Gng4 (G protein subunit gamma 4) - Rat Genome Database

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Gene: Gng4 (G protein subunit gamma 4) Rattus norvegicus
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Symbol: Gng4
Name: G protein subunit gamma 4
RGD ID: 620806
Description: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell growth. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in synapse. Orthologous to human GNG4 (G protein subunit gamma 4); PARTICIPATES IN chemokine mediated signaling pathway; glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanine nucleotide binding protein (G protein), gamma 4; guanine nucleotide binding protein (G protein), gamma 4 subunit; guanine nucleotide binding protein 4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; heterotrimeric guanine nucleotide-binding protein 3c; Hg3c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81793,432,791 - 93,481,709 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1793,433,195 - 93,481,709 (+)EnsemblGRCr8
mRatBN7.21786,448,708 - 86,497,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1786,449,022 - 86,495,254 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1790,687,122 - 90,735,625 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01794,523,029 - 94,571,532 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01788,539,549 - 88,588,049 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1794,833,192 - 94,881,697 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1793,627,689 - 93,676,198 (+)NCBILyon_Normotensive
Lyon_Hypertensive1795,114,760 - 95,163,265 (+)NCBILyon_Hypertensive
F344_StmMcwi1791,647,928 - 91,696,428 (+)NCBIF344_StmMcwi
Rnor_6.01790,266,571 - 90,316,278 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,266,794 - 90,315,492 (-)Ensemblrn6Rnor6.0
Rnor_5.01791,928,440 - 91,976,187 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1785,118,055 - 85,165,657 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, etal., Neuroscience 1998 Jul;85(2):475-86.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15824735   PMID:23533145  


Genomics

Comparative Map Data
Gng4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81793,432,791 - 93,481,709 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1793,433,195 - 93,481,709 (+)EnsemblGRCr8
mRatBN7.21786,448,708 - 86,497,560 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1786,449,022 - 86,495,254 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1790,687,122 - 90,735,625 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01794,523,029 - 94,571,532 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01788,539,549 - 88,588,049 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1794,833,192 - 94,881,697 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1793,627,689 - 93,676,198 (+)NCBILyon_Normotensive
Lyon_Hypertensive1795,114,760 - 95,163,265 (+)NCBILyon_Hypertensive
F344_StmMcwi1791,647,928 - 91,696,428 (+)NCBIF344_StmMcwi
Rnor_6.01790,266,571 - 90,316,278 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1790,266,794 - 90,315,492 (-)Ensemblrn6Rnor6.0
Rnor_5.01791,928,440 - 91,976,187 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1785,118,055 - 85,165,657 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
GNG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381235,547,685 - 235,650,608 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1235,547,685 - 235,650,754 (-)Ensemblhg38GRCh38
GRCh371235,710,985 - 235,813,908 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361233,777,608 - 233,880,677 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341232,040,173 - 232,140,095NCBI
Celera1208,954,277 - 209,057,391 (-)NCBICelera
Cytogenetic Map1q42.3NCBI
HuRef1206,162,071 - 206,265,794 (-)NCBIHuRef
CHM1_11236,983,524 - 237,086,799 (-)NCBICHM1_1
T2T-CHM13v2.01234,943,567 - 235,047,271 (-)NCBIT2T-CHM13v2.0
Gng4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391313,958,644 - 14,002,480 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1313,958,644 - 14,002,481 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381313,784,059 - 13,827,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1313,784,059 - 13,827,896 (+)Ensemblmm10GRCm38
MGSCv371313,876,806 - 13,920,162 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361313,576,665 - 13,620,021 (+)NCBIMGSCv36mm8
Celera1314,090,226 - 14,133,654 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.29NCBI
Gng4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554924,406,154 - 4,432,600 (+)Ensembl
ChiLan1.0NW_0049554924,380,198 - 4,432,551 (+)NCBIChiLan1.0ChiLan1.0
GNG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,527,011 - 13,630,496 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,738,842 - 13,842,571 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01211,109,952 - 211,218,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,121,864 - 216,221,681 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,121,864 - 216,154,657 (-)EnsemblpanPan2panpan1.1
GNG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.144,308,892 - 4,389,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl44,354,050 - 4,387,191 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha44,355,567 - 4,436,458 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.044,330,254 - 4,411,421 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl44,330,185 - 4,411,408 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.144,342,090 - 4,422,944 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,459,681 - 4,540,292 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,680,965 - 4,761,849 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gng4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,783,499 - 40,803,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,951,967 - 16,968,537 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,950,628 - 16,968,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1455,653,034 - 55,726,373 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11455,652,743 - 55,725,085 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21459,779,582 - 59,799,741 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12572,723,600 - 72,817,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605574,760,288 - 74,860,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gng4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477514,916,063 - 14,962,667 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477514,916,047 - 14,962,661 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:58
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000070807
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat

Markers in Region
D13Sfk17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21786,494,931 - 86,495,004 (-)MAPPERmRatBN7.2
Rnor_6.01790,269,358 - 90,269,430NCBIRnor6.0
Rnor_5.01791,930,801 - 91,930,873UniSTSRnor5.0
Celera1785,120,842 - 85,120,914UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 56 147 77 76 45 40 45 6 259 117 1 134 73 85 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000070807   ⟹   ENSRNOP00000065598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1790,266,794 - 90,315,492 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108987   ⟹   ENSRNOP00000091415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1793,433,195 - 93,481,709 (+)Ensembl
mRatBN7.2 Ensembl1786,449,022 - 86,495,254 (+)Ensembl
RefSeq Acc Id: NM_001400370   ⟹   NP_001387299
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81793,433,195 - 93,481,709 (+)NCBI
mRatBN7.21786,449,040 - 86,497,560 (+)NCBI
Dahl_SR_JrHsd1794,833,192 - 94,881,697 (+)NCBI
Lyon_Normotensive1793,627,689 - 93,676,198 (+)NCBI
Lyon_Hypertensive1795,114,760 - 95,163,265 (+)NCBI
F344_StmMcwi1791,647,928 - 91,696,428 (+)NCBI
RefSeq Acc Id: XM_008771924   ⟹   XP_008770146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81793,432,791 - 93,481,709 (+)NCBI
mRatBN7.21786,448,708 - 86,497,560 (+)NCBI
Rnor_6.01790,266,571 - 90,316,278 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001387299 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB82556 (Get FASTA)   NCBI Sequence Viewer  
  CAG9553623 (Get FASTA)   NCBI Sequence Viewer  
  EDL83171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091415.2
RefSeq Acc Id: XP_008770146   ⟸   XM_008771924
- Peptide Label: isoform X1
- UniProtKB: A6KTD1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065598   ⟸   ENSRNOT00000070807
Ensembl Acc Id: ENSRNOP00000091415   ⟸   ENSRNOT00000108987
RefSeq Acc Id: NP_001387299   ⟸   NM_001400370
- UniProtKB: A6KTD1 (UniProtKB/TrEMBL)
Protein Domains
G protein gamma

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R809-F1-model_v2 AlphaFold M0R809 1-75 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620806 AgrOrtholog
BioCyc Gene G2FUF-8450 BioCyc
Ensembl Genes ENSRNOG00000047080 Ensembl
  ENSRNOG00000068923 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000108987.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.10 UniProtKB/TrEMBL
InterPro G-protein_gamma-like_dom UniProtKB/TrEMBL
  GGL_sf UniProtKB/TrEMBL
  Gprotein-gamma UniProtKB/TrEMBL
NCBI Gene 114118 ENTREZGENE
PANTHER PTHR13809 UniProtKB/TrEMBL
Pfam G-gamma UniProtKB/TrEMBL
PhenoGen Gng4 PhenoGen
PRINTS GPROTEING UniProtKB/TrEMBL
PROSITE G_PROTEIN_GAMMA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047080 RatGTEx
  ENSRNOG00000068923 RatGTEx
SMART G_gamma UniProtKB/TrEMBL
  GGL UniProtKB/TrEMBL
Superfamily-SCOP SSF48670 UniProtKB/TrEMBL
UniProt A0A8I6AF64_RAT UniProtKB/TrEMBL
  A6KTD1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Gng4  G protein subunit gamma 4  Gng4  G protein subunit gamma 4  Data merged from RGD:149736400 737654 PROVISIONAL
2021-08-09 Gng4  G protein subunit gamma 4      Symbol and Name status set to provisional 45752 PROVISIONAL
2016-03-15 Gng4  G protein subunit gamma 4  Gng4  guanine nucleotide binding protein (G protein), gamma 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-01 Gng4  guanine nucleotide binding protein (G protein), gamma 4  Gng4  guanine nucleotide binding protein (G protein), gamma 4 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gng4  guanine nucleotide binding protein (G protein), gamma 4 subunit    guanine nucleotide binding protein 4  Name updated 1299863 APPROVED
2002-08-07 Gng4  guanine nucleotide binding protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in dorsal raphe nucleus 632972
gene_process may function in serotonergic transmission 632972