Slc12a2 (solute carrier family 12 member 2) - Rat Genome Database

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Gene: Slc12a2 (solute carrier family 12 member 2) Rattus norvegicus
Analyze
Symbol: Slc12a2
Name: solute carrier family 12 member 2
RGD ID: 620809
Description: Enables sodium:potassium:chloride symporter activity. Involved in several processes, including chloride transport; metal ion transport; and positive regulation of cell volume. Acts upstream of or within gamma-aminobutyric acid signaling pathway and regulation of spontaneous synaptic transmission. Predicted to be located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and neuronal cell body. Predicted to be active in apical plasma membrane. Used to study hypertension and middle cerebral artery infarction. Biomarker of hypertension; sensorineural hearing loss; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78. Orthologous to human SLC12A2 (solute carrier family 12 member 2); INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bsc2; Nkcc1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81853,546,263 - 53,614,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1853,546,333 - 53,614,470 (+)EnsemblGRCr8
mRatBN7.21851,348,282 - 51,416,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1851,348,302 - 51,416,440 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1853,386,123 - 53,454,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01854,100,680 - 54,168,791 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01851,899,024 - 51,967,160 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01852,917,124 - 52,985,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1852,917,124 - 52,985,261 (+)Ensemblrn6Rnor6.0
Rnor_5.01852,104,434 - 52,172,638 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41853,673,215 - 53,741,352 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1849,478,614 - 49,546,320 (+)NCBICelera
RGSC_v3.11853,735,140 - 53,805,295 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
azosemide  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
bumetanide  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin A  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enilconazole  (ISO)
Enterolactone  (ISO)
estriol  (ISO)
estrone  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
fasudil  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furosemide  (EXP,ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycitein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linsidomine  (EXP)
lipoic acid  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methimazole  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nimesulide  (EXP)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
PhIP  (EXP)
Piretanide  (ISO)
pirinixic acid  (EXP,ISO)
procymidone  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
rotenone  (EXP)
rubidium atom  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
sunitinib  (ISO)
tert-butanol  (EXP)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
tienilic acid  (ISO)
titanium dioxide  (ISO)
torasemide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin E  (EXP,ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transmembrane transport  (IBA,IEA,ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
cell volume homeostasis  (IBA,ISO)
cellular response to chemokine  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion  (ISO)
chloride ion homeostasis  (IBA)
chloride transmembrane transport  (IBA,IEA,ISO)
chloride transport  (IMP)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
gamma-aminobutyric acid signaling pathway  (IEP,IMP)
hyperosmotic response  (IMP)
inorganic anion import across plasma membrane  (ISO)
inorganic cation import across plasma membrane  (IEA,ISO)
intracellular chloride ion homeostasis  (ISO)
intracellular potassium ion homeostasis  (ISO)
intracellular sodium ion homeostasis  (ISO)
maintenance of blood-brain barrier  (ISO)
mammary duct terminal end bud growth  (ISO)
monoatomic ion transport  (IEA)
multicellular organism growth  (ISO)
negative regulation of vascular wound healing  (ISO)
positive regulation of aspartate secretion  (ISO)
positive regulation of cell volume  (IMP)
potassium ion homeostasis  (IBA)
potassium ion import across plasma membrane  (IBA,ISO)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA,IMP)
regulation of matrix metallopeptidase secretion  (ISO)
regulation of spontaneous synaptic transmission  (IMP,ISO)
sodium ion homeostasis  (IBA)
sodium ion import across plasma membrane  (ISO)
sodium ion transmembrane transport  (IBA)
sodium ion transport  (IEA,IMP)
T cell chemotaxis  (IEA,ISO)
transepithelial ammonium transport  (IEA,ISO)
transepithelial chloride transport  (IEA,ISO)
transmembrane transport  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Roles of vasopressin and hypertonicity in basolateral Na/K/2Cl cotransporter expression in rat kidney inner medullary collecting duct cells. Anzai N, etal., Jpn J Physiol 1999 Apr;49(2):201-6.
2. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
3. Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Cho HM, etal., Am J Hypertens. 2011 Dec;24(12):1286-93. doi: 10.1038/ajh.2011.136. Epub 2011 Aug 4.
4. Identification of a functionally important conformation-sensitive region of the secretory Na+-K+-2Cl- cotransporter (NKCC1). Dehaye JP, etal., J Biol Chem. 2003 Apr 4;278(14):11811-7. Epub 2003 Jan 29.
