Snai1 (snail family transcriptional repressor 1) - Rat Genome Database

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Gene: Snai1 (snail family transcriptional repressor 1) Rattus norvegicus
Analyze
Symbol: Snai1
Name: snail family transcriptional repressor 1
RGD ID: 620758
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and kinase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; negative regulation of cell differentiation involved in embryonic placenta development; and trophoblast giant cell differentiation. Predicted to be located in cytoplasm; nucleus; and pericentric heterochromatin. Biomarker of rheumatic heart disease. Orthologous to human SNAI1 (snail family transcriptional repressor 1); INTERACTS WITH (+)-schisandrin B; (R)-carnitine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Sna; snail family zinc finger 1; snail homolog; snail homolog 1; snail homolog 1 (Drosophila); snail homolog, (Drosophila); zinc finger protein SNAI1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,667,476 - 176,671,965 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.23156,248,479 - 156,252,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,043,780 - 160,048,265 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,542,842 - 168,547,327 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,284,546 - 166,289,031 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,274,710 - 164,279,199 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,274,710 - 164,279,378 (+)Ensemblrn6Rnor6.0
Rnor_5.03170,425,898 - 170,430,387 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43158,676,980 - 158,681,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,827,543 - 154,832,032 (+)NCBICelera
RGSC_v3.13158,583,924 - 158,586,727 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethylhexan-1-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrolein  (ISO)
acteoside  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-pinene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aucubin  (ISO)
Azoxymethane  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bisphenol P  (ISO)
Bufotalin  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camphor  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celecoxib  (ISO)
CHIR 99021  (ISO)
chloroquine  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
endosulfan  (EXP,ISO)
eplerenone  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galaxolide  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucose  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
Iodine aqueous  (ISO)
jaspamide  (ISO)
ketamine  (ISO)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
loliolide  (ISO)
losartan  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
menadione  (ISO)
metformin  (ISO)
methimazole  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
myriocin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nisin  (ISO)
NMS-873  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
oridonin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
patulin  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
Pervanadate  (ISO)
phenol red  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (EXP,ISO)
pterostilbene  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
reparixin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ridaforolimus  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
roxadustat  (ISO)
sabinene  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
sclareol  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
spathulenol  (ISO)
stattic  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraethylenepentamine  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
withaferin A  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Snail blocks the cell cycle and confers resistance to cell death. Vega S, etal., Genes Dev 2004 May 15;18(10):1131-43.
7. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
8. Snail and Axin2 expression predict the malignant transformation of oral leukoplakia. Zhang X, etal., Oral Oncol. 2017 Oct;73:48-55. doi: 10.1016/j.oraloncology.2017.08.004. Epub 2017 Aug 12.
Additional References at PubMed
PMID:1302246   PMID:9676199   PMID:10655586   PMID:11689706   PMID:11912130   PMID:12477932   PMID:12832491   PMID:12917416   PMID:15314165   PMID:15448698   PMID:15630473   PMID:16096638  
PMID:16801545   PMID:17093497   PMID:17376812   PMID:17692821   PMID:18663143   PMID:18832382   PMID:19502595   PMID:19955572   PMID:20018240   PMID:20128911   PMID:20890042   PMID:20930141  
PMID:23288509   PMID:23460471   PMID:23707238   PMID:23831330   PMID:24209753   PMID:24239292   PMID:24379627   PMID:25303734   PMID:25893292   PMID:26781174   PMID:26884822   PMID:31115509  
PMID:31668740   PMID:32187849   PMID:38615011  


