Hspa2 (heat shock protein family A (Hsp70) member 2) - Rat Genome Database

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Gene: Hspa2 (heat shock protein family A (Hsp70) member 2) Rattus norvegicus
Analyze
Symbol: Hspa2
Name: heat shock protein family A (Hsp70) member 2
RGD ID: 620664
Description: Enables protein-folding chaperone binding activity and tau protein binding activity. Predicted to be involved in several processes, including negative regulation of inclusion body assembly; protein folding; and response to cold. Predicted to act upstream of or within several processes, including male gamete generation; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Predicted to be located in cell surface; meiotic spindle; and nucleus. Predicted to be part of CatSper complex. Predicted to be active in cytosol; nucleus; and plasma membrane. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-carnitine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock 70kDa protein 2; heat shock protein 2; heat shock protein 70.2; heat shock protein alpha 2; heat shock protein family A member 2; heat shock-related 70 kDa protein 2; Hspt70; HST; Hst70; MGC93458; testis-specific heat shock protein-related gene hst70
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,864,172 - 100,866,946 (+)NCBIGRCr8
mRatBN7.2695,128,504 - 95,131,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,128,350 - 95,131,287 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,522,154 - 95,524,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,820,668 - 95,823,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,249,481 - 95,251,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,433,575 - 99,436,288 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,433,550 - 99,436,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,843,592 - 108,846,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,000,541 - 99,003,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,003,760 - 99,006,497 (+)NCBI
Celera693,553,144 - 93,555,644 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(R)-carnitine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dichloroindophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dihydroxyacetone  (ISO)
dinophysistoxin 1  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
phenethyl caffeate  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quartz  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. Carrettiero DC, etal., J Neurosci. 2009 Feb 18;29(7):2151-61. doi: 10.1523/JNEUROSCI.4660-08.2009.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Isolation and nucleotide sequence analysis of the rat testis-specific major heat-shock protein (HSP70)-related gene. Wisniewski J, etal., Biochim Biophys Acta 1990 Jan 30;1048(1):93-9.
Additional References at PubMed
PMID:8622925   PMID:9247342   PMID:9337084   PMID:9409676   PMID:14651853   PMID:14766014   PMID:15914229   PMID:17035236   PMID:17110338   PMID:17634366   PMID:19056867   PMID:19946888  
PMID:21224844   PMID:21231916   PMID:21630459   PMID:22495301   PMID:22516433   PMID:23921388   PMID:24557841   PMID:25043441  


Genomics

Comparative Map Data
Hspa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,864,172 - 100,866,946 (+)NCBIGRCr8
mRatBN7.2695,128,504 - 95,131,281 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,128,350 - 95,131,287 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,522,154 - 95,524,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,820,668 - 95,823,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,249,481 - 95,251,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,433,575 - 99,436,288 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,433,550 - 99,436,289 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06108,843,592 - 108,846,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,000,541 - 99,003,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,003,760 - 99,006,497 (+)NCBI
Celera693,553,144 - 93,555,644 (+)NCBICelera
Cytogenetic Map6q24NCBI
HSPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,535,905 - 64,543,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,535,905 - 64,546,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371465,002,623 - 65,009,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,076,939 - 64,079,708 (+)NCBINCBI36Build 36hg18NCBI36
Build 341464,072,375 - 64,079,705NCBI
Celera1445,064,915 - 45,067,684 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,179,854 - 45,182,623 (+)NCBIHuRef
CHM1_11464,946,881 - 64,949,650 (+)NCBICHM1_1
T2T-CHM13v2.01458,743,704 - 58,751,035 (+)NCBIT2T-CHM13v2.0
Hspa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,450,688 - 76,453,712 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,450,950 - 76,453,712 (+)EnsemblGRCm39 Ensembl
GRCm381276,403,812 - 76,406,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,404,176 - 76,406,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv371277,505,163 - 77,507,925 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,323,016 - 77,325,778 (+)NCBIMGSCv36mm8
Celera1277,495,202 - 77,497,964 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Hspa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,344,366 - 5,347,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554665,344,366 - 5,347,707 (-)NCBIChiLan1.0ChiLan1.0
HSPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,654,654 - 65,657,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,871,169 - 64,874,046 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,124,326 - 45,127,105 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,373,462 - 63,376,240 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,373,840 - 63,375,762 (+)Ensemblpanpan1.1panPan2
HSPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,967,104 - 38,969,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,967,400 - 38,969,313 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,658,560 - 38,661,200 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,188,332 - 39,191,053 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,188,237 - 39,191,347 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,810,203 - 38,812,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,881,460 - 38,884,183 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,241,859 - 39,244,579 (+)NCBIUU_Cfam_GSD_1.0
Hspa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,945,617 - 65,948,642 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364958,243,369 - 8,246,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1788,607,140 - 88,609,947 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2794,987,337 - 94,990,126 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,747,485 - 41,750,266 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,747,864 - 41,749,783 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,924,231 - 29,927,019 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,476,372 - 36,478,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hspa2
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:248
Count of miRNA genes:173
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000008504
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 3 24 16 24
Low 43 44 28 19 28 8 11 50 19 10 11 8
Below cutoff 13 13 13

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008504   ⟹   ENSRNOP00000008504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl695,128,350 - 95,131,287 (+)Ensembl
Rnor_6.0 Ensembl699,433,572 - 99,436,284 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079359   ⟹   ENSRNOP00000069216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl699,433,550 - 99,436,289 (+)Ensembl
RefSeq Acc Id: NM_021863   ⟹   NP_068635
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,864,442 - 100,866,942 (+)NCBI
mRatBN7.2695,128,777 - 95,131,277 (+)NCBI
Rnor_6.0699,433,784 - 99,436,284 (+)NCBI
Rnor_5.06108,843,592 - 108,846,304 (+)NCBI
RGSC_v3.4699,000,541 - 99,003,041 (+)RGD
Celera693,553,144 - 93,555,644 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240247   ⟹   XP_006240309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,864,172 - 100,866,946 (+)NCBI
mRatBN7.2695,128,504 - 95,131,281 (+)NCBI
Rnor_6.0699,433,575 - 99,436,288 (+)NCBI
Rnor_5.06108,843,592 - 108,846,304 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_068635   ⟸   NM_021863
- UniProtKB: P14659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240309   ⟸   XM_006240247
- Peptide Label: isoform X1
- UniProtKB: Q66HL1 (UniProtKB/Swiss-Prot),   P14659 (UniProtKB/Swiss-Prot),   A6HCA7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069216   ⟸   ENSRNOT00000079359
RefSeq Acc Id: ENSRNOP00000008504   ⟸   ENSRNOT00000008504

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14659-F1-model_v2 AlphaFold P14659 1-633 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694676
Promoter ID:EPDNEW_R5201
Type:initiation region
Name:Hspa2_1
Description:heat shock protein family A member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0699,433,553 - 99,433,613EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620664 AgrOrtholog
BioCyc Gene G2FUF-37058 BioCyc
Ensembl Genes ENSRNOG00000006472 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018718 UniProtKB/Swiss-Prot
  ENSRNOG00060028285 UniProtKB/Swiss-Prot
  ENSRNOG00065017251 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008504.6 UniProtKB/Swiss-Prot
  ENSRNOT00055031878 UniProtKB/Swiss-Prot
  ENSRNOT00060049149 UniProtKB/Swiss-Prot
  ENSRNOT00065028741 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112083 IMAGE-MGC_LOAD
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60460 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93458 IMAGE-MGC_LOAD
NCBI Gene 60460 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN 70KDA UniProtKB/TrEMBL
  HEAT SHOCK-RELATED 70 KDA PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa2 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006472 RatGTEx
  ENSRNOG00055018718 RatGTEx
  ENSRNOG00060028285 RatGTEx
  ENSRNOG00065017251 RatGTEx
Superfamily-SCOP Actin-like ATPase domain UniProtKB/TrEMBL
  Heat shock protein 70kD (HSP70), C-terminal subdomain UniProtKB/TrEMBL
  Heat shock protein 70kD (HSP70), peptide-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A6HCA7 ENTREZGENE, UniProtKB/TrEMBL
  HSP72_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL1 ENTREZGENE
UniProt Secondary Q66HL1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Hspa2  heat shock protein family A (Hsp70) member 2  Hspa2  heat shock protein family A member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa2  heat shock protein family A member 2  Hspa2  heat shock protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Hspa2  heat shock protein 2  Hspa2  heat shock protein alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 Hspa2  heat shock protein alpha 2  Hspa2  heat shock protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Hspa2  heat shock protein 2  Hspa2  heat shock 70kDa protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hspa2  heat shock 70kDa protein 2    heat shock protein 2  Name updated 1299863 APPROVED
2004-12-14 Hspa2  heat shock protein 2  Hspt70  testis-specific heat shock protein-related gene hst70  Symbol and Name updated 1299863 APPROVED
2002-08-07 Hspt70  testis-specific heat shock protein-related gene hst70      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains 5' flanking region has TATA-boxes, heat-shock element and estrogen receptor binding site 633062
gene_expression expressed in the testis 633062
gene_protein 2947 bp in size 633062