Clic5 (chloride intracellular channel 5) - Rat Genome Database

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Gene: Clic5 (chloride intracellular channel 5) Rattus norvegicus
Analyze
Symbol: Clic5
Name: chloride intracellular channel 5
RGD ID: 620659
Description: Enables chloride channel activity. Predicted to be involved in chloride transport; inner ear receptor cell stereocilium organization; and sensory perception of sound. Predicted to act upstream of or within several processes, including auditory receptor cell stereocilium organization; diet induced thermogenesis; and neuromuscular process controlling balance. Located in apical plasma membrane; mitochondrial inner membrane; and stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 103. Orthologous to human CLIC5 (chloride intracellular channel 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride intracellular channel protein 5; glutaredoxin-like oxidoreductase CLIC5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,208,455 - 24,310,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl924,208,456 - 24,358,780 (-)EnsemblGRCr8
mRatBN7.2916,710,980 - 16,813,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,710,980 - 16,813,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx925,300,548 - 25,400,082 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,374,783 - 30,474,345 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,663,965 - 28,763,534 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,121,676 - 19,372,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,121,677 - 19,372,673 (-)Ensemblrn6Rnor6.0
Rnor_5.0918,203,018 - 18,251,818 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0918,004,699 - 18,049,825 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4912,370,341 - 12,472,969 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera914,441,285 - 14,540,691 (-)NCBICelera
RGSC_v3.1912,367,663 - 12,470,290 (-)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
crocidolite asbestos  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function. Gagnon LH, etal., J Neurosci. 2006 Oct 4;26(40):10188-98.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Molecular identity of cardiac mitochondrial chloride intracellular channel proteins. Ponnalagu D, etal., Mitochondrion. 2016 Mar;27:6-14. doi: 10.1016/j.mito.2016.01.001. Epub 2016 Jan 9.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI. Salles FT, etal., Cytoskeleton (Hoboken). 2014 Jan;71(1):61-78. doi: 10.1002/cm.21159. Epub 2013 Dec 10.
10. Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease. Steinmeyer K, etal., J Biol Chem 1995 Dec 29;270(52):31172-7.
Additional References at PubMed
PMID:10793131   PMID:12163479   PMID:19056867   PMID:20357015   PMID:20664558   PMID:22871113   PMID:24781754  


