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Gene:
Ptpn6 ( Rattus norvegicus )
protein tyrosine phosphatase, non-receptor type 6
Description:plays a role in activation and proliferation of glial cells and astrocytes
Synonyms:Shp-1; Ptph6; MGC124580;  (details...)
ArrayIDs:GE22050; A_42_P471271; 1368010_at; 6681267; 6323054; U77038_g_at; 6567652; 5751007; 6244902; 6603887; 6597264; 6398504; 6144624; 6534800; 6291589; 6665381; 5735851; 6358072; U77038_at; 6456184; 5980812; 5754995;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: PTPN6     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ptpn6     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusPtpn6genome assembly 3.14161088634 - 161113792
  Rat Celera Assembly4146264699 - 146289047
  RGSC genome assembly v3.44160843702 - 160868854
  Cytogenetic4q42
Mus musculusPtpn6Mouse genome assembly build 36.16124670736 - 124688727
  Cytogenetic66 F2
Homo sapiensPTPN6human genome assembly126930762 - 6940740
  Human genome assembly build 36.2126926001 - 6940740
  Cytogenetic12p13
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
Gene Ontology
protein binding,  SH3 domain binding,  SH2 domain binding ...  (details...)
Biological Process
Gene Ontology
negative regulation of T cell receptor signaling pathway,  B cell receptor signaling pathway,  response to wounding ...  (details...)
Cellular Component
Gene Ontology
nucleus,  cytoplasm,  alpha-beta T cell receptor complex ...  (details...)
Pathway
Ontology
Jak-Stat signaling pathway (details...)
 
 External Links
Databases
DATABASEIDSOURCE
SMART:SH2IPI
SMART:PTPcIPI
PROSITE:TYR_PHOSPHATASE_1IPI
PROSITE:TYR_PHOSPHATASE_PTPIPI
PROSITE:TYR_PHOSPHATASE_2IPI
PROSITE:SH2IPI
UNIPARC:UPI0001B7B974IPI
UNIPARC:UPI00000E876FIPI
UNIPARC:UPI0001B7B973IPI
KEGG Report:rno:116689ENTREZGENE
HomoloGene Group ID:56589ENTREZGENE
Germonline:620660
Pfam:SH2IPI
Pfam:Y_phosphataseIPI
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04520ENTREZGENE
KEGG Pathway:04630ENTREZGENE
KEGG Pathway:04650ENTREZGENE
KEGG Pathway:04660ENTREZGENE
InterPro:Tyr_Pase_AS.IPI
InterPro:Dual-sp/Tyr_phosphatase.IPI
InterPro:SH2.IPI
InterPro:Tyr_Pase_non-rcpt_typ-6/11.IPI
InterPro:Tyr_Pase_rcpt/non-rcpt.IPI
Ensembl Protein:ENSRNOP00000061110IPI
Ensembl Protein:ENSRNOP00000019462IPI
Ensembl Protein:ENSRNOP00000059867IPI
IPI:IPI00339114IPI
IPI:IPI00950168IPI
IPI:IPI00949021IPI
Gene3D-CATH:SH2IPI
Entrez Gene:Ptpn6ENTREZGENE
PIRSF:Tyr-Ptase_nr_6IPI
IMAGE_CLONE:IMAGE:7932620IMAGE-MGC_LOAD
MGC_CLONE:MGC:124580IMAGE-MGC_LOAD
UniProt:Q8R5H0_RATIPI
UniProt:PTN6_RATIPI
UniProt:Q499N7_RATIPI
Ensembl Genes:ENSRNOG00000014294IPI
PRINTS:SH2DOMAIN.IPI
PRINTS:PRTYPHPHTASE.IPI
Sequences
Nucleotide:NM_053908Get FASTASearch GEO Profiles
Nucleotide:CH473964Get FASTASearch GEO Profiles
Nucleotide:AF468653Get FASTASearch GEO Profiles
Nucleotide:BC099824Get FASTASearch GEO Profiles
Nucleotide:U77038Get FASTASearch GEO Profiles
(View all 5 Nucleotide Accessions)
Protein:Q499N7Get FASTA
Protein:AAD00262Get FASTA
Protein:P81718Get FASTA
Protein:Q8R5H0Get FASTA
Protein:EDM01945Get FASTA
Protein:NP_446360Get FASTA
Protein:AAL77056Get FASTA
Protein:EDM01944Get FASTA
Protein:AAH99824Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene:18985
 
 References
Curated References
7 references in RGD related to Ptpn6
Other References
13 other references at PubMed related to Ptpn6
 
 Database Information
RGD ID620660
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
20-JAN-05: Ptpn6 protein tyrosine phosphatase, non-receptor type 6 Ptph6 APPROVED Symbol updated 1299863
07-AUG-02: Ptph6 protein tyrosine phosphatase, non-receptor type 6 PROVISIONAL Symbol and Name status set to provisional 70820

       

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