Dnase1l3 (deoxyribonuclease 1L3) - Rat Genome Database

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Gene: Dnase1l3 (deoxyribonuclease 1L3) Rattus norvegicus
Analyze
Symbol: Dnase1l3
Name: deoxyribonuclease 1L3 (Ensembl:deoxyribonuclease 1-like 3)
RGD ID: 620669
Description: Enables DNA binding activity and DNA endonuclease activity. Predicted to be involved in several processes, including apoptotic DNA fragmentation; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1 like 3); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyribonuclease 1-like 3; deoxyribonuclease gamma; deoxyribonuclease gamma-like; deoxyribonuclease I-like 3; DNase gamma; DNase I-like 3; DNaseY; LOC103690049; MGC108624
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,351,683 - 19,378,536 (+)NCBIGRCr8
mRatBN7.21516,922,335 - 16,948,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,097,088 - 19,122,996 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,055,563 - 20,081,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,310,474 - 18,336,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,710,492 - 18,736,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01521,913,671 - 21,925,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01522,676,702 - 22,702,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,909,363 - 18,935,347 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,909,362 - 18,935,344 (+)NCBI
Celera1516,878,636 - 16,904,597 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
Echimidine  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (ISO)
glucose  (ISO)
glyphosate  (ISO)
Heliotrine  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Host DNases prevent vascular occlusion by neutrophil extracellular traps. Jiménez-Alcázar M, etal., Science. 2017 Dec 1;358(6367):1202-1206. doi: 10.1126/science.aam8897.
4. DNaseY: a rat DNaseI-like gene coding for a constitutively expressed chromatin-bound endonuclease. Liu QY, etal., Biochemistry 1998 Jul 14;37(28):10134-43.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma. Shiokawa D and Tanuma S, Biochem J 1998 Jun 15;332 ( Pt 3):713-20.
12. Identification of an endonuclease responsible for apoptosis in rat thymocytes. Shiokawa D, etal., Eur J Biochem 1994 Nov 15;226(1):23-30.
Additional References at PubMed
PMID:9307016   PMID:9328279   PMID:12050166   PMID:12477932   PMID:15118903   PMID:15167901   PMID:15489334   PMID:23229555  


Genomics

Comparative Map Data
Dnase1l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,351,683 - 19,378,536 (+)NCBIGRCr8
mRatBN7.21516,922,335 - 16,948,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,097,088 - 19,122,996 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,055,563 - 20,081,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,310,474 - 18,336,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,710,492 - 18,736,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01521,913,671 - 21,925,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01522,676,702 - 22,702,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,909,363 - 18,935,347 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,909,362 - 18,935,344 (+)NCBI
Celera1516,878,636 - 16,904,597 (+)NCBICelera
Cytogenetic Map15p14NCBI
DNASE1L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,192,257 - 58,210,972 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,192,257 - 58,214,697 (-)EnsemblGRCh38hg38GRCh38
GRCh37358,177,984 - 58,196,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,153,394 - 58,175,438 (-)NCBINCBI36Build 36hg18NCBI36
Build 34358,153,393 - 58,175,438NCBI
Celera358,192,880 - 58,214,912 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,275,239 - 58,293,591 (-)NCBIHuRef
CHM1_1358,128,540 - 58,147,077 (-)NCBICHM1_1
T2T-CHM13v2.0358,232,673 - 58,251,379 (-)NCBIT2T-CHM13v2.0
Dnase1l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,475,014 - 14,504,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,475,200 - 14,505,240 (+)EnsemblGRCm39 Ensembl
GRCm38147,965,187 - 7,994,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,964,533 - 7,994,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv37148,797,701 - 8,826,696 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,757,066 - 6,786,061 (-)NCBIMGSCv36mm8
Celera143,588,560 - 3,617,542 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.67NCBI
Dnase1l3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,867,109 - 7,892,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554307,867,172 - 7,892,079 (-)NCBIChiLan1.0ChiLan1.0
DNASE1L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,162,226 - 58,181,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,167,000 - 58,186,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,127,491 - 58,146,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,542,243 - 59,560,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,542,243 - 59,560,363 (-)Ensemblpanpan1.1panPan2
DNASE1L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,350,138 - 32,379,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,358,110 - 32,379,245 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,279,076 - 32,308,726 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,622,923 - 32,652,898 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,631,042 - 32,653,137 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,078,710 - 32,108,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,434,957 - 32,464,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,607,074 - 32,636,716 (+)NCBIUU_Cfam_GSD_1.0
Dnase1l3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118175,291,652 - 175,356,649 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364738,430,231 - 8,457,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364738,430,235 - 8,495,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,958,387 - 39,975,946 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,958,384 - 39,976,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,927,674 - 43,932,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,487,767 - 19,496,019 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,487,596 - 19,496,129 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,331,166 - 147,373,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnase1l3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821849,434 - 871,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821845,631 - 871,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnase1l3
241 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000012532
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat

Markers in Region
RH130735  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21516,948,041 - 16,948,225 (+)MAPPERmRatBN7.2
Rnor_6.01518,736,196 - 18,736,379NCBIRnor6.0
Rnor_6.01517,944,832 - 17,945,015NCBIRnor6.0
Rnor_5.01522,702,650 - 22,702,833UniSTSRnor5.0
Rnor_5.01521,925,089 - 21,925,272UniSTSRnor5.0
RGSC_v3.41518,935,067 - 18,935,250UniSTSRGSC3.4
Celera1516,904,317 - 16,904,500UniSTS
RH 3.4 Map15139.0UniSTS
Cytogenetic Map15p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 19 19 19
Low 1 9 30 22 22 8 10 5 10 22 10 8
Below cutoff 6 1 40 17 15 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF039852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000012532   ⟹   ENSRNOP00000012532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)Ensembl
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090768   ⟹   ENSRNOP00000081557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,922,335 - 16,948,315 (+)Ensembl
RefSeq Acc Id: NM_053907   ⟹   NP_446359
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,352,552 - 19,378,536 (+)NCBI
mRatBN7.21516,922,335 - 16,948,322 (+)NCBI
Rnor_6.01518,710,492 - 18,736,476 (+)NCBI
Rnor_5.01522,676,702 - 22,702,930 (+)NCBI
RGSC_v3.41518,909,363 - 18,935,347 (+)RGD
Celera1516,878,636 - 16,904,597 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273913   ⟹   XP_063129983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,351,683 - 19,378,536 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446359   ⟸   NM_053907
- Peptide Label: precursor
- UniProtKB: O89107 (UniProtKB/Swiss-Prot),   A6K0C3 (UniProtKB/TrEMBL),   A0A8I5ZSG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012532   ⟸   ENSRNOT00000012532
RefSeq Acc Id: ENSRNOP00000081557   ⟸   ENSRNOT00000090768
RefSeq Acc Id: XP_063129983   ⟸   XM_063273913
- Peptide Label: isoform X1
- UniProtKB: O89107 (UniProtKB/Swiss-Prot),   A6K0C3 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89107-F1-model_v2 AlphaFold O89107 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699592
Promoter ID:EPDNEW_R10115
Type:multiple initiation site
Name:Dnase1l3_2
Description:deoxyribonuclease 1-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10116  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,710,477 - 18,710,537EPDNEW
RGD ID:13699593
Promoter ID:EPDNEW_R10116
Type:multiple initiation site
Name:Dnase1l3_1
Description:deoxyribonuclease 1-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10115  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,710,665 - 18,710,725EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620669 AgrOrtholog
BioCyc Gene G2FUF-14284 BioCyc
Ensembl Genes ENSRNOG00000009291 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055013867 UniProtKB/Swiss-Prot
  ENSRNOG00060020997 UniProtKB/Swiss-Prot
  ENSRNOG00065008865 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012532 ENTREZGENE
  ENSRNOT00000012532.5 UniProtKB/Swiss-Prot
  ENSRNOT00000090768.2 UniProtKB/TrEMBL
  ENSRNOT00055023854 UniProtKB/Swiss-Prot
  ENSRNOT00060036436 UniProtKB/Swiss-Prot
  ENSRNOT00065014155 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325326 IMAGE-MGC_LOAD
InterPro Deoxyribonuclease-1_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNase_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108624 IMAGE-MGC_LOAD
NCBI Gene 116687 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEOXYRIBONUCLEASE GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dnase1l3 PhenoGen
PIRSF DNase_I_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DNASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNASE_I_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009291 RatGTEx
  ENSRNOG00055013867 RatGTEx
  ENSRNOG00060020997 RatGTEx
  ENSRNOG00065008865 RatGTEx
SMART DNaseIc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZSG6 ENTREZGENE, UniProtKB/TrEMBL
  A6K0C3 ENTREZGENE, UniProtKB/TrEMBL
  DNSL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-29 Dnase1l3  deoxyribonuclease 1L3  Dnase1l3  deoxyribonuclease 1-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Dnase1l3  deoxyribonuclease 1-like 3  LOC103690049  deoxyribonuclease gamma-like  Data merged from RGD:9371112 737654 PROVISIONAL
2014-08-25 LOC103690049  deoxyribonuclease gamma-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Dnase1l3  deoxyribonuclease 1-like 3  Dnase1l3  deoxyribonuclease I-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dnase1l3  deoxyribonuclease I-like 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dnase1l3  deoxyribonuclease I-like 3      Symbol and Name status set to provisional 70820 PROVISIONAL