGATGGGAATCCCAAATGTTTAACCAAGATCAACTACGGTGGGGAGATTCCCAAGTCCATGTAT
GTGCGTGACCAGGTGAAGACCCAGTATGAGCACTCGGTGCAGATTAGCCGCGGCTCCTCCCATC
AGGTGGAATACGAGATCCTGTTCCCAGGCTGCGTCCTCAGGTGGCAGTTCTCATCTGATGGAGC
AGACATTGGCTTTGGAGTTTTCCTCAAGACCAAGATGGGGGAGAGGCAGAAGGCAGGGGAGATG
ACCGAGGTGCTAACCAGCCAGCGCTACAATGCCCACATGGTGCCTGAGGATGGGAGCCTCACCT
GCACCGAGGCTGGTGTCTATGTCCTGCGCTTTGACAACACCTATAGCTTCGTCCATGCCAAGAA
GGTCAGCTTCACGGTTGAAGTGCTTCTCCCAGATGAGGGCATGCAGAAGTACGATGAGGAGCTC
ACCCCTATCTAGGTGGACCCCCCCACTTCTCAGAGACCCCACGCTCTGTTTTCCCTCTTCTCTC
CTTTCATTCCTAAACCTGATCATTAGTCGGGCTTACTCTGTGACACCAGTGCGCAGAGGAAGAG
ATTGCCCGGAGAAGATTTATCTGCTGTAGTCAAATTGCAAAATGACGAAAGGTTGGAGGTATAA
AGATTGCAAAAGAGAAAGAAGCACAAGGAAAAGACAGAAGATGGGTGTCACTGGGGTCTAAGAA
TAGGGAAAGGGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGCAAGCGCAAGGCCC
TGGGTTCGGTCCTCAGCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092398 ⟹ XP_038948326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	83,168,154 - 83,181,240 (+)	NCBI
mRatBN7.2	14	78,944,568 - 78,955,608 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_072130	(Get FASTA)	NCBI Sequence Viewer
	XP_038948326	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI62038	(Get FASTA)	NCBI Sequence Viewer
	CAA10644	(Get FASTA)	NCBI Sequence Viewer
	EDM00208	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006116
	ENSRNOP00000006116.2
	ENSRNOP00000069897.1
	ENSRNOP00000089732.1
	ENSRNOP00000093206.1
	ENSRNOP00065001648
	ENSRNOP00065001736
	ENSRNOP00065041159
GenBank Protein	Q9Z1J8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_072130 ⟸ NM_022608

- UniProtKB:

B1WC82 (UniProtKB/TrEMBL), A0A0G2JWI8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGRVGDLSPKQAETLAKFRENVQDVLPALPNPDDYFLLRWLRARNFDLQKSEAMLRKYMEFRK
TMDIDHILDWQPPEVIQKYMPGGLCGYDRDGCPLWYDIIGPLDPKGLLFSVTKQDLLKTKMRDC
ERILHECDLQTERLGRKIETIVMIFDCEGLGLKHFWKPLVEVYQEFFGLLEENYPETLKFMLIV
KATKLFPVGYNLMKPFLSEDTRRKIVVLGNSWKEGLLKLISPEELPAHFGGTLTDPDGNPKCLT
KINYGGEIPKSMYVRDQVKTQYEHSVQISRGSSHQVEYEILFPGCVLRWQFSSDGADIGFGVFL
KTKMGERQKAGEMTEVLTSQRYNAHMVPEDGSLTCTEAGVYVLRFDNTYSFVHAKKVSFTVEVL
LPDEGMQKYDEELTPI

hide sequence

RefSeq Acc Id:

ENSRNOP00000006116 ⟸ ENSRNOT00000006116

RefSeq Acc Id:

ENSRNOP00000006053 ⟸ ENSRNOT00000006053

RefSeq Acc Id:

ENSRNOP00000069897 ⟸ ENSRNOT00000087383

RefSeq Acc Id:

ENSRNOP00000074130 ⟸ ENSRNOT00000078271

RefSeq Acc Id:	XP_038948326 ⟸ XM_039092398
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JWI8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000093206 ⟸ ENSRNOT00000113444

RefSeq Acc Id:

ENSRNOP00000089732 ⟸ ENSRNOT00000103465

Protein Domains

CRAL-TRIO GOLD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9Z1J8-F1-model_v2	AlphaFold	Q9Z1J8	1-400	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699437

Promoter ID:

EPDNEW_R9961

Type:

initiation region

Name:

Sec14l4_2

Description:

SEC14-like lipid binding 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9960

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	84,306,430 - 84,306,490	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620812	AgrOrtholog
BioCyc Gene	G2FUF-15198	BioCyc
Ensembl Genes	ENSRNOG00000004555	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00065001759	UniProtKB/Swiss-Prot
	ENSRNOG00065001878	UniProtKB/Swiss-Prot
	ENSRNOG00065028987	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006116	ENTREZGENE
	ENSRNOT00000006116.4	UniProtKB/TrEMBL
	ENSRNOT00000087383.2	UniProtKB/TrEMBL
	ENSRNOT00000103465.1	UniProtKB/TrEMBL
	ENSRNOT00000113444.1	UniProtKB/TrEMBL
	ENSRNOT00065002355	UniProtKB/Swiss-Prot
	ENSRNOT00065002509	UniProtKB/Swiss-Prot
	ENSRNOT00065050093	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.525.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GOLD domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099625	IMAGE-MGC_LOAD
InterPro	CRAL-TRIO_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CRAL-TRIO_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CRAL/TRIO_N_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CRAL/TRIO_N_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GOLD_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GOLD_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64543	UniProtKB/TrEMBL
MGC_CLONE	MGC:187966	IMAGE-MGC_LOAD
NCBI Gene	64543	ENTREZGENE
PANTHER	SEC14 RELATED PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SEC14-LIKE PROTEIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CRAL_TRIO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CRAL_TRIO_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sec14l3	PhenoGen
PRINTS	CRETINALDHBP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CRAL_TRIO	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GOLD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004555	RatGTEx
	ENSRNOG00065001759	RatGTEx
	ENSRNOG00065001878	RatGTEx
	ENSRNOG00065028987	RatGTEx
SMART	CRAL_TRIO_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SEC14	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF101576	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF46938	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52087	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JWI8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AWQ0_RAT	UniProtKB/TrEMBL
	A0A8I6GIC4_RAT	UniProtKB/TrEMBL
	A0A8L2Q1W7_RAT	UniProtKB/TrEMBL
	A6IKE4_RAT	UniProtKB/TrEMBL
	B1WC82	ENTREZGENE, UniProtKB/TrEMBL
	Q9Z1J8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-30	Sec14l3	SEC14-like lipid binding 3	Sec14l3	SEC14-like 3 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Sec14l3	SEC14-like 3 (S. cerevisiae)	AJ132352	secretory protein, 45kD	Symbol and Name updated	1299863	APPROVED
2002-08-07	AJ132352	secretory protein, 45kD			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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