Genomics

Comparative Map Data
Snai1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,667,476 - 176,671,965 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.23156,248,479 - 156,252,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3160,043,780 - 160,048,265 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,542,842 - 168,547,327 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03166,284,546 - 166,289,031 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03164,274,710 - 164,279,199 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,274,710 - 164,279,378 (+)Ensemblrn6Rnor6.0
Rnor_5.03170,425,898 - 170,430,387 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43158,676,980 - 158,681,471 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3154,827,543 - 154,832,032 (+)NCBICelera
RGSC_v3.13158,583,924 - 158,586,727 (+)NCBI
Cytogenetic Map3q42NCBI
SNAI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,982,980 - 49,988,886 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,982,980 - 49,988,886 (+)Ensemblhg38GRCh38
GRCh372048,599,517 - 48,605,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,032,934 - 48,038,830 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342048,032,933 - 48,038,825NCBI
Celera2045,304,074 - 45,309,984 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,348,282 - 45,354,192 (+)NCBIHuRef
CHM1_12048,504,120 - 48,510,030 (+)NCBICHM1_1
T2T-CHM13v2.02051,752,473 - 51,758,373 (+)NCBIT2T-CHM13v2.0
Snai1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,380,115 - 167,384,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,380,115 - 167,384,734 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382167,538,195 - 167,542,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,538,195 - 167,542,814 (+)Ensemblmm10GRCm38
MGSCv372167,363,727 - 167,368,314 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362167,229,432 - 167,234,019 (+)NCBIMGSCv36mm8
Celera2173,478,489 - 173,483,072 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.33NCBI
Snai1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,231,924 - 8,237,996 (-)Ensembl
ChiLan1.0NW_0049554458,232,084 - 8,237,893 (-)NCBIChiLan1.0ChiLan1.0
SNAI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,722,221 - 55,732,559 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,715,326 - 55,725,666 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02046,321,075 - 46,328,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12047,384,818 - 47,390,738 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2047,384,818 - 47,390,733 (+)EnsemblpanPan2panpan1.1
SNAI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,498,343 - 36,503,623 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,498,062 - 36,503,628 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2435,741,546 - 35,747,503 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02437,204,007 - 37,209,960 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,204,036 - 37,209,945 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,445,442 - 36,451,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,578,693 - 36,584,651 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,122,272 - 37,128,230 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Snai1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,002,837 - 189,012,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,456,484 - 4,462,987 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,456,498 - 4,462,436 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNAI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,546,477 - 51,552,499 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11751,546,446 - 51,552,498 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SNAI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,988,059 - 13,993,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,988,024 - 13,993,746 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605062,416,997 - 62,422,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snai1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,509,311 - 5,515,266 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247905,509,541 - 5,515,240 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Snai1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15150,462,095 - 150,466,774 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:375
Count of miRNA genes:200
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000012939
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 88 59 6 345 188 11 139 74 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012939   ⟹   ENSRNOP00000012939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3156,248,485 - 156,252,969 (+)Ensembl
Rnor_6.0 Ensembl3164,274,710 - 164,279,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077581   ⟹   ENSRNOP00000071187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3164,275,095 - 164,279,378 (+)Ensembl
RefSeq Acc Id: NM_053805   ⟹   NP_446257
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83176,667,476 - 176,671,965 (+)NCBI
mRatBN7.23156,248,479 - 156,252,969 (+)NCBI
Rnor_6.03164,274,710 - 164,279,199 (+)NCBI
Rnor_5.03170,425,898 - 170,430,387 (+)NCBI
RGSC_v3.43158,676,980 - 158,681,471 (+)RGD
Celera3154,827,543 - 154,832,032 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446257 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31598 (Get FASTA)   NCBI Sequence Viewer  
  AAH79210 (Get FASTA)   NCBI Sequence Viewer  
  EDL96401 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446257   ⟸   NM_053805
- UniProtKB: Q6AY35 (UniProtKB/TrEMBL),   E9PU82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071187   ⟸   ENSRNOT00000077581
Ensembl Acc Id: ENSRNOP00000012939   ⟸   ENSRNOT00000012939
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY35-F1-model_v2 AlphaFold Q6AY35 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692692
Promoter ID:EPDNEW_R3217
Type:single initiation site
Name:Snai1_1
Description:snail family transcriptional repressor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03164,274,701 - 164,274,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620758 AgrOrtholog
BioCyc Gene G2FUF-46731 BioCyc
Ensembl Genes ENSRNOG00000009594 Ensembl
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131806 IMAGE-MGC_LOAD
InterPro Snail/Krueppel_Znf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:116490 UniProtKB/TrEMBL
MGC_CLONE MGC:94272 IMAGE-MGC_LOAD
NCBI Gene 116490 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN SNAI1 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Snai1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009594 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt E9PU82 ENTREZGENE
  Q6AY35 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9PU82 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Snai1  snail family transcriptional repressor 1  Snai1  snail family zinc finger 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Snai1  snail family zinc finger 1  Snai1  snail homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Snai1  snail homolog 1 (Drosophila)    snail homolog, (Drosophila)  Name updated 1299863 APPROVED
2004-09-10 Snai1  snail homolog, (Drosophila)  Sna    Symbol and Name updated 1299863 APPROVED
2002-08-07 Sna  snail homolog, (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL