Slc37a4 (solute carrier family 37 member 4) - Rat Genome Database

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Gene: Slc37a4 (solute carrier family 37 member 4) Rattus norvegicus
Analyze
Symbol: Slc37a4
Name: solute carrier family 37 member 4
RGD ID: 62066
Description: Enables glucose-6-phosphate transmembrane transporter activity. Involved in glucose-6-phosphate transport; response to glucose; and response to nutrient. Predicted to be located in endomembrane system and organelle membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIw; glycogen storage disease Ib; and glycogen storage disease Ic. Orthologous to human SLC37A4 (solute carrier family 37 member 4); PARTICIPATES IN electron transport chain pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G6pt1; glucose-6-phosphatase transport protein 1; glucose-6-phosphatase, transport protein 1; glucose-6-phosphate exchanger SLC37A4; glucose-6-phosphate translocase; solute carrier family 37 (glucose-6-phosphate transporter), member 4; solute carrier family 37 (glycerol-6-phosphate transporter), member 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,619,952 - 53,626,110 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,620,141 - 53,626,110 (+)EnsemblGRCr8
mRatBN7.2844,723,216 - 44,729,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,723,339 - 44,729,301 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx850,219,432 - 50,225,517 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,498,149 - 48,504,234 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,368,147 - 46,374,232 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,716,914 - 48,723,024 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,716,939 - 48,723,024 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,335,891 - 47,341,995 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,363,896 - 47,369,981 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,309,446 - 44,315,531 (+)NCBICelera
RGSC_v3.1847,372,661 - 47,378,744 (+)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bufotalin  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicyclanil  (ISO)
dioxygen  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
fructose  (EXP)
fumonisin B1  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
heptachlor  (EXP)
ivermectin  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Mumbaistatin  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Evidence for glucose-6-phosphate transport in rat liver microsomes. Gerin I and Van Schaftingen E, FEBS Lett. 2002 Apr 24;517(1-3):257-60.
3. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib. Gerin I, etal., FEBS Lett. 1997 Dec 15;419(2-3):235-8.
4. Effects of fasting and refeeding on the activity of hepatic glucose-6-phosphatase in rats. Khan A, etal., Acta Physiol Scand. 1985 Aug;124(4):591-6.
5. Diabetes affects similarly the catalytic subunit and putative glucose-6-phosphate translocase of glucose-6-phosphatase. Li Y, etal., J Biol Chem. 1999 Nov 26;274(48):33866-8.
6. Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. Lin B, etal., J Biol Chem 1998 Nov 27;273(48):31656-60.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
11. Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase. Parker JC, etal., Diabetes. 1998 Oct;47(10):1630-6.
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10318794   PMID:11121425   PMID:11140953   PMID:12560945   PMID:12925567   PMID:15661744   PMID:16891306   PMID:17303657   PMID:17588937   PMID:18337460   PMID:19946888   PMID:21949678  


Genomics

Comparative Map Data
Slc37a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,619,952 - 53,626,110 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,620,141 - 53,626,110 (+)EnsemblGRCr8
mRatBN7.2844,723,216 - 44,729,301 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,723,339 - 44,729,301 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx850,219,432 - 50,225,517 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,498,149 - 48,504,234 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,368,147 - 46,374,232 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,716,914 - 48,723,024 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,716,939 - 48,723,024 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,335,891 - 47,341,995 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,363,896 - 47,369,981 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,309,446 - 44,315,531 (+)NCBICelera
RGSC_v3.1847,372,661 - 47,378,744 (+)NCBI
Cytogenetic Map8q22NCBI
SLC37A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,024,112 - 119,030,877 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,023,751 - 119,030,906 (-)Ensemblhg38GRCh38
GRCh3711118,894,822 - 118,901,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,400,274 - 118,406,800 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411118,400,273 - 118,406,629NCBI
Celera11116,053,114 - 116,059,668 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11114,834,720 - 114,841,274 (-)NCBIHuRef
CHM1_111118,781,352 - 118,787,906 (-)NCBICHM1_1
T2T-CHM13v2.011119,044,474 - 119,051,238 (-)NCBIT2T-CHM13v2.0
Slc37a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,308,243 - 44,314,263 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,308,149 - 44,314,265 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38944,396,946 - 44,402,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,396,852 - 44,402,968 (+)Ensemblmm10GRCm38
MGSCv37944,206,259 - 44,211,049 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36944,149,171 - 44,153,961 (+)NCBIMGSCv36mm8
Celera941,645,753 - 41,650,553 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
Slc37a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,133,652 - 20,139,542 (-)Ensembl
ChiLan1.0NW_00495541220,133,652 - 20,140,134 (-)NCBIChiLan1.0ChiLan1.0
SLC37A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29119,729,117 - 119,736,189 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111120,832,867 - 120,840,028 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011113,862,537 - 113,869,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111117,792,700 - 117,799,269 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,792,700 - 117,799,269 (-)EnsemblpanPan2panpan1.1
SLC37A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,823,485 - 14,830,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,823,499 - 14,830,004 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha514,876,420 - 14,882,925 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0514,766,724 - 14,773,278 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,766,743 - 14,773,278 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,905,007 - 14,911,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,808,746 - 14,815,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,849,134 - 14,855,669 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc37a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,058,817 - 101,065,693 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365423,980,236 - 3,987,066 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365423,980,538 - 3,987,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC37A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,247,282 - 46,254,031 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1946,247,278 - 46,254,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,282,374 - 51,289,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC37A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,396,133 - 110,402,737 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,395,612 - 110,401,358 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604315,631,589 - 15,638,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc37a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,415,395 - 14,421,944 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478414,415,385 - 14,421,953 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc37a4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1838,944,148 - 38,950,275 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc37a4
49 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:69
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000015810
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH127561  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,728,982 - 44,729,197 (+)MAPPERmRatBN7.2
Rnor_6.0848,722,706 - 48,722,920NCBIRnor6.0
Rnor_5.0847,341,677 - 47,341,891UniSTSRnor5.0
RGSC_v3.4847,369,663 - 47,369,877UniSTSRGSC3.4
Celera844,315,213 - 44,315,427UniSTS
RH 3.4 Map8438.4UniSTS
Cytogenetic Map8q22UniSTS
RH129457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,728,836 - 44,729,041 (+)MAPPERmRatBN7.2
Rnor_6.0848,722,560 - 48,722,764NCBIRnor6.0
Rnor_5.0847,341,531 - 47,341,735UniSTSRnor5.0
RGSC_v3.4847,369,517 - 47,369,721UniSTSRGSC3.4
Celera844,315,067 - 44,315,271UniSTS
RH 3.4 MapX164.6UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001416484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF080468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015810   ⟹   ENSRNOP00000015810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,620,208 - 53,626,110 (+)Ensembl
mRatBN7.2 Ensembl844,723,339 - 44,729,301 (+)Ensembl
Rnor_6.0 Ensembl848,716,939 - 48,723,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089763   ⟹   ENSRNOP00000068889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,620,141 - 53,626,106 (+)Ensembl
mRatBN7.2 Ensembl844,723,339 - 44,729,301 (+)Ensembl
Rnor_6.0 Ensembl848,718,329 - 48,723,024 (+)Ensembl
RefSeq Acc Id: NM_001416484   ⟹   NP_001403413
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,208 - 53,626,110 (+)NCBI
mRatBN7.2844,723,399 - 44,729,301 (+)NCBI
RefSeq Acc Id: NM_001416485   ⟹   NP_001403414
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,208 - 53,626,110 (+)NCBI
mRatBN7.2844,723,399 - 44,729,301 (+)NCBI
RefSeq Acc Id: NM_031589   ⟹   NP_113777
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,025 - 53,626,110 (+)NCBI
mRatBN7.2844,723,216 - 44,729,301 (+)NCBI
Rnor_6.0848,716,939 - 48,723,024 (+)NCBI
Rnor_5.0847,335,891 - 47,341,995 (+)NCBI
RGSC_v3.4847,363,896 - 47,369,981 (+)RGD
Celera844,309,446 - 44,315,531 (+)RGD
Sequence:
RefSeq Acc Id: XM_008766151   ⟹   XP_008764373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,171 - 53,626,110 (+)NCBI
mRatBN7.2844,724,819 - 44,728,792 (+)NCBI
Rnor_6.0848,718,591 - 48,723,024 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080967   ⟹   XP_038936895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,173 - 53,626,110 (+)NCBI
mRatBN7.2844,724,920 - 44,729,293 (+)NCBI
RefSeq Acc Id: XM_063265020   ⟹   XP_063121090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,441 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265021   ⟹   XP_063121091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,123 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265022   ⟹   XP_063121092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,619,952 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265023   ⟹   XP_063121093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,443 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265025   ⟹   XP_063121095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,619,952 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265026   ⟹   XP_063121096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,619,952 - 53,626,110 (+)NCBI
RefSeq Acc Id: XM_063265027   ⟹   XP_063121097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,620,442 - 53,626,110 (+)NCBI
RefSeq Acc Id: NP_113777   ⟸   NM_031589
- UniProtKB: Q6IRK4 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764373   ⟸   XM_008766151
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTY3 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068889   ⟸   ENSRNOT00000089763
Ensembl Acc Id: ENSRNOP00000015810   ⟸   ENSRNOT00000015810
RefSeq Acc Id: XP_038936895   ⟸   XM_039080967
- Peptide Label: isoform X3
- UniProtKB: F7EWB7 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403414   ⟸   NM_001416485
- UniProtKB: Q6IRK4 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403413   ⟸   NM_001416484
- UniProtKB: Q6IRK4 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121095   ⟸   XM_063265025
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTY3 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121096   ⟸   XM_063265026
- Peptide Label: isoform X3
- UniProtKB: F7EWB7 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121092   ⟸   XM_063265022
- Peptide Label: isoform X2
- UniProtKB: Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121091   ⟸   XM_063265021
- Peptide Label: isoform X2
- UniProtKB: Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121090   ⟸   XM_063265020
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTY3 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121097   ⟸   XM_063265027
- Peptide Label: isoform X3
- UniProtKB: F7EWB7 (UniProtKB/TrEMBL),   Q9Z296 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121093   ⟸   XM_063265023
- Peptide Label: isoform X2
- UniProtKB: Q9Z296 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTY3-F1-model_v2 AlphaFold A0A0G2JTY3 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695896
Promoter ID:EPDNEW_R6418
Type:multiple initiation site
Name:Slc37a4_1
Description:solute carrier family 37 member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,718,412 - 48,718,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62066 AgrOrtholog
BioCyc Gene G2FUF-30721 BioCyc
Ensembl Genes ENSRNOG00000011361 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015810 ENTREZGENE
  ENSRNOT00000015810.7 UniProtKB/TrEMBL
  ENSRNOT00000089763 ENTREZGENE
  ENSRNOT00000089763.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098680 IMAGE-MGC_LOAD
InterPro GlpT_transporter UniProtKB/TrEMBL
  Major_facilitator_SF UniProtKB/TrEMBL
  MFS_1 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  OPA_Antiporter UniProtKB/TrEMBL
  Sugar-P_transporter_CS UniProtKB/TrEMBL
MGC_CLONE MGC:91631 IMAGE-MGC_LOAD
NCBI Gene 29573 ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 UniProtKB/TrEMBL
  GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Slc37a4 PhenoGen
PIRSF Hexose_phosphate_transp UniProtKB/TrEMBL
PROSITE GLPT UniProtKB/TrEMBL
  MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011361 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
TIGR TC218217
UniProt A0A0G2JTY3 ENTREZGENE, UniProtKB/TrEMBL
  A6J3Y2_RAT UniProtKB/TrEMBL
  F7EWB7 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRK4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z296 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc37a4  solute carrier family 37 member 4  Slc37a4  solute carrier family 37 (glucose-6-phosphate transporter), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-24   solute carrier family 37 (glucose-6-phosphate transporter), member 4  Slc37a4  solute carrier family 37 (glycerol-6-phosphate transporter), member 4  Name updated 1299863 APPROVED
2004-09-10 Slc37a4  solute carrier family 37 (glycerol-6-phosphate transporter), member 4  G6pt1  glucose-6-phosphatase, transport protein 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 G6pt1  glucose-6-phosphatase, transport protein 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in liver, kidney, and intestine 61591