Pygl (glycogen phosphorylase L) - Rat Genome Database

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Gene: Pygl (glycogen phosphorylase L) Rattus norvegicus
Analyze
Symbol: Pygl
Name: glycogen phosphorylase L
RGD ID: 620687
Description: Enables carbohydrate binding activity; glycogen phosphorylase activity; and identical protein binding activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process and glycogen catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Used to study glycogen storage disease VI and lactic acidosis. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L); PARTICIPATES IN glycogen degradation pathway; glycogen metabolic pathway; congenital sucrase-isomaltase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycogen phosphorylase; glycogen phosphorylase, liver form; liver glycogen phosphorylase; phosphorylase, glycogen, liver
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,433,558 - 94,476,219 (-)NCBIGRCr8
mRatBN7.2688,697,598 - 88,740,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,697,593 - 88,740,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx689,096,834 - 89,133,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0689,396,285 - 89,433,272 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,835,817 - 88,872,806 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,597,759 - 92,643,734 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,597,706 - 92,643,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06102,045,144 - 102,091,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4692,298,339 - 92,341,347 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1692,301,796 - 92,344,803 (-)NCBI
Celera687,191,869 - 87,228,313 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxyacetophenone  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
acrylamides  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (EXP)
alpha-Zearalanol  (EXP)
aluminium phosphide  (EXP)
alvocidib  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
baicalein  (ISO)
benzamide  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
Calcimycin  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorvos  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythromycin estolate  (EXP)
fenofibrate  (EXP)
Geniposide  (EXP)
glafenine  (EXP)
glucose  (EXP)
glyphosate  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
malathion  (EXP)
metformin  (EXP)
methylarsonite  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
neostigmine  (EXP)
nickel dichloride  (EXP)
nicotinamide  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
omeprazole  (EXP)
orotic acid  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phentolamine  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
procyanidin B1  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanillin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IEA)

References

References - curated
# Reference Title Reference Citation
1. High frequency of missense mutations in glycogen storage disease type VI. Beauchamp NJ, etal., J Inherit Metab Dis. 2007 Oct;30(5):722-34. Epub 2007 Aug 21.
2. Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Birch AM, etal., Bioorg Med Chem Lett. 2007 Jan 15;17(2):394-9. Epub 2006 Oct 19.
3. Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures. Boer P and Sperling O, Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1235-9.
4. Structural relationships among regulated and unregulated phosphorylases. Buchbinder JL, etal., Annu Rev Biophys Biomol Struct. 2001;30:191-209.
5. Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes. Carabaza A, etal., FEBS Lett. 1992 Jan 20;296(2):211-4.
6. Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI. Chang S, etal., Hum Mol Genet. 1998 May;7(5):865-70.
7. Liver glycogen storage diseases due to phosphorylase system deficiencies: diagnosis thanks to non invasive blood enzymatic and molecular studies. Davit-Spraul A, etal., Mol Genet Metab. 2011 Sep-Oct;104(1-2):137-43. doi: 10.1016/j.ymgme.2011.05.010. Epub 2011 May 17.
8. Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. Dixon CJ, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):334-41. Epub 2004 May 19.
9. Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations. Fosgerau K, etal., J Biol Chem 2002 Aug 9;277(32):28648-55.
10. The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences. Froman BE, etal., Gene 1991 Dec 30;109(2):269-74.
11. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Glaser T, etal., Genomics 1989 Oct;5(3):510-21.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Rapid activation of glycogen phosphorylase by steroid hormones in cultured rat hepatocytes. Gomez-Munoz A, etal., Biochem J. 1989 Sep 1;262(2):417-23.
16. Glycogen phosphorylase: control by phosphorylation and allosteric effectors. Johnson LN FASEB J. 1992 Mar;6(6):2274-82.
17. Glycogen synthesis by rat hepatocytes. Katz J, etal., Biochem J. 1979 May 15;180(2):389-402.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species. Lelli SM, etal., Toxicology. 2005 Dec;216(1):49-58. Epub 2005 Aug 24.
20. Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a non-tumorigenic liver cell line. Comparison with the liver and brain enzymes. Mayer D, etal., Biochem J. 1992 Mar 15;282 ( Pt 3):665-73.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Isolation of partial cDNAs for rat liver and muscle glycogen phosphorylase isozymes. Osawa S, etal., FEBS Lett 1986 Jul 7;202(2):282-8.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Effects of the specific cAMP antagonist, (Rp)-adenosine cyclic 3',5'-phosphorothioate, on the cAMP-dependent protein kinase-induced activity of hepatic glycogen phosphorylase and glycogen synthase. Rothermel JD, etal., J Biol Chem. 1984 Dec 25;259(24):15294-300.
31. Glycogen-binding protein components of rat tissues. Satoh K and Sato K, Biochem Biophys Res Commun. 1980 Sep 16;96(1):28-33.
32. Electron microscopical study of a cytosolic enzyme in unfixed cryostat sections: demonstration of glycogen phosphorylase activity in rat liver and heart tissue. Schellens JP, etal., Histochem J. 1995 Aug;27(8):609-14.
33. The nucleotide sequence of rat liver glycogen phosphorylase cDNA. Schiebel K, etal., Biochim Biophys Acta 1992 Apr 6;1130(3):349-51.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Proteomic investigation of signatures for geniposide-induced hepatotoxicity. Wei J, etal., J Proteome Res. 2014 Dec 5;13(12):5724-33. doi: 10.1021/pr5007119. Epub 2014 Oct 30.
Additional References at PubMed
PMID:3209063   PMID:8482535   PMID:9529348   PMID:10949035   PMID:10980448   PMID:11960689   PMID:12204691   PMID:12519761   PMID:12823547   PMID:15489334   PMID:17693424   PMID:18298402  
PMID:19498109   PMID:22225877   PMID:23012479   PMID:23533145   PMID:32357304  


