Chd8 Rat Gene (chromodomain helicase DNA binding protein 8)

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Keyword

Gene:
Chd8 ( Rattus norvegicus )
chromodomain helicase DNA binding protein 8
Description: binds directly to the Armadillo repeats of beta-catenin inhibiting Tcf binding resulting in inhibition of beta-catenin signaling functions
Synonyms: beta-catenin binding protein; Loc65027;
ArrayIDs: 6400817; 6680534; 1369426_at; 6612195; 6167229; 6262473; A_44_P604267; 5737814; 1375527_at; rc_AI044903_at; 6550113; 6338878; 6033046; 6190337; 6426283; rc_AI113244_at; 5727029; 6697117; 6364515; 6471636; 5695778; 6652236; 5634343; 6421463; 6700413; 5847203; 6594812; 5679598; A_43_P12339; 6663747; 6662995; 6068901; 6421381; 6661957; 6380201; 5943441; A_44_P652617; 5875770; 6267310; GE1230259; 5749265; 6105966; 5972527; 6032301; GE1242883; 5792709; 6173070; 5768133; 6647284; 6599182; 6457937; 6654425; 6167026; 6435335; 6183858; 6592675; 5710475; 5804331; 6606232; 5906062; 6421357;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: CHD8     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Chd8     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Chd8 genome assembly 3.1 15 27684891 - 27696816
Rat Celera Assembly 15 25209585 - 25247940
RGSC genome assembly v3.4 15 27642761 - 27681116
Cytogenetic 15 p14
Mus musculus Chd8 Mouse genome assembly build 36.1 14 52817826 - 52857247
Cytogenetic 14 14 C2
Homo sapiens CHD8 Human genome assembly build 36.2 14 20923470 - 20975242
Cytogenetic 14 q11.2

View comparative maps:      NCBI MapViewer

Genome
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Browsers:

Annotation
Molecular Function

Gene Ontology

DNA binding,  transcription activator activity,  DNA helicase activity ... (details...)
Biological Process

Note Reference

involved in inhibition of beta-catenin-dependent Tcf activation and axis formation

Gene Ontology

positive regulation of transcription from RNA polymerase II promoter,  negative regulation of Wnt receptor signaling pathway,  negative regulation of apoptosis ... (details...)
Cellular Component

Note Reference

localized to the nucleus

Gene Ontology

protein complex,  nucleus (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: DEXDc IPI
SMART: BRK IPI
SMART: CHROMO IPI
SMART: HELICc IPI
PROSITE: HELICASE_CTER IPI
PROSITE: HELICASE_ATP_BIND_1 IPI
PROSITE: CHROMO_2 IPI
UNIPARC: UPI0000DA3CDD IPI
UNIPARC: UPI00000E7317 IPI
KEGG Report: rno:65027 ENTREZGENE
HomoloGene Group ID: 72405 ENTREZGENE
Germonline: 620696
Pfam: Helicase_C IPI
Pfam: SNF2_N IPI
Pfam: Chromo IPI
Pfam: BRK IPI
KEGG Pathway: 04310 ENTREZGENE
InterPro: BRK_domain. IPI
InterPro: Chromodomain-like. IPI
InterPro: Chromodomain. IPI
InterPro: DEAD-like_N. IPI
InterPro: DNA/RNA_helicase_C. IPI
InterPro: SNF2_N. IPI
InterPro: Helicase_SF1/SF2_ATP-bd. IPI
IPI: IPI00923717 IPI
IPI: IPI00201110 IPI
Ensembl Protein: ENSRNOP00000022593 IPI
Entrez Gene: Chd8 ENTREZGENE
UniProt: CHD8_RAT IPI
UniProt: CHD8_RAT IPI
Ensembl Genes: ENSRNOG00000025011 IPI
Superfamily-SCOP: Chromodomain-like IPI
Sequences
Nucleotide: XM_001075710 Get FASTA Search GEO Profiles
Nucleotide: CH474040 Get FASTA Search GEO Profiles
Nucleotide: XM_573762 Get FASTA Search GEO Profiles
Nucleotide: AF169825 Get FASTA Search GEO Profiles
Nucleotide: NM_022933 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: XP_573762 Get FASTA
Protein: XP_001075710 Get FASTA
Protein: NP_075222 Get FASTA
Protein: EDL88472 Get FASTA
Protein: EDL88473 Get FASTA
Protein: AAF89678 Get FASTA
Protein: Q9JIX5 Get FASTA
(View all 7 Protein Accessions)
Clusters
UniGene: 98337

References
Curated References
4 references in RGD related to Chd8

Other References
1 other references at PubMed related to Chd8

Database Information
RGD ID 620696
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

30-MAR-06: Chd8 chromodomain helicase DNA binding protein 8 Loc65027 beta-catenin binding protein APPROVED Symbol and Name updated 1299863

07-AUG-02: Loc65027 beta-catenin binding protein PROVISIONAL Symbol and Name status set to provisional 70820