Gene:	Lat ( Rattus norvegicus ) linker for activation of T cells
Description:	an adaptor protein; involved in signalling after T-cell activation
Synonyms:	MGC108666;  (details...)
ArrayIDs:	6677656; 6598755; A_42_P641528; 6406013; 6548417; 6319417; 1368723_at; 6126825; A_44_P267041; 6221517; 6577578; GE21506; 5924172; 6018636; GE1249754; 6234068; 5943609; AJ001184_at; 6281290; 6284835;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: LAT     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Lat     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Lat genome assembly 3.1 1 185600035 - 185605061     Rat Celera Assembly 1 178597456 - 178602481     RGSC genome assembly v3.4 1 185450155 - 185455180     Cytogenetic 1 q36 Mus musculus Lat Mouse genome assembly build 36.1 7 133507341 - 133513048     Cytogenetic 7 7 F3 Homo sapiens LAT human genome assembly 16 28904161 - 28909595     Human genome assembly build 36.2 16 28903648 - 28909605     Cytogenetic 16 p11.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology SH3/SH2 adaptor activity,  protein binding (details...)
Biological Process	Gene Ontology regulation of T cell activation,  gene expression,  integrin-mediated signaling pathway ...  (details...)
Cellular Component	Gene Ontology immunological synapse,  integral to membrane,  plasma membrane (details...)
Physical interaction	Note Reference associates with phospholipase Cgamma-1 and Grb2 after being phosphorylated 729083
External Links
Databases	DATABASE ID SOURCE Ensembl Protein: ENSRNOP00000023563 IPI IPI: IPI00200381 IPI Entrez Gene: Lat ENTREZGENE IMAGE_CLONE: IMAGE:7382238 IMAGE-MGC_LOAD UNIPARC: UPI000012E23B IPI MGC_CLONE: MGC:108666 IMAGE-MGC_LOAD KEGG Report: rno:81511 ENTREZGENE Ensembl Genes: ENSRNOG00000017429 IPI UniProt: Q5M8B3_RAT IPI UniProt: LAT_RAT IPI HomoloGene Group ID: 7811 ENTREZGENE Germonline: 620802 KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: Linker_for_activat_Tcells_prot. IPI PRINTS: LATPROTEIN. IPI
Sequences	Nucleotide: CH473956 Get FASTA Search GEO Profiles Nucleotide: BC088130 Get FASTA Search GEO Profiles Nucleotide: NM_030853 Get FASTA Search GEO Profiles Nucleotide: AJ001184 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_110480 Get FASTA Protein: O70601 Get FASTA Protein: EDM17489 Get FASTA Protein: EDM17490 Get FASTA Protein: EDM17491 Get FASTA Protein: CAA04577 Get FASTA Protein: AAH88130 Get FASTA Protein: Q5M8B3 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 9773
References
Curated References	4 references in RGD related to Lat
Other References	4 other references at PubMed related to Lat
Database Information
RGD ID	620802
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Lat linker for activation of T cells APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Lat linker for activation of T cells PROVISIONAL Symbol and Name status set to provisional 70820