5. NKCC1 transporter facilitates seizures in the developing brain. Dzhala VI, etal., Nat Med. 2005 Nov;11(11):1205-13. Epub 2005 Oct 9.
6. Unique 5'-end of a Na(+)-K(+)-2Cl- cotransporter-like mRNA expressed in rat skeletal muscle. Fu L, etal., DNA Seq 1999;10(2):127-32.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle. Jiang G, etal., Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1552-7.
10. Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter. Kurihara K, etal., Am J Physiol Cell Physiol 2002 Apr;282(4):C817-23.
11. Postnatal maturation of Na+, K+, 2Cl- cotransporter expression and inhibitory synaptogenesis in the rat hippocampus: an immunocytochemical analysis. Marty S, etal., Eur J Neurosci 2002 Jan;15(2):233-45.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Molecular and topological characterization of the rat parotid Na+-K+-2Cl- cotransporter1. Moore-Hoon ML and Turner RJ, Biochim Biophys Acta 1998 Aug 14;1373(1):261-9.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Amygdala kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex. Okabe A, etal., Neurosci Res 2002 Oct;44(2):225-9.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Expression and regulation of the Na(+)/K(+)/2Cl(-) cotransporter NKCC1 in rat liver and human HuH-7 hepatoma cells. Schliess F, etal., Arch Biochem Biophys 2002 May 15;401(2):187-97.
19. Cross talk between the GABA(A) receptor and the Na-K-Cl cotransporter is mediated by intracellular Cl-. Schomberg SL, etal., J Neurophysiol 2003 Jan;89(1):159-67.
20. Contribution of Na(+)-K(+)-Cl(-) cotransporter to high-[K(+)](o)- induced swelling and EAA release in astrocytes. Su G, etal., Am J Physiol Cell Physiol 2002 May;282(5):C1136-46.
21. Long-lasting changes in the cochlear K recycling structures after acute energy failure. Takiguchi Y, etal., Neurosci Res. 2013 Jul 1. pii: S0168-0102(13)00159-4. doi: 10.1016/j.neures.2013.06.003.
22. Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain. Wang C, etal., Brain Res Dev Brain Res 2002 Nov 15;139(1):59-66.
23. Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1. Yamada J, etal., J Physiol. 2004 Jun 15;557(Pt 3):829-41. Epub 2004 Apr 16.
24. Inhibition of Na(+)-K(+)-Cl(-) cotransporter during focal cerebral ischemia decreases edema and neuronal damage. Yan Y, etal., Brain Res. 2003 Jan 24;961(1):22-31.
25. Signalling mechanisms underlying the rapid and additive stimulation of NKCC activity by insulin and hypertonicity in rat L6 skeletal muscle cells. Zhao H, etal., J Physiol. 2004 Oct 1;560(Pt 1):123-36. Epub 2004 Jul 29.
Additional References at PubMed
PMID:7629105   PMID:8864124   PMID:11940530   PMID:12040017   PMID:12386165   PMID:12456807   PMID:12740379   PMID:12832529   PMID:12904508   PMID:12946942   PMID:14656769   PMID:15347682  
PMID:15350966   PMID:15356206   PMID:15661361   PMID:16529873   PMID:16669787   PMID:16859673   PMID:16904086   PMID:17090779   PMID:17146765   PMID:17259435   PMID:17308011   PMID:17355320  
PMID:17478539   PMID:17490438   PMID:17548052   PMID:17687039   PMID:17904674   PMID:18032481   PMID:18273442   PMID:18417545   PMID:18430034   PMID:18590550   PMID:18799000   PMID:18849345  
PMID:19129177   PMID:19199708   PMID:19307180   PMID:19686239   PMID:20458337   PMID:20458365   PMID:20536931   PMID:20932645   PMID:21056502   PMID:21308994   PMID:21705333   PMID:21970294  
PMID:22238094   PMID:22419034   PMID:22441038   PMID:22723696   PMID:22871113   PMID:23645634   PMID:23932891   PMID:24006039   PMID:24236060   PMID:24769233   PMID:24811174   PMID:24990918  
PMID:25201604   PMID:25253692   PMID:25585037   PMID:25716834   PMID:25817889   PMID:25881895   PMID:26090759   PMID:26169500   PMID:26924708   PMID:27077366   PMID:27345384   PMID:27400149  
PMID:27871891   PMID:28577991   PMID:30590202   PMID:32645929   PMID:32678166   PMID:32930727   PMID:33110147   PMID:33316378   PMID:35163352   PMID:35658898   PMID:35729645   PMID:37328833  
PMID:37458846   PMID:37830575   PMID:38160798  


Genomics

Comparative Map Data
Slc12a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81853,546,263 - 53,614,478 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1853,546,333 - 53,614,470 (+)EnsemblGRCr8
mRatBN7.21851,348,282 - 51,416,448 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1851,348,302 - 51,416,440 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1853,386,123 - 53,454,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01854,100,680 - 54,168,791 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01851,899,024 - 51,967,160 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01852,917,124 - 52,985,281 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1852,917,124 - 52,985,261 (+)Ensemblrn6Rnor6.0