Genomics

Comparative Map Data
Pygl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8694,433,558 - 94,476,219 (-)NCBIGRCr8
mRatBN7.2688,697,598 - 88,740,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl688,697,593 - 88,740,310 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx689,096,834 - 89,133,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0689,396,285 - 89,433,272 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0688,835,817 - 88,872,806 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0692,597,759 - 92,643,734 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl692,597,706 - 92,643,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06102,045,144 - 102,091,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4692,298,339 - 92,341,347 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1692,301,796 - 92,344,803 (-)NCBI
Celera687,191,869 - 87,228,313 (-)NCBICelera
Cytogenetic Map6q24NCBI
PYGL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381450,905,217 - 50,944,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1450,857,891 - 50,944,483 (-)EnsemblGRCh38hg38GRCh38
GRCh371451,371,935 - 51,411,201 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361450,441,687 - 50,480,984 (-)NCBINCBI36Build 36hg18NCBI36
Build 341450,441,688 - 50,480,984NCBI
Celera1431,238,983 - 31,278,301 (-)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1431,497,509 - 31,536,798 (-)NCBIHuRef
CHM1_11451,310,446 - 51,349,770 (-)NCBICHM1_1
T2T-CHM13v2.01445,111,656 - 45,150,908 (-)NCBIT2T-CHM13v2.0
Pygl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391270,237,589 - 70,274,457 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1270,237,585 - 70,278,262 (-)EnsemblGRCm39 Ensembl
GRCm381270,190,815 - 70,227,683 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1270,190,811 - 70,231,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv371271,291,802 - 71,328,670 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361271,109,416 - 71,146,222 (-)NCBIMGSCv36mm8
Celera1271,292,479 - 71,327,360 (-)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1229.01NCBI
Pygl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540911,970,112 - 12,007,102 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540911,970,112 - 12,007,102 (+)NCBIChiLan1.0ChiLan1.0
PYGL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21552,042,469 - 52,082,068 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11451,234,331 - 51,299,970 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01431,494,172 - 31,533,545 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11449,793,210 - 49,832,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1449,746,309 - 49,832,786 (-)Ensemblpanpan1.1panPan2
PYGL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1827,264,778 - 27,307,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl827,223,273 - 27,307,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha827,018,142 - 27,061,230 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0827,443,863 - 27,486,861 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl827,401,678 - 27,486,986 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1827,098,985 - 27,141,894 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0827,171,662 - 27,214,570 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0827,519,107 - 27,562,008 (-)NCBIUU_Cfam_GSD_1.0
Pygl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864059,463,043 - 59,498,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649514,692,332 - 14,730,231 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649514,692,688 - 14,728,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PYGL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1180,620,314 - 180,719,979 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11180,645,849 - 180,704,124 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,933,155 - 200,991,988 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PYGL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12427,987,676 - 28,030,919 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2427,987,649 - 28,030,869 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605316,283,872 - 16,325,710 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pygl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473117,990,977 - 18,028,186 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473117,990,877 - 18,028,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pygl
333 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000009183
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
RH131951  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2142,223,328 - 2,223,512 (+)MAPPERmRatBN7.2
Rnor_6.0692,629,544 - 92,629,727NCBIRnor6.0
Rnor_6.0143,240,565 - 3,240,748NCBIRnor6.0
Rnor_5.0143,241,157 - 3,241,340UniSTSRnor5.0
Rnor_5.06102,076,929 - 102,077,112UniSTSRnor5.0
RGSC_v3.4142,781,150 - 2,781,333UniSTSRGSC3.4
Celera142,241,986 - 2,242,169UniSTS
RH 3.4 Map1437.2UniSTS
Cytogenetic Map14p22UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009183   ⟹   ENSRNOP00000009183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl688,697,593 - 88,740,310 (-)Ensembl
Rnor_6.0 Ensembl692,597,706 - 92,643,847 (-)Ensembl
RefSeq Acc Id: NM_022268   ⟹   NP_071604
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8694,433,558 - 94,476,219 (-)NCBI
mRatBN7.2688,697,598 - 88,740,260 (-)NCBI
Rnor_6.0692,597,759 - 92,643,734 (-)NCBI
Rnor_5.06102,045,144 - 102,091,119 (-)NCBI
RGSC_v3.4692,298,339 - 92,341,347 (-)RGD
Celera687,191,869 - 87,228,313 (-)RGD
Sequence:
RefSeq Acc Id: NP_071604   ⟸   NM_022268
- UniProtKB: P09811 (UniProtKB/Swiss-Prot),   A6HBY8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009183   ⟸   ENSRNOT00000009183