Genomics

Comparative Map Data
Clic5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,208,455 - 24,310,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl924,208,456 - 24,358,780 (-)EnsemblGRCr8
mRatBN7.2916,710,980 - 16,813,502 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl916,710,980 - 16,813,427 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx925,300,548 - 25,400,082 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0930,374,783 - 30,474,345 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0928,663,965 - 28,763,534 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0919,121,676 - 19,372,673 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl919,121,677 - 19,372,673 (-)Ensemblrn6Rnor6.0
Rnor_5.0918,203,018 - 18,251,818 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0918,004,699 - 18,049,825 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4912,370,341 - 12,472,969 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera914,441,285 - 14,540,691 (-)NCBICelera
RGSC_v3.1912,367,663 - 12,470,290 (-)NCBI
Cytogenetic Map9q13NCBI
CLIC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,880,827 - 46,129,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl645,880,827 - 46,080,348 (-)Ensemblhg38GRCh38
GRCh37645,866,188 - 46,097,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36645,974,171 - 46,091,553 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34645,977,485 - 46,091,545NCBI
Celera647,419,073 - 47,600,603 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef645,589,507 - 45,771,107 (-)NCBIHuRef
CHM1_1645,869,674 - 46,051,333 (-)NCBICHM1_1
T2T-CHM13v2.0645,716,118 - 45,964,907 (-)NCBIT2T-CHM13v2.0
Clic5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391744,445,671 - 44,591,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1744,445,659 - 44,591,059 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381744,134,762 - 44,280,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1744,188,584 - 44,280,172 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1744,134,768 - 44,280,172 (+)Ensemblmm10GRCm38
MGSCv371744,325,521 - 44,417,117 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361743,651,627 - 43,743,223 (+)NCBIMGSCv36mm8
Celera1747,604,897 - 47,706,768 (+)NCBICelera
Cytogenetic Map17B3NCBI
cM Map1720.53NCBI
Clic5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,053,885 - 11,118,255 (-)Ensembl
ChiLan1.0NW_00495543711,053,885 - 11,118,150 (-)NCBIChiLan1.0ChiLan1.0
CLIC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2560,387,381 - 60,505,130 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1656,253,426 - 56,371,209 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0645,474,797 - 45,592,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1646,753,007 - 46,934,100 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl646,753,013 - 46,934,100 (-)EnsemblpanPan2panpan1.1
CLIC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,160,524 - 14,318,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1214,144,390 - 14,318,582 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1214,193,104 - 14,350,325 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01214,660,621 - 14,818,027 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1214,644,744 - 14,818,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,177,139 - 14,334,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01214,265,255 - 14,422,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01214,361,798 - 14,519,297 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clic5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494649,578,625 - 49,741,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647614,283,006 - 14,381,634 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647614,234,447 - 14,381,582 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLIC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl740,682,907 - 40,863,886 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1740,683,044 - 40,808,017 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2746,946,099 - 47,128,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLIC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11726,231,192 - 26,364,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1726,231,728 - 26,343,346 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604445,867,551 - 46,089,886 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clic5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475414,370,425 - 14,434,269 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475414,335,173 - 14,433,721 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Clic5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1485,592,234 - 85,687,481 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clic5
762 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:612
Count of miRNA genes:265
Interacting mature miRNAs:335
Transcripts:ENSRNOT00000073667
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
D9Got213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2916,808,480 - 16,808,679 (+)MAPPERmRatBN7.2
Rnor_6.0919,367,803 - 19,368,001NCBIRnor6.0
Rnor_5.0918,246,948 - 18,247,146UniSTSRnor5.0
RGSC_v3.4912,468,011 - 12,468,209UniSTSRGSC3.4
Celera914,535,914 - 14,536,112UniSTS
Cytogenetic Map9q12UniSTS
D9Got215  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8924,286,742 - 24,287,006 (+)Marker Load Pipeline
mRatBN7.2916,789,281 - 16,789,545 (+)MAPPERmRatBN7.2
Rnor_6.0919,348,552 - 19,348,815NCBIRnor6.0
Rnor_5.0918,227,697 - 18,227,960UniSTSRnor5.0
RGSC_v3.4912,448,811 - 12,449,074UniSTSRGSC3.4
Celera914,516,711 - 14,516,975UniSTS
Cytogenetic Map9q12UniSTS
AU046523  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8924,254,450 - 24,254,546 (+)Marker Load Pipeline
mRatBN7.2916,756,986 - 16,757,082 (+)MAPPERmRatBN7.2
Rnor_6.0919,167,595 - 19,167,690NCBIRnor6.0
Rnor_5.0918,050,402 - 18,050,497UniSTSRnor5.0
RGSC_v3.4912,416,519 - 12,416,614UniSTSRGSC3.4
Celera914,487,249 - 14,487,344UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 356 192 11 134 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000073667   ⟹   ENSRNOP00000067890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl919,121,677 - 19,372,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079517   ⟹   ENSRNOP00000072035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl916,710,980 - 16,813,427 (-)Ensembl
Rnor_6.0 Ensembl919,123,498 - 19,372,673 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154945   ⟹   ENSRNOP00000105837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl924,208,456 - 24,310,889 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000162595   ⟹   ENSRNOP00000108591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl924,208,456 - 24,358,780 (-)Ensembl
RefSeq Acc Id: NM_053603   ⟹   NP_446055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8924,208,455 - 24,310,964 (-)NCBI
mRatBN7.2916,710,980 - 16,813,502 (-)NCBI
Rnor_6.0919,121,676 - 19,372,673 (-)NCBI
Rnor_5.0918,004,699 - 18,049,825 (-)NCBI
Rnor_5.0918,203,018 - 18,251,818 (-)NCBI
RGSC_v3.4912,370,341 - 12,472,969 (-)RGD
Celera914,441,285 - 14,540,691 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446055 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG49367 (Get FASTA)   NCBI Sequence Viewer  
  EDM18716 (Get FASTA)   NCBI Sequence Viewer  
  EDM18717 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072035.1
  ENSRNOP00000105837
GenBank Protein Q9EPT8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446055   ⟸   NM_053603
- UniProtKB: Q9EPT8 (UniProtKB/Swiss-Prot),   A6JJ16 (UniProtKB/TrEMBL),   A6JJ15 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072035   ⟸   ENSRNOT00000079517
Ensembl Acc Id: ENSRNOP00000067890   ⟸   ENSRNOT00000073667
Ensembl Acc Id: ENSRNOP00000105837   ⟸   ENSRNOT00000154945
Ensembl Acc Id: ENSRNOP00000108591   ⟸   ENSRNOT00000162595
Protein Domains
GST C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPT8-F1-model_v2 AlphaFold Q9EPT8 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696550
Promoter ID:EPDNEW_R7073
Type:initiation region
Name:Clic5_1
Description:chloride intracellular channel 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0919,372,745 - 19,372,805EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620659 AgrOrtholog
BioCyc Gene G2FUF-28135 BioCyc
Ensembl Genes ENSRNOG00000047218 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000074354 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000079517.2 UniProtKB/Swiss-Prot
  ENSRNOT00000154945 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro CLIC UniProtKB/Swiss-Prot
  CLIC5_C_GST UniProtKB/Swiss-Prot
  CLIC_N UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:94272 UniProtKB/Swiss-Prot
NCBI Gene 94272 ENTREZGENE
PANTHER CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED UniProtKB/Swiss-Prot
  PTHR45476:SF4 UniProtKB/Swiss-Prot
Pfam CLIC-like_N UniProtKB/Swiss-Prot
  GST_C_2 UniProtKB/Swiss-Prot
PhenoGen Clic5 PhenoGen
PRINTS INTCLCHANNEL UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047218 RatGTEx
  ENSRNOG00000074354 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0ABK0LRK3_RAT UniProtKB/TrEMBL
  A6JJ15 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ16 ENTREZGENE, UniProtKB/TrEMBL
  CLIC5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Clic5  chloride intracellular channel 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Clic5  chloride intracellular channel 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog may cause Dent's disease, X-linked hereditary nephrolithiasis 1302221