Rnor_5.01852,104,434 - 52,172,638 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41853,673,215 - 53,741,352 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1849,478,614 - 49,546,320 (+)NCBICelera
RGSC_v3.11853,735,140 - 53,805,295 (+)NCBI
Cytogenetic Map18q12.1NCBI
SLC12A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385128,083,766 - 128,189,677 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5128,083,714 - 128,189,677 (+)Ensemblhg38GRCh38
GRCh375127,419,458 - 127,525,369 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365127,447,382 - 127,553,279 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345127,447,381 - 127,553,278NCBI
Celera5123,551,492 - 123,657,387 (+)NCBICelera
Cytogenetic Map5q23.3NCBI
HuRef5122,610,291 - 122,716,113 (+)NCBIHuRef
CHM1_15126,852,070 - 126,957,950 (+)NCBICHM1_1
T2T-CHM13v2.05128,602,602 - 128,708,515 (+)NCBIT2T-CHM13v2.0
Slc12a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391858,011,505 - 58,079,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1858,011,750 - 58,079,893 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381857,878,512 - 57,946,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1857,878,678 - 57,946,821 (+)Ensemblmm10GRCm38
MGSCv371858,038,332 - 58,106,475 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361858,004,047 - 58,072,174 (+)NCBIMGSCv36mm8
Celera1859,157,060 - 59,258,313 (+)NCBICelera
Cytogenetic Map18D3NCBI
cM Map1832.15NCBI
Slc12a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554151,137,327 - 1,219,241 (+)Ensembl
ChiLan1.0NW_0049554151,138,297 - 1,219,241 (+)NCBIChiLan1.0ChiLan1.0
SLC12A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24123,393,538 - 123,499,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15121,533,101 - 121,638,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05123,499,267 - 123,603,777 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15129,260,476 - 129,364,563 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5129,262,134 - 129,364,563 (+)EnsemblpanPan2panpan1.1
SLC12A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,143,943 - 17,256,248 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,143,943 - 17,253,695 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1115,939,385 - 16,051,806 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,881,289 - 17,994,035 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,881,289 - 17,991,854 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,604,869 - 16,717,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,450,079 - 16,562,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,054,476 - 17,167,223 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc12a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213139,804,839 - 139,891,490 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365041,378,810 - 1,465,623 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365041,378,812 - 1,465,463 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2131,016,418 - 131,109,299 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12131,016,430 - 131,109,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22136,368,254 - 136,460,658 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC12A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12331,028,514 - 31,132,263 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2331,029,026 - 31,132,289 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603446,918,396 - 47,021,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477413,236,306 - 13,335,412 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc12a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11573,914,126 - 73,981,960 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc12a2
661 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1138
Count of miRNA genes:325
Interacting mature miRNAs:445
Transcripts:ENSRNOT00000021921
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
BF403957  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,352,337 - 51,352,528 (+)MAPPERmRatBN7.2
Rnor_6.01852,921,160 - 52,921,350NCBIRnor6.0
Rnor_5.01852,108,470 - 52,108,660UniSTSRnor5.0
RGSC_v3.41853,677,251 - 53,677,441UniSTSRGSC3.4
Celera1849,482,428 - 49,482,618UniSTS