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09811-F1-model_v2 AlphaFold P09811 1-850 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694644
Promoter ID:EPDNEW_R5166
Type:initiation region
Name:Pygl_1
Description:glycogen phosphorylase L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0692,643,810 - 92,643,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620687 AgrOrtholog
BioCyc Gene G2FUF-37214 BioCyc
BioCyc Pathway PWY-5941 [glycogen degradation II] BioCyc
BioCyc Pathway Image PWY-5941 BioCyc
Ensembl Genes ENSRNOG00000006388 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055008990 UniProtKB/Swiss-Prot
  ENSRNOG00060006655 UniProtKB/Swiss-Prot
  ENSRNOG00065006991 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009183.6 UniProtKB/Swiss-Prot
  ENSRNOT00055015198 UniProtKB/Swiss-Prot
  ENSRNOT00060010914 UniProtKB/Swiss-Prot
  ENSRNOT00065010917 UniProtKB/Swiss-Prot
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100896 IMAGE-MGC_LOAD
InterPro Glycg_phsphrylas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_trans_35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal_P_attach_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91696 IMAGE-MGC_LOAD
NCBI Gene 64035 ENTREZGENE
PANTHER GLYCOGEN PHOSPHORYLASE UniProtKB/TrEMBL
  GLYCOGEN PHOSPHORYLASE, LIVER FORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11468 UniProtKB/Swiss-Prot
Pfam Phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pygl PhenoGen
PIRSF Pprylas_GlgP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PHOSPHORYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006388 RatGTEx
  ENSRNOG00055008990 RatGTEx
  ENSRNOG00060006655 RatGTEx
  ENSRNOG00065006991 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HBY8 ENTREZGENE, UniProtKB/TrEMBL
  A6HBY9_RAT UniProtKB/TrEMBL
  A6HBZ0_RAT UniProtKB/TrEMBL
  P09811 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-18 Pygl  glycogen phosphorylase L  Pygl  phosphorylase, glycogen, liver  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Pygl  phosphorylase, glycogen, liver  Pygl  liver glycogen phosphorylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pygl  liver glycogen phosphorylase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pygl  liver glycogen phosphorylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease inhibition of enzyme activity inhibits glyocogenolysis without altering gluconeogenesis and may have application to treatment of type 2 diabetes 729891