Cytogenetic Map18q12.1UniSTS
RH137302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,416,270 - 51,416,430 (+)MAPPERmRatBN7.2
Rnor_6.01852,985,092 - 52,985,251NCBIRnor6.0
Rnor_5.01852,172,449 - 52,172,608UniSTSRnor5.0
RGSC_v3.41853,741,183 - 53,741,342UniSTSRGSC3.4
Celera1849,546,151 - 49,546,310UniSTS
Cytogenetic Map18q12.1UniSTS
RH139514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21851,415,271 - 51,415,454 (+)MAPPERmRatBN7.2
Rnor_6.01852,984,093 - 52,984,275NCBIRnor6.0
Rnor_5.01852,171,450 - 52,171,632UniSTSRnor5.0
RGSC_v3.41853,740,184 - 53,740,366UniSTSRGSC3.4
Celera1849,545,152 - 49,545,334UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021921   ⟹   ENSRNOP00000021921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1853,546,333 - 53,614,470 (+)Ensembl
mRatBN7.2 Ensembl1851,348,302 - 51,416,440 (+)Ensembl
Rnor_6.0 Ensembl1852,917,124 - 52,985,261 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102056   ⟹   ENSRNOP00000079755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1853,546,333 - 53,614,470 (+)Ensembl
mRatBN7.2 Ensembl1851,348,302 - 51,416,440 (+)Ensembl
RefSeq Acc Id: NM_031798   ⟹   NP_113986
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81853,546,333 - 53,614,470 (+)NCBI
mRatBN7.21851,348,302 - 51,416,440 (+)NCBI
Rnor_6.01852,917,124 - 52,985,261 (+)NCBI
Rnor_5.01852,104,434 - 52,172,638 (+)NCBI
RGSC_v3.41853,673,215 - 53,741,352 (+)RGD
Celera1849,478,614 - 49,546,320 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254752   ⟹   XP_006254814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81853,546,263 - 53,614,478 (+)NCBI
mRatBN7.21851,348,282 - 51,416,448 (+)NCBI
Rnor_6.01852,917,155 - 52,985,281 (+)NCBI
Rnor_5.01852,104,434 - 52,172,638 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113986   ⟸   NM_031798
- UniProtKB: E9PTX9 (UniProtKB/TrEMBL),   Q9QX10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254814   ⟸   XM_006254752
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZP25 (UniProtKB/TrEMBL),   Q9QX10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021921   ⟸   ENSRNOT00000021921
Ensembl Acc Id: ENSRNOP00000079755   ⟸   ENSRNOT00000102056
Protein Domains
Amino acid permease N-terminal   Amino acid permease/ SLC12A   SLC12A transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTX9-F1-model_v2 AlphaFold E9PTX9 1-1203 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700795
Promoter ID:EPDNEW_R11319
Type:multiple initiation site
Name:Slc12a2_1
Description:solute carrier family 12 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01852,917,093 - 52,917,153EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620809 AgrOrtholog
BioCyc Gene G2FUF-7410 BioCyc
Ensembl Genes ENSRNOG00000015971 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021921 ENTREZGENE
  ENSRNOT00000021921.6 UniProtKB/TrEMBL
  ENSRNOT00000102056 ENTREZGENE
  ENSRNOT00000102056.2 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA-permease_dom UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  K/Cl_cotranspt_1/3 UniProtKB/TrEMBL
  Na/K/Cl_cotranspt UniProtKB/TrEMBL
  Na/K/Cl_cotranspt1 UniProtKB/TrEMBL
  Na/K/Cl_cotransptS UniProtKB/TrEMBL
KEGG Report rno:83629 UniProtKB/TrEMBL
NCBI Gene 83629 ENTREZGENE
PANTHER PTHR11827 UniProtKB/TrEMBL
  PTHR11827:SF58 UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  SLC12 UniProtKB/TrEMBL
PhenoGen Slc12a2 PhenoGen
PRINTS NAKCLTRNSPRT UniProtKB/TrEMBL
  NAKCLTRSPRT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015971 RatGTEx
UniProt A0A8I5ZP25 ENTREZGENE, UniProtKB/TrEMBL
  E9PTX9 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX10 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc12a2  solute carrier family 12 member 2  Slc12a2  solute carrier family 12 (sodium/potassium/chloride transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc12a2  solute carrier family 12 (sodium/potassium/chloride transporter), member 2  Slc12a2  solute carrier family 12 (sodium/potassium/chloride transporters), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Slc12a2  solute carrier family 12 (sodium/potassium/chloride transporters), member 2  Slc12a2  solute carrier family 12, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc12a2  solute carrier family 12, member 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc12a2  solute carrier family 12, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activation results from activation of the GABA(A) receptor 634055